Prognostic Significance of Blood-Based Multi-cancer Detection in Plasma Cell-Free DNA

por Chen, Xiaoji, Dong, Zhao, Hubbell, Earl, Kurtzman, Kathryn N., Oxnard, Geoffrey R., Venn, Oliver, Melton, Collin, Clarke, Christina A., Shaknovich, Rita, Ma, Ting, Meixiong, Gerry, Seiden, Michael V., Klein, Eric A., Fung, Eric T., Liu, Minetta C.
Publicado 2021

Early circulating tumor DNA dynamics as a pan‐tumor biomarker for long‐term clinical outcome in patients treated with durvalumab and tremelimumab

por Kansara, Maya, Bhardwaj, Neeru, Thavaneswaran, Subotheni, Xu, Chang, Lee, Jessica K., Chang, Lo‐Bin, Madison, Russell W., Lin, Frank, Hsu, Eugene, Patel, Vipul Kumar, Aleshin, Alexey, Oxnard, Geoffrey R., Simes, John, Nimeiri, Halla, Thomas, David M.
Publicado 2022

Acquired EGFR C797S mediates resistance to AZD9291 in advanced non-small cell lung cancer harboring EGFR T790M

por Thress, Kenneth S., Paweletz, Cloud P., Felip, Enriqueta, Cho, Byoung Chul, Stetson, Daniel, Dougherty, Brian, Lai, Zhongwu, Markovets, Aleksandra, Vivancos, Ana, Kuang, Yanan, Ercan, Dalia, Matthews, Sarah, Cantarini, Mireille, Barrett, J. Carl, Jänne, Pasi A., Oxnard, Geoffrey R.
Publicado 2015

Genomic Biomarkers and Genome-Wide Loss-of-Heterozygosity Scores in Metastatic Prostate Cancer Following Progression on Androgen-Targeting Therapies

por Zurita, Amado J., Graf, Ryon P., Villacampa, Guillermo, Raskina, Kira, Sokol, Ethan, Jin, Dexter, Antonarakis, Emmanuel S., Li, Gerald, Huang, Richard S. P., Casanova-Salas, Irene, Vivancos, Ana, Carles, Joan, Ross, Jeffrey S., Schrock, Alexa B., Oxnard, Geoffrey R., Mateo, Joaquin
Publicado 2022

Tumor Fraction Correlates With Detection of Actionable Variants Across > 23,000 Circulating Tumor DNA Samples

por Husain, Hatim, Pavlick, Dean C., Fendler, Bernard J., Madison, Russell W., Decker, Brennan, Gjoerup, Ole, Parachoniak, Christine A., McLaughlin-Drubin, Molly, Erlich, Rachel L., Schrock, Alexa B., Frampton, Garrett M., Das Thakur, Meghna, Oxnard, Geoffrey R., Tukachinsky, Hanna
Publicado 2022

Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations

por Ogino, Atsuko, Choi, Jihyun, Lin, Mika, Wilkens, Margaret K., Calles, Antonio, Xu, Man, Adeni, Anika E., Chambers, Emily S., Capelletti, Marzia, Butaney, Mohit, Gray, Nathanael S., Gokhale, Prafulla C., Palakurthi, Sangeetha, Kirschmeier, Paul, Oxnard, Geoffrey R., Sholl, Lynette M., Jänne, Pasi A.
Publicado 2020

SPACEWALK: A Remote Participation Study of ALK Resistance Leveraging Plasma Cell-Free DNA Genotyping

por Lawrence, Marissa N., Tamen, Rubii M., Martinez, Pablo, Sable-Hunt, Alicia, Addario, Tony, Barbour, Pete, Shaffer, Tristan, Hosseini, Seyed Ali, Bertucci, Caterina, Lim, Lee P., Hong, Fangxin, Michael, Kesi, Simon, George R., Riess, Jonathan W., Awad, Mark M., Oxnard, Geoffrey R.
Publicado 2021

