“…PIWI proteins and PIWI-interacting RNAs (piRNAs) are part of a cellular pathway that has evolved to protect genomes against the proliferation of transposable elements (TEs). …”
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“…For the generation of tRNA(HisGUG)-derived piRNAs, BmThg1l-mediated nucleotide addition to −1 position of tRNA(HisGUG) was required, revealing an important function of BmThg1l in piRNA biogenesis. …”
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“…PIWI proteins and their partner small RNAs, termed piRNAs, are known to control transposable elements (TEs) in the germline. …”
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“…This review features our current understandings of mammalian PIWI-interacting RNAs (piRNAs) and their role in TE regulation in spermatogenesis. …”
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“…Mature piRNAs are processed from longer transcripts, piRNA precursors (pre-piRNAs). …”
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“…PIWI-interacting RNAs (piRNAs) and associated proteins comprise a conserved pathway for silencing transposons in metazoan germlines. piRNA pathway components are also expressed in multipotent somatic stem cells in various organisms. piRNA functions have been extensively explored in bilaterian model systems, however, comprehensive studies in non-bilaterian phyla remain limited. …”
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“…They are PIWI-interacting RNA (piRNA) clusters involved in repression of Transposable Elements. …”
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“…BACKGROUND: piRNAs have a constitutive role in genome defence by silencing transposable elements in the germline. …”
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“…In addition, we found four large piRNA clusters that also resemble flatworm piRNAs but not those earlier described for nematodes. …”
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“…Piwi-interacting RNAs (piRNAs) have been shown to function in germline or gonadal development. …”
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“…The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. …”
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“…We show that the sncRNAome from CSF-derived exosomes is dominated not only by microRNAs (miRNAs) but also by PIWI-interacting RNAs (piRNAs). We define a combined signature consisting of three miRNAs and three piRNAs that are suitable to detect AD with an AUC of 0.83 in a replication cohort and furthermore predict the conversion of mild–cognitive impaired (MCI) patients to AD dementia with an AUC of 0.86 for the piRNA signature. …”
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“…PIWI proteins utilize small RNAs called piRNAs to silence transposable elements, thereby protecting germline integrity. …”
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“…The loss of the piRNA pathway in mice causes male sterility while females remain fertile. …”
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“…BACKGROUND: The piwi-interacting RNAs (piRNAs) are small non-coding RNAs that specifically repress transposable elements (TEs) in the germline of Drosophila. …”
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“…IMC is primarily enriched with various Piwi-interacting RNA (piRNA) proteins and mainly functions as piRNA biogenesis, transposon silencing, mRNA translation, and mitochondria fusion. …”
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“…Because the piRNA pathway genes are involved in piRNA biogenesis and TE control, we sequenced and characterized nine key genes from this pathway in Drosophila buzzatii and Drosophila koepferae species and studied their expression pattern in ovaries of both species and their F1 hybrids. …”
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“…In Caenorhabditis elegans, the binding of Piwi protein to a non-coding RNA form, called piRNA, has been found to be important to both reproductive and aging processes. …”
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“…The development of new biomarkers to improve its prevention and patient management is critical for disease control. piRNAs are small regulatory RNAs important for gene silencing mechanisms, mainly associated with the silencing of transposable elements. piRNA pathways may also be involved in gene regulation and the deregulation of piRNAs may be an important factor in carcinogenic processes. …”
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“…Here we show that a satellite repeat in the mosquito Aedes aegypti promotes sequence-specific gene silencing via the expression of two PIWI-interacting RNAs (piRNAs). Whereas satellite repeats and piRNA sequences generally evolve extremely fast(5–7), this locus was conserved for approximately 200 million years, suggesting a central function in mosquito biology. piRNA production commenced shortly after egg-laying, and inactivation of the more abundant of the piRNAs resulted in failure to degrade maternally provided transcripts and developmental arrest. …”
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