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141por Lin, Min-Han, Chuang, Shang-Ju, Chen, Chiao-Che, Cheng, Shu-Chun, Cheng, Kai-Wen, Lin, Chao-Hsiung, Sun, Chiao-Yin, Chou, Chi-Yuan“…The steady-state kinetic and deubiquitination activity assays indicated that MERS-CoV PL(pro) exhibits potent deubiquitination activity but lower proteolytic activity, compared with SARS-CoV PL(pro). A natural mutation, Leu105, is the major reason for this difference. …”
Publicado 2014
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142“…URS episode duration and severity were also not influenced by PRO. A significant time × group interaction effect was observed for plasma CMV antibody titres in CMV seropositive participants (p < 0.01) with antibody titre falling in the PRO group but remaining unchanged in the PLA group over time. …”
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143por Drewnowski, Adam, Mognard, Elise, Gupta, Shilpi, Ismail, Mohd Noor, Karim, Norimah A., Tibère, Laurence, Laporte, Cyrille, Alem, Yasmine, Khusun, Helda, Februhartanty, Judhiastuty, Anggraini, Roselynne, Poulain, Jean-Pierre“…Energy and nutrient intakes were estimated using Nutritionist Pro. A novel recipe-based frequency count coded protein sources as meat (chicken, beef, pork, and mutton), fish, eggs, dairy, and plants (cereals, pulses, tubers). …”
Publicado 2020
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144“…One of them showed that folic acid inhibits the furin protease which the virus needs in order to enter its host cell, while the other one explained that folic acid inactivates protease 3CL(pro), a protein that the virus needs to replicate. …”
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145por Hsieh, Ching-Lin, Goldsmith, Jory A., Schaub, Jeffrey M., DiVenere, Andrea M., Kuo, Hung-Che, Javanmardi, Kamyab, Le, Kevin C., Wrapp, Daniel, Lee, Alison G., Liu, Yutong, Chou, Chia-Wei, Byrne, Patrick O., Hjorth, Christy K., Johnson, Nicole V., Ludes-Meyers, John, Nguyen, Annalee W., Park, Juyeon, Wang, Nianshuang, Amengor, Dzifa, Lavinder, Jason J., Ippolito, Gregory C., Maynard, Jennifer A., Finkelstein, Ilya J., McLellan, Jason S.“…Testing combinations of beneficial substitutions resulted in the identification of HexaPro, a variant with six beneficial proline substitutions exhibiting ~10-fold higher expression than its parental construct and the ability to withstand heat stress, storage at room temperature, and three freeze-thaw cycles. …”
Publicado 2020
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146“…When compared with the results of the freezing point depression method used by the OsmoPro, a percentage of the measured urine osmolality by the UF‐5000 was outside the allowable limit.…”
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147por Chen, Zinuo, Cui, Qinghua, Cooper, Laura, Zhang, Pin, Lee, Hyun, Chen, Zhaoyu, Wang, Yanyan, Liu, Xiaoyun, Rong, Lijun, Du, Ruikun“…Moreover, our study demonstrated that the two hit compounds are dual inhibitors targeting the SARS-CoV-2 3-chymotrypsin-like protease (3CL(pro)) in addition to PL(pro). A mechanism of action study using enzyme kinetics further characterized the two compounds as irreversible inhibitors against both 3CL(pro) and PL(pro). …”
Publicado 2021
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148por Logger, Jade G. M., Driessen, Rieke J. B., de Jong, Elke M. G. J., van Erp, Piet E. J.“…This study aimed to determine the value of GPSkin Pro, a new handheld device determining both SCH and TEWL, to measure skin barrier impairment and to monitor barrier function in rosacea in daily practice. …”
Publicado 2020
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149por Markelova, Natalia, Glazunova, Olga, Alikina, Olga, Panyukov, Valeriy, Shavkunov, Konstantin, Ozoline, Olga“…Of the two fragments secreted by P. copri, one abolished the stimulatory effect of E. coli RNA derived from the 3′-UTR of ProA mRNA, while the other inhibited bacterial growth only in the double-stranded state with complementary RNA. …”
Publicado 2021
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150por Sawant, Sanjay, Patil, Rajesh, Khawate, Manoj, Zambre, Vishal, Shilimkar, Vaibhav, Jagtap, Suresh“…Recently, main protease (M(pro)), a potential drug target from SARS-CoV-2 has been successfully crystallised. …”
