-
101“…Caenorhabditis elegans piRNAs promote genome surveillance by triggering siRNA-mediated silencing of nonself DNA in competition with licensing programs that support endogenous gene expression.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
102por Ipsaro, Jonathan J., Haase, Astrid D., Knott, Simon R., Joshua-Tor, Leemor, Hannon, Gregory J.“…PIWI-family proteins and their associated small RNAs (piRNAs) act in an evolutionarily conserved innate immune mechanism that provides an essential protection for germ cell genomes against the activity of mobile genetic elements(1). piRNA populations comprise a molecular definition of transposons that permits them to be distinguished from host genes and selectively silenced. piRNAs can be generated in two distinct ways. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
103por Honda, Shozo, Kirino, Yoriko, Maragkakis, Manolis, Alexiou, Panagiotis, Ohtaki, Akashi, Murali, Ramachandran, Mourelatos, Zissimos, Kirino, Yohei“…PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) protect genome integrity by silencing transposons in animal germlines. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
104por Ferreira, Humberto J, Heyn, Holger, Garcia del Muro, Xavier, Vidal, August, Larriba, Sara, Muñoz, Clara, Villanueva, Alberto, Esteller, Manel“…Herein we have studied the putative existence of epigenetic aberrations in the activity of PIWI proteins, an Argonaute family protein subclass, and the small regulatory PIWI-interacting RNAs (piRNAs) in testicular cancer, as the PIWI/piRNA pathway plays a critical role in male germline development. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
105por Song, Jimin, Liu, Jixia, Schnakenberg, Sandra L., Ha, Hongseok, Xing, Jinchuan, Chen, Kevin C.“…Although approximately 20% of novel TE insertions induced de novo piRNA production, the abundance of de novo piRNAs was low and did not markedly affect the global pool of ovarian piRNAs. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
106por Zhang, Peng, Kang, Jun-Yan, Gou, Lan-Tao, Wang, Jiajia, Xue, Yuanchao, Skogerboe, Geir, Dai, Peng, Huang, Da-Wei, Chen, Runsheng, Fu, Xiang-Dong, Liu, Mo-Fang, He, Shunmin“…The piRNA machinery is known for its role in mediating epigenetic silencing of transposons. …”
Publicado 2015
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
107por Seyeddokht, Atefeh, Aslaminejad, Ali Asghar, Masoudi-Nejad, Ali, Nassiri, Mohammadreza, Zahiri, Javad, Sadeghi, Balal“…BACKGROUND: Piwi-interacting RNAs (piRNAs) are small non-coding RNAs (ncRNAs), with a length of about 24–32 nucleotides, which have been discovered recently. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
108por Xu, Lu, Qiu, Lingling, Chang, Guobin, Guo, Qixin, Liu, Xiangping, Bi, Yulin, Zhang, Yu, Wang, Hongzhi, Li, Zhiteng, Guo, Xiaoming, Wan, Fang, Zhang, Yang, Xu, Qi, Chen, Guohong“…Piwi-interacting RNAs (piRNAs) play a key role in spermatogenesis. Here, we describe the piRNAs profiling of primordial germ cells (PGCs), spermatogonial stem cells (SSCs), and the spermatogonium (Sp) during early-stage spermatogenesis in chicken. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
109por Liu, Peiwen, Dong, Yunqiao, Gu, Jinbao, Puthiyakunnon, Santhosh, Wu, Yang, Chen, Xiao-Guang“…BACKGROUND: In eukaryotic organisms, Piwi-interacting RNAs (piRNAs) control the activities of mobile genetic elements and ensure genome maintenance. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
110“…Besides this well-established antiviral machinery, the PIWI-interacting RNA (piRNA) pathway processes viral RNA into piRNAs. In recent years, significant progress has been made in characterizing the biogenesis and function of these viral piRNAs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
111por Ryazansky, Sergei, Radion, Elizaveta, Mironova, Anastasia, Akulenko, Natalia, Abramov, Yuri, Morgunova, Valeriya, Kordyukova, Maria Y., Olovnikov, Ivan, Kalmykova, Alla“…In the Drosophila germline, transposable elements (TEs) are silenced by PIWI-interacting RNA (piRNA) that originate from distinct genomic regions termed piRNA clusters and are processed by PIWI-subfamily Argonaute proteins. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
112“…This is accomplished through the TFIIA-L paralog Moonshiner, which is recruited to piRNA clusters via the Heterochromatin Protein-1 variant Rhino. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
113por Gong, Jishang, Zhang, Quanwei, Wang, Qi, Ma, Youji, Du, Jiaxiang, Zhang, Yong, Zhao, Xingxu“…More than 80% of the 3,106,033 putative piRNAs were mapped to 4637 piRNA-producing genomic clusters using RPKM. 6388 candidate piRNAs were identified from clean reads and the annotations were compared with the yak reference genome repeat region. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
114por Teixeira, Felipe Karam, Okuniewska, Martyna, Malone, Colin D., Coux, Rémi-Xavier, Rio, Donald C., Lehmann, Ruth“…Here, we show that piRNAs and piRNA biogenesis components regulate pre-mRNA splicing of P transposable element transcripts in vivo, leading to the production of the non-transposase-encoding mature mRNA isoform in germ cells. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
115por Zhang, Huan, Ali, Asim, Gao, Jianing, Ban, Rongjun, Jiang, Xiaohua, Zhang, Yuanwei, Shi, Qinghua“…With the development of sequencing technologies, length variations of piRNAs have been identified in several species. However, the extent to which, piRNA isoforms exist, and whether these isoforms are functionally distinct from canonical piRNAs remain uncharacterized. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
116por Barckmann, Bridlin, El-Barouk, Marianne, Pélisson, Alain, Mugat, Bruno, Li, Blaise, Franckhauser, Céline, Fiston Lavier, Anna-Sophie, Mirouze, Marie, Fablet, Marie, Chambeyron, Séverine“…The Piwi-interacting RNAs (piRNAs) pathway is assumed to maintain Drosophila genome homeostasis by downregulating transcriptional and post-transcriptional TE expression in the ovary. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
117por Parhad, Swapnil S., Yu, Tianxiong, Zhang, Gen, Rice, Nicholas P., Weng, Zhiping, Theurkauf, William E.“…In Drosophila, transposon-silencing piRNAs are derived from heterochromatic clusters and a subset of euchromatic transposon insertions, which are bound by the Rhino-Deadlock-Cutoff complex. …”
Publicado 2020
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
118“…This pathway starts from transcribing piRNA clusters to generate long piRNA precursors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
119por Loubalova, Zuzana, Fulka, Helena, Horvat, Filip, Pasulka, Josef, Malik, Radek, Hirose, Michiko, Ogura, Atsuo, Svoboda, Petr“…PIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
120por Wang, Xiaoyang, Zeng, Chenming, Liao, Shanhui, Zhu, Zhongliang, Zhang, Jiahai, Tu, Xiaoming, Yao, Xuebiao, Feng, Xuezhu, Guang, Shouhong, Xu, Chao“…By incorporating two mutually exclusive factors, PID-1 and TOST-1, C. elegans PICS complex plays important roles in piRNA biogenesis, chromosome segregation and cell division. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto
