Mostrando 181 - 200 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.15s Limitar resultados
  1. 181
    “…However, it is unclear whether vaccines using non-glycosylated RBD (non-glycoRBD) can induce protective immunity. …”
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    Non-glycosylated SARS-CoV-2 RBD elicited a robust neutralizing antibody response in mice
  2. 182
    “…To confirm this possibility, two monoclonal antibodies (mAbs 127 and 150) which could bind to both S1-RBD and ACE2 were isolated from S1-RBD-immunized mice. …”
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    Antigenic Cross-Reactivity Between SARS-CoV-2 S1-RBD and Its Receptor ACE2
  3. 183
    “…Herein, we designed an mRNA-based vaccine encoding the receptor-binding domain (RBD) of SARS-CoV-2 encapsulated in lipid nanoparticles (LNPs). …”
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    Development of an LNP-Encapsulated mRNA-RBD Vaccine against SARS-CoV-2 and Its Variants
  4. 184
    “…In silico docking, mutational analysis, and smFRET revealed that VE607 binds to the receptor binding domain (RBD)-ACE2 interface and stabilizes RBD in its “up” conformation. …”
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    VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry
  5. 185
    por Hoter, Abdullah, Naim, Hassan Y.
    Publicado 2022
    “…In the current study, we analyzed the biosynthesis and secretion of the RBD double mutants L452R and E484Q in comparison to the wild-type RBD and the individual mutations N501 and E484K in mammalian cells. …”
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    Biochemical Characterization of SARS-CoV-2 Spike RBD Mutations and Their Impact on ACE2 Receptor Binding
  6. 186
    “…We utilized a baculovirus–silkworm expression system to produce the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. First, we had to develop a strategy for constructing a recombinant baculovirus for RBD expression. …”
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    Utilization of Recombinant Baculovirus Expression System to Produce the RBD Domain of SARS-CoV-2 Spike Protein
  7. 187
    “…Here, we adapted our protein-protein conjugate vaccine technology to generate a vaccine based on receptor-binding domain (RBD) antigen. RBD was conjugated to a carrier protein, EcoCRM®, to generate two types of conjugates: crosslinked and radial conjugates. …”
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    Protein-protein conjugation enhances the immunogenicity of SARS-CoV-2 receptor-binding domain (RBD) vaccines
  8. 188
    “…Using fuzzy C-means clustering we combined evolutionary and structural features of RBD and identified a critical region. Subsequently, we used computational drug screening using a library of 1615 small molecules and identified one lead molecule, which is expected to target the identified region, critical for evolvability and structural stability of RBD. …”
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    An integrated understanding of the evolutionary and structural features of the SARS-CoV-2 spike receptor binding domain (RBD)
  9. 189
    “…Constipation and REM sleep behavior disorder (RBD) may present prior to clinical diagnosis. Yet, little is known about esophageal dysfunction and its connection to constipation in early PD. …”
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    Intestinal Transit in Early Moderate Parkinson's Disease Correlates with Probable RBD: Subclinical Esophageal Dysmotility Does Not Correlate
  10. 190
    “…Here, we describe the development of an RBD-based ELISA for the detection of specific antibodies in large numbers of samples. …”
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    An RBD-Based Diagnostic Method Useful for the Surveillance of Protective Immunity against SARS-CoV-2 in the Population
  11. 191
    “…Three independently derived escape mutants to the RBD antibody harbored mutations in the RBD at the position T478 or S477. …”
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    Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD
  12. 192
    “…Surface plasmon resonance (SPR) analysis showed the binding kinetics of SGP RBD from WT and Delta variants were very similar while Omicron variant SGP showed a much higher association rate. …”
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    Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants
  13. 193
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    An updated RBD-Fc fusion vaccine booster increases neutralization of SARS-CoV-2 Omicron variants
  14. 194
    “…Mechanistically, we confirmed that extended vaccination with RBD boosters overturned the protective immune memories by promoting adaptive immune tolerance. …”
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    Extended SARS-CoV-2 RBD booster vaccination induces humoral and cellular immune tolerance in mice
  15. 195
    “…Both mAbs had neutralizing activity against wild-type SARS-CoV-2 and Delta, but not Omicron. NIBIC-71 binds to the RBD, whereas 7G7 recognizes the N-terminal domain of the S1. …”
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    Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein
  16. 196
    “…In its nature form, the electropherogram fingerprints of the trimeric RBD were presented under optimized experimental conditions. …”
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    Fingerprinting trimeric SARS-CoV-2 RBD by capillary isoelectric focusing with whole-column imaging detection
  17. 197
    “…Identified compounds were then re-docked into of RBD/ACE2. The best ranked compound was validated for RBD/ACE2 inhibition using commercial kit. …”
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    Benzimidazole compound abrogates SARS-COV-2 receptor-binding domain (RBD)/ACE2 interaction In vitro
  18. 198
    “…Here, we report the development of a bacterial vector COVID-19 vaccine (aPA-RBD) that carries the gene for the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. …”
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    Delivery of spike-RBD by bacterial type three secretion system for SARS-CoV-2 vaccine development
  19. 199
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    Corrigendum to “Potency, toxicity and protection evaluation of PastoCoAd candidate vaccines: Novel preclinical mix and match rAd5 S, rAd5 RBD-N and SOBERANA dimeric-RBD protein” [Vaccine 40(20) (2022) 2856–2868]
  20. 200
    “…FINDINGS: In RAW cells, RBD peptide was cytotoxic, but not for BV2 cells. …”
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    In vitro immunogenic profile of recombinant SARS-CoV2 S1-RBD peptide in murine macrophage and microglial cells
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