Mostrando 541 - 560 Resultados de 1,200 Para Buscar '"Pirna"', tiempo de consulta: 0.30s Limitar resultados
  1. 541
    por Kumar, M. Senthil, Chen, Kevin C.
    Publicado 2012
    “…Piwi-interacting RNAs (piRNAs) and CRISPR RNAs (crRNAs) are two recently discovered classes of small noncoding RNA that are found in animals and prokaryotes, respectively. …”
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    Evolution of animal Piwi-interacting RNAs and prokaryotic CRISPRs
  2. 542
    “…Eukaryotic genomes are colonized by transposons whose uncontrolled activity causes genomic instability. The piRNA pathway silences transposons in animal gonads, yet how this is achieved molecularly remains controversial. …”
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    Transcriptional Silencing of Transposons by Piwi and Maelstrom and Its Impact on Chromatin State and Gene Expression
  3. 543
    “…The Piwi–piRNA pathway represents a small RNA-based mechanism responsible for the recognition and silencing of invading DNA. …”
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    PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans
  4. 544
    “…In 2014, we discovered that Fem is a precursor of a single W chromosome-derived PIWI-interacting RNA (piRNA). Fem-derived piRNA binds to PIWI protein, and this complex then cleaves the mRNA of the Z-linked Masculinizer (Masc) gene, which encodes a protein required for both masculinization and dosage compensation. …”
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    Unique sex determination system in the silkworm, Bombyx mori: current status and beyond
  5. 545
    por Fridrich, Arie, Moran, Yehu
    Publicado 2023
    “…Genome integrity in animals depends on silencing of mobile elements by Piwi-interacting RNAs (piRNAs). A new study in this issue of PLOS Biology reveals recent evolutionary losses of key piRNA biogenesis factors in flies, highlighting adaptability by rapid shift to alternative piRNA biogenesis strategies.…”
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    Some flies do not play ping-pong
  6. 546
    “…Of interest, the analysis of the co-expression of the detected piRNAs revealed a less tightly regulated pattern of piRNA-823, -4153 and -16659 expression in RASF. …”
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    Expression and Regulation of PIWIL-Proteins and PIWI-Interacting RNAs in Rheumatoid Arthritis
  7. 547
    “…Using bioinformatics tools and quantitative PCR, we characterized and validated the miRNA and piRNA processing pathway genes in B. glabrata. In silico analyses showed that genes involved in miRNA and piRNA pathways were highly conserved in protein domain distribution, catalytic site residue conservation and phylogenetic analysis. …”
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    Differential expression of small RNA pathway genes associated with the Biomphalaria glabrata/Schistosoma mansoni interaction
  8. 548
    “…The discovery of novel microRNA (miRNA) and piwi-interacting RNA (piRNA) is an important task for the understanding of many biological processes. …”
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    Prediction of Mature MicroRNA and Piwi-Interacting RNA without a Genome Reference or Precursors
  9. 549
    “…This is accompanied by changes in nuage morphology, expression of large loci (PGC-expressed non-coding RNA loci, PERLs) that are enriched for retro-transposons and piRNAs, and a rise in piRNA biogenesis signatures. …”
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    Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish
  10. 550
    “…Here we show that complex satDNAs (>100-bp repeat units) are transcribed into long noncoding RNAs and processed into piRNAs (PIWI interacting RNAs). This satDNA piRNA production depends on the Rhino-Deadlock-Cutoff complex and the transcription factor Moonshiner—a previously described non-canonical pathway that licenses heterochromatin-dependent transcription of dual-strand piRNA clusters. …”
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    Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline
  11. 551
    “…However, the role of piRNAs has not yet been fully elucidated, and sRNA-seq studies continue to reveal different piRNA activities in the genome. …”
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    A Review of Discovery Profiling of PIWI-Interacting RNAs and Their Diverse Functions in Metazoans
  12. 552
    por Yu, Yong, Ren, Kai-Ming, Chen, Xiao-Long
    Publicado 2021
    “…AIM: To investigate the expression of P-element-induced wimpy testis-interacting RNA (piRNA) in proliferative DR mice and select piRNA related to RNV. …”
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    Expression and role of P-element-induced wimpy testis-interacting RNA in diabetic-retinopathy in mice
  13. 553
    “…Transposable elements (TEs) are silenced in germ cells by a mechanism in which PIWI proteins generate and use PIWI-interacting ribonucleic acid (piRNA) to repress expression of TE genes. piRNA biogenesis occurs by an amplification cycle in microscopic organelles called nuage granules, which are localized to the outer face of the nuclear envelope. …”
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    Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins
  14. 554
    “…As a currently identified small non-coding RNAs (ncRNAs) category, the PIWI-interacting RNAs (piRNAs) are crucial mediators of cell biology. The human genome comprises over 30.000 piRNA genes. …”
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    PIWI interacting RNAs perspectives: a new avenues in future cancer investigations
  15. 555
    “…The piRNA (PIWI-interacting RNA) is P-Element induced wimpy testis (PIWI)-interacting RNA which is a small molecule, non-coding RNA with a length of 24-32nt. …”
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    Emerging roles and potential application of PIWI-interacting RNA in urological tumors
  16. 556
    “…PIWI-interacting RNAs (piRNAs) are small noncoding RNAs that regulate gene expression, yet their molecular functions in neurobiology are unclear. …”
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    PIWI-interacting RNA expression regulates pathogenesis in a Caenorhabditis elegans model of Lewy body disease
  17. 557
    “…As a highly conserved piRNA pathway component, Piwi is widely expressed in both germ cells and somatic cells in the Drosophila ovary and is required for piRNA production in both cell types. …”
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    Piwi Is Required in Multiple Cell Types to Control Germline Stem Cell Lineage Development in the Drosophila Ovary
  18. 558
    “…However, substantial dynamics were also evident in piRNA and snoRNA populations. One miRNA and 2 piRNAs were identified as moderately accurate (area under the curve [AUC] = 0.70 to 0.74) biomarkers for LTBI, as were 1 miRNA, 1 piRNA, and 2 snoRNAs (AUC = 0.79 to 0.91) for accomplished LTBI treatment. …”
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    Reprogramming of Small Noncoding RNA Populations in Peripheral Blood Reveals Host Biomarkers for Latent and Active Mycobacterium tuberculosis Infection
  19. 559
    “…Piwi-interacting RNAs (piRNAs), whose role in germline maintenance has been established, are now also being classified as post-transcriptional regulators of gene expression in somatic cells. …”
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    Piwi-interacting RNAs and PIWI genes as novel prognostic markers for breast cancer
  20. 560
    “…TEX15 is predominantly a nuclear protein that is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing. …”
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    TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing
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