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321por Wang, Zheng, Li, Dan, Chen, Yulu, Sun, Yeping, Jin, Changzhong, Hu, Caiqin, Feng, Yi, Su, Junwei, Ren, Li, Hao, Yanling, Wang, Shuo, Zhu, Meiling, Liu, Ying, Qi, Jianxun, Zhu, Biao, Shao, Yiming“…Then, we resolved antibody-RBD complex structures of potent RBD-specific neutralizing antibodies by X-ray diffraction method. …”
Publicado 2023
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322por Shahab, Muhammad, Akter, Shahina, Sarkar, Md Murshed Hasan, Banu, Tanjina Akhtar, Goswami, Barna, Chowdhury, Sanjana Fatema, Naser, Showti Raheel, Habib, Md Ahashan, Shaikh, Aftab Ali, Saki, Morteza, Zheng, Guojun, Khan, Md Salim“…In this study, computational drug design, such as pharmacophore-based virtual screening and MD simulation has been concentrated, in order to find a novel small molecular inhibitor that prevents hACE2 from binding to the receptor binding domain (RBD). three medicinal compound databases: North-East African, North African, and East African were screened and carried out a multi-step screening approach that identified three compounds, which are thymoquinol 2-O-beta-glucopyranoside (C1), lanneaflavonol (C2), and naringenin-4′-methoxy-7-O-Alpha-L-rhamnoside (C3), with excellent anti-viral properties against the RBD of the omicron variant. …”
Publicado 2023
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323por Brzuska, Gabriela, Zimna, Marta, Baranska, Klaudia, Szewczyk, Boguslaw, Strakova, Petra, Ruzek, Daniel, Krol, Ewelina“…Here, we compared the effect of four different adjuvants (AddaS03, Alhydrogel/MPLA, Alhydrogel/ODN2395, Quil A) on the immunogenicity of a mixture of recombinant RBD and N SARS-CoV-2 proteins. We have analyzed the antibody and T-cell response specific to RBD and N proteins and assessed the impact of adjuvants on virus neutralization. …”
Publicado 2023
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324por Ni, Tao, Mendonça, Luiza, Zhu, Yanan, Howe, Andrew, Radecke, Julika, Shah, Pranav M., Sheng, Yuewen, Krebs, Anna-Sophia, Duyvesteyn, Helen M.E., Allen, Elizabeth, Lambe, Teresa, Bisset, Cameron, Spencer, Alexandra, Morris, Susan, Stuart, David I., Gilbert, Sarah, Zhang, Peijun“…We show that ChAdOx1-vectored vaccines expressing the Beta SARS-CoV-2 variant produce abundant native prefusion spikes predominantly in one-RBD-up conformation. Furthermore, the ChAdOx1-vectored HexaPro-stabilized spike yields higher cell surface expression, enhanced RBD exposure, and reduced shedding of S1 compared to the wild type. …”
Publicado 2023
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325por Nagar, Gaurav, Jain, Siddharth, Rajurkar, Meghraj, Lothe, Rakesh, Rao, Harish, Majumdar, Sourav, Gautam, Manish, Rodriguez-Aponte, Sergio A., Crowell, Laura E., Love, J. Christopher, Dandekar, Prajakta, Puranik, Amita, Gairola, Sunil, Shaligram, Umesh, Jain, Ratnesh“…This two-step purification process produced RBD with an overall productivity of ~21 mg/L at >99% purity. …”
Publicado 2023
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326por Hau, Derrick, Pflughoeft, Kathryn J., Gates-Hollingsworth, Marcellene A., Kaur, Simranjit, Hill, Haydon J., Arias-Umana, Jose, Chung, Chelsea C., Smith, Valerie L., Riddle, Mark S., Healy, Sara A., AuCoin, David P.“…A cohort study comprised of 121 convalescent individuals from northern Nevada was conducted looking at anti-RBD antibody levels by enzyme-linked immunosorbent assay. …”
Publicado 2023
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327“…SARS-CoV-2 and SARS-CoV recognize angiotensin-converting enzyme 2 (ACE2) receptor via the receptor-binding domain (RBD). Here, we identified six SARS-CoV RBD-specific neutralizing monoclonal antibodies (nAbs) that cross-reacted with SARS-CoV-2 RBD, two of which, 18F3 and 7B11, neutralized SARS-CoV-2 infection. 18F3 recognized conserved epitopes on SARS-CoV and SARS-CoV-2 RBDs, whereas 7B11 recognized epitopes on SARS-CoV RBD not fully conserved in SARS-CoV-2 RBD. …”
