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281por Yang, Lin, Guo, Shuai, Hou, Chengyu, Jiang, Shenda, Shi, Liping, Ma, Xiaoliang, Zheng, Bing, Fang, Yi, Ye, Lin, He, Xiaodong“…The infectivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is primarily determined by the binding affinity between the receptor-binding domain (RBD) of the spike protein and the angiotensin-converting enzyme 2 (ACE2) receptor. …”
Publicado 2023
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282por García-Cerdán, José G., Furst, Ariel L., McDonald, Kent L., Schünemann, Danja, Francis, Matthew B., Niyogi, Krishna K.“…RBD1 also interacts with PSII intermediate complexes containing cytochrome b(559). …”
Publicado 2019
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283por Zhou, Yunjiao, Liu, Zezhong, Li, Shibo, Xu, Wei, Zhang, Qianqian, Silva, Israel T., Li, Cheng, Wu, Yanling, Jiang, Qingling, Liu, Zhenmi, Wang, Qiujing, Guo, Yu, Wu, Jianbo, Gu, Chengjian, Cai, Xia, Qu, Di, Mayer, Christian T., Wang, Xiangxi, Jiang, Shibo, Ying, Tianlei, Yuan, Zhenghong, Xie, Youhua, Wen, Yumei, Lu, Lu, Wang, Qiao“…Monoclonal antibodies isolated from memory B cells target four groups of five non-overlapping receptor-binding domain (RBD) epitopes. Antibodies to one group of these RBD epitopes mediate ADE of entry in Raji cells via an Fcγ receptor-dependent mechanism. …”
Publicado 2021
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284por González-Stegmaier, R., Cereceda, K., Briones, J. L., Beltran-Pávez, C., Oyarzún-Arrau, A., Riquelme-Barrios, S., Selman, C., Yarad, F., Mahave, M., Caglevic, C., Morales, R., Aguirre, A., Valiente-Echeverría, F., Soto-Rifo, R., Marsiglia, H., Gazitua, R., Villarroel-Espindola, F.“…As part of the clinical trial NCT04384588, we quantified IgG against S1-RBD of SARS-CoV-2 (anti-RBD) in recovered people in Santiago and evaluated their suitability as COVID-19 convalescent plasma donors. …”
Publicado 2021
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285por Sun, Shihui, He, Lei, Zhao, Zhongpeng, Gu, Hongjing, Fang, Xin, Wang, Tiecheng, Yang, Xiaolan, Chen, Shaolong, Deng, Yongqiang, Li, Jiangfan, Zhao, Jian, Li, Liang, Li, Xinwang, He, Peng, Li, Ge, Li, Hao, Zhao, Yuee, Gao, Chunrun, Lang, Xiaoling, Wang, Xin, Fei, Guoqiang, Li, Yan, Geng, Shusheng, Gao, Yuwei, Wei, Wenjin, Hu, Zhongyu, Han, Gencheng, Sun, YansongEnlace del recurso
Publicado 2021
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286por Guevara, Ángel, Vivero, Sandra, Nipaz, Victoria, Guaraca, Victor, Coloma, Josefina“…This in-house anti-IgG rRBD ELISA offers an economic and simple alternative to determine IgG immune responses after SARS-CoV-2 infection.…”
Publicado 2021
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287por Lainšček, Duško, Fink, Tina, Forstnerič, Vida, Hafner-Bratkovič, Iva, Orehek, Sara, Strmšek, Žiga, Manček-Keber, Mateja, Pečan, Peter, Esih, Hana, Malenšek, Špela, Aupič, Jana, Dekleva, Petra, Plaper, Tjaša, Vidmar, Sara, Kadunc, Lucija, Benčina, Mojca, Omersa, Neža, Anderluh, Gregor, Pojer, Florence, Lau, Kelvin, Hacker, David, Correia, Bruno E., Peterhoff, David, Wagner, Ralf, Bergant, Valter, Herrmann, Alexander, Pichlmair, Andreas, Jerala, Roman“…In order to compare polypeptide scaffolds of different size and oligomerization state with respect to their efficiency, including anti-scaffold immunity, we compared several strategies of presentation of the RBD domain of the SARS-CoV-2 spike protein, an antigen aiming to generate neutralizing antibodies. …”
Publicado 2021
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288por Yan, Qihong, He, Ping, Huang, Xiaohan, Luo, Kun, Zhang, Yudi, Yi, Haisu, Wang, Qian, Li, Feng, Hou, Ruitian, Fan, Xiaodi, Li, Pingchao, Liu, Xinglong, Liang, Huan, Deng, Yijun, Chen, Zhaoming, Chen, Yunfei, Mo, Xiaoneng, Feng, Liqiang, Xiong, Xiaoli, Li, Song, Han, Jian, Qu, Linbing, Niu, Xuefeng, Chen, Ling“…Monoclonal antibodies (mAbs) encoded by IGHV3-53 (VH3-53) targeting the spike receptor-binding domain (RBD) have been isolated from different COVID-19 patients. …”
Publicado 2021
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289por Yang, Ge, Li, Ziyue, Mohammed, Irfan, Zhao, Liping, Wei, Wei, Xiao, Haihua, Guo, Weisheng, Zhao, Yongxiang, Qu, Feng, Huang, YuanyuEnlace del recurso
Publicado 2021
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290por Lu, Lu, Chu, Allen Wing-Ho, Zhang, Ricky Ruiqi, Chan, Wan-Mui, Ip, Jonathan Daniel, Tsoi, Hoi-Wah, Chen, Lin-lei, Cai, Jian-Piao, Lung, David Christopher, Tam, Anthony Raymond, Yau, Yat-Sun, Kwan, Mike Yat-Wah, To, Wing-Kin, Tsang, Owen Tak-Yin, Lee, Larry Lap-Yip, Yi, Haisu, Ip, Tak-Chuen, Poon, Rosana Wing-Shan, Siu, Gilman Kit-Hang, Mok, Bobo Wing-Yee, Cheng, Vincent Chi-Chung, Chan, Kwok Hung, Yuen, Kwok-Yung, Hung, Ivan Fan-Ngai, To, Kelvin Kai-Wang“…BACKGROUND: Several SARS-CoV-2 lineages with spike receptor binding domain (RBD) N501Y mutation have spread globally. We evaluated the impact of N501Y on neutralizing activity of COVID-19 convalescent sera and on anti-RBD IgG assays. …”
Publicado 2021
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291por Spaeth, Alexander, Masetto, Thomas, Brehm, Jessica, Wey, Leoni, Kochem, Christian, Brehm, Martin, Peter, Christoph, Grimmler, Matthias“…Furthermore, we also evaluated the suitability of N-, S1- and RBD-antigens for quantifying the SARS-CoV-2 specific immune response. …”
Publicado 2021
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292por García-Cordero, Julio, Mendoza-Ramírez, Juvenal, Fernández-Benavides, David, Roa-Velazquez, Daniela, Filisola-Villaseñor, Jessica, Martínez-Frías, Sandra Paola, Sanchez-Salguero, Erik Saul, Miguel-Rodríguez, Carlos E., Maravillas Montero, Jose L., Torres-Ruiz, Jose J., Gómez-Martín, Diana, Argumedo, Leopoldo Santos, Morales-Ríos, Edgar, Alvarado-Orozco, Juan M., Cedillo-Barrón, Leticia“…In this study, we designed plasmids, pcDNA3.1/S1 and pcDNA3.1/N, and optimized their expression of the recombinant S1 and N proteins from SARS-CoV-2 in a mammalian system. The RBD was used as a control. The antigens were successfully purified from Expi293 cells, with high yields of the S1, N, and RBD proteins. …”
Publicado 2021
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293por Bayarri-Olmos, Rafael, Johnsen, Laust Bruun, Rosbjerg, Anne, Helgstrand, Charlotte, Bak-Thomsen, Theresa, Garred, Peter, Skjoedt, Mikkel-OleEnlace del recurso
Publicado 2021
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294por Rodrigues, Kristen A., Rodriguez-Aponte, Sergio A., Dalvie, Neil C., Lee, Jeong Hyun, Abraham, Wuhbet, Carnathan, Diane G., Jimenez, Luis E., Ngo, Julia T., Chang, Jason Y. H., Zhang, Zeli, Yu, Jingyou, Chang, Aiquan, Nakao, Catherine, Goodwin, Benjamin, Naranjo, Christopher A., Zhang, Libin, Silva, Murillo, Barouch, Dan H., Silvestri, Guido, Crotty, Shane, Love, J. Christopher, Irvine, Darrell J.“…Thus, phosphate-mediated coanchoring of RBD and molecular adjuvants to alum is an effective strategy to enhance the efficacy of SARS-CoV-2 subunit vaccines.…”
