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121por Ravanfar, Raheleh, Sheng, Yuling, Shahgholi, Mona, Lomenick, Brett, Jones, Jeff, Chou, Tsui-Fen, Gray, Harry B., Winkler, Jay R.“…The SARS-CoV-2 main protease (M(pro)) is responsible for cleaving twelve nonstructural proteins from the viral polyprotein. M(pro), a cysteine protease, is characterized by a large number of noncatalytic cysteine (Cys) residues, none involved in disulfide bonds. …”
Publicado 2022
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122“…We then developed DecontPro, a novel Bayesian hierarchical model that can decontaminate ADT data by estimating and removing contamination from these sources. …”
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123“…We will use Prolific Academic (ProA: https://www.prolific.co) to recruit participants and host our study on the Gorilla™ platform (www.gorilla.sc). …”
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124por Jelušić, Aleksandra, Scortichini, Marco, Marković, Sanja, Mitrović, Petar, Iličić, Renata, Stanković, Slaviša, Popović Milovanović, Tatjana“…Phylogeographic relatedness was reconstructed using the Templeton, Crandall, and Sing’s (TCS) haplotype network based on concatenated sequences of the housekeeping genes dnaX, icdA, mdh, and proA, while pairwise genetic distances were computed by applying the p-distance model. …”
Publicado 2023
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125“…METHODS: Sixty healthy people (24 men and 36 women) have undergone tests for ankle strength and range of motion, using Biodex System 4 Pro; a one-leg balance, including postural sway and stability index using a Balance System; in which data were collected in a self-reported Desmond fall risk questionnaire. …”
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126“…Additionally, the search tool provides pre-computed PROSITE motifs for each sequence in the database with appropriate hyperlinks to InterPro. A search facility is also available through the web server. …”
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127“…Interestingly, a number of Epichloë festucae genes that are required for hyphal cell–cell fusion, such as noxA, noxR, proA, mpkA and mkkA, are also required for the establishment of a mutualistic symbiotic interaction with Lolium perenne. …”
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128“…Moreover, NeuroMatic has the advantage of working within Igor Pro, a platform-independent environment that includes an extensive library of built-in functions, a history window for reviewing the user's workflow and the ability to produce publication-quality graphics. …”
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129por Pasin, Fabio, Shan, Hongying, García, Beatriz, Müller, Maren, San León, David, Ludman, Márta, Fresno, David H., Fátyol, Károly, Munné-Bosch, Sergi, Rodrigo, Guillermo, García, Juan Antonio“…Here, we show that P1Pro, a plum pox virus clone that lacks the P1 autoinhibitory domain, triggers complex reprogramming of the host transcriptome and high levels of abscisic acid (ABA) accumulation. …”
Publicado 2020
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130“…To improve oral bioavailability and therapeutic/healthy efficacy of hydrophobic drugs and nutrients, herein, protamine (PRO), a cationic cell-penetrating peptide, was introduced into protein and polysaccharide complex emulsion. …”
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131por Koudelka, Tomas, Boger, Juliane, Henkel, Alessandra, Schönherr, Robert, Krantz, Stefanie, Fuchs, Sabine, Rodríguez, Estefanía, Redecke, Lars, Tholey, Andreas“…The genome of coronaviruses, including SARS‐CoV‐2, encodes for two proteases, a papain like (PL(pro)) protease and the so‐called main protease (M(pro)), a chymotrypsin‐like cysteine protease, also named 3CL(pro) or non‐structural protein 5 (nsp5). …”
Publicado 2020
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132por Bernabe-Valero, Gloria, Blasco-Magraner, José Salvador, Aguilar-Moya, Remedios, Moret-Tatay, Carmen“…A sample of 306 north Americans was recruited by crowdsourcing platform ProA to obtain a representative sample based on age and gender. …”
