Mostrando 281 - 300 Resultados de 1,200 Para Buscar '"Pirna"', tiempo de consulta: 0.16s Limitar resultados
  1. 281
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    3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs
  2. 282
    por Haase, Astrid D.
    Publicado 2022
    “…A distinct feature of piRNAs is their origin from single-stranded instead of double-stranded RNA precursors, and piRNAs require a unique set of processing factors. …”
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    An introduction to PIWI-interacting RNAs (piRNAs) in the context of metazoan small RNA silencing pathways
  3. 283
    “…PIWI-interacting RNAs (piRNAs), which protect genome from the attack by transposons, are produced and amplified in membraneless granules called nuage. …”
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    Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis
  4. 284
    “…Specific regions in the genome, called piRNA clusters, are thought to define each species’ piRNA repertoire and therefore its capacity to recognize and silence specific transposon families. …”
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    Unistrand piRNA clusters are an evolutionarily conserved mechanism to suppress endogenous retroviruses across the Drosophila genus
  5. 285
    “…piRNAs are a class of small non-coding RNAs that play essential roles in modulating gene expression and abundant biological processes. …”
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    First Characterization and Regulatory Function of piRNAs in the Apis mellifera Larval Response to Ascosphaera apis Invasion
  6. 286
    “…In Drosophila, Piwi proteins associate with Piwi-interacting RNAs (piRNAs) and protect the germline genome by silencing mobile genetic elements. …”
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    Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila
  7. 287
    “…However, we report here that infection of mosquitoes with an alphavirus also triggers the production of another class of virus-derived small RNAs that exhibit many similarities to ping-pong-dependent piwi-interacting RNAs (piRNAs). However, unlike ping-pong-dependent piRNAs that have been described previously from repetitive elements or piRNA clusters, our work suggests production in the soma. …”
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    Production of Virus-Derived Ping-Pong-Dependent piRNA-like Small RNAs in the Mosquito Soma
  8. 288
    “…In animal gonads, PIWI proteins and their bound 23–30 nt piRNAs guard genome integrity by the sequence specific silencing of transposons. …”
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    The Cochaperone Shutdown Defines a Group of Biogenesis Factors Essential for All piRNA Populations in Drosophila
  9. 289
    “…Piwi-interacting RNAs (piRNAs) fulfill a critical, conserved role in defending the genome against foreign genetic elements. …”
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    A Conserved Upstream Motif Orchestrates Autonomous, Germline-Enriched Expression of Caenorhabditis elegans piRNAs
  10. 290
    “…Less is known about the role of the PIWI-interacting RNA pathway, or piRNA pathway, in antiviral responses. Viral piRNA-like molecules have recently been described following infection of mosquitoes and derived cell lines with several arboviruses. …”
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    Knockdown of piRNA pathway proteins results in enhanced Semliki Forest virus production in mosquito cells
  11. 291
    “…To date, nearly all piRNA studies have been conducted in model organisms and little is known about piRNA diversity, target specificity and biological function in human. …”
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    A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements
  12. 292
    “…As a result of the detailed genetic analyses performed by certain laboratories and of the sophisticated genetic tools they developed, this locus has played a major role in our understanding of piRNA mediated TE repression in animals. Here we review the first discovery of this locus and retrace decades of studies that led to our current understanding of the relationship between genomes and their TE targets.…”
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    History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster
  13. 293
    “…The Piwi-piRNA pathway is active in animal germ cells where its functions are required for germ cell maintenance and gamete differentiation. …”
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    The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells
  14. 294
    “…In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence. However, the evolutionary relationships among piRNAs and other small RNA pathways targeting transposable elements are poorly resolved. …”
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    Ancient and Novel Small RNA Pathways Compensate for the Loss of piRNAs in Multiple Independent Nematode Lineages
  15. 295
    “…BACKGROUND: Piwi-interacting RNAs (piRNAs) are a class of small RNAs; distinct types of piRNAs are expressed in the mammalian testis at different stages of development. …”
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    piRNA-like small RNAs mark extended 3’UTRs present in germ and somatic cells
  16. 296
    “…Here we report a functional somatic piRNA pathway in the adult Drosophila fat body including the presence of the piRNA effector protein Piwi and canonical 23–29 nt long TE-mapping piRNAs. …”
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    A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
  17. 297
    “…Protecting genome integrity against transposable elements is achieved by intricate molecular mechanisms involving PIWI proteins, their associated small RNAs (piRNAs), and epigenetic modifiers such as DNA methylation. …”
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    Contrasting Sex-and Caste-Dependent piRNA Profiles in the Transposon Depleted Haplodiploid Honeybee Apis mellifera
  18. 298
    “…Pachytene piRNAs are MIWI-/MILI-bound small RNAs abundantly expressed in pachytene spermatocytes and round spermatids in adult mouse testes. …”
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    Paternal pachytene piRNAs are not required for fertilization, embryonic development and sperm-mediated epigenetic inheritance in mice
  19. 299
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    PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice
  20. 300
    “…Aub needs to be loaded with piRNAs to control GSC self‐renewal and acts through direct mRNA regulation. …”
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    Aubergine and piRNAs promote germline stem cell self‐renewal by repressing the proto‐oncogene Cbl
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