Publicado 2021
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151por van Rossen, Tessel M., Ooijevaar, Rogier E., Kuyvenhoven, Johan Ph., Eck, Anat, Bril, Herman, Buijsman, René, Boermeester, Marja A., Stockmann, Hein B. A. C., de Korte, Niels, Budding, Andries E.“…Microbiota composition was analyzed with IS-pro, a 16S-23S based bacterial profiling technique. …”
Publicado 2021
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152“…One possible solution to the present problem is to develop drugs that can inhibit SARS-CoV-2 main protease (M(pro)), a coronavirus protein that been considered as one among many drug targets. …”
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153“…One of the most attractive coronaviral drug targets is the main protease (M(pro)). A promising M(pro) inhibitor of clinical relevance is the peptidomimetic nirmatrelvir (PF-07321332). …”
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154por Sutanto, Clarinda Nataria, Loh, Wen Wei, Toh, Darel Wee Kiat, Lee, Delia Pei Shan, Kim, Jung Eun“…PRO intake was further categorized into plant and animal PRO. A multivariate multiple linear regression (MLR) was performed to assess the association between PRO intake and sleep quality. …”
Publicado 2022
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155por Yang, Kai S., Alex Kuo, Syuan-Ting, Blankenship, Lauren R., Geng, Zhi Zachary, Li, Shuhua G., Russell, David H., Yan, Xin, Xu, Shiqing, Liu, Wenshe Ray“…For prompt and effective development of antivirals for SARS-CoV-2, the pathogen of COVID-19, drug repurposing has been broadly conducted by targeting the main protease (M(Pro)), a key enzyme responsible for the replication of virus inside the host. …”
Publicado 2022
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156por Ben Hlima, Hajer, Farhat, Ameny, Akermi, Sarra, Khemakhem, Bassem, Ben Halima, Youssef, Michaud, Philippe, Fendri, Imen, Abdelkafi, Slim“…In this context, therapies against protease M(pro), a conserved viral target, would be essential to contain the spread of the virus and reduce mortality. …”
Publicado 2022
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157por Cano-Ortiz, Antonio, Sánchez-Ventosa, Álvaro, González-Cruces, Timoteo, Cerdán-Palacios, David, Díaz-Mesa, Vanesa, Gallego-Ordóñez, Rubén, Gálvez-Gómez, Teresa, García Parrizas, Jose A., Zurera Baena, Javier, Villarrubia-Cuadrado, Alberto“…The main objective was to evaluate distance, intermediate, and near vision in patients who have undergone cataract extraction with bilateral implantation of a new trifocal diffractive intraocular lens (IOL), along with patient-reported outcomes (PRO). A total of 50 eyes from 25 patients after Asqelio(TM) Trifocal IOL (AST Products, Inc., Billerica MA, USA) implantation were assessed in this study. …”
Publicado 2022
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158“…SARS-CoV-2 3C-like protease (3CL(pro)), a potential therapeutic target for COVID-19, consists of a chymotrypsin fold and a C-terminal α-helical domain (domain III), the latter of which mediates dimerization required for catalytic activation. …”
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159por Fu, Yuhua, Liu, Hong, Dou, Jingwen, Wang, Yue, Liao, Yong, Huang, Xin, Tang, Zhenshuang, Xu, JingYa, Yin, Dong, Zhu, Shilin, Liu, Yangfan, Shen, Xiong, Liu, Hengyi, Liu, Jiaqi, Yang, Xin, Zhang, Yi, Xiang, Yue, Li, Jingjin, Zheng, Zhuqing, Zhao, Yunxia, Ma, Yunlong, Wang, Haiyan, Du, Xiaoyong, Xie, Shengsong, Xu, Xuewen, Zhang, Haohao, Yin, Lilin, Zhu, Mengjin, Yu, Mei, Li, Xinyun, Liu, Xiaolei, Zhao, Shuhong“…IAnimal (https://ianimal.pro/), a cross-species, multi-omics knowledgebase, was developed to improve the utilization of massive public data and simplify the integration of multi-omics information to mine the genetic mechanisms of objective traits. …”
Publicado 2022
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160“…This study outlines the functional and nutritional properties of EverPro, a brewer’s spent grain protein, in comparison to commercial plant protein isolates, indicating the potential for the inclusion of new, sustainable plant-based protein sources in human nutrition, in particular dairy alternative applications.…”
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