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Mostrando 41 - 60 Resultados de 4,339 Para Buscar '"Prion"', tiempo de consulta: 0.55s Limitar resultados
  1. 41
    “…Many questions surround the underlying mechanism for the differential metabolic processing observed for the prion protein (PrP) in healthy and prion-infected mammals. …”
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    Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions
  2. 42
    por Ma, Jiyan, Zhang, Jingjing, Yan, Runchuan
    Publicado 2022
    “…Generating a prion with exogenously produced recombinant prion protein is widely accepted as the ultimate proof of the prion hypothesis. …”
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    Recombinant Mammalian Prions: The “Correctly” Misfolded Prion Protein Conformers
  3. 43
    “…Previous studies have revealed that the infectious scrapie isoform of prion protein (PrP(Sc)) harbored in the skin tissue of patients or animals with prion diseases can be amplified and detected through the serial protein misfolding cyclic amplification (sPMCA) or real-time quaking-induced conversion (RT-QuIC) assays. …”
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    Decrease in Skin Prion-Seeding Activity of Prion-Infected Mice Treated with a Compound Against Human and Animal Prions: a First Possible Biomarker for Prion Therapeutics
  4. 44
    por Eraña, Hasier
    Publicado 2019
    “…However, instead of encompassing all these amyloidogenic proteins under the umbrella term "prion", new terminology has raised including the terms prion-like, prionoid, quasi-prion or propagon. …”
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    The Prion 2018 round tables (II): Aβ, tau, α-synuclein… are they prions, prion-like proteins, or what?
  5. 45
    “…Prion diseases and the prion protein are only partially understood so far in many aspects. …”
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    Human prion diseases and the prion protein – what is the current state of knowledge?
  6. 46
    “…H-type prions failed to infect the mice.…”
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    Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
  7. 47
    “…The four glycoforms of the cellular prion protein (PrP(C)) variably glycosylated at the two N-linked glycosylation sites are converted into their pathological forms (PrP(Sc)) in most cases of sporadic prion diseases. …”
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    Glycoform-Selective Prion Formation in Sporadic and Familial Forms of Prion Disease
  8. 48
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    Neurotoxicity of Prion Peptides Mimicking the Central Domain of the Cellular Prion Protein
  9. 49
    “…Prion diseases are fatal neurodegenerative sporadic, inherited, or acquired disorders. …”
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    From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases
  10. 50
    por Ma, Qian, Hu, Ji-Ying, Chen, Jie, Liang, Yi
    Publicado 2013
    “…Prion diseases and prion- like protein misfolding diseases are related to the accumulation of abnormal aggregates of the normal host proteins including prion proteins and Tau protein. …”
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    The Role of Crowded Physiological Environments in Prion and Prion-like Protein Aggregation
  11. 51
    “…BACKGROUND: Prions are a particular type of amyloids related to a large variety of important processes in cells, but also responsible for serious diseases in mammals and humans. …”
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    PrionScan: an online database of predicted prion domains in complete proteomes
  12. 52
    por Dong, Xiao-Ping
    Publicado 2014
    “…Through human prion disease cases, infectious animal models, cell models and prion proteins, the neuropathological and pathogenic characteristics of prion diseases, the cytotoxicity of pathological prion, the conversion and replication of prion and the infectivity of prion strains were comprehensively evaluated. …”
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    146 Understanding the pathogenesis of prion and surveillance for human prion diseases in China
  13. 53
    “…INTRODUCTION: The prion protein (PrP) binds to various molecular partners, but little is known about their potential impact on the pathogenesis of prion diseases RESULTS: Here, we show that PrP can interact in vitro with acetylcholinesterase (AChE), a key protein of the cholinergic system in neural and non-neural tissues. …”
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    Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases
  14. 54
    “…Antibodies targeting the globular domain (GD) of the cellular prion protein PrP(C) trigger a neurotoxic syndrome morphologically and molecularly similar to prion disease. …”
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    Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication
  15. 55
    “…Prions are unique infectious agents that replicate without a genome and cause neurodegenerative diseases that include chronic wasting disease (CWD) of cervids. …”
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    Prion Amplification and Hierarchical Bayesian Modeling Refine Detection of Prion Infection
  16. 56
    “…We found that prions can convert, but the efficiency of conversion is affected by polymorphic variation in the cervid and human prion protein genes. …”
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    Susceptibility of Human Prion Protein to Conversion by Chronic Wasting Disease Prions
  17. 57
    “…Prions are pathogens formed from abnormal conformers (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)). …”
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    Host prion protein expression levels impact prion tropism for the spleen
  18. 58
    “…The progressive spreading of these inclusions from initially affected sites to interconnected brain areas is reminiscent of the behavior of bona fide prions in transmissible spongiform encephalopathies (TSEs), hence the term prion-like proteins has been coined. …”
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    C. elegans Models to Study the Propagation of Prions and Prion-Like Proteins
  19. 59
    por Hara, Hideyuki, Sakaguchi, Suehiro
    Publicado 2020
    “…The normal cellular isoform of prion protein, designated PrP(C), is constitutively converted to the abnormally folded, amyloidogenic isoform, PrP(Sc), in prion diseases, which include Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals. …”
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    N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases
  20. 60
    por Cherry, Pearl, Gilch, Sabine
    Publicado 2020
    “…Prion diseases are fatal and transmissible neurodegenerative diseases in which the cellular form of the prion protein ‘PrP(c)’, misfolds into an infectious and aggregation prone isoform termed PrP(Sc), which is the primary component of prions. …”
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    The Role of Vesicle Trafficking Defects in the Pathogenesis of Prion and Prion-Like Disorders
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