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261por Chen, Yaozong, Prévost, Jérémie, Ullah, Irfan, Romero, Hugo, Lisi, Veronique, Tolbert, William D., Grover, Jonathan R., Ding, Shilei, Gong, Shang Yu, Beaudoin-Bussières, Guillaume, Gasser, Romain, Benlarbi, Mehdi, Vézina, Dani, Anand, Sai Priya, Chatterjee, Debashree, Goyette, Guillaume, Grunst, Michael W., Yang, Ziwei, Bo, Yuxia, Zhou, Fei, Béland, Kathie, Bai, Xiaoyun, Zeher, Allison R., Huang, Rick K., Nguyen, Dung N., Sherburn, Rebekah, Wu, Di, Piszczek, Grzegorz, Paré, Bastien, Matthies, Doreen, Xia, Di, Richard, Jonathan, Kumar, Priti, Mothes, Walther, Côté, Marceline, Uchil, Pradeep D., Lavallée, Vincent-Philippe, Smith, Martin A., Pazgier, Marzena, Haddad, Elie, Finzi, Andrés“…While EH3 represents the prevalent IGHV3-53 NAb whose epitope substantially overlaps with the ACE2 binding site, EH8 recognizes a narrow epitope exposed in both RBD-up and RBD-down conformations. When tested in vivo, a single-dose prophylactic administration of EH3 fully protected stringent K18-hACE2 mice from lethal challenge with Delta VOC. …”
Publicado 2022
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262por Lü, Xudong, Feng, Cuiyue, Lü, Ruijie, Wei, Xiyu, Fan, Shuai, Yan, Maocai, Zhu, Xiandui, Zhang, Zhifei, Yang, Zhaoyong“…The receptor binding domain (RBD) of the spike protein, which is responsible for recognition and binding of the human ACE2 receptor protein, is a potential drug target. …”
Publicado 2022
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263por Wahba, Mohamed A., Mofed, Dina, Ghareeb, Doaa A., Omran, Jihad I., Salem, Tamer Z.“…Therefore, two pseudotyped baculoviruses were constructed to display the RBD, AcRBD-sfGFP-64, and AcRBD-sfGFP-V, using two different displaying strategies based on gp64 and VSV-G envelope glycoproteins, from Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and vesicular stomatitis virus (VSV), respectively. …”
Publicado 2023
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264por Montgomerie, Isabelle, Bird, Thomas W., Palmer, Olga R., Mason, Ngarangi C., Pankhurst, Theresa E., Lawley, Blair, Hernández, Leonor C., Harfoot, Rhodri, Authier-Hall, Astrid, Anderson, Danielle E., Hilligan, Kerry L., Buick, Kaitlin H., Mbenza, Naasson M., Mittelstädt, Gerd, Maxwell, Samara, Sinha, Shubhra, Kuang, Joanna, Subbarao, Kanta, Parker, Emily J., Sher, Alan, Hermans, Ian F., Ussher, James E., Quiñones-Mateu, Miguel E., Comoletti, Davide, Connor, Lisa M.“…SARS-CoV-2 receptor binding domain (RBD)-based vaccines are suitable candidates for booster vaccines, eliciting a focused antibody response enriched for virus neutralizing activity. …”
Publicado 2023
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265por Lee, Dan Bi, Kim, Hyojin, Jeong, Ju Hwan, Jang, Ui Soon, Jang, Yuyeon, Roh, Seokbeom, Jeon, Hyunbum, Kim, Eun Jeong, Han, Su Yeon, Maeng, Jin Young, Magez, Stefan, Radwanska, Magdalena, Mun, Ji Young, Jun, Hyun Sik, Lee, Gyudo, Song, Min-Suk, Lee, Hye-Ra, Chung, Mi Sook, Baek, Yun Hee, Kim, Kyung Hyun“…Prime-boost immunizations with 6RBD-np in mice induced significantly high Ab titers against RBD antigens derived from α- and β-CoV and increased interferon (IFN-γ) production, with full protection against the SARS-CoV-2 wild type and Delta challenges. …”
Publicado 2023
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266por Liguori, R., Donadio, V., Wang, Z., Incensi, A., Rizzo, G., Antelmi, E., Biscarini, F., Pizza, F., Zou, Wq, Plazzi, G.“…To compare the diagnostic accuracy of the immunofluorescence (IF) technique and aSyn-seed amplification assay (aSyn-SAA) of skin and cerebrospinal fluid (CSF) in disclosing pathological α-syn in idiopathic idiopathic REM sleep behavior disorder (iRBD) as early phase of a synucleinopathy. We prospectively recruited 41 patients with iRBD and 40 matched clinical controls including RBD associated with type 1 Narcolepsy (RBD-NT1, 21 patients), iatrogenic causes (2 pt) or OSAS (6 pt) and 11 patients with peripheral neuropathies. …”
Publicado 2023
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267por Dickey, Thayne H., Ma, Rui, Orr-Gonzalez, Sachy, Ouahes, Tarik, Patel, Palak, McAleese, Holly, Butler, Brandi, Eudy, Elizabeth, Eaton, Brett, Murphy, Michael, Kwan, Jennifer L., Salinas, Nichole D., Holbrook, Michael R., Lambert, Lynn E., Tolia, Niraj H.“…Here, we develop a potent and easily manufactured nanoparticle vaccine displaying the spike receptor-binding domain (RBD). Computational design to stabilize the RBD, eliminate glycosylation, and focus the immune response to neutralizing epitopes results in an RBD immunogen that resolves issues hindering the efficient nanoparticle display of the native RBD. …”
Publicado 2023
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268“…We previously identified a fusion inhibitory peptide (HR2P-M2) targeting the MERS-CoV S2 protein HR1 domain and a highly potent neutralizing monoclonal antibody (m336) specific to the S1 spike protein receptor-binding domain (RBD). However, m336 was found to have reduced efficacy against MERS-CoV strains with mutations in RBD, and HR2P-M2 showed low potency, thus limiting the clinical application of each when administered separately. …”
