Mostrando 181 - 200 Resultados de 1,200 Para Buscar '"Pirna"', tiempo de consulta: 0.25s Limitar resultados
  1. 181
    “…Our data present a multigenerational epigenetic inheritance mechanism induced by piRNAs.…”
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    piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans
  2. 182
    “…The piRNA pathway protects genomes by silencing mobile elements. …”
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    “Dot COM”, a Nuclear Transit Center for the Primary piRNA Pathway in Drosophila
  3. 183
    “…Piwi-interacting RNAs (piRNAs) guide Piwi Argonautes to suppress transposon activity in animal gonads. …”
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    The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs
  4. 184
    “…Spermatogenesis in mammals is characterized by two waves of piRNA expression: one corresponds to classic piRNAs responsible for silencing retrotransponsons and the second wave is predominantly derived from nontransposon intergenic regions in pachytene spermatocytes, but the function of these pachytene piRNAs is largely unknown. …”
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    Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis
  5. 185
    “…The Piwi-interacting RNA (piRNA) pathway is responsible for germline specification, gametogenesis, transposon silencing, and genome integrity. …”
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    Rapid Evolution of piRNA Pathway in the Teleost Fish: Implication for an Adaptation to Transposon Diversity
  6. 186
    “…As with miRNAs, nbr mutation led to longer length piRNAs – an effect that was dependent on the catalytic residues of the exonuclease domain. …”
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    The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila
  7. 187
    “…Here, we analyzed the effect of Miwi2 deficiency on piRNA biogenesis and transposon repression. Miwi2 deficiency had only a minor impact on piRNA biogenesis; however, the piRNA profile of Miwi2-knockout mice indicated overexpression of several LINE1 TE families that led to activation of the ping-pong piRNA cycle. …”
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    MIWI2 and MILI Have Differential Effects on piRNA Biogenesis and DNA Methylation
  8. 188
    “…In addition, small RNA analysis of human, crab-eating macaque and cattle revealed that piRNAs are also expressed in the female germline and closely resemble piRNAs from testis. …”
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    Piwi proteins and piRNAs in mammalian oocytes and early embryos: From sample to sequence
  9. 189
    “…In animal gonads, nuclear Argonaute proteins of the PIWI clade complexed with small guide RNAs (piRNAs) serve as sequence specificity determinants in this process. …”
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    Silencio/CG9754 connects the Piwi–piRNA complex to the cellular heterochromatin machinery
  10. 190
    “…Hence, a key goal in understanding piRNA pathways is to determine mechanisms that modulate piRNA sequences. …”
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    Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3′ ends in Drosophila
  11. 191
    “…BACKGROUND: Piwi-interacting RNA (piRNA) is the largest class of small non-coding RNA molecules. …”
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    Accurate Prediction of Transposon-Derived piRNAs by Integrating Various Sequential and Physicochemical Features
  12. 192
    “…Germline genes often become re-expressed in soma-derived human cancers as “cancer/testis antigens” (CTAs), and piRNA (PIWI-interacting RNA) pathway proteins are found among CTAs. …”
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    Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway
  13. 193
    “…PIWI-interacting RNAs (piRNAs) are effectors of transposable element (TE) silencing in the reproductive apparatus. …”
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    Export of piRNA precursors by EJC triggers assembly of cytoplasmic Yb-body in Drosophila
  14. 194
    “…In animals, PIWI-interacting RNAs (piRNAs) play a crucial role in genome defense. Moreover, because piRNAs can be maternally transmitted, they contribute to the epigenetic profile of inheritance. …”
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    What Drives Positive Selection in the Drosophila piRNA Machinery? The Genomic Autoimmunity Hypothesis
  15. 195
    “…In larval gonads, we detect rhino-dependent piRNAs indicating de novo biogenesis of functional piRNAs during development. …”
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    From Embryo to Adult: piRNA-Mediated Silencing throughout Germline Development in Drosophila
  16. 196
    “…We do not know how piRNAs co-evolve with TEs in chickens. Here we reported that all active TEs in the chicken germ line are targeted by piRNAs, and as TEs lose their activity, the corresponding piRNAs erode away. …”
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    Domestic chickens activate a piRNA defense against avian leukosis virus
  17. 197
    “…Many computational tools have been proposed during the two last decades for predicting piRNAs, which are molecules with important role in post-transcriptional gene regulation. …”
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    IpiRId: Integrative approach for piRNA prediction using genomic and epigenomic data
  18. 198
    “…Maternal loading of piRNAs in oocytes is further required for the inheritance of piRNA-mediated transposon defence. …”
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    Abundant expression of somatic transposon-derived piRNAs throughout Tribolium castaneum embryogenesis
  19. 199
    “…We noted that identical transgenes located in different genomic sites vary considerably in piRNA production and classified them as “strong” and “weak” piRNA clusters. …”
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    Transcriptional and chromatin changes accompanying de novo formation of transgenic piRNA clusters
  20. 200
    “…The cytoplasmic PIWI protein MILI mediates piRNA-guided transposon RNA cleavage as well as piRNA amplification. …”
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    A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming
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