Uncoupling conformational states from activity in an allosteric enzyme

por Pisco, João P., de Chiara, Cesira, Pacholarz, Kamila J., Garza-Garcia, Acely, Ogrodowicz, Roksana W., Walker, Philip A., Barran, Perdita E., Smerdon, Stephen J., de Carvalho, Luiz Pedro S.
Publicado 2017

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

por Philippeos, Christina, Telerman, Stephanie B., Oulès, Bénédicte, Pisco, Angela O., Shaw, Tanya J., Elgueta, Raul, Lombardi, Giovanna, Driskell, Ryan R., Soldin, Mark, Lynch, Magnus D., Watt, Fiona M.
Publicado 2018

Transcriptomic profiling of blood from autoimmune hepatitis patients reveals potential mechanisms with implications for management

por Tana, Michele May-Sien, Klepper, Arielle, Lyden, Amy, Pisco, Angela Oliveira, Phelps, Maira, McGee, Breann, Green, Kelsey, Feng, Sandy, DeRisi, Joseph, Crawford, Emily Dawn, Lammert, Craig S.
Publicado 2022

Perceptions on Extending the Use of Technology after the COVID-19 Pandemic Resolves: A Qualitative Study with Older Adults

por Diehl, Ceci, Tavares, Rita, Abreu, Taiane, Almeida, Ana Margarida Pisco, Silva, Telmo Eduardo, Santinha, Gonçalo, Rocha, Nelson Pacheco, Seidel, Katja, MacLachlan, Mac, Silva, Anabela G., Ribeiro, Oscar
Publicado 2022

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

por Lavrado, João, Brito, Hugo, Borralho, Pedro M., Ohnmacht, Stephan A., Kim, Nam-Soon, Leitão, Clara, Pisco, Sílvia, Gunaratnam, Mekala, Rodrigues, Cecília M. P., Moreira, Rui, Neidle, Stephen, Paulo, Alexandra
Publicado 2015

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

por Mishra, Ajay, Oulès, Bénédicte, Pisco, Angela Oliveira, Ly, Tony, Liakath-Ali, Kifayathullah, Walko, Gernot, Viswanathan, Priyalakshmi, Tihy, Matthieu, Nijjher, Jagdeesh, Dunn, Sara-Jane, Lamond, Angus I, Watt, Fiona M
Publicado 2017

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation

por Kober, Katharina Isabelle, Cano, Amparo, Géraud, Cyrill, Sipilä, Kalle, Mobasseri, Seyedeh Atefeh, Philippeos, Christina, Pisco, Angela Oliveira, Stannard, Andrew, Martin, Alberto, Salvador, Fernando, Santos, Vanesa, Boutros, Michael, Rognoni, Emanuel, Watt, Fiona M.
Publicado 2018

Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase

por Pacholarz, Kamila J., Burnley, Rebecca J., Jowitt, Thomas A., Ordsmith, Victoria, Pisco, João Pedro, Porrini, Massimiliano, Larrouy-Maumus, Gérald, Garlish, Rachel A., Taylor, Richard J., de Carvalho, Luiz Pedro Sório, Barran, Perdita E.
Publicado 2017

Developmental origin and local signals cooperate to determine septal astrocyte identity

por Xie, Yajun, Reid, Christopher M., Granados, Alejandro A., Garcia, Miguel Turrero, Dale-Huang, Fiona, Hanson, Sarah M., Mancia, Walter, Liu, Jonathan, Adam, Manal, Mosto, Olivia, Pisco, Angela O., Alvarez-Buylla, Arturo, Harwell, Corey C.
Publicado 2023

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

por Walko, Gernot, Woodhouse, Samuel, Pisco, Angela Oliveira, Rognoni, Emanuel, Liakath-Ali, Kifayathullah, Lichtenberger, Beate M., Mishra, Ajay, Telerman, Stephanie B., Viswanathan, Priyalakshmi, Logtenberg, Meike, Renz, Lisa M., Donati, Giacomo, Quist, Sven R., Watt, Fiona M.
Publicado 2017

A 2-Gene Host Signature for Improved Accuracy of COVID-19 Diagnosis Agnostic to Viral Variants

por Albright, Jack, Mick, Eran, Sanchez-Guerrero, Estella, Kamm, Jack, Mitchell, Anthea, Detweiler, Angela M., Neff, Norma, Tsitsiklis, Alexandra, Hayakawa Serpa, Paula, Ratnasiri, Kalani, Havlir, Diane, Kistler, Amy, DeRisi, Joseph L., Pisco, Angela Oliveira, Langelier, Charles R.
Publicado 2022

Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing

por Liu, Jonathan, Tran, Vanessa, Vemuri, Venkata Naga Pranathi, Byrne, Ashley, Borja, Michael, Kim, Yang Joon, Agarwal, Snigdha, Wang, Ruofan, Awayan, Kyle, Murti, Abhishek, Taychameekiatchai, Aris, Wang, Bruce, Emanuel, George, He, Jiang, Haliburton, John, Oliveira Pisco, Angela, Neff, Norma F
Publicado 2022

Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells

por Brignall, Ruth, Cauchy, Pierre, Bevington, Sarah L., Gorman, Bethany, Pisco, Angela O., Bagnall, James, Boddington, Christopher, Rowe, William, England, Hazel, Rich, Kevin, Schmidt, Lorraine, Dyer, Nigel P., Travis, Mark A., Ott, Sascha, Jackson, Dean A., Cockerill, Peter N., Paszek, Pawel
Publicado 2017

The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease

por Ohkubo, Rika, Mu, Wei-Chieh, Wang, Chih-Ling, Song, Zehan, Barthez, Marine, Wang, Yifei, Mitchener, Nathaniel, Abdullayev, Rasul, Lee, Yeong Rim, Ma, Yuze, Curtin, Megan, Srinivasan, Suraj, Zhang, Xingjia, Yang, Fanghan, Sudmant, Peter H., Pisco, Angela Oliveira, Neff, Norma, Haynes, Cole M., Chen, Danica
Publicado 2022

Upper airway gene expression reveals a more robust innate and adaptive immune response to SARS-CoV-2 in children compared with older adults

por Mick, Eran, Tsitsiklis, Alexandra, Spottiswoode, Natasha, Caldera, Saharai, Serpa, Paula Hayakawa, Detweiler, Angela M., Neff, Norma, Pisco, Angela Oliveira, Li, Lucy M., Retallack, Hanna, Ratnasiri, Kalani, Williamson, Kayla M., Soesanto, Victoria, Simões, Eric A. F., Kistler, Amy, Wagner, Brandie D., DeRisi, Joseph L., Ambroggio, Lilliam, Mourani, Peter M., Langelier, Charles R.
Publicado 2021

Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2

por Mick, Eran, Kamm, Jack, Pisco, Angela Oliveira, Ratnasiri, Kalani, Babik, Jennifer M., Calfee, Carolyn S., Castañeda, Gloria, DeRisi, Joseph L., Detweiler, Angela M., Hao, Samantha, Kangelaris, Kirsten N., Kumar, G. Renuka, Li, Lucy M., Mann, Sabrina A., Neff, Norma, Prasad, Priya A., Serpa, Paula Hayakawa, Shah, Sachin J., Spottiswoode, Natasha, Tan, Michelle, Christenson, Stephanie A., Kistler, Amy, Langelier, Charles
Publicado 2020

Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children

por Mick, Eran, Tsitsiklis, Alexandra, Spottiswoode, Natasha, Caldera, Saharai, Serpa, Paula Hayakawa, Detweiler, Angela M., Neff, Norma, Pisco, Angela Oliveira, Li, Lucy M., Retallack, Hanna, Ratnasiri, Kalani, Williamson, Kayla M., Soesanto, Victoria, Simões, Eric A. F., Smith, Christiana, Abuogi, Lisa, Kistler, Amy, Wagner, Brandie D., DeRisi, Joseph L., Ambroggio, Lilliam, Mourani, Peter M., Langelier, Charles R.
Publicado 2022

Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults

por Kalantar, Katrina L., Neyton, Lucile, Abdelghany, Mazin, Mick, Eran, Jauregui, Alejandra, Caldera, Saharai, Serpa, Paula Hayakawa, Ghale, Rajani, Albright, Jack, Sarma, Aartik, Tsitsiklis, Alexandra, Leligdowicz, Aleksandra, Christenson, Stephanie A., Liu, Kathleen, Kangelaris, Kirsten N., Hendrickson, Carolyn, Sinha, Pratik, Gomez, Antonio, Neff, Norma, Pisco, Angela, Doernberg, Sarah B., Derisi, Joseph L., Matthay, Michael A., Calfee, Carolyn S., Langelier, Charles R.
Publicado 2022

Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses

por Mick, Eran, Kamm, Jack, Pisco, Angela Oliveira, Ratnasiri, Kalani, Babik, Jennifer M., Castañeda, Gloria, DeRisi, Joseph L., Detweiler, Angela M., Hao, Samantha L., Kangelaris, Kirsten N., Kumar, G. Renuka, Li, Lucy M., Mann, Sabrina A., Neff, Norma, Prasad, Priya A., Serpa, Paula Hayakawa, Shah, Sachin J., Spottiswoode, Natasha, Tan, Michelle, Calfee, Carolyn S., Christenson, Stephanie A., Kistler, Amy, Langelier, Charles
Publicado 2020

Aging hallmarks exhibit organ-specific temporal signatures

por Schaum, Nicholas, Lehallier, Benoit, Hahn, Oliver, Pálovics, Róbert, Hosseinzadeh, Shayan, Lee, Song E., Sit, Rene, Lee, Davis P., Losada, Patricia Morán, Zardeneta, Macy E., Fehlmann, Tobias, Webber, James, McGeever, Aaron, Calcuttawala, Kruti, Zhang, Hui, Berdnik, Daniela, Mathur, Vidhu, Tan, Weilun, Zee, Alexander, Tan, Michelle, Pisco, Angela, Karkanias, Jim, Neff, Norma F., Keller, Andreas, Darmanis, Spyros, Quake, Stephen R., Wyss-Coray, Tony
Publicado 2020