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181“…However, it is unclear whether vaccines using non-glycosylated RBD (non-glycoRBD) can induce protective immunity. …”
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182por Lai, Yen-Chung, Cheng, Yu-Wei, Chao, Chiao-Hsuan, Chang, Yu-Ying, Chen, Chi-De, Tsai, Wei-Jiun, Wang, Shuying, Lin, Yee-Shin, Chang, Chih-Peng, Chuang, Woei-Jer, Chen, Li-Yin, Wang, Ying-Ren, Chang, Sui-Yuan, Huang, Wenya, Wang, Jen-Ren, Tseng, Chin-Kai, Lin, Chun-Kuang, Chuang, Yung-Chun, Yeh, Trai-Ming“…To confirm this possibility, two monoclonal antibodies (mAbs 127 and 150) which could bind to both S1-RBD and ACE2 were isolated from S1-RBD-immunized mice. …”
Publicado 2022
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183por Liu, Cong, Rcheulishvili, Nino, Shen, Zhigao, Papukashvili, Dimitri, Xie, Fengfei, Wang, Ziqian, Wang, Xingyun, He, Yunjiao, Wang, Peng George“…Herein, we designed an mRNA-based vaccine encoding the receptor-binding domain (RBD) of SARS-CoV-2 encapsulated in lipid nanoparticles (LNPs). …”
Publicado 2022
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184por Ding, Shilei, Ullah, Irfan, Gong, Shang Yu, Grover, Jonathan R., Mohammadi, Mohammadjavad, Chen, Yaozong, Vézina, Dani, Beaudoin-Bussières, Guillaume, Verma, Vijay Tailor, Goyette, Guillaume, Gaudette, Fleur, Richard, Jonathan, Yang, Derek, Smith, Amos B., Pazgier, Marzena, Côté, Marceline, Abrams, Cameron, Kumar, Priti, Mothes, Walther, Uchil, Pradeep D., Finzi, Andrés, Baron, Christian“…In silico docking, mutational analysis, and smFRET revealed that VE607 binds to the receptor binding domain (RBD)-ACE2 interface and stabilizes RBD in its “up” conformation. …”
Publicado 2022
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185“…In the current study, we analyzed the biosynthesis and secretion of the RBD double mutants L452R and E484Q in comparison to the wild-type RBD and the individual mutations N501 and E484K in mammalian cells. …”
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186por Fan, Youpeng, Wei, Junhong, Wang, Wei, Li, Chunfeng, Pan, Guoqing, Keiffer, Timothy, Bao, Jialing, Zhou, Zeyang“…We utilized a baculovirus–silkworm expression system to produce the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. First, we had to develop a strategy for constructing a recombinant baculovirus for RBD expression. …”
Publicado 2022
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187por Scaria, Puthupparampil V., Rowe, Chris G., Chen, Beth B., Dickey, Thayne H., Renn, Jonathan P., Lambert, Lynn E., Barnafo, Emma K., Rausch, Kelly M., Tolia, Niraj H., Duffy, Patrick E.“…Here, we adapted our protein-protein conjugate vaccine technology to generate a vaccine based on receptor-binding domain (RBD) antigen. RBD was conjugated to a carrier protein, EcoCRM®, to generate two types of conjugates: crosslinked and radial conjugates. …”
Publicado 2022
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188por Sanyal, Dwipanjan, Banerjee, Suharto, Bej, Aritra, Chowdhury, Vaidehi Roy, Uversky, Vladimir N., Chowdhury, Sourav, Chattopadhyay, Krishnananda“…Using fuzzy C-means clustering we combined evolutionary and structural features of RBD and identified a critical region. Subsequently, we used computational drug screening using a library of 1615 small molecules and identified one lead molecule, which is expected to target the identified region, critical for evolvability and structural stability of RBD. …”
Publicado 2022
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189por Skjærbæk, Casper, Knudsen, Karoline, Kinnerup, Martin, Hansen, Kim Vang, Borghammer, Per“…Constipation and REM sleep behavior disorder (RBD) may present prior to clinical diagnosis. Yet, little is known about esophageal dysfunction and its connection to constipation in early PD. …”
Publicado 2022
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190por Ayón-Núñez, Dolores Adriana, Cervantes-Torres, Jacquelynne, Cabello-Gutiérrez, Carlos, Rosales-Mendoza, Sergio, Rios-Valencia, Diana, Huerta, Leonor, Bobes, Raúl J., Carrero, Julio César, Segura-Velázquez, René, Fierro, Nora Alma, Hernández, Marisela, Zúñiga-Ramos, Joaquín, Gamba, Gerardo, Cárdenas, Graciela, Frías-Jiménez, Emmanuel, Herrera, Luis Alonso, Fragoso, Gladis, Sciutto, Edda, Suárez-Güemes, Francisco, Laclette, Juan Pedro“…Here, we describe the development of an RBD-based ELISA for the detection of specific antibodies in large numbers of samples. …”
