“…This connectedness and evolvability of robust networks may be a general organizational principle of biological networks. In addition, it exists also for RNA and protein structures, and may thus be a general organizational principle of all biological systems.…”
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“…In this study, we present a principled and biologically motivated computational framework that more effectively exploits the unlabeled data by only using the sequence regions that are more likely to be biologically relevant for better prediction accuracy. …”
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“…Proper preoperative planning, surgical intervention wherever needed at a centre with backing of equipment and implants, selection of appropriate anaesthesia and application of the principle of biological fixation, rigid enough to allow early mobilisation are all very important for a good functional outcome. …”
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“…The second part examines the fascinating mechanistic and conceptual challenges posed by a stem cell system that epitomizes a universal design principle of biological systems: the dynamic steady state.…”
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“…We anticipate that these principles from biological systems can be applied to the rational design of new nanocomposites with improved performance.…”
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“…Dynamics of protein-protein interactions (PPIs) reveals the recondite principles of biological processes inside a cell. Shown in a wealth of study, just a small group of proteins, rather than the majority, play more essential roles at crucial points of biological processes. …”
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“…A focused theme in systems biology is to uncover design principles of biological networks, that is, how specific network structures yield specific systems properties. …”
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“…Sparse sensing with neural-inspired encoding establishes an alternative paradigm in hyperefficient, embodied sensing of spatiotemporal data and sheds light on principles of biological sensing for agile flight control.…”
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“…Here, we used a novel software package, Methcon5, to explore whether the principle of biologic conservation can be used to identify expressed genes. …”
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“…Given a particular state of entropy, we establish levels of information as a novel approach which can unveil general principles of biological organization. Thirty-five geometric aggregates are tested (biological, non-biological, and polygonal simulations) in order to obtain the theoretical and experimental results of their spatial heterogeneity. …”
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“…These observations offer insights into the design principles of biological networks containing these motifs and can help devise optimal strategies for the integration of these motifs into larger synthetic networks.…”
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“…Design approaches, working principles, and biological applications for each example are discussed in detail.…”
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“…The design of novel synthetic transcriptional networks with targeted behaviors will be key to understand the design principles underlying biological networks. In this work, we evolve transcriptional networks towards a targeted dynamics, by using a library of promoters and coding sequences, to design a complex biological memory device. …”
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“…This offers a mechanism to understand a common architectural principle of biological systems, and a way to quantitate the effective rank of the goals under which they evolved.…”
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“…Our systematic approach resulting in experimentally-testable predictions provides insights into a design principle of biological clockwork, with implications for synthetic biology.…”
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“…On a mesoscopic level of protein networks, modules are of significant importance because these building blocks may be the next elementary functional level above individual proteins allowing to gain insight into fundamental organizational principles of biological cells. RESULTS: In this paper, we provide a comparative analysis of five popular and four novel module detection algorithms. …”
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“…One model is based on a simple stimulus counter and the other on the Information Bottleneck (IB) framework which suggests a more general, theoretically justifiable principle for biological and cognitive phenomena. These models are applied to analyze a novelty-detection event-related potential commonly known as the P300. …”
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“…As proof-of-principle for biological particles, astrocytes were focused in hydrogel droplets using the same principle. …”
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“…Long non-coding RNAs (lncRNAs) can crosstalk with each other by post-transcriptionally co-regulating genes involved in the same or similar functions; however, the regulatory principles and biological insights in tumor-immune are still unclear. …”
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“…His research activities are mainly in the fields of the brain-behaviour relation at a high level of description, seeking principles of biological organisation. He worked as a senior scientist at the Hospital for Sick Children in Toronto and was Professor at the University of Toronto, where he taught a graduate course on consciousness and self-awareness, which derived in part from his book The Brain-Behaviour Continuum (World Scientific). …”
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