Publicado 2021
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295Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2por Han, Pengcheng, Li, Linjie, Liu, Sheng, Wang, Qisheng, Zhang, Di, Xu, Zepeng, Han, Pu, Li, Xiaomei, Peng, Qi, Su, Chao, Huang, Baihan, Li, Dedong, Zhang, Rong, Tian, Mingxiong, Fu, Lutang, Gao, Yuanzhu, Zhao, Xin, Liu, Kefang, Qi, Jianxun, Gao, George F., Wang, Peiyi“…The complex structures of omicron RBD-hACE2 and delta RBD-hACE2 reveal the structural basis of how RBD-specific mutations bind to hACE2.…”
Publicado 2022
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296por Zhang, Ye, Wang, Ruixin, He, Chunyan, Zhang, Yu-Fang, Luo, Zhongrui, Luo, Jia, Chen, Sisi, Jin, Yu, Xie, Bowen, Liu, Ye“…In performance evaluation experiments, the mixture of AAS and dimeric RBD significantly enhances RBD-specific humoral responses (4-fold IgG, 3.5-fold IgG2a, 3.3-fold IgG2b, 3.8-fold IgG3 and 1.3-fold IgM), in comparison to aluminum adjuvant-assistant dimeric RBD. …”
Publicado 2022
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297por Liu, Fei, Feng, Canbin, Xu, Shiqi, Wu, Qiang, Tang, Jian, Chen, Yan, Xu, Ruisheng, Chen, Fuliang, Gao, Ni, Xu, Zhengzheng, Gu, Shihui, Lan, Yang, Zhou, Haibo, Hu, Xinde, Wang, Xiaojing“…Guided by this strong promise of using AAVs, we here designed, optimized, and developed an AAV-based vaccines (including AAV-RBD(max), AAV-RBD(wt), AAV-2xRBD, and AAV-3xRBD) that elicit strong immune responses against the RBD domain of the SARS-CoV-2 S protein. …”
Publicado 2022
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298por Wu, Peng, Yang, Qin, Zhao, Xiaoli, Liu, Qingqing, Xi, Jing, Zhang, Fan, He, Jinke, Yang, Hang, Zhang, Chao, Ma, Zhongchen, Deng, Xiaoyu, Wang, Yong, Chen, Chuangfu“…In this study, SARS-CoV-2 Spike RBD protein was used to make the nanobody. Nanobodies binding to the SARS-CoV-2 Spike RBD protein was obtained. …”
Publicado 2022
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299por Liang, Qingtai, Wang, Yifeng, Zhang, Shuyuan, Sun, Jing, Sun, Wenbo, Li, Jizhou, Liu, Yaping, Li, Mingxi, Cheng, Lin, Jiang, Yuhang, Wang, Ruoke, Zhang, Rui, Yang, Zihan, Ren, Yifei, Chen, Peng, Gao, Peng, Yan, Huayuan, Zhang, Zheng, Zhang, Qi, Shi, Xuanling, Wang, Jianbin, Liu, Wanli, Wang, Xinquan, Ying, Bo, Zhao, Jincun, Qi, Hai, Zhang, Linqi“…Collectively, these results demonstrate that the RBD trimer mRNA vaccine serves as a promising vaccine candidate against SARS-CoV-2 variants and beyond.…”
Publicado 2022
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300por Mao, Ling, Liu, Chang, Liu, Jing-Yi, Jin, Zi-Li, Jin, Zhe, Xue, Ruo-Yi, Feng, Rang, Li, Guo-Cheng, Deng, Yan, Cheng, Hao, Zou, Quan-Ming, Li, Hai-Bo“…Furthermore, the possibility of LP1-34, LP2-2 and Pam(2)CSK(4) as the mucosal adjuvant for the SARS-CoV-2 recombinant RBD (rRBD) was investigated. Intranasally immunized with rRBD plus either the novel lipopeptide or Pam(2)CSK(4) significantly increased the levels of specific serum and respiratory mucosal IgG and IgA, while rRBD alone failed to induce specific immune response due to its low immunogenicity. …”
Publicado 2022
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