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9381por Gago Quintela, Elena Estefania, Blasco, Berta, Miñano, Maria José, Tost Bonet, Meritxell, Pérez, Sara, Montalvo, Itziar, David Barbero, Juan, Olasz, Irina, Antonio Monreal, José, Palao, Diego, Pàmias, Montserrat, Labad, Javier“…All participants completed on-line questionnaires to explore psychotic-like experiences (15-item Community Assessment of Psychic Experiences – Positive Scale [CAPE-P15]), cognitive biases (Cognitive Biases Questionnaire for Psychosis [CBQp], with some items adapted for adolescents) and bullying (Adolescent Peer Relations Instrument [APRI]). …”
Publicado 2020
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9382por Hemager, Nicoline, Christiani, Camilla, Amalie Thorup, Anne, Søborg Spang, Katrine, Ellersgaard, Ditte V, Klee Burton, Birgitte, Neergaard Greve, Aja, Lou Gantriis, Ditte, Nudel, Ron, Mors, Ole, Jessica Plessen, Kerstin, Nordentoft, Merete, Jepsen, Jens Richardt Møllegaard“…Distinct neurocognitive subgroups in young adults with clinical high risk of psychosis or familial risk of bipolar disorder have been identified with an increased risk of conversion to illness and poorer functioning in the most neurocognitively impaired subgroup. …”
Publicado 2020
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9383por Spangaro, Marco, Bosia, Marta, Bechi, Margherita, Buonocore, Mariachiara, Martini, Francesca, Cavallaro, Roberto“…Moreover, the striking majority of TRS patients do not respond to first-line antipsychotic therapy since disease onset and present more severe cognitive deficits since first episode of psychosis, further suggesting the presence of a distinct and more disrupted neurobiological substrate. …”
Publicado 2020
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9384“…Participants had symptoms of ongoing psychosis as determined by a score of four or more on at least one of the following PANSS (Positive and Negative Syndrome Scale) items: P1 (delusions), P3 (hallucinations), P5 (grandiosity), P6 (suspiciousness/persecution) or G9 (unusual thought content). …”
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9385por Carter, Cameron, Lesh, Tyler, Iosef, Ana-Maria, Tanase, Costin, Vaslova, Rosa, Styner, Martin, Maddock, Richard, Bauman, Melissa“…Here we report findings from an ongoing study of a unique cohort on non-human primates (NHP) who underwent MIA (compared to controls) on a promising biomarker of neuroimmune perturbation in vivo--extracellular free water--a diffusion magnetic resonance imaging measure obtained with a multi-shell acquisition, which we have shown in multiple studies to be increased in young people with early psychosis. METHODS: Fourteen pregnant rhesus monkeys (Macaca mulatta) received polyICLC and 14 control animals have been scanned prospectively from both to their current age of 3.5 years. …”
Publicado 2020
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9386por Potheegadoo, Jevita, Blondiaux, Eva, Stripeikyte, Giedre, Jenni, Laurent, Bernasconi, Fosco, Pouillard, Virginie, Maeder, Johanna, Schneider, Maude, Eliez, Stephan, Blanke, Olaf“…Taken together, our results suggest that 22q11DS is an interesting model to study the development of prodromal signs of psychosis at a very early stage before the onset of schizophrenia.…”
Publicado 2020
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9387por Mętel, Dagmara, Arciszewska-Leszczuk, Aleksandra, Frydecka, Dorota, Cechnicki, Andrzej, Gawęda, Łukasz“…Limited studies involving individuals with ‘at risk mental state’ have demonstrated that they have lower levels of resilience than healthy controls, and that baseline resilience is lower among those who convert to frank psychosis than among those who do not. What is more, at risk individuals are characterized by a wide range of cognitive impairments, including general intelligence, executive function, verbal and visual memory, verbal fluency, attention, working memory, processing speed and social cognition. …”
