“…Thus, after 35 years of constitutive target gene expression in AAB, we now have the first regulatable expression systems for AAB in hand and further regulatable expression systems for AAB can be expected. KEY POINTS: • Literature search revealed developments and usage of expression systems in AAB. • Only recently 2 regulatable plasmid systems became available for only 2 AAB genera. • Further regulatable expression systems for AAB are in sight.…”
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“…Similarly, a review looking at life-threatening organ complications in AOSD demonstrated that 50% of these cases also required second-line therapies including IVIg or anakinra; however these patients had lower ferritin levels and less severe disease overall. KEY LEARNING POINTS: Literature so far suggests the key severe manifestations of AOSD leading to intensive care admission are cardiogenic failure secondary to myocarditis or cardiogenic shock, non-cardiogenic shock, respiratory failure from ARDS or pleural effusion and haematological complications including macrophage activation syndrome and disseminated intravascular coagulation. …”
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“…METHODS: The Vision Academy Steering Committee met to discuss the principles of an ideal treatment regimen, using evidence from the literature to substantiate each point. Literature searches were performed using the MEDLINE/PubMed database (cut-off date: March 2016) and restricted to English-language publications. …”
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