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301“…Conversely, knockdown of miR290-5p/292-5p in AMuLV pro-B cells blunts drug-induced activation of κGT. …”
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302por Stadhouders, Ralph, de Bruijn, Marjolein J. W., Rother, Magdalena B., Yuvaraj, Saravanan, de Almeida, Claudia Ribeiro, Kolovos, Petros, Van Zelm, Menno C., van Ijcken, Wilfred, Grosveld, Frank, Soler, Eric, Hendriks, Rudi W.“…These revealed that already in pro-B cells the κ enhancers robustly interact with the ∼3.2 Mb V(κ) region and its flanking sequences. …”
Publicado 2014
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303por Zhou, Yan, Li, Yue-Sheng, Bandi, Srinivasa Rao, Tang, Lingjuan, Shinton, Susan A., Hayakawa, Kyoko, Hardy, Richard R.“…Finally, we identify the Arid3a transcription factor as a key target of Let-7, whose ectopic expression is sufficient to induce B-1 development in adult pro-B cells and whose silencing by knockdown blocks B-1 development in fetal pro-B cells.…”
Publicado 2015
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304por Prieto, Cristina, Marschalek, Rolf, Kühn, Alessa, Bursen, Adelheid, Bueno, Clara, Menéndez, Pablo“…Unlike other MLL translocations, MLL-AF4-induced proB-ALL is exceptionally difficult to model in mice/humans. …”
Publicado 2017
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305por Arends, Tessa, Dege, Carissa, Bortnick, Alexandra, Danhorn, Thomas, Knapp, Jennifer R., Jia, Haiqun, Harmacek, Laura, Fleenor, Courtney J., Straign, Desiree, Walton, Kendra, Leach, Sonia M., Feeney, Ann J., Murre, Cornelis, O’Connor, Brian P., Hagman, James R.“…In the absence of CHD4 in B cell progenitors in vivo, development of these cells is arrested at an early pro-B-like stage that is unresponsive to IL-7 receptor signaling and unable to efficiently complete V(D)J rearrangements at Igh loci. …”
Publicado 2019
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306“…BACKGROUND: Elevated cardiac biomarkers, such as high-sensitivity cardiac Troponin T and N-terminal pro-B-type natriuretic peptide improve the prediction of major adverse cardiac events. …”
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307“…SIC4.8R also labeled bovine PP B cells, a murine pro-B cell line, and pre-B cells in human bone marrow. …”
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308por Yuan, Shi-Min“…METHODS: Postoperative detections of troponin I, creatine kinase isoenzyme MB (CK-MB) and N-terminal pro-B-type natriuretic peptide revealed elevated troponin I and CK-MB and normal N-terminal pro-B-type natriuretic peptide. …”
Publicado 2015
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309por Ba, Zhaoqing, Lou, Jiangman, Ye, Adam Yongxin, Dai, Hai-Qiang, Dring, Edward W., Lin, Sherry G., Jain, Suvi, Kyritsis, Nia, Kieffer-Kwon, Kyong-Rim, Casellas, Rafael, Alt, Frederick W.“…RAG endonuclease initiates V(D)J recombination in progenitor (pro)-B cells(1). Upon binding a recombination center (RC)-based J(H), RAG scans upstream chromatin via loop extrusion, potentially mediated by cohesin, to locate Ds and assemble a DJ(H)-based RC(2). …”
Publicado 2020
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310por Bossen, Claudia, Murre, Caroline S, Chang, Aaron N, Mansson, Robert, Rodewald, Hans-Reimer, Murre, Cornelis“…In committed pro-B cells Brg1 suppressed a pre-B lineage-specific pattern of gene expression. …”
Publicado 2015
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311por Dalkıran, Tahir, Kara, Emine M, Ünsal, Velid, Yurttutan, Sadık, İpek, Sevcan, Dağoğlu, Besra, Kandur, Yaşar“…The mean pro-B-type natriuretic peptide levels at three time points were significantly higher in patients with severe cases than in mild-moderate cases. …”
Publicado 2023
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312por Dengler, Hart S., Baracho, Gisele V., Omori, Sidne A., Bruckner, Shane, Arden, Karen, Castrillon, Diego H., DePinho, Ronald A., Rickert, Robert C.“…Early deletion of Foxo1 caused a severe block at the pro-B cell stage, due to a failure to express interleukin 7 receptor α (IL-7Rα). …”
Publicado 2008
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313por Perlot, Thomas, Pawlitzky, Inka, Manis, John P., Zarrin, Ali A., Brodeur, Peter H., Alt, Frederick W.“…The 5′ end of the IgH locus contains a cluster of DNaseI hypersensitive sites, one of which (HS1) was shown to be pro-B cell specific and to contain binding sites for the transcription factors PU.1, E2A, and Pax5. …”
Publicado 2010
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314por Kumar, Satyendra, Wuerffel, Robert, Achour, Ikbel, Lajoie, Bryan, Sen, Ranjan, Dekker, Job, Feeney, Ann J., Kenter, Amy L.“…Chromatin studies reveal that in pro-B cells, the spatial organization of the Igh locus may restrict switching to this subset of isotypes. …”
Publicado 2013
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315“…It is expressed on a fraction of pro-B (pre-BI) cells and most large pre-B(II) cells, and has been implicated in IgH chain allelic exclusion and down-regulation of the recombination machinery, assessment of the expressed μH chains and shaping the IgH repertoire, transition from the pro-B to pre-B stage, pre-B cell expansion, and cessation.…”
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316por Wei, Lingyu, Liu, Can, Wang, Jia, Zheng, Xiang, Peng, Qiu, Ye, Qiurong, Qin, Zailong, Li, Zhengshuo, Zhang, Xiaoyue, Wu, Yangge, Wen, Yuqing, Zhang, Xuemei, Yan, Qun, Ma, Jian“…Lactoferrin-deficient (Lf(−/−)) C57BL/6 mice showed systematic reduction in total B cells, which was attributed to the arrest of early B cell development from pre-pro-B to pro-B stage. Although the Lf(−/−) B cell “seeds” generated greater pro-B cells comparing to wild type (WT) littermates, the Lf(−/−) mice bone marrow had less stromal cells, and lower CXCL12 expression, produced a less favorable “microenvironment” for early B cell development. …”
Publicado 2021
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317“…The diagnostic potential of microR-423-5p and N-terminal pro-B-type natriuretic peptide was assessed by ROC curve analysis and multivariate linear regression model. …”
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318“…V(D)J recombination is required for the successful maturation of B cells from pro-B to pre-B to immature-B and then to mature B cells in the bone marrow. …”
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319por Lamprea‐Montealegre, Julio A., Zelnick, Leila R., Shlipak, Michael G., Floyd, James S., Anderson, Amanda H., He, Jiang, Christenson, Rob, Seliger, Stephen L., Soliman, Elsayed Z., Deo, Rajat, Ky, Bonnie, Feldman, Harold I., Kusek, John W., deFilippi, Christopher R., Wolf, Myles S., Shafi, Tariq, Go, Alan S., Bansal, Nisha“…Cardiac biomarkers, measured at baseline, were NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), high‐sensitivity troponin T, galectin‐3, growth differentiation factor‐15, and soluble ST‐2. …”
Publicado 2019
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320“…The common lymphoid progenitor (CLP) and preproB populations but not proB cells express Cebpa, and pan-hematopoietic deletion of the +37 kb Cebpa enhancer using Mx1-Cre leads not only to reduced GMP but also to 2-fold reduced marrow preproB and >15-fold reduced proB and preB cells. …”
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