Publicado 2020
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9388por Okuneye, Victoria, Clementz, Brett, Gershon, Elliot, Keshavan, Matcheri, McDowell, Jennifer E, Pearlson, Godfrey, Tamminga, Carol, Sweeney, John, Keedy, Sarah“…This provides further evidence that dysconnectivity of prediction error system is a biomarker of delusions in psychosis. Furthermore, these transdiagnostic results implicate frontostriatal dysconnectivity as common neuropathology in delusions.…”
Publicado 2020
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9389por Martins, Dayane, de Oliveira Lapa, Clara, Hasse-Sousa, Mathias, Julia Britto, Maria, Reckziegel, Ramiro, Bosini Remus, Isadora, Czepielewski, Letícia, Severino Gama, Clarissa“…Cognitive impairments are shown to be present even in premorbid stages of psychosis, which is related to the neurodevelopmental model of SZ. …”
Publicado 2020
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9390por Fowler, Justin, Cope, Nathan, Knights, Jonathan, Fang, Hui, Skubiak, Taisa, Phiri, Peter, Rathod, Shanaya, Peters-Strickland, Timothy“…BACKGROUND: This was a multicentre, 8-week, single-arm, open-label, pragmatic trial to explore the acceptance and performance of using the Digital Medicine System (DMS) with health care professionals (HCPs) and adult subjects with schizophrenia, schizoaffective disorder (SAD), or first episode psychosis (FEP) on an oral atypical antipsychotic (aripiprazole, olanzapine, quetiapine, or risperidone). …”
Publicado 2020
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9391“…This information is of importance to understand the transition of transient and harmless hallucinations towards distressing ones, which is a crucial step in the development of psychosis. We examined the effect of drug usage on the risks of experiencing distress from AH and VH across the Dutch population (≥ 14 years of age) by means of an online survey. …”
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9392“…METHODS: The sample (N=81) included in- and outpatients with schizophrenia or another non-affective psychosis (N=32), outpatients with schizotypal disorder (N=15) or other mental illness (N=16) and healthy controls (N=18). …”
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9393por Cooper, Rebecca, Van Rheenen, Tamsyn, Zalesky, Andrew, Wannan, Cassandra, Wang, Ya, Bousman, Chad, Everall, Ian, Pantelis, Christos, Cropley, Vanessa“…One of the most commonly cited pieces of evidence for this theory is the presence of neurological soft signs (NSS) in individuals prior to the onset of psychosis. Increased NSS is also reported in unaffected individuals with a family history of schizophrenia, suggesting that NSS may also have a familial component. …”
Publicado 2020
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9394por Lenroot, Rhoshel, Upston, Joel, Mayer, Grace, Jones, Thomas, Maudsley, Andrew, Gasparovic, Charles, Tohen, Mauricio, Bustillo, Juan“…In this study we used whole brain 1H-MRS to examine glutamine-plus-glutamate (Glx) in early schizophrenia and bipolar disorder to examine metabolic abnormalities associated with affective and non-affective psychosis and with exposure to antipsychotic medication. …”
Publicado 2020
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9395“…METHODS: We analyzed reports of 3 positive images from 31 subjects (10 matched controls and 21 at the first episode of psychosis - 11 with schizophrenia and 10 with bipolar disorder as a final diagnosis after 6 months of follow-up). …”
