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  1. 2501
    “…We present a data-driven approach to unveil the pharmaceutical technologies of cyclodextrins (CDs) by analyzing a dataset of CD pharmaceutical patents. First, we implemented network science techniques to represent CD patents as a single structure and provide a framework for unsupervised detection of keywords in the patent dataset. …”
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    When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining
  2. 2502
    por Liu, Yufei, Wang, Guan, Zhou, Yuan, Liu, Yuhan
    Publicado 2022
    “…On the other hand, the progressive evolutionary process from scientific grants to academic papers and then to patents was not considered. Therefore, this paper proposes a novel framework based on a separated three-layer knowledge graph with several time slices using grant data, paper data, and patent data. …”
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    Advanced Technology Evolution Pathways of Nanogenerators: A Novel Framework Based on Multi-Source Data and Knowledge Graph
  3. 2503
    por Lewis, Kenrick M., Couderc, Sabine
    Publicado 2022
    “…It was published in January 1947. The landmark patent interference (§) and priority (§) case law associated with the Mackenzie et al. and Wagner et al., applications is well known to patent attorneys. …”
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    1946 and the Early History of Hydrosilylation
  4. 2504
    “…Most of the product patents claim a large number of compounds based on a Markush structure. …”
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    Deconstructing Markush: Improving the R&D Efficiency Using Library Selection in Early Drug Discovery
  5. 2505
    “…Expert-derived technologies outside of the top performing patents areas were additionally explored. RESULTS: Between 1960 and 2010, 4,651 patents and 43,118 publications related to plastic surgery were identified. …”
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    Fifty Years of Innovation in Plastic Surgery
  6. 2506
    “…In patent document recovery, Derwent Innovation Index (DWPI) and PatentInspiration databases were used. …”
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    Technological Advancements in Monoclonal Antibodies
  7. 2507
    “…A total of 565 patents and 390 clinical trials were found, focusing on probiotic applications for 83 indications. …”
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    Reviewing the state of the art of probiotics as clinical modalities for brain–gut–microbiota axis associated disorders
  8. 2508
    “…Main diseases covered by African patents were HIV/AIDS, cardiovascular diseases, cancers and tumors. …”
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    The role of intellectual property rights on access to medicines in the WHO African region: 25 years after the TRIPS agreement
  9. 2509
    por Lexchin, Joel
    Publicado 2021
    “…OBJECTIVES: This study examines the length of time between when a patent application is filed in Canada for a new drug and when it is available for patients (time to market) and various components of that time. …”
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    Time to market for drugs approved in Canada between 2014 and 2018: an observational study
  10. 2510
    “…Brazil produces non-patented generic antiretroviral drugs (ARVs), procures many patented ARVs with negotiated price reductions, and recently issued a compulsory license to import one patented ARV. …”
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    Evolution of Antiretroviral Drug Costs in Brazil in the Context of Free and Universal Access to AIDS Treatment
  11. 2511
    “…The thrombotic complications of pancreatic cancer, in combination with a large, patent foramen ovale, support the mechanism of a paradoxical embolism through the patent foramen ovale as the cause of cerebral ischaemic stroke.…”
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    Diagnostic dilemmas in a patient with multivascular embolic stroke
  12. 2512
    por Lesser, William
    Publicado 2017
    “…Here, subsequent changes in patent law, public research support, and surveys of researchers are summarized. …”
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    Whither the Research Anticommons?
  13. 2513
    “…CONCLUSIONS: Pharmaceutical companies were actively adding non-OD indications and were emphasizing the use of patent rights by registering extensions of substance or use patents for exclusive marketing periods. …”
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    Lifecycle management of orphan drugs approved in Japan
  14. 2514
    “…The study explores the relationship between globalization, GDP, the carbon intensity of GDP, patents, and its effect on consumption-based carbon emissions (CCO(2)E). …”
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    The asymmetric and long-run effect of environmental innovation and CO(2) intensity of GDP on consumption-based CO(2) emissions in Denmark
  15. 2515
    “…The results show that 93% of patents were granted since 2000, the majority belonging to the United States and Europe, although the share of patents from developing countries has increased. …”
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    Dengue Vaccines: A Perspective from the Point of View of Intellectual Property
  16. 2516
    “…The presence of an unknown intracardiac shunt due to a patent foramen ovale may be an unusual cause of hypoxemia. …”
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    Persistent hypoxemia after an asthma attack
  17. 2517
    “…OBJECTIVE: PATENT-1 and CHEST-1 were pivotal, international phase III trials assessing riociguat for pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). …”
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    Riociguat for the treatment of pulmonary hypertension: Chinese subgroup analyses and comparison
  18. 2518
    “…Search and publish the clinical RCT of these 7 kinds of oral liquid of Chinese patent medicine compared with ribavirin or oral liquid of Chinese patent medicine. …”
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    Network meta-analysis of heat-clearing and detoxifying oral liquid of Chinese medicines in treatment of children's hand-foot-mouth disease: A protocol for systematic review and meta-analysis
  19. 2519
    “…The proposed internal transcribed spacer 2 (ITS2) has been used to identify raw medicinal materials, but it is not suitable for the identification of Chinese patent medicine ingredients. Therefore, a short barcode for the identification of processed American ginseng and its corresponding Chinese patent medicines would be profitable. …”
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    A Nucleotide Signature for the Identification of American Ginseng and Its Products
  20. 2520
    por Moreno, Santiago G., Ray, Joshua A.
    Publicado 2016
    “…Incidence patients and off-patent prices are identified as two key missing features preventing the conventional CEA approach from capturing 1) benefit to future patients and 2) future savings from off-patent prices. …”
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    The value of innovation under value-based pricing
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