Mostrando 601 - 620 Resultados de 1,200 Para Buscar '"Pirna"', tiempo de consulta: 0.52s Limitar resultados
  1. 601
    “…The regularity of Piwi-interacting RNA (piRNA) biogenesis is crucial to germline development. …”
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    Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish
  2. 602
    “…We suggest that BELLE acts as important element in the piRNA-mediated regulation of the TEs and raise the hypothesis that this specific regulation could represent another level of post-transcriptional control adopted by the clock to ensure the proper rhythmicity.…”
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    The RNA Helicase BELLE Is Involved in Circadian Rhythmicity and in Transposons Regulation in Drosophila melanogaster
  3. 603
    “…Here we show that two Nups of the inner channel, Nup54 and Nup58, are essential for transposon silencing via the PIWI-interacting RNA (piRNA) pathway in the Drosophila ovary. In ovarian follicle cells, loss of Nup54 and Nup58 results in compromised piRNA biogenesis exclusively from the flamenco locus, whereas knockdowns of other NPC subunits have widespread consequences. …”
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    Channel nuclear pore complex subunits are required for transposon silencing in Drosophila
  4. 604
    por Blair, Carol D.
    Publicado 2019
    “…The piRNAs that target transposons originate from piRNA clusters in transposon-rich regions of the Drosophila genome and are processed by three PIWI family proteins. …”
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    Deducing the Role of Virus Genome-Derived PIWI-Associated RNAs in the Mosquito–Arbovirus Arms Race
  5. 605
    “…This study aimed to explore the expression profiles and diagnostic values of piRNAs in LUAD. METHODS: Small RNA sequencing was performed to investigate tissue piRNA profiles of LUAD. …”
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    PIWI‐interacting RNAs are aberrantly expressed and may serve as novel biomarkers for diagnosis of lung adenocarcinoma
  6. 606
    “…PIWI-interacting RNAs (piRNAs), an emergent type of non-coding RNAs during oncogenesis, play critical roles in regulating tumor microenvironment. …”
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    Pan-cancer landscape of immunology PIWI-interacting RNAs
  7. 607
    por Genzor, Pavol, Bortvin, Alex
    Publicado 2015
    “…Piwi-interacting piRNAs are a major and essential class of small RNAs in the animal germ cells with a prominent role in transposon control. …”
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    A Unique HMG-Box Domain of Mouse Maelstrom Binds Structured RNA but Not Double Stranded DNA
  8. 608
    “…PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human genome. …”
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    Piwi-interacting RNAs in cancer: emerging functions and clinical utility
  9. 609
    “…Nearly all of the W chromosome is devoted to piRNA production, and T. ni siRNAs are not 2´-O-methylated. …”
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    The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology
  10. 610
    “…A bioinformatics analysis of piRNA interaction network, followed by experimental validation, revealed the Notch signaling pathway as one of the immediate effectors of MIWI2. …”
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    Somatic MIWI2 Hinders Direct Lineage Reprogramming From Fibroblast to Hepatocyte
  11. 611
    “…The chromosome assemblies obtained using this pipeline also allowed recovering piRNA cluster sequences, which was impossible using short-read sequencing. …”
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    A Transposon Story: From TE Content to TE Dynamic Invasion of Drosophila Genomes Using the Single-Molecule Sequencing Technology from Oxford Nanopore
  12. 612
    “…In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions. …”
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    Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila
  13. 613
    “…Some of the described SINEs and their degenerate copies can be localized both in the introns of genes and loci known as piRNA clusters. piRNAs originating from piRNA clusters are shown to be mapped to seven of the nine types of SINEs described, including copies of SINEs localized in gene introns. …”
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    Identification and functional characterization of the German cockroach, Blattella germanica, short interspersed nuclear elements
  14. 614
    “…Piwi family proteins are essential for germline development and bind piwi-interacting RNAs (piRNAs 1 2 3). The grandchildless gene aub of Drosophila melanogaster encodes the piRNA-binding protein Aub that is essential for formation of primordial germ cells (PGCs) 4. …”
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    Arginine methylation of Piwi proteins, catalyzed by dPRMT5, is required for Ago3 and Aub stability
  15. 615
    “…A disease-associated DNA methylation profile, characterized by targeting members of the PIWI-associated RNA (piRNA) processing machinery, was obtained. Bisulfite genomic sequencing and pyrosequencing in a large cohort (n = 46) of samples validated the altered DNA methylation patterns observed in piRNA-processing genes. …”
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    Epigenetic Disruption of the PIWI Pathway in Human Spermatogenic Disorders
  16. 616
    por Blair, Carol D., Olson, Ken E.
    Publicado 2015
    “…More recent studies suggest that the piRNA and miRNA pathways might also have important roles in arbovirus-vector interactions. …”
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    The Role of RNA Interference (RNAi) in Arbovirus-Vector Interactions
  17. 617
    “…P-element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) have been previously demonstrated to be involved in epigenetic regulation in germline cells. …”
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    The meaning of PIWI proteins in cancer development
  18. 618
    “…Continued up-regulation of the piRNA defense commonly found in the germline of animals can explain the long life of termite reproductives, implying somatic cooption of germline defense during social evolution. …”
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    Longevity and transposon defense, the case of termite reproductives
  19. 619
    “…At the center of the epigenetic control of TEs are small interfering RNAs of the piRNA class, which trigger heterochromatinization of TE sequences. …”
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    Dynamic Interactions Between the Genome and an Endogenous Retrovirus: Tirant in Drosophila simulans Wild-Type Strains
  20. 620
    “…PIWI-interacting RNAs (piRNAs) are a class of non-coding RNAs initially thought to be restricted exclusively to germline cells. …”
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    PIWI-interacting RNAs are differentially expressed during cardiac differentiation of human pluripotent stem cells
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