Integration of immunotherapy into adjuvant therapy for resected non-small-cell lung cancer: ALCHEMIST chemo-IO (ACCIO)

por Sands, Jacob M, Mandrekar, Sumithra J, Kozono, David, Oxnard, Geoffrey R, Hillman, Shauna L, Wigle, Dennis A, Govindan, Ramaswamy, Carlisle, Jennifer, Gray, Jhanelle, Salama, Joseph K, Raez, Luis, Ganti, Apar, Foster, Nathan, Malik, Shakun, Bradley, Jeffrey, Kelly, Karen, Ramalingam, Suresh S, Stinchcombe, Thomas E
Publicado 2021

The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice

por Nadauld, Lincoln D., McDonnell, Charles H., Beer, Tomasz M., Liu, Minetta C., Klein, Eric A., Hudnut, Andrew, Whittington, Richard A., Taylor, Bruce, Oxnard, Geoffrey R., Lipson, Jafi, Lopatin, Margarita, Shaknovich, Rita, Chung, Karen C., Fung, Eric T., Schrag, Deborah, Marinac, Catherine R.
Publicado 2021

Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors

por Lee, Jessica K., Sivakumar, Smruthy, Schrock, Alexa B., Madison, Russell, Fabrizio, David, Gjoerup, Ole, Ross, Jeffrey S., Frampton, Garrett M., Napalkov, Pavel, Montesion, Meagan, Schutzman, Jennifer L., Ye, Xin, Hegde, Priti S., Nagasaka, Misako, Oxnard, Geoffrey R., Sokol, Ethan S., Ou, Sai-Hong Ignatius, Shi, Zhen
Publicado 2022

Detection of BRCA1, BRCA2, and ATM Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound

por Chi, Kim N., Barnicle, Alan, Sibilla, Caroline, Lai, Zhongwu, Corcoran, Claire, Barrett, J. Carl, Adelman, Carrie A., Qiu, Ping, Easter, Ashley, Dearden, Simon, Oxnard, Geoffrey R., Agarwal, Neeraj, Azad, Arun, de Bono, Johann, Mateo, Joaquin, Olmos, David, Thiery-Vuillemin, Antoine, Harrington, Elizabeth A.
Publicado 2023

A longitudinal circulating tumor DNA-based model associated with survival in metastatic non-small-cell lung cancer

por Assaf, Zoe June F., Zou, Wei, Fine, Alexander D., Socinski, Mark A., Young, Amanda, Lipson, Doron, Freidin, Jonathan F., Kennedy, Mark, Polisecki, Eliana, Nishio, Makoto, Fabrizio, David, Oxnard, Geoffrey R., Cummings, Craig, Rode, Anja, Reck, Martin, Patil, Namrata S., Lee, Mark, Shames, David S., Schulze, Katja
Publicado 2023

Circulating Tumor DNA Monitoring on Chemo-immunotherapy for Risk Stratification in Advanced Non–Small Cell Lung Cancer

por Pellini, Bruna, Madison, Russell W., Childress, Merrida A., Miller, Shoshana T., Gjoerup, Ole, Cheng, Jason, Huang, Richard S.P., Krainock, Michael, Gupta, Pratyush, Zou, Wei, Shames, David S., Moshkevich, Solomon, Ballinger, Marcus, Liu, Minetta C., Young, Amanda, Srivastava, Minu K., Oxnard, Geoffrey R., Socinski, Mark A.
Publicado 2023

Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy by Tumor Mutational Burden in Metastatic Castration-Resistant Prostate Cancer

por Graf, Ryon P., Fisher, Virginia, Weberpals, Janick, Gjoerup, Ole, Tierno, Marni B., Huang, Richard S. P., Sayegh, Nicolas, Lin, Douglas I., Raskina, Kira, Schrock, Alexa B., Severson, Eric, Haberberger, James F., Ross, Jeffrey S., Creeden, James, Levy, Mia A., Alexander, Brian M., Oxnard, Geoffrey R., Agarwal, Neeraj
Publicado 2022

Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer

por Sivakumar, Smruthy, Jin, Dexter X., Tukachinsky, Hanna, Murugesan, Karthikeyan, McGregor, Kimberly, Danziger, Natalie, Pavlick, Dean, Gjoerup, Ole, Ross, Jeffrey S., Harmon, Robert, Chung, Jon, Decker, Brennan, Dennis, Lucas, Frampton, Garrett M., Molinero, Luciana, Oesterreich, Steffi, Venstrom, Jeffrey M., Oxnard, Geoffrey R., Hegde, Priti S., Sokol, Ethan S.
Publicado 2022

