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201por Sergeeva, Alina P., Katsamba, Phinikoula S., Liao, Junzhuo, Sampson, Jared M., Bahna, Fabiana, Mannepalli, Seetha, Morano, Nicholas C., Shapiro, Lawrence, Friesner, Richard A., Honig, Barry“…The strength of binding between human angiotensin converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of viral spike protein plays a role in the transmissibility of the SARS-CoV-2 virus. …”
Publicado 2023
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202por Servian, Carolina do Prado, Spadafora-Ferreira, Mônica, dos Anjos, Déborah Carolina Carvalho, Guilarde, Adriana Oliveira, Gomes-Junior, Antonio Roberto, Borges, Moara Alves Santa Bárbara, Masson, Letícia Carrijo, Silva, João Marcos Maia, de Lima, Matheus Henrique Assis, Moraes, Brenda Grazielli Nogueira, Souza, Sueli Meira, Xavier, Luiz Eterno, de Oliveira, Denise Cristina André, Batalha-Carvalho, João Victor, Moro, Ana Maria, Bocca, Anamélia Lorenzetti, Pfrimer, Irmtraut Araci Hoffmann, Costa, Nádia Lago, Feres, Valéria Christina de Rezende, Fiaccadori, Fabiola Souza, Souza, Menira, Gardinassi, Luiz Gustavo, Durigon, Edison Luiz, Romão, Pedro Roosevelt Torres, Jorge, Soraia Attie Calil, Coelho, Verônica, Botosso, Viviane Fongaro, Fonseca, Simone Gonçalves“…The mild group presented lower levels of anti-NP IgG, and IgA (vs moderate and severe), anti-NP IgM (vs severe, critical and fatal), anti-Spike IgA (vs severe and fatal), and anti-RBD IgG (vs severe). The moderate group presented higher levels of anti-RBD IgA, comparing with severe group. …”
Publicado 2023
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203por Boggiano-Ayo, Tammy, Palacios-Oliva, Julio, Lozada-Chang, Sumlai, Relova-Hernandez, Ernesto, Gomez-Perez, Jose, Oliva, Gonzalo, Hernandez, Lourdes, Bueno-Soler, Alexi, Montes de Oca, Daidee, Mora, Osvaldo, Machado-Santisteban, Roberto, Perez-Martinez, Dayana, Perez-Masson, Beatriz, Cabrera Infante, Yanelys, Calzadilla-Rosado, Lisandra, Ramirez, Yaima, Aymed-Garcia, Judey, Ruiz-Ramirez, Ingrid, Romero, Yamile, Gomez, Tania, Espinosa, Luis A., Gonzalez, Luis Javier, Cabrales, Annia, Guirola, Osmany, de la Luz, Kathya Rashida, Pi-Estopiñan, Franciscary, Sanchez-Ramirez, Belinda, Garcia-Rivera, Dagmar, Valdes-Balbin, Yuri, Rojas, Gertrudis, Leon-Monzon, Kalet, Ojito-Magaz, Eduardo, Hardy, Eugenio“…The two RBD forms - monomeric and dimeric RBD - were also produced on a large scale (500 L). …”
Publicado 2023
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204“…Almost one-third of the MSA patients of both groups presented features of RLS on video-polysomnography. RBD was described in 8/11 (73%) patients with MSA-C and 19/25 (76%) patients with MSA-P (P = 0.849). …”
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205por ali, Mohammad Tuhin, Morshed, Mohammed Monzur, Gazi, Md. Amran, Musa, Md. Abu, Kibria, Md Golam, Uddin, Md Jashim, Khan, Md. Anik Ashfaq, Hasan, Shihab“…In this study, the receptor binding domain (RBD) of Spike (S) glycoprotein of MERS-CoV was analyzed through Computational Immunology approach to identify the antigenic determinants (epitopes). …”
Publicado 2014
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206“…Combined genetic and biochemical studies showed that the cytoplasmic tail of Rbd2 binds directly to PtdIns(4,5)P2 and is sufficient for Rbd2's role in actin regulation. …”
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207por Wang, Shuai, Bai, Ge, Wang, Shu, Yang, Leiyun, Yang, Fen, Wang, Yi, Zhu, Jian-Kang, Hua, Jian“…RBD1 is expressed in the green tissues and is localized in the chloroplast nucleoid. …”
Publicado 2016
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208“…While both dsRBDs adopt the canonical α−β−β−β−α fold, key structural differences and ms-μs dynamics located at the RNA binding region were observed for dsRBD1. These features favor dsRBD1 to orient itself and make stronger tripartite contact with dsRNA, a feature missing in dsRBD2. …”
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209por Dhingra, Sourabh, Kowalski, Caitlin H., Thammahong, Arsa, Beattie, Sarah R., Bultman, Katherine M., Cramer, Robert A.Enlace del recurso
Publicado 2019
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210por Tai, Wanbo, Zhang, Xiujuan, Drelich, Aleksandra, Shi, Juan, Hsu, Jason C., Luchsinger, Larry, Hillyer, Christopher D., Tseng, Chien-Te K., Jiang, Shibo, Du, LanyingEnlace del recurso
Publicado 2020
