Mostrando 161 - 180 Resultados de 1,200 Para Buscar '"Pirna"', tiempo de consulta: 0.44s Limitar resultados
  1. 161
    por Li, Zhiqing, Tang, Xiaoyin, Shen, En-Zhi
    Publicado 2020
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    How mammalian piRNAs instruct de novo DNA methylation of transposons
  2. 162
    “…SIMPLE SUMMARY: The PIWI-piRNA ribonucleoproteic complexes are pivotal regulators of genome integrity, differentiation and homeostasis and their dysregulation has recently been implicated in carcinogenesis. …”
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    Biopathological Significance of PIWI–piRNA Pathway Deregulation in Invasive Breast Carcinomas
  3. 163
    “…However, within the Dipteran clade of insects, Drosophilid fruit flies and Culicids mosquitoes have evolved several unique mechanistic aspects of their RNAi defenses to combat invading transposons and viruses, with the Piwi-piRNA arm of the RNAi pathways showing the greatest degree of novel evolution. …”
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    Diverse Defenses: A Perspective Comparing Dipteran Piwi-piRNA Pathways
  4. 164
    “…Aub guided by piRNAs ensures genome integrity by cleaving retrotransposons, and genome propagation by trapping mRNAs to form the germplasm that instructs germ cell formation. …”
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    Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation
  5. 165
    “…The piRNA pathway is a specialized small RNA interference that in mosquitoes is mechanistically distant from analogous biology in the Drosophila model. …”
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    Leaning Into the Bite: The piRNA Pathway as an Exemplar for the Genetic Engineering Need in Mosquitoes
  6. 166
    “…X-linked tandem testis-specific Stellate genes encode proteins homologous to the regulatory β-subunit of protein kinase CK2, but they are permanently repressed in wild-type flies by the piRNA pathway via piRNAs originating from the homologous Y-linked Su(Ste) locus. …”
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    Stellate Genes and the piRNA Pathway in Speciation and Reproductive Isolation of Drosophila melanogaster
  7. 167
    “…PIWI-interacting small RNAs (piRNAs) protect the germline genome and are essential for fertility. piRNAs originate from transposable element (TE) RNAs, long non-coding RNAs, or 3´ untranslated regions (3´UTRs) of protein-coding messenger genes, with the last being the least characterized of the three piRNA classes. …”
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    Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs
  8. 168
    “…Emerging studies demonstrate that PIWI-interacting RNAs (piRNAs) are associated with various human cancers. …”
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    Identification of piRNA Targets in Urinary Extracellular Vesicles for the Diagnosis of Prostate Cancer
  9. 169
    “…Piwi-interacting RNAs (piRNAs) regulate many biological processes through mechanisms that are not fully understood. …”
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    Dual roles for piRNAs in promoting and preventing gene silencing in C. elegans
  10. 170
    por Zhang, Tianjiao, Wong, Garry
    Publicado 2022
    “…In germline tissues, piRNAs are amplified via a “ping-pong cycle” to produce secondary piRNAs, which act in transposon silencing. …”
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    Dysregulation of Human Somatic piRNA Expression in Parkinson’s Disease Subtypes and Stages
  11. 171
    “…PIWI-interacting RNAs (piRNAs) are small RNAs required to recognize and silence transposable elements. …”
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    An evolutionarily conserved stop codon enrichment at the 5′ ends of mammalian piRNAs
  12. 172
    “…The second cluster of BSs 39 piRNAs also encodes the oligopeptide. The third cluster of 24 piRNA BS encodes the oligopeptide. …”
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    In Silico Study of piRNA Interactions with the SARS-CoV-2 Genome
  13. 173
    “…PIWI-interacting RNAs (piRNAs), as a novel class of small non-coding RNAs that have been shown to be indispensable in germline integrity and stem cell development. …”
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    Expression characteristics of piRNAs in ovine luteal phase and follicular phase ovaries
  14. 174
    “…Genome integrity of the animal germline is protected from transposable element activity by PIWI-interacting RNAs (piRNAs). While piRNA biogenesis is intensively explored, little is known about the genetical determination of piRNA clusters, the genomic sources of piRNAs. …”
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    The histone demethylase Kdm3 prevents auto-immune piRNAs production in Drosophila
  15. 175
    “…Piwi-interacting RNAs (piRNAs) are a class of non-coding RNAs that play a key role in spermatogenesis. …”
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    Global expression and functional analysis of human piRNAs during HSV-1 infection
  16. 176
    “…Recently, a database of human piRNAs (piwi-interacting RNAs) was created, which allows the study of the binding of many piRNAs to the mRNAs of genes involved in many diseases, including cancer. …”
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    Interactions of piRNAs with the mRNA of Candidate Genes in Esophageal Squamous Cell Carcinoma
  17. 177
    por Lim, Ai Khim, Tao, Liheng, Kai, Toshie
    Publicado 2009
    “…Nuage, a well-conserved perinuclear organelle found in germline cells, is thought to mediate retroelement repression in Drosophila melanogaster by regulating the production of Piwi-interacting RNAs (piRNAs). In this study, we present evidence that the nuage–piRNA pathway components can be found in cytoplasmic foci that also contain retroelement transcripts, antisense piRNAs, and proteins involved in messenger RNA (mRNA) degradation. …”
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    piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline
  18. 178
    por Chuma, Shinichiro, Pillai, Ramesh S.
    Publicado 2009
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    Retrotransposon Silencing by piRNAs: Ping-Pong Players Mark Their Sub-Cellular Boundaries
  19. 179
    “…Furthermore, these cells produce endogenous piRNAs that mapped to transposable elements. Our results show that these mosquito cells can initiate de novo piRNA production and recapitulate the ping-pong dependent piRNA pathway upon viral infection. …”
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    Arbovirus-Derived piRNAs Exhibit a Ping-Pong Signature in Mosquito Cells
  20. 180
    por Rosenkranz, David, Zischler, Hans
    Publicado 2012
    “…Most piRNAs are generated from genomic piRNA clusters. …”
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    proTRAC - a software for probabilistic piRNA cluster detection, visualization and analysis
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