Molecular residual disease detection in resected, muscle-invasive urothelial cancer with a tissue-based comprehensive genomic profiling–informed personalized monitoring assay

por Powles, Thomas, Young, Amanda, Nimeiri, Halla, Madison, Russell W., Fine, Alexander, Zollinger, Daniel R., Huang, Yanmei, Xu, Chang, Gjoerup, Ole V., Aushev, Vasily N., Wu, Hsin-Ta, Aleshin, Alexey, Carter, Corey, Davarpanah, Nicole, Degaonkar, Viraj, Gupta, Pratyush, Mariathasan, Sanjeev, Schleifman, Erica, Assaf, Zoe June, Oxnard, Geoffrey, Hegde, Priti S.
Publicado 2023

Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial

por Subbiah, Vivek, Gainor, Justin F., Oxnard, Geoffrey R., Tan, Daniel S.W., Owen, Dwight H., Cho, Byoung Chul, Loong, Herbert H., McCoach, Caroline E., Weiss, Jared, Kim, Yu Jung, Bazhenova, Lyudmila, Park, Keunchil, Daga, Haruko, Besse, Benjamin, Gautschi, Oliver, Rolfo, Christian, Zhu, Edward Y., Kherani, Jennifer F., Huang, Xin, Kang, Suhyun, Drilon, Alexander
Publicado 2021

Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors

por Kobayashi, Yoshihisa, Oxnard, Geoffrey R., Cohen, Elizabeth F., Mahadevan, Navin R., Alessi, Joao V., Hung, Yin P., Bertram, Arrien A., Heppner, David E., Ribeiro, Mauricio F., Sacardo, Karina P., Saddi, Rodrigo, Macedo, Mariana P., Blasco, Rafael B., Li, Jiaqi, Kurppa, Kari J., Nguyen, Tom, Voligny, Emma, Ananda, Guruprasad, Chiarle, Roberto, Katz, Artur, Tolstorukov, Michael Y., Sholl, Lynette M., Jänne, Pasi A.
Publicado 2022

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

por Solomon, Benjamin J., Tan, Lavinia, Lin, Jessica J., Wong, Stephen Q., Hollizeck, Sebastian, Ebata, Kevin, Tuch, Brian B., Yoda, Satoshi, Gainor, Justin F., Sequist, Lecia V., Oxnard, Geoffrey R., Gautschi, Oliver, Drilon, Alexander, Subbiah, Vivek, Khoo, Christine, Zhu, Edward Y., Nguyen, Michele, Henry, Dahlia, Condroski, Kevin R., Kolakowski, Gabrielle R., Gomez, Eliana, Ballard, Joshua, Metcalf, Andrew T., Blake, James F., Dawson, Sarah-Jane, Blosser, Wayne, Stancato, Louis F., Brandhuber, Barbara J., Andrews, Steve, Robinson, Bruce G., Rothenberg, S. Michael
Publicado 2020

Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer

por Eser, Pınar Özden, Paranal, Raymond M., Son, Jieun, Ivanova, Elena, Kuang, Yanan, Haikala, Heidi M., To, Ciric, Okoro, Jeffrey J., Dholakia, Kshiti H., Choi, Jihyun, Eum, Yoonji, Ogino, Atsuko, Missios, Pavlos, Ercan, Dalia, Xu, Man, Poitras, Michael J., Wang, Stephen, Ngo, Kenneth, Dills, Michael, Yanagita, Masahiko, Lopez, Timothy, Lin, Mika, Tsai, Jeanelle, Floch, Nicolas, Chambers, Emily S., Heng, Jennifer, Anjum, Rana, Santucci, Alison D., Michael, Kesi, Schuller, Alwin G., Cross, Darren, Smith, Paul D., Oxnard, Geoffrey R., Barbie, David A., Sholl, Lynette M., Bahcall, Magda, Palakurthi, Sangeetha, Gokhale, Prafulla C., Paweletz, Cloud P., Daley, George Q., Jänne, Pasi A.
Publicado 2021