Publicado 2022
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191por Peter, Antonia Sophia, Grüner, Eva, Socher, Eileen, Fraedrich, Kirsten, Richel, Elie, Mueller-Schmucker, Sandra, Cordsmeier, Arne, Ensser, Armin, Sticht, Heinrich, Überla, Klaus“…Three independently derived escape mutants to the RBD antibody harbored mutations in the RBD at the position T478 or S477. …”
Publicado 2022
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192por Gelbach, Adrianne L., Zhang, Fuming, Kwon, Seok-Joon, Bates, John T., Farmer, Andrew P., Dordick, Jonathan S., Wang, Chunyu, Linhardt, Robert J.“…Surface plasmon resonance (SPR) analysis showed the binding kinetics of SGP RBD from WT and Delta variants were very similar while Omicron variant SGP showed a much higher association rate. …”
Publicado 2022
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193por Luo, Deyan, Yang, Xiaolan, Li, Tao, Ning, Nianzhi, Jin, Song, Shi, Zhuangzhuang, Gu, Hongjing, Li, Deyu, Gao, Yuwei, Wang, HuiEnlace del recurso
Publicado 2022
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194por Gao, Feng-Xia, Wu, Rui-Xin, Shen, Mei-Ying, Huang, Jing-Jing, Li, Ting-Ting, Hu, Chao, Luo, Fei-Yang, Song, Shu-Yi, Mu, Song, Hao, Ya-Nan, Han, Xiao-Jian, Wang, Ying-Ming, Li, Luo, Li, Sheng-Long, Chen, Qian, Wang, Wang, Jin, Ai-Shun“…Mechanistically, we confirmed that extended vaccination with RBD boosters overturned the protective immune memories by promoting adaptive immune tolerance. …”
Publicado 2022
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195por Otsubo, Ryota, Minamitani, Takeharu, Kobiyama, Kouji, Fujita, Junso, Ito, Toshihiro, Ueno, Shiori, Anzai, Itsuki, Tanino, Hiroki, Aoyama, Hiroshi, Matsuura, Yoshiharu, Namba, Keiichi, Imadome, Ken-Ichi, Ishii, Ken J., Tsumoto, Kouhei, Kamitani, Wataru, Yasui, Teruhito“…Both mAbs had neutralizing activity against wild-type SARS-CoV-2 and Delta, but not Omicron. NIBIC-71 binds to the RBD, whereas 7G7 recognizes the N-terminal domain of the S1. …”
Publicado 2022
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196por Du, Jialiang, Wu, Gang, Chen, Quanyao, Yu, Chuanfei, Xu, Gangling, Liu, Anhui, Wang, Lan“…In its nature form, the electropherogram fingerprints of the trimeric RBD were presented under optimized experimental conditions. …”
Publicado 2023
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197por Omotuyi, Olaposi, Olatunji, Olusina M., Nash, Oyekanmi, Oyinloye, Babatunji, Soremekun, Opeyemi, Ijagbuji, Ayodeji, Fatumo, Segun“…Identified compounds were then re-docked into of RBD/ACE2. The best ranked compound was validated for RBD/ACE2 inhibition using commercial kit. …”
Publicado 2023
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198por Zhou, Yuchen, Qu, Jing, Sun, Xiaomeng, Yue, Zhuo, Liu, Yingzi, Zhao, Keli, Yang, Fan, Feng, Jie, Pan, Xiaolei, Jin, Yongxin, Cheng, Zhihui, Yang, Liang, Ha, Un-Hwan, Wu, Weihui, Li, Liang, Bai, Fang“…Here, we report the development of a bacterial vector COVID-19 vaccine (aPA-RBD) that carries the gene for the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. …”
Publicado 2023
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199por Pouriayevali, Mohammad Hassan, Teimoori, Ali, Esmaeili, Saber, Abdoli, Asghar, Doroud, Delaram, Salehi-Vaziri, Mostafa, Shahali, Maryam, Kadkhodazadeh, Maryam, Sabouni, Talieh, Ali Khosravi, Mohammad, Panahi, Mohammad, Khoshroo, Fereidoon, Bahmanjeh, Anahita, Valdes-Balbin, Yury, Garcia-Rivera, Dagmar, Verez-Bencomo, Vicente, Biglari, Alireza, Baesi, KazemEnlace del recurso
Publicado 2022
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200por Chaves, Adriano José Maia, Jucá, Paloma Marinho, Soares, Michelle Verde Ramo, de Oliveira, Caio Andrade, de Sousa, Raul Cavalcante, Lós, Deniele Bezerra, Russo, Remo Castro, Yaochite, Juliana Navarro Ueda, Macedo, Danielle S“…FINDINGS: In RAW cells, RBD peptide was cytotoxic, but not for BV2 cells. …”
Publicado 2023
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