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9396por Paterson, Ross W, Brown, Rachel L, Benjamin, Laura, Nortley, Ross, Wiethoff, Sarah, Bharucha, Tehmina, Jayaseelan, Dipa L, Kumar, Guru, Raftopoulos, Rhian E, Zambreanu, Laura, Vivekanandam, Vinojini, Khoo, Anthony, Geraldes, Ruth, Chinthapalli, Krishna, Boyd, Elena, Tuzlali, Hatice, Price, Gary, Christofi, Gerry, Morrow, Jasper, McNamara, Patricia, McLoughlin, Benjamin, Lim, Soon Tjin, Mehta, Puja R, Levee, Viva, Keddie, Stephen, Yong, Wisdom, Trip, S Anand, Foulkes, Alexander J M, Hotton, Gary, Miller, Thomas D, Everitt, Alex D, Carswell, Christopher, Davies, Nicholas W S, Yoong, Michael, Attwell, David, Sreedharan, Jemeen, Silber, Eli, Schott, Jonathan M, Chandratheva, Arvind, Perry, Richard J, Simister, Robert, Checkley, Anna, Longley, Nicky, Farmer, Simon F, Carletti, Francesco, Houlihan, Catherine, Thom, Maria, Lunn, Michael P, Spillane, Jennifer, Howard, Robin, Vincent, Angela, Werring, David J, Hoskote, Chandrashekar, Jäger, Hans Rolf, Manji, Hadi, Zandi, Michael S“…Five major categories emerged: (i) encephalopathies (n = 10) with delirium/psychosis and no distinct MRI or CSF abnormalities, and with 9/10 making a full or partial recovery with supportive care only; (ii) inflammatory CNS syndromes (n = 12) including encephalitis (n = 2, para- or post-infectious), acute disseminated encephalomyelitis (n = 9), with haemorrhage in five, necrosis in one, and myelitis in two, and isolated myelitis (n = 1). …”
Publicado 2020
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9397por Newbold, A., Warren, F. C., Taylor, R. S., Hulme, C., Burnett, S., Aas, B., Botella, C., Burkhardt, F., Ehring, T., Fontaine, J. R. J., Frost, M., Garcia-Palacios, A., Greimel, E., Hoessle, C., Hovasapian, A., Huyghe, VEI, Lochner, J., Molinari, G., Pekrun, R., Platt, B., Rosenkranz, T., Scherer, K. R., Schlegel, K., Schulte-Korne, G., Suso, C., Voigt, V., Watkins, E. R.“…In total, 2142 participants aged 16 to 22 years, with no current or past history of major depression, bipolar disorder or psychosis will be recruited across UK, Germany, Spain, and Belgium. …”
Publicado 2020
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9398por Silva, Manuela, Antunes, Ana, Azeredo-Lopes, Sofia, Loureiro, Adriana, Saraceno, Benedetto, Caldas-de-Almeida, José Miguel, Cardoso, Graça“…RESULTS: An increment of involuntary hospitalizations was associated with male gender [exp([Formula: see text] ) = 1.31; 95%CI 1.06–1.62, p < 0.05], having secondary and higher education [exp([Formula: see text] ) = 1.45; 95%CI 1.05–2.01, p < 0.05, and exp([Formula: see text] ) = 1.89; 95%CI 1.38–2.60, p < 0.001, respectively], a psychiatric diagnosis of psychosis [exp([Formula: see text] ) = 2.02; 95%CI 1.59–2.59, p < 0.001], and being admitted in 2007 and in 2012 [exp([Formula: see text] ) = 1.61; 95%CI 1.21–2.16, p < 0.01, and exp([Formula: see text] ) = 1.73; 95%CI 1.31–2.32, p < 0.001, respectively]. …”
Publicado 2021
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9399por Purves-Tyson, Tertia D., Brown, Amelia M., Weissleder, Christin, Rothmond, Debora A., Shannon Weickert, Cynthia“…While reduced midbrain GABAergic inhibitory neurotransmission may contribute to the hyperdopaminergia thought to underpin psychosis in schizophrenia, molecular changes consistent with this have not been reported. …”
Publicado 2021
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9400por Alavi, Nazanin, Stephenson, Callum, Yang, Megan, Kumar, Anchan, Shao, Yijia, Miller, Shadé, Yee, Caitlin S, Stefatos, Anthi, Gholamzadehmir, Maedeh, Abbaspour, Zara, Jagayat, Jasleen, Shirazi, Amirhossein, Omrani, Mohsen, Patel, Archana, Patel, Charmy, Groll, Dianne“…Exclusion criteria include active psychosis, acute mania, severe alcohol or substance use disorder, and active suicidal or homicidal ideation. …”
Publicado 2021
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