“…Our study demonstrated that RND2 functions as an endogenous repressor of the p38 MAPK phosphorylation complex. RND2 physically interacted with p38 and decreased p38 phosphorylation, thereby inhibiting p38 MAPK signalling activities. …”
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“…Mechanistic investigations revealed that TRIM59 physically interacts with abhydrolase domain containing 5 (ABHD5) and directly induced the ubiquitination of ABHD5 and led to its proteasome-dependent degradation. …”
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“…The interactions between CV and MNP/CTAB–EC were interpreted using advanced statistical physics models (ASPM) in order to elucidate the adsorption mechanism. …”
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“…LINC00261 repressed c-Myc transcription by physically interacting and binding with the bromo domain of p300/CBP, preventing the recruitment of p300/CBP to the promoter region of c-Myc and decreasing the H3K27Ac level. …”
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“…It addresses the historically-situated concept of a good death and a bad death and suggests why dying alone, whether completely alone or without significant others physically present, may be considered a bad death. METHODS: As evidence for collective fears about dying alone, we explored the treatment of these deaths in media using headline examples from the US New York Times and the English Guardian newspaper from the 19th century through Sept. 2020. …”
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“…Psychological intervention for patients with CP/CPPS, which is difficult to treat with drugs and physics, can effectively improve clinical efficacy and improve the psychological condition. …”
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“…Foxd4l1.1 directly bound within the promoter of endogenous neural repressor ventx1.1 and inhibited ventx1.1 transcription. Foxd4l1.1 also physically interacted with Xbra in the nucleus and inhibited Xbra-induced ventx1.1 transcription. …”
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“…Recent biochemical studies by a chemically-defined reconstitution approach reveal that, in addition to the structurally-diverse classic tethering factors such as coiled-coil tethering proteins and multisubunit tethering complexes, Rab-family small GTPases also retain the inherent membrane tethering functions to directly and physically bridge two distinct lipid bilayers by themselves. …”
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“…A predominant hallmark of PDAC is the intense fibro-inflammatory stroma which not only physically collapses vasculature but also functionally suppresses anti-tumor immunity. …”
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“…More than 80% of caregivers responded that child care is physically very burdensome. The only statistically significant relationships was between economic status and financial burden (p = 0.026). …”
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“…Besides solving the fundamental question of missing physics in established simulations, this finally allows for the quantitative evaluation of low-angle scattering, which contains valuable information about the material investigated.…”
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“…In addition, we also found that Orais and IGFBP3 were physically associated and regulated each other’s expression levels. …”
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“…Evidence is drawn from various sources, including building physics models, modelled outdoor air pollution levels, time–activity surveys, housing stock surveys, geographical data, and peer-reviewed research. …”
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“…We use this method to explore the potential for improving child nutrition outcomes, in particular stunting, through targeted improvements in dietary diversity in a physically and socio-economically diverse country, namely Zimbabwe. …”
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“…Twenty-four post-stroke participants who were physically inactive took part in the study. The wMRT(OFF) was correlated with the following: skeletal muscle mass (r(s) = -0.46), skeletal muscle mass index (r(s) = -0.45), augmentation index (r(s) = 0.44), augmentation index normalized to a heart rate of 75 bpm (r(s) = 0.64), reflection magnitude (r(s) = 0.43), erythrocyte (r(s) = -0.61), hemoglobin (r(s) = -0.54), hematocrit (r(s) = -0.52) and high-sensitivity C-reactive protein (r(s) = 0.58), all p < 0.05. …”
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“…We posited that visually and physically exploring an unknown environment may be subject to CMI for older adults. …”
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“…The NS and NCSD were characterized for crystallinity, crystal size, assay and dissolution. The NCSD was physically mixed with 0.3% Aerosil(®) 200, 1.76% croscarmellose sodium (CCS) and 0.4% sodium stearyl fumarate (SSF) and filled into size 0 hard gelatin capsules. …”
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“…Eventually, through the identification of two key fluid physic parameters, turbulent energy and shear stress, we succeeded in scaling up the bioreactor to qualitatively and quantitatively achieve clinically applicable levels. …”
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“…In a first approach, we investigated the integration of 1 to 10% CaCl(2) in order to test the hypothesis that small CaCl(2) amounts can be physically entrapped and slowly released from hybrid glass scaffolds. …”
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“…CVH metrics were scored 1 point for each of the following: not smoking, being physically active, normal body mass index, no hypertension, no diabetes mellitus, and no dyslipidemia, or 0 points if otherwise. …”
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