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  1. 5821
    por Heinemann, L., Home, P. D., Hompesch, M.
    Publicado 2015
    “…Biosimilar insulins are approved copies of insulins outside patent protection. Advantages may include greater market competition and potential cost reduction, but clinicians and users lack a clear perspective on ‘biosimilarity’ for insulins. …”
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    Biosimilar insulins: guidance for data interpretation by clinicians and users
  2. 5822
    “…Each of these predictions is substantiated by our results: sex‐specific differences in home range size and intrasexual territoriality in wolverine are patently reflected in the spatial and temporal configuration of noninvasively collected genetic samples. …”
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    Noninvasive genetic sampling reveals intrasex territoriality in wolverines
  3. 5823
    “…He showed mild facial dysmorphism, physical growth retardation, a hearing disability, and had a history of patent ductus arteriosus. White matter abnormality on brain magnetic resonance images was also noted. …”
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    A new mosaic der(18)t(1;18)(q32.1;q21.3) with developmental delay and facial dysmorphism
  4. 5824
    “…In addition, the large temperature coefficient problem of permanent magnet can be effectively controlled by using a high quality temperature controller and deuterium external locking technique. Combining our patents such as gradient coil, RF coil, and integration computer software, two kinds of small animal Micro-MRI instruments are developed, by which the high quality MRI images of mice were obtained.…”
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    Development of High-Field Permanent Magnetic Circuits for NMRI/MRI and Imaging on Mice
  5. 5825
    “…With potent statins now off-patent, the overall cost has reduced considerably, and combining these three factors, a familial hypercholesterolaemia service based around DNA-cascade testing is now less than 25% of that estimated by NICE in 2008. …”
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    Improving the cost-effectiveness equation of cascade testing for familial hypercholesterolaemia
  6. 5826
    por Ding, Wenjiang
    Publicado 2016
    “…However, these materials are often subjected to an uncontrolled and fast degradation, acute toxic responses and rapid structural failure presumably due to a localized, too rapid corrosion process. The patented Mg–Nd–Zn–based alloys (JiaoDa BioMg [JDBM]) have been developed in Shanghai Jiao Tong University in recent years. …”
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    Opportunities and challenges for the biodegradable magnesium alloys as next-generation biomaterials
  7. 5827
    “…CONCLUSION: Our case describes a complex aneurysm treatment that consisted of aneurysm trapping, thrombus removal and an STA-M3 MCA branch bypass creation for the protection of the patent M3 insular MCA branch and prevention of further ischemia. …”
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    Middle cerebral artery fusiform aneurysm presented with stroke and delayed subarachnoid hemorrhage trapping, thrombectomy, and bypass
  8. 5828
    “…Considering this, we developed a comprehensive user-friendly data repository of antimicrobial peptides (DRAMP), which holds 17349 antimicrobial sequences, including 4571 general AMPs, 12704 patented sequences and 74 peptides in drug development. …”
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    DRAMP: a comprehensive data repository of antimicrobial peptides
  9. 5829
    “…The mean follow-up length was 24 months (range: 6–38 months). All grafts remained patent without any sign of endoleaks. There were no aneurysm ruptures, deaths, or other complications related to pelvic flow. …”
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    Using a Surgeon-modified Iliac Branch Device to Preserve the Internal Iliac Artery during Endovascular Aneurysm Repair: Single-center Experiences and Early Results
  10. 5830
    “…Nevertheless, access to these highly effective treatments remains an unmet medical need for many people around the world. As patents expire for existing licensed biologic (originator) products, biosimilar products can be approved by regulatory authorities and enter clinical use. …”
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    Clinical and regulatory perspectives on biosimilar therapies and intended copies of biologics in rheumatology
  11. 5831
    “…In Europe, the domestic dog is apparently the main definitive host, but patent infections occur also in other species of carnivores. …”
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    Role of golden jackals (Canis aureus) as natural reservoirs of Dirofilaria spp. in Romania
  12. 5832
    “…Mutations in human AP-2 TF have been linked with bronchio-occular-facial syndrome and Char Syndrome, congenital birth defects characterized by craniofacial deformities and patent ductus arteriosus, respectively. How mutations in AP-2 TF cause the disease phenotypes is not well understood. …”
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    The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis
  13. 5833
    “…In all four patients, postthrombolysis head CT examinations were negative for hemorrhage; CT angiogram showed patent cervical and intracranial arterial vasculature; CT perfusion imaging revealed hyperperfusion with increased relative cerebral blood flow and relative cerebral blood volume and decreased mean transit time along with decreased time to peak in the clinically related artery territory. …”
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    Imaging Evidence for Cerebral Hyperperfusion Syndrome after Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke
  14. 5834
    “…RESULTS: At a median follow-up of 41 months, median PFS and OS were 7 and 21 months, respectively. Patents with a PFS longer than 7 months had a significantly longer OS, compared with patients with a PFS equal to or shorter than 7 months (36 vs 15 months; p<0.001). …”
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    Predictive Factors of Lapatinib and Capecitabine Activity in Patients with HER2-Positive, Trastuzumab-Resistant Metastatic Breast Cancer: Results from the Italian Retrospective Multicenter HERLAPAC Study
  15. 5835
    “…Unfortunately, difficulty with stair climbing often persists and prolongs the challenges of TKR patents. Complete understanding of loading at the knee is of great interest in order to aid patient populations, implant manufacturers, rehabilitation, and future healthcare research. …”
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    Knee Joint Loads and Surrounding Muscle Forces during Stair Ascent in Patients with Total Knee Replacement
  16. 5836
    por Choi, Kwang Ho, Baek, Hye Jin
    Publicado 2016
    “…DISCUSSION: The canal of Nuck is an abnormal patent pouch of the parietal peritoneum extending to the round ligament of the uterus into the labia majora through the inguinal ring. …”
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    Incarcerated ovarian herniation of the canal of Nuck in a female infant: Ultrasonographic findings and review of literature
  17. 5837
    “…The results for 22 compounds show that the most potent MIF inhibitors bind with K(d) values of ca. 50 nM; two are from our laboratory, and the other is a compound from the patent literature. X-ray crystal structures for two of the most potent compounds bound to MIF are also reported here. …”
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    A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors
  18. 5838
    “…Xin-Ke-Shu (XKS) is a traditional Chinese patent medicine used for treatment of coronary heart diseases in China. …”
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    Standardized Chinese Formula Xin-Ke-Shu inhibits the myocardium Ca(2+) overloading and metabolic alternations in isoproterenol-induced myocardial infarction rats
  19. 5839
    “…After an initial course of patent parasitemia and first recrudescence, CB but not AS parasites were observed to recrudesce again in most animals that became pregnant. …”
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    Heterologous Infection of Pregnant Mice Induces Low Birth Weight and Modifies Offspring Susceptibility to Malaria
  20. 5840
    por Ramareddy, Raghu S., Alladi, Anand
    Publicado 2016
    “…Transmission of the organism had varied routes include fallopian tube [1], urethra ejaculatory reflux [4], hematogenous [2], and the patent process of vaginalis [2]. Two of the nine required extensive evaluation for further management. …”
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    Scrotal abscess: Varied etiology, associations, and management
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