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269por Nagy-Fazekas, Dóra, Stráner, Pál, Ecsédi, Péter, Taricska, Nóra, Borbély, Adina, Nyitray, László, Perczel, András“…We demonstrate using ECD spectroscopy that the bacterially produced RBD is well-folded. The bacterially produced nanobody was shown to bind strongly to the recombinant RBD, with a K(d) of 10 nM. …”
Publicado 2023
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270“…Results: Mutations detected in VOCs and VOIs led to the reduction of binding free energy of the RBD–ACE2 complex, forming additional chemical bonds with ACE2, and to an increase of RBD–ACE2 complex stability. …”
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271por Sun, Ting, Wang, Yuchen, Song, Xiaoyu, Li, Ruili, Mei, Fanghua, Yang, Mengliu, Huang, Xiaojie, Li, Yan, Zhou, Xuwei, Wang, Haoyu, Li, Wendong, Li, Jing, Wang, Lu, Shi, Wei, Cai, Kun, Li, Hongjun, Zhang, Jing“…Here, we conducted surveillance of anti-Spike receptor-binding domain (RBD) antibody levels in a large cohort of 534 healthy Chinese subjects vaccinated with two doses of inactivated SARS-CoV-2 vaccines. …”
Publicado 2023
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272por Solla, Paolo, Wang, Qian, Frau, Claudia, Floris, Valentina, Loy, Francesco, Sechi, Leonardo Antonio, Masala, Carla“…Results: Among 590 PD patients included in this study, 111 patients with possible RBD were found (18.8%). RBD was less frequent in female PD patients (p ≤ 0.011). …”
Publicado 2023
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273por Volosnikova, Ekaterina A., Merkuleva, Iuliia A., Esina, Tatiana I., Shcherbakov, Dmitry N., Borgoyakova, Mariya B., Isaeva, Anastasiya A., Nesmeyanova, Valentina S., Volkova, Natalia V., Belenkaya, Svetlana V., Zaykovskaya, Anna V., Pyankov, Oleg V., Starostina, Ekaterina V., Zadorozhny, Alexey M., Zaitsev, Boris N., Karpenko, Larisa I., Ilyichev, Alexander A., Danilenko, Elena D.“…Considering the predominance of the production of neutralizing antibodies targeting the receptor-binding domain (RBD) of S-protein after natural infection or vaccination, it makes sense to choose RBD as a vaccine immunogen. …”
Publicado 2023
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274por Li, Yuanyuan, Zhang, Yanan, Zhou, Yu, Li, Yan, Xu, Jiao, Ai, Yuanbao, Xu, Lei, Xiao, Xiuli, Zhang, Bo, Jin, JingEnlace del recurso
Publicado 2023
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275por Wang, Zhenzhen, Li, Zhenhua, Shi, Weiwei, Zhu, Dashuai, Hu, Shiqi, Dinh, Phuong-Uyen C., Cheng, Ke“…This double-hit vaccine (Flu-RBD) not only induced protective immunities against SARS-CoV-2 but also remained functional as a flu vaccine. …”
Publicado 2023
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276por Laotee, Sedthawut, Duangkaew, Methawee, Jivapetthai, Araya, Tharakhet, Kittipan, Kaewpang, Papatsara, Prompetchara, Eakachai, Phumiamorn, Supaporn, Sapsutthipas, Sompong, Trisiriwanich, Sakalin, Somsaard, Thitiporn, Roytrakul, Sittiruk, Duangkhae, Parichat, Ongpipattanakul, Boonsri, Limpikirati, Patanachai, Pornputtapong, Natapol, Arunmanee, Wanatchaporn“…In this report, we combined recombinant RBD with human IgG(1) Fc to create an RBD dimer. …”
Publicado 2023
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277“…The results indicated that the stability of RBD-ACE2 complexes depends on both amino acid residues in the ACE2 sequences of animal species and on mutations in the RBDs of SARS-CoV-2 variants, with the residues in the interface of the RBD-ACE2 complex being the most important. …”
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278“…Mucosal vaccine for sublingual route was prepared with recombinant SARS-CoV-2 spike protein receptor binding domain (RBD) antigen and poly(I:C) adjuvant components. …”
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279por Bognár, Zsófia, Supala, Eszter, Yarman, Aysu, Zhang, Xiaorong, Bier, Frank F., Scheller, Frieder W., Gyurcsányi, Róbert E.“…Application for SARS-CoV-2 RBD protein’ by Zsófia Bognár et al., Chem. Sci., 2022, 13, 1263–1269, https://doi.org/10.1039/D1SC04502D.…”
Publicado 2023
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280por Mittal, Nidhi, Kumar, Sahil, Rajmani, Raju S., Singh, Randhir, Lemoine, Céline, Jakob, Virginie, BJ, Sowrabha, Jagannath, Nayana, Bhat, Madhuraj, Chakraborty, Debajyoti, Pandey, Suman, Jory, Aurélie, SA, Suba Soundarya, Kleanthous, Harry, Dubois, Patrice, Ringe, Rajesh P., Varadarajan, Raghavan“…In hamsters, SWE-formulated RS2 (a genetic fusion of stabilized RBD with S2) showed enhanced immunogenicity and efficacy relative to corresponding RBD and Spike formulations. …”
Publicado 2023
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