“…These observations suggest that (1) Pol II elongation speed affects the nucleotide-level dwell time allowing polyadenylation to occur, (2) poly(A) site clusters are linked to the local elongation rate, and hence do not arise simply by intrinsically imprecise cleavage and polyadenylation of the RNA substrate, (3) DNA sequence elements can affect Pol II elongation and poly(A) profiles, and (4) the cleavage/polyadenylation and Pol II elongation complexes are spatially, and perhaps physically, coupled so that polyadenylation occurs rapidly upon emergence of the nascent RNA from the Pol II elongation complex.…”
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“…METHODOLOGY: During ninety minutes of the TSAFT(90) football simulation, the BFlh FL and single-leg hop distance were measured three times (before, at half-time and after 90 minutes of simulated match-play), and maximal hamstrings eccentric strength and SLHB test scores were recorded twice (before and after simulated match-play) for both legs in physically active participants (n = 15). RESULTS: Maximal eccentric hamstrings’ strength (dominant leg (D): p < 0.001, Hedges’ (adjusted) g effect size = -0.969; non-dominant leg (ND): p < 0.001, g = -0.929) and the SLHB performance (D: p < 0.001, g = -1.249; ND: p < 0.001, g = -1.108) showed large decrements immediately after the TSAFT(90) intervention. …”
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“…Because of its advantages in biology and physics properties, carbon-ion radiotherapy (CIRT) was attempted for the treatment of head and neck ACC; however, the use of CIRT specifically for NACC has not been investigated. …”
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“…BACKGROUND: Chronic diseases and the associated risk factors are preventable with lifestyle changes such as eating a healthier diet and being more physically active. In Malaysia, the prevalence of chronic diseases, including diabetes, hypertension, and heart diseases, has risen. …”
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“…Analysis revealed the following trends in annual prevalence rates (2020; 2021; 2022): lonely (43.2%; 39.3%; 40.9%), severely lonely (9.2%; 12.1%; 15.1%), 14+ physically unhealthy days (24.3%; 19.9%; 39.3%). In regression analysis, loneliness score increased by 0.05 (95CI: 0.02 - 0.07) per quarter over the 27 months. …”
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“…The combination of pH-sensitivity and shear responsiveness leads to excellent injectability and self-healing properties, given that it flows easily upon applying a low stress and recovers instantly in the site of injection. Therefore, the physically cross-linked PAA-g-P(b-LL) hydrogel exhibits remarkable features, namely biocompatibility, biodegradability of cross-links, pH responsiveness, shear-induced injectability and instantaneous self-healing, making it a potential candidate for various biomedical applications.…”
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“…The processing temperature affects the velocity at which the water molecules flow unidirectionally through the nanopores, and could, thus, alter the overall transformation of the PVA chains into a physically crosslinked 3D network. Therefore, the temperature setting during UND can control the mechanical properties of the hydrogel membrane to meet the requirements of various biomaterial applications. …”
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“…Before and after MIP, as well as during the retention test, participants had to physically perform the same sequence as fast and accurately as possible. …”
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“…We develop a finite element multi-physics model to investigate particle tracing in both air and medium phases to replicate the in vivo conditions. …”
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“…Various nutritional and dietary strategies have shown beneficial effects on exercise performance and health and are widely used by athletes and other physically active populations. There is also evidence that some of these practices may dampen the pathophysiological features of EHS, suggesting possible protection or abatement of injury severity. …”
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“…BDBT is a non-canonical FK506-binding protein that physically interacts with Drosophila DBT. The phylogeny of FK506-binding proteins suggests that BDBT is either absent or highly modified in non-dipteran insects. …”
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“…[Image: see text] Biological motors function at the interface of biology, physics, and chemistry, and it remains unsettled what rules from which disciplines account for how these motors work. …”
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“…We pull from the fields of Active Matter Physics, Soft Robotics, and Basal Cognition literature to suggest that the imbrication between material and cognitive processes is closer than standard accounts of multiple realisability suggest. …”
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“…In order to study an in vivo near system of immunologically relevant human cells under physically real microgravity, we performed parabolic flight experiments with primary human M1 macrophages under highly standardized conditions and performed chromatin immunoprecipitation DNA sequencing (ChIP-Seq) for whole-genome epigenetic detection of the DNA-binding loci of the main transcription complex RNA polymerase II and the transcription-associated epigenetic chromatin modification H3K4me3. …”
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“…The attempts to make the building block design methodology for composite structures more efficient via combinations of experiments and related modelling look promising, but models require input data with low scatter and, even more importantly, insight into the physics of the microscopic damage processes yielding delamination initiation and propagation.…”
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“…This study brings forward data on understanding the effect of a major salt supplement, KCl, on the chemical physics of a major muscle protein.…”
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“…Patients described several factors contributing to these feelings including: the challenges of physically getting to the treatment center, particularly in adverse weather conditions; being a burden on family and friends; difficulties accessing the treatment facility; issues with public transport; and financial worries related to high costs. …”
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“…This review starts with a brief introduction to the EDM process, the physics behind the EDM process, and the science of the surface modification process in EDM. …”
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“…However, predicting the exact value of engine out emissions using conventional physics-based or data-driven models is still a challenge for engine researchers due to the complexity the of combustion and emission formation. …”
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“…Our findings may also be of interest to related models of spreading dynamics in epidemiology, biology, finance, and statistical physics.…”
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