“…Additionally, the decoction significantly reduced the serum levels of Creatine Kinase, Creatine Kinase-MB, and N-terminal pro-B-type natriuretic peptide. Furthermore, the relative expression of Aquarporin-1, 4, and 7mRNAs and proteins in the hearts of rats with chronic heart failure was down-regulated upon treatment. …”
Enlace del recurso
Enlace del recurso

“…The majority of the lines corresponded phenotypically to Lyb-2+, Ly-5(B220)+, ThB- large pre-B cells, although some were classified as pro-B cells because of their Lyb-2+, Ly-17+, Ly-5(B220)- phenotype. …”
Enlace del recurso
Enlace del recurso

“…The severe combined immunodeficiency (scid) mouse has a defective V(D)J recombinase activity that results in arrested lymphoid development at the pro-B cell stage in the B lineage. The defect is not absolute and scid mice do attempt gene rearrangement. …”
Enlace del recurso
Enlace del recurso

“…Bone marrow B lymphopoiesis was blocked at the transition from pro-B to pre-B cells. Thymic cellularity was reduced 20-fold, but retained normal distribution of CD4 and CD8. …”
Enlace del recurso
Enlace del recurso

“…We have recently demonstrated a significant reduction in pro-B and pre-B lymphocytes in transgenic mice that overexpress HSA. …”
Enlace del recurso
Enlace del recurso

“…In mice lacking a functional pre-BCR, active Blk supported maturation beyond the pro–B cell stage, suppressed V(H) to DJ(H) rearrangement, relieved selection for productive heavy chain rearrangement, and stimulated κ rearrangement. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Most BCR/ABL + N17 H-Ras mice eventually developed pro-B lymphoblastic leukemia/lymphoma (B-ALL). These results suggest that Ras activation is essential for the development of lymphoid and erythroid cells but not myeloid cells and that Ras is a critical target of BCR/ABL in the pathogenesis of CML, but not B-ALL.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Defective ATP11c decreased the rate of phosphatidylserine translocation in pro-B cells, greatly reduced pre-B and B cell numbers independent of Bcl2-inhibited apoptosis or immunoglobulin gene rearrangement and abolished pre-B cell expansion in response to an Il7 transgene. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The as yet undescribed scenario of pro-B cell acute lymphoblastic leukemia arising in CALR mutated essential thrombocythemia is presented. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, using a selective cell deletion strategy, we demonstrate that a subset of mesenchymal cells expressing osterix, a marker of bone precursors in the adult, serve to regulate the maturation of early B lymphoid precursors by promoting pro-B to pre-B cell transition through insulin-like growth factor 1 (IGF-1) production. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our model has been validated using ProB by applying the different provided scenarios. …”
Enlace del recurso
Enlace del recurso

“…Our model has been validated using ProB by applying the different provided scenarios. …”
Enlace del recurso
Enlace del recurso

“…Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Laboratory results revealed elevated lactate dehydrogenase (LDH), pro-B-type natriuretic peptide (pro-BNP), and D-dimer levels. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We report a case of a 25-year-old male who presented with jaundice, and vomiting for 6 days, associated with maculopapular rash (Mucocutaneous features), elevated pro-B-type natriuretic peptide (pro-BNP), erythrocyte sedimentation rate (ESR), transaminitis (> 1000 U/L), thrombocytopenia, echocardiogram evidenced stigmata of heart failure after his third dose of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In terms of N-terminal pro-B-type natriuretic peptide outcome indexes, SGLT2i was superior to SOC (MD = −134.63, 95% CI: −237.70 to −31.56). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among the B cell subsets, pro-B cells had relatively higher levels of MM and MMP, while the mitochondrial metabolism level of mature B cells was relatively low. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), as retrospectively measured in archived serum samples, were suggestive of pre-existent (sub-clinical) left ventricular dysfunction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A cell line, HAFTL-1, derived by in vitro transformation of fetal liver cells with v-Ha-ras, was found to have molecular and phenotypic characteristics of pro-B cells recently committed to the Ly-1+ B cell differentiation pathway. …”
Enlace del recurso
Enlace del recurso

“…Finally, enforced expression of Pax5 induces AID transcription in pro–B cell lines. Our results provide evidence that the balance between Pax5 and Id2 activities has a key role in AID gene expression.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso