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3181por Luo, Ningdi, Li, Yuanyuan, Niu, Mengyue, Zhou, Liche, Yao, Mengsha, Zhu, Lin, Ye, Guanyu, Kang, Wenyan, Liu, Jun“…Methods: Fifty PD patients were recruited with 38 v-PSG confirmed PD+RBD patients, and the median follow-up period was 30 months. …”
Publicado 2019
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3182por Wang, Nianshuang, Rosen, Osnat, Wang, Lingshu, Turner, Hannah L., Stevens, Laura J., Corbett, Kizzmekia S., Bowman, Charles A., Pallesen, Jesper, Shi, Wei, Zhang, Yi, Leung, Kwanyee, Kirchdoerfer, Robert N., Becker, Michelle M., Denison, Mark R., Chappell, James D., Ward, Andrew B., Graham, Barney S., McLellan, Jason S.“…Potently neutralizing antibodies targeting the receptor-binding domain (RBD) on MERS-CoV spike (S) protein have been characterized, but much less is known about antibodies targeting non-RBD epitopes. …”
Publicado 2019
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3183por Jiaming, Lan, Yanfeng, Yao, Yao, Deng, Yawei, Hu, Linlin, Bao, Baoying, Huang, Jinghua, Yan, Gao, George F., Chuan, Qin, Wenjie, Tan“…Previous studies have focused mainly on the receptor-binding domain (RBD) on the spike protein of MERS-CoV. Herein, we investigated the immunogenicity and protective potential of the recombinant N-terminal domain (rNTD) of spike proteins as a vaccine candidate. …”
Publicado 2017
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3184por Wang, Qihui, Zhang, Yanfang, Wu, Lili, Niu, Sheng, Song, Chunli, Zhang, Zengyuan, Lu, Guangwen, Qiao, Chengpeng, Hu, Yu, Yuen, Kwok-Yung, Wang, Qisheng, Zhou, Huan, Yan, Jinghua, Qi, Jianxun“…However, atomic details at the binding interface demonstrate that key residue substitutions in SARS-CoV-2-CTD slightly strengthen the interaction and lead to higher affinity for receptor binding than SARS-RBD. Additionally, a panel of murine monoclonal antibodies (mAbs) and polyclonal antibodies (pAbs) against SARS-CoV-S1/receptor-binding domain (RBD) were unable to interact with the SARS-CoV-2 S protein, indicating notable differences in antigenicity between SARS-CoV and SARS-CoV-2. …”
Publicado 2020
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3185por Cai, Yu-ming, Hutchin, Andrew, Craddock, Jack, Walsh, Martin A., Webb, Jeremy S., Tews, Ivo“…We document opposed physiological roles for the genes ΔrbdA and Δpa2072 that encode proteins with identical domain structure: while ΔrbdA showed elevated c-di-GMP levels, restricted motility and promoted biofilm formation, c-di-GMP levels were decreased in Δpa2072, and biofilm formation was inhibited, compared to wild type. …”
Publicado 2020
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3186por Brouwer, Philip J. M., Caniels, Tom G., van der Straten, Karlijn, Snitselaar, Jonne L., Aldon, Yoann, Bangaru, Sandhya, Torres, Jonathan L., Okba, Nisreen M. A., Claireaux, Mathieu, Kerster, Gius, Bentlage, Arthur E. H., van Haaren, Marlies M., Guerra, Denise, Burger, Judith A., Schermer, Edith E., Verheul, Kirsten D., van der Velde, Niels, van der Kooi, Alex, van Schooten, Jelle, van Breemen, Mariëlle J., Bijl, Tom P. L., Sliepen, Kwinten, Aartse, Aafke, Derking, Ronald, Bontjer, Ilja, Kootstra, Neeltje A., Wiersinga, W. Joost, Vidarsson, Gestur, Haagmans, Bart L., Ward, Andrew B., de Bree, Godelieve J., Sanders, Rogier W., van Gils, Marit J.“…Competition and electron microscopy studies illustrate that the SARS-CoV-2 spike protein contains multiple distinct antigenic sites, including several receptor-binding domain (RBD) epitopes as well as non-RBD epitopes. In addition to providing guidance for vaccine design, the antibodies described here are promising candidates for COVID-19 treatment and prevention.…”
Publicado 2020
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3187por Lv, Zhe, Deng, Yong-Qiang, Ye, Qing, Cao, Lei, Sun, Chun-Yun, Fan, Changfa, Huang, Weijin, Sun, Shihui, Sun, Yao, Zhu, Ling, Chen, Qi, Wang, Nan, Nie, Jianhui, Cui, Zhen, Zhu, Dandan, Shaw, Neil, Li, Xiao-Feng, Li, Qianqian, Xie, Liangzhi, Wang, Youchun, Rao, Zihe, Qin, Cheng-Feng, Wang, Xiangxi“…Here we reported a humanized monoclonal antibody, H014, efficiently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2 at nM level by engaging the S receptor binding domain (RBD). Importantly, H014 administration reduced SARS-CoV-2 titers in the infected lungs and prevented pulmonary pathology in hACE2 mouse model. …”
Publicado 2020
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3188por Zhou, Runhong, To, Kelvin Kai-Wang, Wong, Yik-Chun, Liu, Li, Zhou, Biao, Li, Xin, Huang, Haode, Mo, Yufei, Luk, Tsz-Yat, Lau, Thomas Tsz-Kan, Yeung, Pauline, Chan, Wai-Ming, Wu, Alan Ka-Lun, Lung, Kwok-Cheung, Tsang, Owen Tak-Yin, Leung, Wai-Shing, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, Chen, Zhiwei“…Moreover, acute RBD- and NP-specific T cell responses included relatively more CD4 T cells than CD8 T cells. …”
Publicado 2020
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3189“…Monoclonal antibodies (mAbs) that bind to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein or block the interaction between SARS-CoV-2 RBD and the human angiotensin-converting enzyme 2 receptor have been found to be very promising as a countermeasure for tackling the SARS-CoV-2 infection, and clinical trials are underway. …”
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3190por Chi, Xiaojing, Liu, Xiuying, Wang, Conghui, Zhang, Xinhui, Li, Xiang, Hou, Jianhua, Ren, Lili, Jin, Qi, Wang, Jianwei, Yang, Wei“…Here, using SARS-CoV-2 spike receptor-binding domain (RBD) as a bait, we generate a panel of humanized single domain antibodies (sdAbs) from a synthetic library. …”
Publicado 2020
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3191por Li, Wendong, Li, Lin, Sun, Ting, He, Yufei, Liu, Guang, Xiao, Zixuan, Fan, Yubo, Zhang, Jing“…The five epitopes identified in hotspot regions of RBD were found fully exposed based on the 3D structure of the Spike protein. …”
Publicado 2020
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3192por Mor, Michael, Werbner, Michal, Alter, Joel, Safra, Modi, Chomsky, Elad, Hada-Neeman, Smadar, Polonsky, Ksenia, Nowell, Cameron J., Clark, Alex E., Roitburd-Berman, Anna, Shalom, Noam Ben, Navon, Michal, Rafael, Dor, Sharim, Hila, Kiner, Evgeny, Griffis, Eric, Gershoni, Jonathan M., Kobiler, Oren, Leibel, Sandra Lawrynowicz, Zimhony, Oren, Carlin, Aaron F., Yaari, Gur, Dassau, Moshe, Gal-Tanamy, Meital, Hagin, David, Croker, Ben A., Freund, Natalia T.“…Using peptide libraries, competition ELISA and RBD mutagenesis, we mapped the epitopes of the neutralizing antibodies (nAbs) to three different sites on the Spike. …”
Publicado 2020
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3193por Kim, Sinae, Lee, Jong Ho, Lee, Siyoung, Shim, Saerok, Nguyen, Tam T., Hwang, Jihyeong, Kim, Heijun, Choi, Yeo-Ok, Hong, Jaewoo, Bae, Suyoung, Jhun, Hyunjhung, Yum, Hokee, Lee, Youngmin, Chan, Edward D., Yu, Liping, Azam, Tania, Kim, Yong-Dae, Yeom, Su Cheong, Yoo, Kwang Ha, Kang, Lin-Woo, Shin, Kyeong-Cheol, Kim, Soohyun“…New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. …”
Publicado 2020
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3194“…MATERIALS AND METHODS: From various studies on the SARS-CoV-2 reported in the literature, we chose possible drug targets (Chymotrypsin-like protease, RNA dependant RNA polymerase, Papain like protease, Spike RBD and ACE2 receptor with spike RBD) which are vital proteins. …”
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3195por Weissman, Drew, Alameh, Mohamad-Gabriel, de Silva, Thushan, Collini, Paul, Hornsby, Hailey, Brown, Rebecca, LaBranche, Celia C., Edwards, Robert J., Sutherland, Laura, Santra, Sampa, Mansouri, Katayoun, Gobeil, Sophie, McDanal, Charlene, Pardi, Norbert, Hengartner, Nick, Lin, Paulo J.C., Tam, Ying, Shaw, Pamela A., Lewis, Mark G., Boesler, Carsten, Şahin, Uğur, Acharya, Priyamvada, Haynes, Barton F., Korber, Bette, Montefiori, David C.“…The G614 pseudovirus also was more susceptible to neutralization by receptor-binding domain (RBD) monoclonal antibodies and convalescent sera from people infected with either form of the virus. …”
Publicado 2021
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3196“…The putative recombination region is located inside the receptor-binding domain (RBD) of the spike glycoprotein (S protein), which may represent the origin of SARS-CoV-2. …”
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3197por Morgenlander, William, Henson, Stephanie, Monaco, Daniel, Chen, Athena, Littlefield, Kirsten, Bloch, Evan M., Fujimura, Eric, Ruczinski, Ingo, Crowley, Andrew R., Natarajan, Harini, Butler, Savannah E., Weiner, Joshua A., Li, Mamie Z., Bonny, Tania S., Benner, Sarah E., Ashwin Balagopal, Sullivan, David, Shoham, Shmuel, Quinn, Thomas C., Eshleman, Susan, Casadevall, Arturo, Redd, Andrew D., Laeyendecker, Oliver, Ackerman, Margaret E., Pekosz, Andrew, Elledge, Stephen J., Robinson, Matthew, Tobian, Aaron A.R., Larman, H. Benjamin“…We also found that plasma preferentially reactive to the CoV2 receptor binding domain (RBD), versus the betacoronavirus HKU1 RBD, had higher neutralizing titer. …”
Publicado 2020
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3198“…We show that the synonymous divergence between the bat-derived viruses and SARS-CoV-2 is larger than between GD410721 and SARS-CoV-2 in the RBD, providing strong additional support for the recombination hypothesis. …”
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3199por Rathe, Jennifer A, Hemann, Emily A, Eggenberger, Julie, Li, Zhaoqi, Knoll, Megan L, Stokes, Caleb, Hsiang, Tien-Ying, Netland, Jason, Takehara, Kennidy K, Pepper, Marion, Gale, Michael“…Spike IgG3 provided the highest accuracy for predicting serologically positive individuals with virus neutralization activity (misidentified 1/20 unknowns compared to 2/20 for RBD and NP IgG). CONCLUSIONS: The coupling of virus neutralization analysis to a spike IgG3 antibody test is optimal to categorize patients for correlates of SARS-CoV-2 immune protection status.…”
Publicado 2020
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3200“…Residue-specific NMR characterization showed ATP specifically binds the RNA-binding domain (RBD) of the N protein with the average Kd of 3.3 ± 0.4 mM. …”
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