Publicado 2021
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133“…In this study, we implemented a structure-based virtual screening (VS) protocol in search of compounds that could inhibit the viral M(pro). A library of >eight hundred compounds was screened by molecular docking into multiple structures of M(pro), and the result was analyzed by consensus strategy. …”
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134“…In the current study, we demonstrate direct coupling of protein A affinity chromatography with native mass spectrometry (ProA-MS) for development of a robust method that can be used to generate information on the PQA profile of mAbs and related products in as little as 5 min. …”
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135por Kandagalla, Shivananada, Rimac, Hrvoje, Gurushankar, Krishnamoorthy, Novak, Jurica, Grishina, Maria, Potemkin, Vladimir“…We selected 11 specific withanolide compounds, such as withaphysalin, withasomniferol, and withafastuosin, through manual literature curation against 3CL(pro). A molecular similarity analysis showed their similarity with compounds that have an established inhibitory activity against the SARS-CoV-2. …”
Publicado 2022
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136por Schaeffer, R. Dustin, Zhang, Jing, Kinch, Lisa N., Pei, Jimin, Cong, Qian, Grishin, Nick V.“…A portion (6.3%) of these classified globular domains lack sequence-based annotation in InterPro. A quarter (23%) have not been structurally modeled by homology, and they contain 2,540 known disease-causing single amino acid variations whose pathogenesis can now be inferred using AF models. …”
Publicado 2023
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137por Nagao, Shigeki, Yakushijin, Kimikazu, Higashime, Ako, Kawaguchi, Koji, Watanabe, Marika, Sakai, Rina, Ichikawa, Hiroya, Mizutani, Yu, Goto, Hideaki, Kakiuchi, Seiji, Kurata, Keiji, Kitao, Akihito, Miyata, Yoshiharu, Imamura, Yoshinori, Hirota, Yushi, Takahashi, Michiko, Kawamoto, Shinichiro, Yamamoto, Katsuya, Matsuoka, Hiroshi, Minami, Hironobu“…Hyperglycemia in the early days following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a well-known risk factor for acute graft-versus-host disease (GVHD) and non-relapse mortality. The FreeStyle Libre Pro, a factory calibrated continuous glucose monitoring (CGM) device, has been used for the retrospective analysis of glucose testing in patients with diabetes. …”
Publicado 2023
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138por Barrack, Kaitlyn E., Hampton, Thomas H., Valls, Rebecca A., Surve, Sarvesh V., Gardner, Timothy B., Sanville, Julie L., Madan, Juliette C., O’Toole, George A.“…Additionally, microbial communities passaged in CF-MiPro produce significantly less immunomodulatory short chain fatty acids (SCFA), including propionate and butyrate, than communities passaged in MiPro, a culture medium representative of healthy gut physiology, confirming not only a shift in microbial composition but altered community function. …”
Publicado 2023
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139por Sun, Qiangzheng, Lan, Ruiting, Wang, Yiting, Wang, Jianping, Luo, Xia, Zhang, Shaomin, Li, Peijing, Wang, Yan, Ye, Changyun, Jing, Huaiqi, Xu, Jianguo“…PCR and sequencing revealed that SfI and SfX were integrated in tandem into the proA-yaiC region of the host chromosome. CONCLUSIONS: These findings suggest a new S. flexneri serotype could be created in nature. …”
Publicado 2011
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140por Christensen, Heidi M, Schou, Morten, Goetze, Jens P, Faber, Jens, Frystyk, Jan, Flyvbjerg, Allan, Kistorp, Caroline“…METHODS: In a cross-sectional study including 171 patients with CHF and a left ventricular ejection fraction (LVEF) ≤45% the impact of BMI on circulating plasma concentrations of adiponectin, α-defensins, high sensitivity C-reactive protein (hsCRP), copeptin, mid-regional pro-adrenomedullin (MR-proADM), NT-proBNP, and mid-regional pro-A-type natriuretic peptide (MR-proANP) were evaluated. …”
Publicado 2013
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