Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

por Chouchani, Edward T., Pell, Victoria R., Gaude, Edoardo, Aksentijević, Dunja, Sundier, Stephanie Y., Robb, Ellen L., Logan, Angela, Nadtochiy, Sergiy M., Ord, Emily N. J., Smith, Anthony C., Eyassu, Filmon, Shirley, Rachel, Hu, Chou-Hui, Dare, Anna J., James, Andrew M., Rogatti, Sebastian, Hartley, Richard C., Eaton, Simon, Costa, Ana S.H., Brookes, Paul S., Davidson, Sean M., Duchen, Michael R., Saeb-Parsy, Kourosh, Shattock, Michael J., Robinson, Alan J., Work, Lorraine M., Frezza, Christian, Krieg, Thomas, Murphy, Michael P.
Publicado 2014

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model

por Dare, Anna J., Logan, Angela, Prime, Tracy A., Rogatti, Sebastian, Goddard, Martin, Bolton, Eleanor M., Bradley, J. Andrew, Pettigrew, Gavin J., Murphy, Michael P., Saeb-Parsy, Kourosh
Publicado 2015

Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal transplantation

por Hosgood, Sarah A, Saeb-Parsy, Kourosh, Wilson, Colin, Callaghan, Christopher, Collett, Dave, Nicholson, Michael L
Publicado 2017

scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation

por Madissoon, E., Wilbrey-Clark, A., Miragaia, R. J., Saeb-Parsy, K., Mahbubani, K. T., Georgakopoulos, N., Harding, P., Polanski, K., Huang, N., Nowicki-Osuch, K., Fitzgerald, R. C., Loudon, K. W., Ferdinand, J. R., Clatworthy, M. R., Tsingene, A., van Dongen, S., Dabrowska, M., Patel, M., Stubbington, M. J. T., Teichmann, S. A., Stegle, O., Meyer, K. B.
Publicado 2019

Cells of the adult human heart

por Litviňuková, Monika, Talavera-López, Carlos, Maatz, Henrike, Reichart, Daniel, Worth, Catherine L., Lindberg, Eric L., Kanda, Masatoshi, Polanski, Krzysztof, Heinig, Matthias, Lee, Michael, Nadelmann, Emily R., Roberts, Kenny, Tuck, Liz, Fasouli, Eirini S., DeLaughter, Daniel M., McDonough, Barbara, Wakimoto, Hiroko, Gorham, Joshua M., Samari, Sara, Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Patone, Giannino, Boyle, Joseph J., Zhang, Hongbo, Zhang, Hao, Viveiros, Anissa, Oudit, Gavin Y., Bayraktar, Omer Ali, Seidman, J. G., Seidman, Christine E., Noseda, Michela, Hubner, Norbert, Teichmann, Sarah A.
Publicado 2020

Ex vivo normothermic perfusion of isolated segmental porcine bowel: a novel functional model of the small intestine

por Hamed, M O, Barlow, A D, Dolezalova, N, Khosla, S, Sagar, A, Gribble, F M, Davies, S, Murphy, M P, Hosgood, S A, Nicholson, M L, Saeb-Parsy, K
Publicado 2021

Efficacy and safety of the EMS Swiss LithoClast® Trilogy for PCNL: results of the European multicentre prospective study on behalf of European Section of UroTechnology

por Thakare, N., Tanase, F., Saeb-Parsy, K., Atassi, N., Endriss, R., Kamphuis, G., Pérez-Fentes, D., Hasan, M., Brehmer, M., Osther, P., Jung, H., Turney, B., Finch, W., Burgess, N., Irving, S., Dragos, L., Liatsikos, E., Knoll, T., Cauni, V., Wiseman, O.
Publicado 2021

Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids

por Rimland, Casey A., Tilson, Samantha G., Morell, Carola M., Tomaz, Rute A., Lu, Wei‐Yu, Adams, Simone E., Georgakopoulos, Nikitas, Otaizo‐Carrasquero, Francisco, Myers, Timothy G., Ferdinand, John R., Gieseck, Richard L., Sampaziotis, Fotios, Tysoe, Olivia C., Ross, Alexander, Kraiczy, Judith M., Wesley, Brandon, Muraro, Daniele, Zilbauer, Matthias, Oniscu, Gabriel C., Hannan, Nicholas R.F., Forbes, Stuart J., Saeb‐Parsy, Kourosh, Wynn, Thomas A., Vallier, Ludovic
Publicado 2021

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

por Garcia-Alonso, Luz, Handfield, Louis-François, Roberts, Kenny, Nikolakopoulou, Konstantina, Fernando, Ridma C., Gardner, Lucy, Woodhams, Benjamin, Arutyunyan, Anna, Polanski, Krzysztof, Hoo, Regina, Sancho-Serra, Carmen, Li, Tong, Kwakwa, Kwasi, Tuck, Elizabeth, Lorenzi, Valentina, Massalha, Hassan, Prete, Martin, Kleshchevnikov, Vitalii, Tarkowska, Aleksandra, Porter, Tarryn, Mazzeo, Cecilia Icoresi, van Dongen, Stijn, Dabrowska, Monika, Vaskivskyi, Vasyl, Mahbubani, Krishnaa T., Park, Jong-eun, Jimenez-Linan, Mercedes, Campos, Lia, Kiselev, Vladimir Yu., Lindskog, Cecilia, Ayuk, Paul, Prigmore, Elena, Stratton, Michael R., Saeb-Parsy, Kourosh, Moffett, Ashley, Moore, Luiza, Bayraktar, Omer A., Teichmann, Sarah A., Turco, Margherita Y., Vento-Tormo, Roser
Publicado 2021

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

por Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.
Publicado 2022

The discovAIR project: a roadmap towards the Human Lung Cell Atlas

por Luecken, Malte D., Zaragosi, Laure-Emmanuelle, Madissoon, Elo, Sikkema, Lisa, Firsova, Alexandra B., De Domenico, Elena, Kümmerle, Louis, Saglam, Adem, Berg, Marijn, Gay, Aurore C.A., Schniering, Janine, Mayr, Christoph H., Abalo, Xesús M., Larsson, Ludvig, Sountoulidis, Alexandros, Teichmann, Sarah A., van Eunen, Karen, Koppelman, Gerard H., Saeb-Parsy, Kourosh, Leroy, Sylvie, Powell, Pippa, Sarkans, Ugis, Timens, Wim, Lundeberg, Joakim, van den Berge, Maarten, Nilsson, Mats, Horváth, Peter, Denning, Jessica, Papatheodorou, Irene, Schultze, Joachim L., Schiller, Herbert B., Barbry, Pascal, Petoukhov, Ilya, Misharin, Alexander V., Adcock, Ian M., von Papen, Michael, Theis, Fabian J., Samakovlis, Christos, Meyer, Kerstin B., Nawijn, Martijn C.
Publicado 2022

Impact of artificial intelligence in breast cancer screening with mammography

por Dang, Lan-Anh, Chazard, Emmanuel, Poncelet, Edouard, Serb, Teodora, Rusu, Aniela, Pauwels, Xavier, Parsy, Clémence, Poclet, Thibault, Cauliez, Hugo, Engelaere, Constance, Ramette, Guillaume, Brienne, Charlotte, Dujardin, Sofiane, Laurent, Nicolas
Publicado 2022

Spatially resolved multiomics of human cardiac niches

por Kanemaru, Kazumasa, Cranley, James, Muraro, Daniele, Miranda, Antonio M. A., Ho, Siew Yen, Wilbrey-Clark, Anna, Patrick Pett, Jan, Polanski, Krzysztof, Richardson, Laura, Litvinukova, Monika, Kumasaka, Natsuhiko, Qin, Yue, Jablonska, Zuzanna, Semprich, Claudia I., Mach, Lukas, Dabrowska, Monika, Richoz, Nathan, Bolt, Liam, Mamanova, Lira, Kapuge, Rakeshlal, Barnett, Sam N., Perera, Shani, Talavera-López, Carlos, Mulas, Ilaria, Mahbubani, Krishnaa T., Tuck, Liz, Wang, Lu, Huang, Margaret M., Prete, Martin, Pritchard, Sophie, Dark, John, Saeb-Parsy, Kourosh, Patel, Minal, Clatworthy, Menna R., Hübner, Norbert, Chowdhury, Rasheda A., Noseda, Michela, Teichmann, Sarah A.
Publicado 2023

Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids

por Georgakopoulos, Nikitas, Prior, Nicole, Angres, Brigitte, Mastrogiovanni, Gianmarco, Cagan, Alex, Harrison, Daisy, Hindley, Christopher J., Arnes-Benito, Robert, Liau, Siong-Seng, Curd, Abbie, Ivory, Natasha, Simons, Benjamin D., Martincorena, Inigo, Wurst, Helmut, Saeb-Parsy, Kourosh, Huch, Meritxell
Publicado 2020

Cells of the human intestinal tract mapped across space and time

por Elmentaite, Rasa, Kumasaka, Natsuhiko, Roberts, Kenny, Fleming, Aaron, Dann, Emma, King, Hamish W., Kleshchevnikov, Vitalii, Dabrowska, Monika, Pritchard, Sophie, Bolt, Liam, Vieira, Sara F., Mamanova, Lira, Huang, Ni, Perrone, Francesca, Goh Kai’En, Issac, Lisgo, Steven N., Katan, Matilda, Leonard, Steven, Oliver, Thomas R. W., Hook, C. Elizabeth, Nayak, Komal, Campos, Lia S., Domínguez Conde, Cecilia, Stephenson, Emily, Engelbert, Justin, Botting, Rachel A., Polanski, Krzysztof, van Dongen, Stijn, Patel, Minal, Morgan, Michael D., Marioni, John C., Bayraktar, Omer Ali, Meyer, Kerstin B., He, Xiaoling, Barker, Roger A., Uhlig, Holm H., Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Zilbauer, Matthias, Clatworthy, Menna R., Haniffa, Muzlifah, James, Kylie R., Teichmann, Sarah A.
Publicado 2021

Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo

por Prag, Hiran A., Pala, Laura, Kula-Alwar, Duvaraka, Mulvey, John F., Luping, Du, Beach, Timothy E., Booty, Lee M., Hall, Andrew R., Logan, Angela, Sauchanka, Volha, Caldwell, Stuart T., Robb, Ellen L., James, Andrew M., Xu, Zhelong, Saeb-Parsy, Kourosh, Hartley, Richard C., Murphy, Michael P., Krieg, Thomas
Publicado 2020

Diverse mutational landscapes in human lymphocytes

por Machado, Heather E., Mitchell, Emily, Øbro, Nina F., Kübler, Kirsten, Davies, Megan, Leongamornlert, Daniel, Cull, Alyssa, Maura, Francesco, Sanders, Mathijs A., Cagan, Alex T. J., McDonald, Craig, Belmonte, Miriam, Shepherd, Mairi S., Vieira Braga, Felipe A., Osborne, Robert J., Mahbubani, Krishnaa, Martincorena, Iñigo, Laurenti, Elisa, Green, Anthony R., Getz, Gad, Polak, Paz, Saeb-Parsy, Kourosh, Hodson, Daniel J., Kent, David G., Campbell, Peter J.
Publicado 2022

A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

por Madissoon, Elo, Oliver, Amanda J., Kleshchevnikov, Vitalii, Wilbrey-Clark, Anna, Polanski, Krzysztof, Richoz, Nathan, Ribeiro Orsi, Ana, Mamanova, Lira, Bolt, Liam, Elmentaite, Rasa, Pett, J. Patrick, Huang, Ni, Xu, Chuan, He, Peng, Dabrowska, Monika, Pritchard, Sophie, Tuck, Liz, Prigmore, Elena, Perera, Shani, Knights, Andrew, Oszlanczi, Agnes, Hunter, Adam, Vieira, Sara F., Patel, Minal, Lindeboom, Rik G. H., Campos, Lia S., Matsuo, Kazuhiko, Nakayama, Takashi, Yoshida, Masahiro, Worlock, Kaylee B., Nikolić, Marko Z., Georgakopoulos, Nikitas, Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Bayraktar, Omer Ali, Clatworthy, Menna R., Stegle, Oliver, Kumasaka, Natsuhiko, Teichmann, Sarah A., Meyer, Kerstin B.
Publicado 2022

Clonal dynamics of haematopoiesis across the human lifespan

por Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas, Dawson, Kevin J., Mende, Nicole, Calderbank, Emily F., Jung, Hyunchul, Mitchell, Thomas, Coorens, Tim H. H., Spencer, David H., Machado, Heather, Lee-Six, Henry, Davies, Megan, Hayler, Daniel, Fabre, Margarete A., Mahbubani, Krishnaa, Abascal, Federico, Cagan, Alex, Vassiliou, George S., Baxter, Joanna, Martincorena, Inigo, Stratton, Michael R., Kent, David G., Chatterjee, Krishna, Parsy, Kourosh Saeb, Green, Anthony R., Nangalia, Jyoti, Laurenti, Elisa, Campbell, Peter J.
Publicado 2022

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

por Brevini, Teresa, Maes, Mailis, Webb, Gwilym J., John, Binu V., Fuchs, Claudia D., Buescher, Gustav, Wang, Lu, Griffiths, Chelsea, Brown, Marnie L., Scott, William E., Pereyra-Gerber, Pehuén, Gelson, William T. H., Brown, Stephanie, Dillon, Scott, Muraro, Daniele, Sharp, Jo, Neary, Megan, Box, Helen, Tatham, Lee, Stewart, James, Curley, Paul, Pertinez, Henry, Forrest, Sally, Mlcochova, Petra, Varankar, Sagar S., Darvish-Damavandi, Mahnaz, Mulcahy, Victoria L., Kuc, Rhoda E., Williams, Thomas L., Heslop, James A., Rossetti, Davide, Tysoe, Olivia C., Galanakis, Vasileios, Vila-Gonzalez, Marta, Crozier, Thomas W. M., Bargehr, Johannes, Sinha, Sanjay, Upponi, Sara S., Fear, Corrina, Swift, Lisa, Saeb-Parsy, Kourosh, Davies, Susan E., Wester, Axel, Hagström, Hannes, Melum, Espen, Clements, Darran, Humphreys, Peter, Herriott, Jo, Kijak, Edyta, Cox, Helen, Bramwell, Chloe, Valentijn, Anthony, Illingworth, Christopher J. R., Dahman, Bassam, Bastaich, Dustin R., Ferreira, Raphaella D., Marjot, Thomas, Barnes, Eleanor, Moon, Andrew M., Barritt, Alfred S., Gupta, Ravindra K., Baker, Stephen, Davenport, Anthony P., Corbett, Gareth, Gorgoulis, Vassilis G., Buczacki, Simon J. A., Lee, Joo-Hyeon, Matheson, Nicholas J., Trauner, Michael, Fisher, Andrew J., Gibbs, Paul, Butler, Andrew J., Watson, Christopher J. E., Mells, George F., Dougan, Gordon, Owen, Andrew, Lohse, Ansgar W., Vallier, Ludovic, Sampaziotis, Fotios
Publicado 2022