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  1. 1
    Libro
    En rada /
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    “…We show that RadA/Sms (or its variant, RadA/Sms C13A) binds to the 5′-tail of a reversed fork with longer nascent lagging-strand and unwinds it in the 5′→3′ direction, but RecA and its mediators limit unwinding. …”
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    Bacillus subtilis RadA/Sms-Mediated Nascent Lagging-Strand Unwinding at Stalled or Reversed Forks Is a Two-Step Process: RadA/Sms Assists RecA Nucleation, and RecA Loads RadA/Sms
  3. 3
    “…The recombinase molecules present in the archaea (RadA) and eukaryota (Rad51) are more closely related to each other than to their bacterial counterpart (RecA) and, as a result, RadA makes a suitable model for the eukaryotic system. …”
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    Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA
  4. 4
    “…Gene expression was determined by qRT-PCR, and the rhythmicity was analyzed using the Cosinor model. We identified RadA as a KaiC homologue in E. coli. Expression of radA showed a circadian rhythm persisting at least 3 days, with a peak in the morning. …”
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    RadA, a Key Gene of the Circadian Rhythm of Escherichia coli
  5. 5
    por Li, Yang, He, Yujiong, Luo, Yu
    Publicado 2009
    “…Archaeal RadAs are close homologues of eukaryal Rad51s (∼40% sequence identity). …”
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    Conservation of a conformational switch in RadA recombinase from Methanococcus maripaludis
  6. 6
    por Du, Liqin, Luo, Yu
    Publicado 2012
    “…Archaeal RadA proteins are close homologues of eukaryal Rad51 and DMC1 proteins and are remote homologues of bacterial RecA proteins. …”
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    Structure of a hexameric form of RadA recombinase from Methanococcus voltae
  7. 7
    “…The RadA/Sms protein is a RecA-related protein found universally in eubacteria and plants, implicated in processing of recombination intermediates. …”
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    Genetic analysis of Escherichia coli RadA: functional motifs and genetic interactions
  8. 8
    “…We present crystal structures of both apo and nucleotide‐bound forms of monomeric RadA. These structures reveal that while phosphate groups are tightly bound, RadA presents a shallow, poorly defined binding surface for the nitrogenous bases of nucleotides. …”
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    ATP half‐sites in RadA and RAD51 recombinases bind nucleotides
  9. 9
    “…BACKGROUND: RADA16I represents one of promising hydrogel forming peptides. …”
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    Straightforward and Cost-Effective Production of RADA-16I Peptide in Escherichia coli
  10. 10
    “…LIMITATIONS: Participants were volunteers, may not represent the general population. CONCLUSIONS: The RADaR, derived from community-dwelling older persons, is a brief and valid tool to predict dementia risk at 3 years in older White and Black persons.…”
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    Derivation and validation of the Rapid Assessment of Dementia Risk (RADaR) for older adults
  11. 11
    “…Ionic self-assembly of the peptide RADARADARADARADA (RADA16-1) may form a well-defined nanofiber and eventually a hydrogel scaffold, with a water content of over 99.5%. …”
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    Molecular Mechanisms of RADA16-1 Peptide on Fast Stop Bleeding in Rat Models
  12. 12
    por Cooper, Deani L, Lovett, Susan T
    Publicado 2016
    “…We investigate here the biochemical properties of the E. coli RadA protein and several mutant forms. RadA is a DNA-dependent ATPase, a DNA-binding protein and can stimulate the branch migration phase of RecA-mediated strand transfer reactions. …”
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    Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli
  13. 13
    “…One key actor of this process is the recombinase RadA, which allows the homologous strand search and provides a DNA substrate required for following DNA synthesis and restoring genetic information. …”
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    Role of RadA and DNA Polymerases in Recombination-Associated DNA Synthesis in Hyperthermophilic Archaea
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    “…As well-known self-assembling peptide-based hydrogels, RADA16-I and modified peptides are attractive matrices for neural tissue engineering. …”
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    The Effect of RADA16-I and CDNF on Neurogenesis and Neuroprotection in Brain Ischemia-Reperfusion Injury
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    “…Intracerebral inoculation of 263K Scrapie brain homogenate (PrPsc) with a self-assembling RADA-peptide (RADA) significantly delayed disease onset and increased hamster survival. …”
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    Inoculation of Scrapie with the Self-Assembling RADA-Peptide Disrupts Prion Accumulation and Extends Hamster Survival
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    An archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadA
  17. 17
    por Sun, Lijuan, Zhao, Xiaojun
    Publicado 2012
    “…Mechanical strength of nanofiber scaffolds formed by the self-assembling peptide RADA16-I or its derivatives is not very good and limits their application. …”
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    A self-assembling peptide RADA16-I integrated with spider fibroin uncrystalline motifs
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    “…Here we show in Escherichia coli and in vitro that splicing of the RadA intein located in the ATPase domain of the hyperthermophilic archaeon Pyrococcus horikoshii is strongly regulated by the native exteins, which lock the intein in an inactive state. …”
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    Post-translational environmental switch of RadA activity by extein–intein interactions in protein splicing
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    “…In vitro tests demonstrated that the plateau release amount can be obtained till 72 hours. Moreover, L-RADA16, D-RADA16, and L-RADA16-RGD self-assembling peptide hydrogels containing TGF-beta 1 were used for 3D cell culture of bone mesenchymal stem cells of rats for 2 weeks. …”
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    Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds
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    “…In this study, we prepared two RADA16-I peptide scaffolds with and without tamoxifen. …”
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    Self-Assembling RADA16-I Peptide Hydrogel Scaffold Loaded with Tamoxifen for Breast Reconstruction
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