“…A resurgence of interest in strained carbocyclic species has been prompted by their potential as bioisosteres, high fraction of sp(3) carbons, and limited appearance in the patent literature. Among strained ring systems, bicyclo[1.1.0]butane (BCB) stands apart as the smallest bicyclic carbocycle and is amongst the most strained carbocycles known. …”
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“…In the technological aspects, I carefully examined the technology and clinical development histories of BioNTech and Moderna by searching their publication, patent application and clinical trials. Compared to the case of Japanese company that has not succeeded in the rapid development of mRNA vaccine, years of in-depth technology research and clinical development experience with other diseases and viruses were found to have enhanced BioNTech and Moderna’s technological readiness and contributed to rapid vaccine development against COVID-19 in addition to government administrative support. …”
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“…Despite these exciting advances, important knowledge gaps persist, including optimal dosing and type of thrombolytic agents, inclusion criteria for mechanical thrombectomy, the role of immunomodulatory therapies for focal cerebral arteriopathy, optimal long-term antithrombotic strategies, the role of patent foramen ovale closure in pediatric stroke, and optimal rehabilitation strategies after stroke of the developing brain. …”
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“…Clematis armandii has been used in many Chinese traditional patent medicines all over the world as a form of Caulis Clematidis Armandii. …”
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“…The lack of direct experimental evidence for Wasserman’s catenane has led to it being described as a “prophetic compound”, a technical term used in patents for claimed molecules that have not yet been synthesized. …”
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“…In summary, we will highlight CBD’s promising biological features for its application in dentistry, despite exiting patents that suggest the current compositions for oral care as the main interest of the industry.…”
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“…Patients are asymptomatic for a prolonged duration due to collateral blood supply to the bowel from the patent superior mesenteric and inferior mesenteric arteries. …”
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“…Furthermore, because intracardiac shunting secondary to a patent foramen ovale (PFO) or atrial septal defect (ASD) also results in a positive saline contrast study with echocardiography, PAVM can be easily misdiagnosed as an intracardiac right-toleft shunt. …”
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“…OBJECTIVE: We report a case of paradoxical cerebral embolism caused by patent foramen ovale (PFO) that was treated by the direct aspiration first pass technique (ADAPT). …”
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“…We use data from an OECD inventor database that spans more than forty years to build collaboration networks in which the network nodes are countries and regions, and linkages are patents produced by inventors from different regions and countries. …”
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“…The advance in new technologies for XOs production could decrease their real cost (USD 25–50/kg) on an industrial scale and would increase the volume of market transactions in the prebiotic sector (USD 4.5 billion). In this sense, new patents and innovations are being strategically developed to expand the use of XOs as daily prebiotics.…”
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“…During the past decade, scientists have tried to replace the phenyl ring in bioactive compounds with saturated bioisosteres to obtain novel patentable structures. However, most of the research in this area has been devoted to the replacement of the para-substituted phenyl ring. …”
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“…We sought to determine the cyclodextrins (CDs) best suited to solubilize a patented succinimido-ferrocidiphenol (SuccFerr), a compound from the ferrociphenol family having powerful anticancer activity but low water solubility. …”
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“…We suggest that underexplored chemical space combined with unconventional binding modes provides excellent opportunities for patentable chemotypes for therapeutic intervention.…”
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“…Four months post-procedure, the stent remained patent and the patient reported considerable improvement in their venous congestion symptoms. …”
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“…The results demonstrated successful remote inflation of the balloon system, with the balloon spacer exhibiting sustained patent and functional integrity over an extended observation period of up to 6 months. …”
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“…Finally, some examples of patents related to the MEMs are mentioned in order to contextualize their current industrial use.…”
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“…Transthoracic echocardiography revealed a bidirectional shunt between the descending aorta and pulmonary artery after interventional closure of the patent ductus arteriosus and severe pulmonary hypertension. …”
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“…This review explores these innovative TB treatments, including studies on nanocarriers containing anti-TB drugs and related patents.…”
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“…HAVOH is a recently patented kind of poly(vinyl alcohol) (PVOH) that was modified with diol monomers. …”
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