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211Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2por Huo, Jiangdong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.Enlace del recurso
Publicado 2020
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212por Indenbaum, Victoria, Koren, Ravit, Katz-Likvornik, Shiri, Yitzchaki, Mayan, Halpern, Osnat, Regev-Yochay, Gili, Cohen, Carmit, Biber, Asaf, Feferman, Tali, Cohen Saban, Noy, Dhan, Roni, Levin, Tal, Gozlan, Yael, Weil, Merav, Mor, Orna, Mandelboim, Michal, Sofer, Danit, Mendelson, Ella, Lustig, Yaniv“…IgG antibody levels against the RBD were demonstrated to be up regulated between 1–7 days after COVID-19 detection, earlier than both IgM and IgA antibodies. …”
Publicado 2020
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213por Mathew, Elza Neelima, Hurst, Miranda N., Wang, Baolin, Murthy, Vaibhav, Zhang, Yuntao, DeLong, Robert K.“…Shifts in zeta potential in water, PBS, DMEM and DMEM supplemented with FBS supported NP interaction to RBD. Fluorescence quenching of the NP was concentration-dependent for RBD, Stern–Volmer analysis of this data was used to estimate binding strength which was significant for ZnO-RBD (K(d) < 10(−5)). …”
Publicado 2020
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214“…Many efforts have been made to design or repurpose therapeutics to deactivate RBD or ACE2 and prevent the initial binding. In addition to direct inhibition strategies, small chemical compounds might be able to interfere and destabilize the meta-stable, pre-fusion complex of ACE2-RBD. …”
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215por Su, Qiu-Dong, Zou, Ye-Ning, Yi, Yao, Shen, Li-Ping, Ye, Xiang-Zhong, Zhang, Yang, Wang, Hui, Ke, Hong, Song, Jing-Dong, Hu, Ke-Ping, Cheng, Bo-Lin, Qiu, Feng, Yu, Peng-Cheng, Zhou, Wen-Ting, Zhao, Ran, Cao, Lei, Dong, Gao-Feng, Bi, Sheng-Li, Wu, Gui-Zhen, Gao, George Fu, Zheng, Jerry“…Recombinant SARS-CoV-2 RBD with a built in T helper epitope could stimulate both strong humoral immunity supplemented with cellular immunity in mice, demonstrating that it could be a promising subunit vaccine candidate.…”
Publicado 2021
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216Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2por Huo, Jiandong, Bas, Audrey Le, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.Enlace del recurso
Publicado 2021
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217por Kalathiya, Umesh, Padariya, Monikaben, Fahraeus, Robin, Chakraborti, Soumyananda, Hupp, Ted R.“…The spike-ACE2 protein–protein interaction is mediated through the receptor-binding domain (RBD) of the spike protein. Mutations in the spike RBD can significantly alter interactions with the ACE2 host receptor. …”
Publicado 2021
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218por Du, Yingying, Xu, Yuhua, Feng, Jin, Hu, Longbo, Zhang, Yanan, Zhang, Bo, Guo, Weili, Mai, Runming, Chen, Liyun, Fang, Jianmin, Zhang, Hui, Peng, Tao“…In this study, we generated a recombinant SARS-CoV-2 receptor-binding domain (RBD)-based subunit vaccine. Mice were immunized via intranasal inoculation, microneedle-intradermal injection, or intramuscular injection, after which the RBD-specific immune responses were compared. …”
Publicado 2021
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219por Abayasingam, Arunasingam, Balachandran, Harikrishnan, Agapiou, David, Hammoud, Mohamed, Rodrigo, Chaturaka, Keoshkerian, Elizabeth, Li, Hui, Brasher, Nicholas A., Christ, Daniel, Rouet, Romain, Burnet, Deborah, Grubor-Bauk, Branka, Rawlinson, William, Turville, Stuart, Aggarwal, Anupriya, Stella, Alberto Ospina, Fichter, Christina, Brilot, Fabienne, Mina, Michael, Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Dwyer, Dominic, Sasson, Sarah C., Tea, Fiona, Pilli, Deepti, Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, Bull, Rowena A.“…However, encouragingly, in a selected subset of 13 participants, 12 have detectable RBD-specific memory B cells and these generally are increasing out to 6 months. …”
Publicado 2021
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220por Yao, Hebang, Cai, Hongmin, Li, Tingting, Zhou, Bingjie, Qin, Wenming, Lavillette, Dimitri, Li, Dianfan“…A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the development of neutralizing antibodies, including llama-derived single-chain nanobodies, to target the receptor-binding motif (RBM) and to block ACE2-RBD binding. …”
Publicado 2021
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