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Mostrando 221 - 240 Resultados de 4,339 Para Buscar '"Prion"', tiempo de consulta: 0.62s Limitar resultados
  1. 221
    “…Transmissible Spongiform Encephalopathies (TSEs) are fatal neurological disorders caused by prions, which are composed of a misfolded protein (PrP(Sc)) that self-propagates in the brain of infected individuals by converting the normal prion protein (PrP(C)) into the pathological isoform. …”
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    Treatment with a Non-toxic, Self-replicating Anti-prion Delays or Prevents Prion Disease In vivo
  2. 222
    “…Prion diseases are caused by the propagation of misfolded cellular prion proteins (PrPs). …”
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    Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease
  3. 223
    “…Here, we explored whether the ciliary body (CB), the source of aqueous humor, transports iron, and if the prion protein (PrP(C)) facilitates this process as in the outer retina. …”
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    Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission
  4. 224
    “…Prions are proteinaceous infectious agents responsible for a range of neurodegenerative diseases in animals and humans. …”
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    Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?
  5. 225
    “…The prion hypothesis postulates that PrP(Sc), the pathogenic conformer of host-encoded prion protein (PrP), is the unconventional proteinaceous infectious agent called prion. …”
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    Oral Ingestion of Synthetically Generated Recombinant Prion Is Sufficient to Cause Prion Disease in Wild-Type Mice
  6. 226
    “…Prion diseases are a group of neurodegenerative diseases endemic in humans and several ruminants caused by the misfolding of native prion protein (PrP) into pathological conformations. …”
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    Insight From Animals Resistant to Prion Diseases: Deciphering the Genotype – Morphotype – Phenotype Code for the Prion Protein
  7. 227
    “…Conformational conversion of the cellular prion protein, PrP(C), into the abnormally folded isoform, PrP(Sc), is a key pathogenic event in prion diseases. …”
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    Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91–106
  8. 228
    “…Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic hypothesis in prion disease. …”
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    Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
  9. 229
    “…Misfolding of the cellular prion protein, PrP(C), into the amyloidogenic isoform, PrP(Sc), which forms infectious protein aggregates, the so-called prions, is a key pathogenic event in prion diseases. …”
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    Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells
  10. 230
    “…Prion diseases are transmissible spongiform encephalopathies (TSEs) caused by a conformational conversion of the native cellular prion protein (PrP(C)) to an abnormal, infectious isoform called PrP(Sc). …”
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    Epigenetic Changes in Prion and Prion-like Neurodegenerative Diseases: Recent Advances, Potential as Biomarkers, and Future Perspectives
  11. 231
    “…Sporadic Creutzfeldt-Jakob disease (sCJD) is the most commonly diagnosed human prion disease caused by the abnormal misfolding of the ‘cellular’ prion protein (PrP(C)) into the transmissible ‘scrapie-type’ prion form (PrP(Sc)). …”
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    Minimal change prion retinopathy: Morphometric comparison of retinal and brain prion deposits in Creutzfeldt-Jakob disease
  12. 232
    por Mendoza Vázquez, Héctor
    Publicado 1998
    Tesis Libro
    El prión como agenta infeccioso
  13. 233
    “…The number of yeast prions and prion-like proteins described since 1994 has grown from two to nearly twenty. …”
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    How Big Is the Yeast Prion Universe?
  14. 234
    “…A report on a Joint Cold Spring Harbor Laboratory/Wellcome Trust Conference on 'Prion Biology', Hinxton, UK, 7-11 September 2005.…”
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    Unraveling prion structures and biological functions
  15. 235
    “…BACKGROUND: Bovine spongiform encephalopathy (BSE) is a fatal neurological disorder characterized by abnormal deposits of a protease-resistant isoform of the prion protein. Characterizing linkage disequilibrium (LD) and haplotype networks within the bovine prion gene (PRNP) is important for 1) testing rare or common PRNP variation for an association with BSE and 2) interpreting any association of PRNP alleles with BSE susceptibility. …”
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    Prion gene haplotypes of U.S. cattle
  16. 236
    por Premzl, Marko, Gamulin, Vera
    Publicado 2007
    “…We made use of the present availability of vertebrate genomic sequences, and we have conducted the most comprehensive comparative genomic analysis of the prion protein gene PRNP and its homologues, shadow of prion protein gene SPRN and doppel gene PRND, and prion testis-specific gene PRNT so far. …”
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    Comparative genomic analysis of prion genes
  17. 237
    “…Scrapie and chronic wasting disease are contagious prion diseases affecting sheep and cervids, respectively. …”
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    Direct Detection of Soil-Bound Prions
  18. 238
    por Dove, Alan W.
    Publicado 2002
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    A Prion in yeast Huntington's disease
  19. 239
    por Ryou, Chongsuk, Mays, Charles E.
    Publicado 2008
    “…Prion diseases are caused by proteinaceous pathogens termed prions. …”
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    Prion propagation in vitro: are we there yet?
  20. 240
    “…Capacitor systems, which allow the accumulation of cryptic genetic variation and release it under stressful conditions, might provide such a mechanism. In yeast, the prion [PSI(+)] exposes a large array of previously hidden genetic variation, and the phenotypes it thereby produces are advantageous roughly 25% of the time. …”
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    Prion Switching in Response to Environmental Stress
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