“…The uptake of EM in the RADA16-I-EM in situ hydrogel by tumor cells was analyzed by laser confocal microscope and flow cytometry. …”
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“…Here, we report that splicing of the intein-containing RadA from another archaeon, Thermococcus sibericus, is activated by significantly lower temperatures than is P. horikoshii RadA, consistent with differences in their growth environments. …”
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“…Therefore, matrix morphology and fractal dimension of virgin (RADA)(4) and mixtures of (RADA)(4) and matrix metalloproteinase 2 (MMP-2) cleavable substrate modified (RADA)(4) were characterized over time. …”
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“…In this study, an innovative strategy based on nanomaterials was developed in order to increase the hempseed hydrolysate stability and the anti-diabetic properties, through their encapsulation into ionic self-complementary RADA16 peptide based-hydrogels. Atomic force microscope (AFM) morphological analysis indicated that the new nanomaterials were composed of a nanofibril network, whose increased diameter in respect to native RADA16 suggests the presence of transient non-covalent interactions among the RADA16 supramolecular assemblies and the embedded hempseed peptides. …”
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“…Self-assembled peptide scaffolds based on D-RADA16 are an important matrix for controlled drug release and three-dimensional cell culture. …”
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“…Herein, we described a novel hybrid vaccine “MCL” (Melittin–RADA(32)–CpG–Lysate) which was composed of melittin, RADA(32), CpG and tumor lysate. …”
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“…Modeling of the RadA family mechanism is crucial to understanding the DNA SOS repair process. …”
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“…RESULTS: The 293T cells grew well in the RADA16-I 3D culture system for a prolonged period of time. …”
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“…Designer RADA16-I peptide had well-defined nanofiber networks architecture in hydrogel, which provided nanofiber cell microenvironments analogous to Matrigel and collagen I. 3D-cultured HO-8910PM cells in RADA16-I hydrogel, Matrigel, and collagen I showed viable cell proliferation, proper cell growth, and diverse cell shapes in morphology at the desired time points. …”
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“…Hence, we upregulated A20 expression via transfection of rAd.ATF (recombinant adenovirus vector of artificial transcription factor) and rAd.A20 in rat carotid arteries after balloon dilatation (in vivo) and isolated VSMCs (in vitro). …”
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“…In this study we investigate the cellular response to biological stimuli using functionalized nanofibers from the self-assembling peptide, RADA16. We demonstrate that adding different functional motifs to the RADA16 base peptide can influence the rate of proliferation and migration of keratinocytes and dermal fibroblasts. …”
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“…PURPOSE: Hydrogels containing the nano-self-assembling peptide RADA16-I (Nanogels) were utilized as scaffolds to establish airway organoids and an adenovirus-infected model. …”
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“…RadA and its human homologue RAD51 function as recombinases in the process of homologous recombination. …”
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“…Methods: We designed a series of melittin-(RADA)(n) hybrid peptide sequences with varying self-assembling motifs of RADA and screened out a melittin-(RADA)(6) peptide that has an optimal gel-formation ability and in vitro antitumor activity. …”
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“…We renamed the interview the reactive attachment disorder and disinhibited social engagement disorder assessment (RADA). Foster parents of 320 young people aged 11 to 17 years completed the RADA online. …”
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“…Following gamma irradiation, both Mre11 and RadA are immediately recruited to DNA and remain DNA-bound in the course of DNA repair. …”
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“…Herein, we developed an SAP hydrogel composed of a self-assembling gel-forming core sequence (RADA) modified with SDKP motif with pro-angiogenic and anti-fibrotic activity to be used as a cardioprotective scaffold. …”
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“…As human RAD51 has proved impossible to produce in a form that is compatible with the requirements of fragment-based drug discovery, we have developed a surrogate protein system using RadA from Pyrococcus furiosus. Using a monomerised RadA as our starting point, we have adopted two parallel and mutually instructive approaches to mimic the human enzyme: firstly by mutating RadA to increase sequence identity with RAD51 in the BRC repeat binding sites, and secondly by generating a chimeric archaeal human protein. …”
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“…The main goal of this study was the formation of bone tissue using dexamethasone (DEX)-loaded [COCH(3)]-RADARADARADARADA-[CONH(2)] (RADA 16-I) scaffold that has the ability to release optimal DEX concentration under perfusion force. …”
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