“…At the same time, we cannot neglect the ping-pong effect of the tumour microenvironment, which releases cytokines and promotes self-renewal pathways in CSCs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our results show that, in addition to load balancing flows across APs, our approach avoids the ping-pong effect while enhancing the QoS delivery at runtime. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, the phosphorolytic reaction of cellobiose by CbCBP proceeded via an ordered Bi Bi mechanism, while the synthetic reaction proceeded via a ping pong Bi Bi mechanism. The present study lays the foundation for optimizing the degradation of cellulose and the synthesis of functional oligosaccharides.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…For many piRNAs, phasing and ping-pong biogenesis pathways were identified. Interestingly, piRNAs were found to be highly expressed during early development, suggesting a potential role in regulation in metamorphosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, it reduces the ping-pong effects associated with the VHO in the heterogeneous VLC–WiFi network.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Nevertheless, we also observed fewer P-element insertions in piRNA clusters than expected, which is not compatible with a simple trap model. The ping-pong cycle, which degrades TE transcripts, becomes typically active after the copy number plateaued. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…AVAILABILITY AND IMPLEMENTATION: Data, code and instructions for reproducing the results presented in this manuscript are publicly available at https://github.com/Parsoa/PingPong. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics Advances online.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To explore this topic, we used an in vitro neural network of cortical neurons that was trained to play a simplified game of ‘Pong’ to demonstrate Synthetic Biological Intelligence (SBI). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…AlbC catalyses its two-substrate reaction via a ping-pong mechanism with a covalent intermediate in which l-Phe is shown to be transferred from Phe-tRNA(Phe) to an active serine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In humans, TE-derived sequences comprise ∼45% of the genome and there are several active TE families, including LINE-1 and Alu elements, which are a significant source of de novo mutations and intrapopulation variability. In the “ping-pong model,” piRNAs are thought to alternatively cleave sense and antisense TE transcripts in a positive feedback loop. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Secondary piRNAs arise during the adaptive ping-pong cycle, with their 5' termini being formed by the activity of PIWIs themselves(2,4). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also identified siRNAs derived from precursors with perfect stem–loop structure and that arise from inverted repeats. piRNAs were the most abundant small RNAs in hydra, mapping to transposable elements, the annotated transcriptome and unique non-coding regions on the genome. piRNAs that map to transposable elements and the annotated transcriptome display a ping–pong signature. Further, we have identified several miRNAs and piRNAs whose expression is regulated during hydra head regeneration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Enzyme kinetics and SPR experiments hint at a ping-pong mechanism for PqsD with ACoA as first substrate. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Primary piRNAs bound to the Argonaute protein Aubergine then drive the production of secondary piRNAs through the “ping-pong” amplification mechanism that involves an interplay with piRNAs bound to the Argonaute protein Argonaute-3. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Expanding the analysis, we confirmed the occurrence of somatic piRNA-like RNAs (pilRNAs) that show a ping-pong signature. We detected expression of the Piwi-family protein mRNAs only barely above background, indicating that the somatic pilRNAs may arise from a small sub-population of somatic cells that express a functional piRNA pathway.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNA substrates in a sequential ping-pong mechanism to form a cyclodipeptide. The crystal structures of three CDPSs have been determined and all show a Rossmann-fold domain similar to the catalytic domain of class-I aminoacyl-tRNA synthetases (aaRSs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, we characterize small RNAs in a set of ovary-derived cell lines, including somatic cells (OSS and OSC) and a mixed germline/somatic cell population (fGS/OSS) that exhibits ping-pong piRNA signatures. Collectively, the ovary data reveal new genic piRNA loci, including unusual configurations of piRNA-generating regions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This synergism may be due to the accumulation of secondary piRNAs created by ping-pong cycling between primary piRNAs from the TPs and mRNAs from the non-TPs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These observations indicate that adult porcine piRNAs are predominantly produced by a primary processing pathway or other mechanisms and secondary piRNAs generated by ping-pong mechanism are absent.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The mechanism of both reactions has been proven to follow the two substrate ping-pong mechanism with substrate inhibition, revealing the formation of a nonproductive or dead-end complex between dye and HRP or between H(2)O(2) and the oxidized form of the enzyme. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso