Human Primary Liver Cancer -derived Organoid Cultures for disease modelling and drug screening

por Broutier, Laura, Mastrogiovanni, Gianmarco, Verstegen, Monique M.A., Francies, Hayley E., Gavarró, Lena Morrill, Bradshaw, Charles R, Allen, George E, Arnes-Benito, Robert, Sidorova, Olga, Gaspersz, Marcia P., Georgakopoulos, Nikitas, Koo, Bon-Kyoung, Dietmann, Sabine, Davies, Susan E., Praseedom, Raaj K., Lieshout, Ruby, IJzermans, Jan N. M., Wigmore, Stephen J, Saeb-Parsy, Kourosh, Garnett, Mathew J., van der Laan, Luc J.W., Huch, Meritxell
Publicado 2017

Pancreatic allograft thrombosis: Suggestion for a CT grading system and management algorithm

por Hakeem, A., Chen, J., Iype, S., Clatworthy, M. R., Watson, C. J. E., Godfrey, E. M., Upponi, S., Saeb‐Parsy, K.
Publicado 2017

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

por Martin, Jack L., Costa, Ana S. H., Gruszczyk, Anja V., Beach, Timothy E., Allen, Fay M., Prag, Hiran A., Hinchy, Elizabeth C., Mahbubani, Krishnaa, Hamed, Mazin, Tronci, Laura, Nikitopoulou, Efterpi, James, Andrew M., Krieg, Thomas, Robinson, Alan J., Huang, Margaret H., Caldwell, Stuart T., Logan, Angela, Pala, Laura, Hartley, Richard C., Frezza, Christian, Saeb-Parsy, Kourosh, Murphy, Michael P.
Publicado 2019

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker

por Prag, Hiran A., Kula-Alwar, Duvaraka, Pala, Laura, Caldwell, Stuart T., Beach, Timothy E., James, Andrew M., Saeb-Parsy, Kourosh, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Publicado 2020

Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves

por Gupta, Isha, Cassará, Antonino M., Tarotin, Ilya, Donega, Matteo, Miranda, Jason A., Sokal, David M., Ouchouche, Sebastien, Dopson, Wesley, Matteucci, Paul, Neufeld, Esra, Schiefer, Matthew A., Rowles, Alison, McGill, Paul, Perkins, Justin, Dolezalova, Nikola, Saeb-Parsy, Kourosh, Kuster, Niels, Yazicioglu, Refet Firat, Witherington, Jason, Chew, Daniel J.
Publicado 2020

Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets

por Dolezalova, Nikola, Gruszczyk, Anja, Barkan, Kerry, Gamble, John A., Galvin, Sam, Moreth, Till, O’Holleran, Kevin, Mahbubani, Krishnaa T., Higgins, Jackie A., Gribble, Fiona M., Reimann, Frank, Surmacki, Jakub, Andrews, Simon, Casey, John J., Pampaloni, Francesco, Murphy, Michael P., Ladds, Graham, Slater, Nigel K. H., Saeb-Parsy, Kourosh
Publicado 2021

Modeling human tumor-immune environments in vivo for the preclinical assessment of immunotherapies

por Bareham, Bethany, Georgakopoulos, Nikitas, Matas-Céspedes, Alba, Curran, Michelle, Saeb-Parsy, Kourosh
Publicado 2021

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

por Jarvis, Lorna B., Rainbow, Daniel B., Coppard, Valerie, Howlett, Sarah K., Georgieva, Zoya, Davies, Jessica L., Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T., Coles, Alasdair J., Mousa, Hani S., Pluchino, Stefano, Mahbubani, Krishnaa T., Griffin, Julian L., Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S., Jones, Joanne L.
Publicado 2021

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells

por Inaba, Akimichi, Tuong, Zewen Kelvin, Zhao, Tian X., Stewart, Andrew P., Mathews, Rebeccah, Truman, Lucy, Sriranjan, Rouchelle, Kennet, Jane, Saeb-Parsy, Kourosh, Wicker, Linda, Waldron-Lynch, Frank, Cheriyan, Joseph, Todd, John A., Mallat, Ziad, Clatworthy, Menna R.
Publicado 2023

MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3

por Saeb-Parsy, K, Veerakumarasivam, A, Wallard, M J, Thorne, N, Kawano, Y, Murphy, G, Neal, D E, Mills, I G, Kelly, J D
Publicado 2008

Application of a High Throughput Method of Biomarker Discovery to Improvement of the EarlyCDT(®)-Lung Test

por Macdonald, Isabel K., Murray, Andrea, Healey, Graham F., Parsy-Kowalska, Celine B., Allen, Jared, McElveen, Jane, Robertson, Chris, Sewell, Herbert F., Chapman, Caroline J., Robertson, John F. R.
Publicado 2012

