“…Recent data have identified a dual role in these events for glial cells, such as microglia and astrocytes, which are able both to induce and to protect against damage induced by diverse stresses. Cyclo(His-Pro), a cyclic dipeptide derived from the hydrolytic removal of the amino-terminal pyroglutamic acid residue of the hypothalamic thyrotropin-releasing hormone, may be important in regulating the nature of the glial cell contribution. …”
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“…We test the psychometric properties of the English version of the G20 with a Prolific (ProA) user sample. We assess the adequacy of the G20 for the crowdsourcing population in its English version. …”
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“…Whole-genome sequencing revealed biallelic variants in the POLG gene: a known pathogenic variant [NM_001126131.2:c.2209G>C (p.Gly737Arg)] and a novel likely pathogenic variant [NM_001126131.2:c.3305A>C (p.Gln1102Pro)]. A genetic diagnosis was made before the appearance of more readily recognizable features of mitochondrial disease, allowing us to avoid invasive tissue biopsies or potentially deleterious treatments, such as sodium valproate. …”
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“…Herein, we have generated ssRNA aptamers to inhibit SARS-CoV-2 M(pro), a protease necessary for the SARS-CoV-2 coronavirus replication. …”
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“…Most existing models focus on a few specific syndromes; however, recent evidence from multi-gene panel testing shows that many syndromes are overlapping, motivating the development of models that incorporate family history on several cancers and predict mutations for a comprehensive panel of genes. We present PanelPRO, a new, open-source R package providing a fast, flexible back-end for multi-gene, multi-cancer risk modeling with pedigree data. …”
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“…The LFA also successfully detected RVFV antibodies in reference RVFV sera. Protein A (ProA), which has the ability to bind immunoglobulins from different species, was used in the detection probe, giving the developed RVFV LFA potential for multi-species diagnosis.…”
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“…Une préparation aux diplômes DFP A2, DELF Pro A1 et A2 et au test BULATS En annexes : des tableaux de conjugaison, un mémento des actes de parole, une liste des sigles les plus courants, une carte de France, les transcriptions et les corrigés des autoévaluations + un DVD-ROM encarté pour une autonomie totale de l'apprenant, avec : l'intégralité de l'audio des documents vidéos authentiques des documents complémentaires des fiches portfolio un lexique multilingue interactif…”
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“…By assessing cell viability with the MTT reduction assay, we found that salsolinol exhibited a selective toxicity toward OCT2-expressing cells that was prevented by cyclo(his-pro). A frequent genetic variant of OCT2 with the amino acid substitution R400C reduced the transport efficiency for the cytoprotective cyclo(his-pro) and thereby increased the susceptibility to salsolinol-induced cell death. …”
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“…This was confirmed by studying the response of different mouse strains to two kinds of polypeptides: (T,G)-Pro-A--L 717 and 718 and (T,G)-A-Pro--L 719 and 721. …”
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“…To better utilize the knowledge dispersed in published literature, we developed PhaSepDB (http://db.phasep.pro/), a manually curated database of phase separation associated proteins. …”
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“…Together, the data presented here showed that Pro, a weak opioid analgesic drug, attenuates OxyHb-induced mitochondria-dependent apoptosis in an active-β-catenin-c-Myc-dependent manner.…”
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“…To explore non-peptidic inhibitors of HRV 3C(pro), a series of novel heteroaromatic esters was synthesized and evaluated for inhibitory activity against HRV 3C(pro), to determine the structure–activity relationships. …”
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“…The practical contribution of the study is the use of NodeXL Pro, a unique SNA tool for advanced social media crawling, SNA and advanced network metric analysis.…”
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“…Here, we implement an original virtual screening (VS) protocol for repositioning approved drugs in order to predict which of them could inhibit the main protease of the virus (M-pro), a key target for antiviral drugs given its essential role in the virus’ replication. …”
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“…As proteases, together with polymerases, are main targets of antiviral drug design, we here have performed biochemical high throughput screening (HTS) with recombinantly expressed SARS-CoV-2 M(pro). A fluorescent assay was used to identify inhibitors in a compound library containing known drugs, bioactive molecules and natural products. …”
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“…To identify the functional region of APPV-N(pro), a panel of truncated APPV-N(pro) was constructed, and its influence on the IRF3 activation was investigated. …”
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“…Furthermore, several marine metabolites isolated from diverse sponges and algae have been shown to inhibit main protease (M(pro)), a crucial protein required for the viral life cycle. …”
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“…Understanding the catalytic mechanism of M(pro), a cysteine protease with a catalytic site comprising the noncanonical Cys145–His41 dyad, can help in guiding drug design. …”
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“…Solvation/desolvation energetic contributions play an important role in the transition from the inactive to the active state, with Phe140 moving from an exposed to a buried environment and Asn142 moving from a buried environment to an exposed environment. In new‐inactive M(pro) a new cavity is present near the S2′ subsite, and the N‐terminal and C‐terminal tails, as well as the dimeric interface, are perturbed, with partial destabilization of the dimeric assembly. …”
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“…Here, we present SINATRA Pro, a computational pipeline designed to robustly identify topological differences between two sets of protein structures. …”
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