“…Operons (clusters of co-regulated genes with related functions) are common features of bacterial genomes. …”
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“…The fast pace of bacterial genome sequencing and the resulting dependence on highly automated annotation methods has driven the development of many genome-wide analysis tools. OperonDB, first released in 2001, is a database containing the results of a computational algorithm for locating operon structures in microbial genomes. …”
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“…Operons are a major feature of all prokaryotic genomes, but how and why operon structures vary is not well understood. …”
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“…Operon structures play an important role in co-regulation in prokaryotes. …”
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“…SUMMARY: Operon-mapper is a web server that accurately, easily and directly predicts the operons of any bacterial or archaeal genome sequence. …”
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“…We have predicted operons in P.furiosus by combining the results from three existing algorithms using a neural network (NN). …”
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“…Knowledge of operon structures is crucial to fully understand the pathophysiology of infections. …”
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“…BACKGROUND: The tetracycline operon is a self-regulated system. It is found naturally in bacteria where it confers resistance to antibiotic tetracycline. …”
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“…Many marine organisms lack an operon-type organization of these genes or have mini-operons containing only two trp genes. …”
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“…We present a study on computational identification of uber-operons in a prokaryotic genome, each of which represents a group of operons that are evolutionarily or functionally associated through operons in other (reference) genomes. …”
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“…Searching for similar operons: the database provides a search capability for a user to find operons that have similar composition and structure to a query operon. 3. …”
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“…Specifically, functional annotations are compared within pairs of adjacent co-directional genes, as well as operons of various lengths (i.e. number of member genes), in order to reveal new information about annotative cohesion versus operon length. …”
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“…RESULTS: Genetic analysis of the lac operons in the S. enterica genomes revealed that they all contain intact lacI, lacZ, and lacY genes. …”
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“…The results of studies on mce operons of the causative agent Mycobacterium tuberculosis and actinobacteria are summarized. …”
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“…BACKGROUND: Efficient regulation of bacterial genes in response to the environmental stimulus results in unique gene clusters known as operons. Lack of complete operonic reference and functional information makes the prediction of metagenomic operons a challenging task; thus, opening new perspectives on the interpretation of the host-microbe interactions. …”
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“…Using the classical lipopolysaccharide/O-antigen ‘rfb operon’ in Enterobacteriaceae as a surface antigen model (5-gene-cluster rfbABCDX), and a recent rfbA-typing strategy for strain classification (3), we characterized the architecture/conservancy of the entire rfb operon in Bacteroidota. …”
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“…BACKGROUND: Recent studies have shown that microarray-derived gene-expression data are useful for operon prediction. However, it is apparent that genes within an operon do not conform to the simple notion that they have equal levels of expression. …”
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“…BACKGROUND: The genome of Mycobacterium tuberculosis harbors four copies of a cluster of genes termed mce operons. Despite extensive research that has demonstrated the importance of these operons on infection outcome, their physiological function remains obscure. …”
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“…In some systems, noise in gene expression has been quantified, in among others the lac operon of Escherichia coli. Whether stochastic gene expression in this system is detrimental or beneficial for the cells is, however, still unclear. …”
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