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  1. 104301
    “…The annual number of drug trials increased rapidly in the past twelve years. Among all the trials, the bioequivalence trials (1428; 58.3%) accounted for the largest proportion, followed by phase I (555; 22.5%), phase III (278; 11.3%), phase II (169; 6.9%), and phase IV (26; 1.1%). …”
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    The changing landscape of drug clinical trials on cardiometabolic diseases in China, 2009–2021
  2. 104302
    “…METHODS: Using data collected during 2010–2018 from base regions (population-based surveillance studies in western Kenya and the Kilifi Health and Demographic Surveillance Study), we estimated age-specific rates of acute respiratory illness (ARI), severe acute respiratory illness (SARI—defined as hospitalization with cough or difficulty breathing with onset within the past 10 days), and SARI-associated deaths. We extrapolated the rates from the base regions to other regions of Kenya, while adjusting for risk factors of ARI and healthcare seeking behavior, and finally applied the proportions of RSV-positive cases identified from various sentinel and study facilities to the rates to obtain regional age-specific rates of RSV-associated outpatient and non-medically attended ARI and hospitalized SARI and severe ARI that was not hospitalized (non-hospitalized SARI). …”
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    Estimates of the national burden of respiratory syncytial virus in Kenyan children aged under 5 years, 2010–2018
  3. 104303
    “…While research on HERV elements has in the past been hampered by their high sequence similarity, advanced sequencing technology and analytical tools have empowered the field. …”
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    Confounding factors in profiling of locus-specific human endogenous retrovirus (HERV) transcript signatures in primary T cells using multi-study-derived datasets
  4. 104304
    “…The most frequently reported barriers to care were financial (n = 214; 50.5%), long wait times (n = 202; 47.6%), insufficient resources (n = 165; 38.9%), time constraints (n = 148; 34.9%), stigma (n = 133; 31.4%), cultural barriers (n = 108; 25.5%), and past negative experiences with mental health care (n = 86; 20.3%). …”
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    Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study
  5. 104305
    por Xavier, Joilson, Alcantara, Luiz, Fonseca, Vagner, Lima, Mauricio, Castro, Emerson, Fritsch, Hegger, Oliveira, Carla, Guimarães, Natalia, Adelino, Talita, Evaristo, Mariane, Rodrigues, Evandra S., Santos, Elaine Vieira, de La-Roque, Debora, de Moraes, Laise, Tosta, Stephane, Neto, Adelino, Rosewell, Alexander, Mendonça, Ana Flavia, Leite, Anderson, Vasconcelos, Andreza, Silva de Mello, Arabela L., Vasconcelos, Bergson, Montalbano, Camila A., Zanluca, Camila, Freitas, Carla, de Albuquerque, Carlos F. C., Duarte dos Santos, Claudia Nunes, Santos, Cleiton S., dos Santos, Cliomar Alves, Maymone Gonçalves, Crhistinne C., Teixeira, Dalane, Neto, Daniel F. L., Cabral, Diego, de Oliveira, Elaine C., Noia Maciel, Ethel L., Pereira, Felicidade Mota, Iani, Felipe, de Carvalho, Fernanda P., Andrade, Gabriela, Bezerra, Gabriela, de Castro Lichs, Gislene G., Pereira, Glauco Carvalho, Barroso, Haline, Ferreira Franz, Helena Cristina, Ferreira, Hivylla, Gomes, Iago, Riediger, Irina N., Rodrigues, Isabela, de Siqueira, Isadora C., Silva, Jacilane, Rico, Jairo Mendez, Lima, Jaqueline, Abrantes, Jayra, do Nascimento, Jean Phellipe M., Wasserheit, Judith N., Pastor, Julia, de Magalhães, Jurandy J. F., Luz, Kleber Giovanni, Lima Neto, Lidio G., Frutuoso, Livia C. V., da Silva, Luana Barbosa, Sena, Ludmila, de Sousa, Luis Arthur F., Pereira, Luiz Augusto, Demarchi, Luiz, Câmara, Magaly C. B., Astete, Marcela G., Almiron, Maria, Lima, Maricelia, Umaki Zardin, Marina C. S., Presibella, Mayra M., Falcão, Melissa B., Gale, Michael, Freire, Naishe, Marques, Nelson, de Moura, Noely F. O., Almeida Da Silva, Pedro E., Rabinowitz, Peter, da Cunha, Rivaldo V., Trinta, Karen S., do Carmo Said, Rodrigo F., Kato, Rodrigo, Stabeli, Rodrigo, de Jesus, Ronaldo, Santos, Roselene Hans, Haddad, Simone K., Slavov, Svetoslav N., Andrade, Tamires, Rocha, Themis, Carneiro, Thiago, Nardy, Vanessa, da Silva, Vinicius, Carvalho, Walterlene G., Van Voorhis, Wesley C., Araujo, Wildo N., de Filippis, Ana M.B., Giovanetti, Marta
    Publicado 2023
    “…Faced with this scenario, on-site training activities in genomic surveillance carried out in partnership with the National Network of Public Health Laboratories have led to the generation of 422 CHIKV genomes from 12 Brazilian states over the past two years (2021–2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. …”
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    Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil
  6. 104306
    “…BACKGROUND: Over the past decade, there has been increasing availability of novel therapeutics with improved tolerability and efficacy for advanced non-small cell lung cancer (NSCLC). …”
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    Improved uptake and survival with systemic treatments for metastatic non-small cell lung cancer: younger versus older adults
  7. 104307
    “…Given the U-shaped distribution of risk, past investigations that assume a linear relationship between serum sodium concentration and surgical outcomes may need to be revisited. …”
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    The Association Between Borderline Dysnatremia and Perioperative Morbidity and Mortality: Retrospective Cohort Study of the American College of Surgeons National Surgical Quality Improvement Program Database
  8. 104308
    “…BACKGROUND: The burden of pediatric mental illness in the United States has steadily worsened over the past decade. A recent increase in employer-sponsored behavioral health programs has focused on the needs of the general population. …”
