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504“…Alicia en el país de las maravillas…”
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506por Liu, Yijun, Shu, Longlan, Jiang, Xiaocong, Zhang, Yue, Chen, Qian, Shen, Yang, Yang, Yucheng“…OBJECTIVE: Our study aimed to elucidate the effect of PAI-1 (Plasminogen Activator Inhibitor-1) and t-PA (Tissue-type Plasminogen Activator) in tissue remodeling in nasal polyps patients. …”
Publicado 2023
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507por Higgins, Paul J.“…This review highlights the potential role of PAI-1 and TGF-β1 in this process. Current molecular events associated with TGF-β1-induced PAI-1 transcription are presented with particular relevance to potential targeting of PAI-1 gene expression as a molecular approach to the therapy of neurodegenerative diseases associated with increased PAI-1 expression such as Alzheimer's disease.…”
Publicado 2006
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508por Witte, J H de, Sweep, C G J, Klijn, J G M, Grebenschikov, N, Peters, H A, Look, M P, Tienoven, ThH van, Heuvel, J J T M, Vries, J Bolt-De, Benraad, ThJ, Foekens, J A“…Since the assay could easily be adapted to the assessment of the complex of tPA with its type-1 inhibitor (PAI-1), it was investigated whether the tPA:PAI-1 complex also provides prognostic information. …”
Publicado 1999
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509“…Although the role of PAI-1 acting as cell detachment factor could not be demonstrated in our study, we speculate that the loss of the anti-invasive ME layer in DCIS may be triggered by PAI-1 and could be an early sign of subsequent tumour cell infiltration.…”
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510por Huotari, Anne, Lehto, Soili M., Niskanen, Leo, Herzig, Karl-Heinz, Hintikka, Jukka, Koivumaa-Honkanen, Heli, Tolmunen, Tommi, Honkalampi, Kirsi, Kaikkonen, Noora, Viinamäki, Heimo“…PAI-1 increased linearly across the three groups in men. …”
Publicado 2010
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511por XU, XIN, XIE, YANQI, LIN, YIWEI, XU, XIANGLAI, ZHU, YI, MAO, YEQING, HU, ZHENGHUI, WU, JIAN, CHEN, HONG, ZHENG, XIANGYI, QIN, JIE, XIE, LIPING“…Plasminogen activator inhibitor-1 (PAI-1), belonging to the urokinase plasminogen activation (uPA) system, is involved in cancer development and progression. …”
Publicado 2012
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512por Xu, Kuanfeng, Liu, Xiaoyun, Yang, Fan, Cui, Dai, Shi, Yun, Shen, Chong, Tang, Wei, Yang, Tao“…A meta-analysis was performed to assess the association between the PAI-1 -675 4G/5G polymorphism and susceptibility to diabetes mellitus (DM), diabetic nephropathy (DN), diabetic retinopathy (DR) and diabetic coronary artery disease (CAD). …”
Publicado 2013
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513por Hirahata, Mio, Osaki, Mitsuhiko, Kanda, Yusuke, Sugimoto, Yui, Yoshioka, Yusuke, Kosaka, Nobuyoshi, Takeshita, Fumitaka, Fujiwara, Tomohiro, Kawai, Akira, Ito, Hisao, Ochiya, Takahiro, Okada, Futoshi“…We identified plasminogen activator inhibitor‐1 (PAI‐1) as a direct target gene of miR‐143. To determine the role of PAI‐1 in human osteosarcoma cells, siRNA was transfected into 143B cells for knockdown of PAI‐1 expression. …”
Publicado 2016
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514“…Finally, we demonstrated that Rab11-FIP2 overexpression may contribute to increased secretion of PAI-1 in human colorectal cancer cells. CONCLUSIONS: Our findings reveal a novel mechanism underlying the role of Rab11-FIP2 in colorectal cancer dissemination, suggesting that targeting Rab11-FIP2 might be a promising therapeutic strategy for CRC. …”
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515por Elsman, Ellen Bernadette Maria, van Rens, Gerardus Hermanus Maria Bartholomeus, van Nispen, Ruth Marie Antoinette“…METHODS: Young adults registered at two low vision rehabilitation centers in the Netherlands were invited to complete the 141-item PAI-YA (n = 186) in a test-retest design. To select the best items for the PAI-YA, response frequencies were assessed and a graded response model (GRM) was fitted. …”
Publicado 2018
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516“…Not elevated values of uPA and PAI-1 showed a lower rate of proliferation (average 8.5%) than carcinomas with an increase of uPA and/or PAI-1 (average 13.9%); p = 0.054, Student’s t-test. …”
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517por Adler, Grazyna, Mahmutbegovic, Emir, Valjevac, Amina, Adler, Mateusz A, Mahmutbegovic, Nevena, Safranow, Krzysztof, Czerska, Ewa, Pawinska-Matecka, Anna, Ciechanowicz, Iwona, Marjanovic, Damir“…A systematic review of the scientific literature was conducted with the use of the PubMed and Scopus electronic databases (1991-present), using the following search terms: pregnancy loss, miscarriage, genetic risk of thrombophilia, rs1799889 PAI-1 gen, 4G/5G PAI-1 gene polymorphism, PAI-1 gene locus 4G/5G polymorphism. …”
Publicado 2018
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518por Lampalo, Marina, Jukić, Irena, Bingulac-Popović, Jasna, Safić, Hana, Ferara, Nikola, Popović-Grle, Sanja“…The aim of our study was to investigate the importance of biomarkers of asthma and the role of plasminogen activator inhibitor-1 (PAI-1) gene as a genetic factor that could be involved in the pathogenesis of asthma. …”
Publicado 2018
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519“…In addition, oridonin reduced the levels of Smad2, Smad3, Smad4, PAI-1 and the phosphorylation of Smad2 and Smad3 induced by TGF-β1 in vitro. …”
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520por Wang, Hao-Chen, Lin, Yung-Lun, Hsu, Ching-Cheng, Chao, Ying-Jui, Hou, Ya-Chin, Chiu, Tai-Jan, Huang, Po-Hsien, Tang, Ming-Jer, Chen, Li-Tzong, Shan, Yan-Shen“…Suppression by knocking down PAI-1 in cancer cells demonstrated the requirement of PAI-1 for coculture-induced PSC activation and gel stiffness. …”
Publicado 2019
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