Towards in cellulo virus crystallography

por Duyvesteyn, Helen M. E., Ginn, Helen M., Pietilä, Maija K., Wagner, Armin, Hattne, Johan, Grimes, Jonathan M., Hirvonen, Elina, Evans, Gwyndaf, Parsy, Marie-Laure, Sauter, Nicholas K., Brewster, Aaron S., Huiskonen, Juha T., Stuart, David I., Sutton, Geoff, Bamford, Dennis H.
Publicado 2018

Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

por Kohlhauer, Matthias, Dawkins, Sam, Costa, Ana S. H., Lee, Regent, Young, Timothy, Pell, Victoria R., Choudhury, Robin P., Banning, Adrian P., Kharbanda, Rajesh K., Saeb‐Parsy, Kourosh, Murphy, Michael P., Frezza, Christian, Krieg, Thomas, Channon, Keith M.
Publicado 2018

Tumor-associated autoantibodies in combination with alpha-fetoprotein for detection of early stage hepatocellular carcinoma

por Welberry, Christopher, Macdonald, Isabel, McElveen, Jane, Parsy-Kowalska, Celine, Allen, Jared, Healey, Graham, Irving, William, Murray, Andrea, Chapman, Caroline
Publicado 2020

Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans

por Mende, Nicole, Bastos, Hugo P., Santoro, Antonella, Mahbubani, Krishnaa T., Ciaurro, Valerio, Calderbank, Emily F., Londoño, Mariana Quiroga, Sham, Kendig, Mantica, Giovanna, Morishima, Tatsuya, Mitchell, Emily, Lidonnici, Maria Rosa, Meier-Abt, Fabienne, Hayler, Daniel, Jardine, Laura, Curd, Abbie, Haniffa, Muzlifah, Ferrari, Giuliana, Takizawa, Hitoshi, Wilson, Nicola K., Göttgens, Berthold, Saeb-Parsy, Kourosh, Frontini, Mattia, Laurenti, Elisa
Publicado 2022

Use of human splenocytes in an innovative humanised mouse model for prediction of immunotherapy‐induced cytokine release syndrome

por Matas‐Céspedes, Alba, Brown, Lee, Mahbubani, Krishnaa T, Bareham, Bethany, Higgins, Jackie, Curran, Michelle, de Haan, Lolke, Lapointe, Jean‐Martin, Stebbings, Richard, Saeb‐Parsy, Kourosh
Publicado 2020

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

por Belenguer, Germán, Mastrogiovanni, Gianmarco, Pacini, Clare, Hall, Zoe, Dowbaj, Anna M., Arnes-Benito, Robert, Sljukic, Aleksandra, Prior, Nicole, Kakava, Sofia, Bradshaw, Charles R., Davies, Susan, Vacca, Michele, Saeb-Parsy, Kourosh, Koo, Bon-Kyoung, Huch, Meritxell
Publicado 2022

APOBEC mutagenesis is a common process in normal human small intestine

por Wang, Yichen, Robinson, Philip S., Coorens, Tim H. H., Moore, Luiza, Lee-Six, Henry, Noorani, Ayesha, Sanders, Mathijs A., Jung, Hyunchul, Katainen, Riku, Heuschkel, Robert, Brunton-Sim, Roxanne, Weston, Robyn, Read, Debbie, Nobbs, Beverley, Fitzgerald, Rebecca C., Saeb-Parsy, Kourosh, Martincorena, Iñigo, Campbell, Peter J., Rushbrook, Simon, Zilbauer, Matthias, Buczacki, Simon James Alexander, Stratton, Michael R.
Publicado 2023

D-dimer Release From Livers During Ex Situ Normothermic Perfusion and After In Situ Normothermic Regional Perfusion: Evidence for Occult Fibrin Burden Associated With Adverse Trans...

por Watson, Christopher J.E., MacDonald, Stephen, Bridgeman, Christopher, Brais, Rebecca, Upponi, Sara S., Foukaneli, Theodora, Swift, Lisa, Fear, Corrina, Selves, Linda, Kosmoliaptsis, Vasilis, Allison, Michael, Hogg, Rachel, Parsy, Kourosh Saeb, Thomas, Will, Gaurav, Rohit, Butler, Andrew J.
Publicado 2023

Risk profiles of prostate cancers identified from UK primary care using national referral guidelines

por Serag, H, Banerjee, S, Saeb-Parsy, K, Irving, S, Wright, K, Stearn, S, Doble, A, Gnanapragasam, V J
Publicado 2012