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    Clinical and Psychosocial Outcomes Associated With a Tele-behavioral Health Platform for Families: Retrospective Study
  9. 104309
    “…Several radiolabeled product can be used as (90)Y-loaded microspheres or less frequently radiolabeled lipiodol either with iodine 131 (in the past) or currently with rhenium 188 ((188)Re). Currently used (188)Re-labeled compounds are limited by in vivo instability. …”
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    (188)Re-SSS Lipiodol Radioembolization in HCC Patients: Results of a Phase 1 Trial (Lip-Re-01 Study)
  10. 104310
    “…BACKGROUND: Over the past decade, DNA methylation (DNAm)-based deconvolution methods that leverage cell-specific DNAm markers of immune cell types have been developed to provide accurate estimates of the proportions of leukocytes in peripheral blood. …”
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    Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative using DNA methylation-based methods
  11. 104311
    “…CKD-MBD markers and other clinical data were collected from medical records. Fatigue in the past week was measured by Standardized Outcomes in Nephrology-Hemodialysis (SONG-HD) fatigue measure; fatigue at the end of hemodialysis was measured by numeric rating scale (NRS). …”
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    Serum 25-Hydroxyvitamin D Level Is Negatively Associated with Fatigue in Elderly Maintenance Hemodialysis Patients
  12. 104312
    “…BACKGROUND: Leprosy is an ancient infectious disease with an annual global incidence of around 200,000 over the past decade. Since 2018, the World Health Organization (WHO) recommends single-dose rifampicin as post-exposure prophylaxis (SDR-PEP) for contacts of leprosy patients. …”
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    Protocol, rationale and design of BE-PEOPLE (Bedaquiline enhanced exposure prophylaxis for LEprosy in the Comoros): a cluster randomized trial on effectiveness of rifampicin and bedaquiline as post-exposure prophylaxis of leprosy contacts
  13. 104313
    “…Prior disclosure to a relative, aHR = 0.55, and having more than one sexual partner in the past three months, aHR = 0.74, predicted non-disclosure. …”
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    Incidence of HIV disclosure among HIV affected heterosexual partners using a community health worker led mechanism in rural Uganda; a quasi-experimental study
  14. 104314
    “…Peptostreptococcus was positively correlated with DLco per unit of alveolar volume as a percentage of predicted value (DLco/VA%pred). The patients with past-year exacerbations were more in the Streptococcus cluster. …”
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    Respiratory microbiota and radiomics features in the stable COPD patients
  15. 104315
    “…This fear is partly associated with a fall in the recent past. Because of the associations between fear of falling, avoiding physical activity, and the potential impact of those on health, an association between fear of falling and low health-related quality of life, is suggested. …”
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    The association of fear of falling and physical and mental Health-Related Quality of Life (HRQoL) among community-dwelling older persons; a cross-sectional study of Urban Health Centres Europe (UHCE)
  16. 104316
    “…CONCLUSION: Adherence to malaria treatment was a socio-culturally embedded process during which patients (re-)evaluated the characteristics of the medicines in relation to the course of the illness, their past experiences with illness, and the perceived benefits of the treatment. …”
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    Adherence to 14-day radical cure for Plasmodium vivax malaria in Papua, Indonesia: a mixed-methods study
  17. 104317
    “…The incidence of major arrhythmic events (MAE) may be higher in children (1,3), but most of the past studies recruited a high proportion of patients with congenital heart disease (CHD), treated with outdated pharmacological therapy (1). …”
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    Ventricular pre-excitation in young patients: long term follow-up and natural history in a contemporary cohort
  18. 104318
    “…CONCLUSION: Patients with a higher comorbidity burden undergoing catheter ablation for atrial fibrillation in the past 10 years were not subject to an increased risk for pericardial effusion or drainage. …”
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    High comorbidity burden is not associated with increased risk of periprocedural pericardial effusionduring left atrial ablation procedures: data from a large tertiary-care ablation center
  19. 104319
    “…In addition, migrants aged between 18 and 45 years who relocated to the current city in the past 2–3 years tended to have multiple sexual partners (P < .05). …”
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    Migration experiences and reported commercial and non-commercial sexual behaviors among newly diagnosed HIV infections in China: a cross-sectional study
  20. 104320
    “…Multivariate logistic regression analysis of PrEP use in high-risk MSM showed that more PrEP was used by those who were 26 years or older (OR = 1.86, 95%CI 1.17 ~ 2.99), had master degree or above (OR = 2.37, 95% CI 1.21 ~ 4.72), had unstable work (OR = 1.86, 95% CI 1.16 ~ 2.96), had tested five or more HIV times in the past year (OR = 3.09, 95% CI 1.65 ~ 6.04), had consulted PrEP (OR = 22.05, 95% CI 14.87 ~ 33.91) and had PrEP knowledge awareness (OR = 1.90, 95% CI 1.41 ~ 2.55) (P < 0.05). …”
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    Pre-exposure prophylaxis uptake for high-risk men who have sex with men in China: a multi-city cross-sectional survey
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