Mostrando 21 - 40 Resultados de 1,200 Para Buscar '"Pirna"', tiempo de consulta: 0.13s Limitar resultados
  1. 21
    “…While we observe expression of individual piRNA-pathway genes in cancer, we fail to detect the formation of functional piRNA-silencing complexes. …”
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    Aberrant expression of select piRNA-pathway genes does not reactivate piRNA silencing in cancer cells
  2. 22
    “…Primary piRNAs are defined by the endonuclease Zucchini, while biogenesis of secondary piRNAs depends on piRNA-guided transcript cleavage and results in piRNA amplification. …”
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    piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire
  3. 23
    “…With a regular size range of 21-35 nt, piRNAs are associated with a PIWI-clade of Argonaute family proteins. …”
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    piRNA-IPdb: a PIWI-bound piRNAs database to mining NGS sncRNA data and beyond
  4. 24
    “…Metazoans guard their germlines against transposons and other foreign transcripts with PIWI-interacting RNAs (piRNAs). Due to the robust heritability of the silencing initiated by piRNAs in C.elegans, previous screens using Caenorhabditis elegans were strongly biased to uncover members of this pathway in the maintenance process but not in the initiation process. …”
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    Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing
  5. 25
    por Shpiz, Sergey, Kalmykova, Alla
    Publicado 2011
    “…The abundance of telomeric retroelement transcripts, as well as the frequency of their transpositions onto the chromosome ends, is controlled by a PIWI-interacting RNA (piRNA) pathway. In our recent report, we demonstrate strong evidence of piRNA-mediated transcriptional silencing of telomeric repeats in the Drosophila germline. …”
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    Role of piRNAs in the Drosophila telomere homeostasis
  6. 26
    “…PIWI-interacting RNA (piRNA) clusters act as anti-transposon/retrovirus centers. …”
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    The comprehensive epigenome map of piRNA clusters
  7. 27
    “…The piRNA (PIWI-interacting RNA) pathway is a small RNA silencing system that acts in animal gonads and protects the genome against the deleterious influence of transposons. …”
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    The Genetic Makeup of the Drosophila piRNA Pathway
  8. 28
    “…Information ultimately carried by piRNAs is encoded within genomic loci, termed piRNA clusters. …”
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    Minotaur is critical for primary piRNA biogenesis
  9. 29
    por Whitworth, Cale, Oliver, Brian
    Publicado 2014
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    Flipping the doublesex switch with a piRNA
  10. 30
    “…Most Piwi-interacting RNAs (piRNAs) are derived from genomic piRNA clusters. There has been remarkable progress in our understanding of the mechanisms underlying piRNA biogenesis. …”
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    piRNA clusters and open chromatin structure
  11. 31
    “…Accumulating evidence indicates that a small RNA‐based gene regulatory machinery, the Piwi‐piRNA pathway, represents a shared feature of nonaging (potentially immortal) biological systems, including the germline, somatic cancer stem cells, and certain ‘lower’ eukaryotic organisms like the planarian flatworm and freshwater hydra. …”
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    The Piwi‐piRNA pathway: road to immortality
  12. 32
    por Kim, Kyung Won
    Publicado 2019
    “…PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. …”
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    PIWI Proteins and piRNAs in the Nervous System
  13. 33
    “…Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30 nt in length and bind to Piwi proteins. …”
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    The Biogenesis and Functions of piRNAs in Human Diseases
  14. 34
    “…piRNAs are a class of noncoding RNAs that perform functions in epigenetic regulation and silencing of transposable elements, a mechanism conserved among most mammals. …”
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    Identification and Characterization of Polymorphisms in piRNA Regions
  15. 35
    “…PIWI-interacting RNAs (piRNAs) guide PIWI proteins to suppress transposons in the cytoplasm and nucleus of animal germ cells, but how silencing in the two compartments is coordinated is not known. …”
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    PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway
  16. 36
    “…Maturation of piRNAs involves pre-piRNA trimming followed by 2′-O-methylation at their 3′ termini. …”
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    pre-piRNA trimming and 2′-O-methylation protect piRNAs from 3′ tailing and degradation in C. elegans
  17. 37
    “…PIWI proteins use guide piRNAs to repress selfish genomic elements, protecting the genomic integrity of gametes and ensuring the fertility of animal species. …”
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    Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
  18. 38
    “…In the germline of animals, PIWI interacting (pi)RNAs protect the genome against the detrimental effects of transposon mobilization. In Drosophila, piRNA-mediated cleavage of transposon RNA triggers the production of responder piRNAs via ping-pong amplification. …”
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    Endogenous piRNA-guided slicing triggers responder and trailer piRNA production from viral RNA in Aedes aegypti mosquitoes
  19. 39
    “…In Aedes aegypti mosquitoes, the piRNA pathway also contributes to gene regulation in somatic tissues, illustrating additional roles for piRNAs and PIWI proteins besides transposon repression. …”
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    A piRNA-lncRNA regulatory network initiates responder and trailer piRNA formation during mosquito embryonic development
  20. 40
    por Ng, Lui, Navarro, Alfons, Law, Wai-Lun
    Publicado 2023
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    Editorial: Evolving roles of piRNAs in solid tumors
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