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328por Fu, Wenyu, Chen, Yujianan, Wang, Kaidi, Hettinghouse, Aubryanna, Hu, Wenhuo, Wang, Jing-Quan, Lei, Zi-Ning, Chen, Zhe-Sheng, Stapleford, Kenneth A., Liu, Chuan-juEnlace del recurso
Publicado 2020
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329por Liu, Zezhong, Xu, Wei, Xia, Shuai, Gu, Chenjian, Wang, Xinling, Wang, Qian, Zhou, Jie, Wu, Yanling, Cai, Xia, Qu, Di, Ying, Tianlei, Xie, Youhua, Lu, Lu, Yuan, Zhenghong, Jiang, Shibo“…The receptor-binding domain (RBD) in the spike protein of SARS-CoV-2 is responsible for its binding to angiotensin-converting enzyme 2 (ACE2) receptor. …”
Publicado 2020
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330por Perreault, Josée, Tremblay, Tony, Fournier, Marie-Josée, Drouin, Mathieu, Beaudoin-Bussières, Guillaume, Prévost, Jérémie, Lewin, Antoine, Bégin, Philippe, Finzi, Andrés, Bazin, RenéeEnlace del recurso
Publicado 2020
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331por Gurung, Arun Bahadur, Ali, Mohammad Ajmal, Lee, Joongku, Farah, Mohammad Abul, Al-Anazi, Khalid Mashay“…The virus infection is initiated upon recognition and binding of the spike (S) protein receptor-binding domain (RBD) to the host cell surface receptor, angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2021
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332“…The results are indicative of better potential of solanine, acetoside, and rutin, as Mpro and spike glycoprotein RBD dual inhibitors. Acetoside and curcumin were found to inhibit Mpro covalently. …”
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333por Amanat, Fatima, Thapa, Mahima, Lei, Tinting, Sayed Ahmed, Shaza M., Adelsberg, Daniel C., Carreno, Juan Manuel, Strohmeier, Shirin, Schmitz, Aaron J., Zafar, Sarah, Zhou, Julian Q, Rijnink, Willemijn, Alshammary, Hala, Borcherding, Nicholas, Reiche, Ana Gonzalez, Srivastava, Komal, Sordillo, Emilia Mia, van Bakel, Harm, Turner, Jackson S., Bajic, Goran, Simon, Viviana, Ellebedy, Ali H., Krammer, Florian“…Neutralizing activity of NTD mAbs but not RBD mAbs against a clinical viral isolate carrying E484K as well as extensive changes in the NTD was abolished, suggesting that a proportion of vaccine induced RBD binding antibodies may provide substantial protection against viral variants carrying single E484K RBD mutations.…”
Publicado 2021
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334“…All the SARS-CoV-2 variants reported to date have multiple mutations in the spike (S) protein, specifically in the receptor-binding domain (RBD). Here, we employed an integrated computational approach involving structure and sequence based predictions to study the effect of naturally occurring variations in the S-RBD on its stability and ACE2 binding affinity. …”
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335por Yadav, Naveen, Vishwakarma, Preeti, Khatri, Ritika, Siddqui, Gazala, Awasthi, Amit, Ahmed, Shubbir, Samal, Sweety“…Here, we have assessed the humoral and cellular responses of a RBD-based peptide immunogen when administered intradermally in BALB/c mice and side-by-side compared with the intramuscular immunization route. …”
Publicado 2021
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336por Kim, Young Soo, Chung, Hwan-Suck, Noh, Sang Gyun, Lee, Bonggi, Chung, Hae Young, Choi, Jang-GiEnlace del recurso
Publicado 2021
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337por Zou, Jintao, Jing, Haiming, Zhang, Xiaoli, Liu, Yiheng, Zhao, Zhuo, Duan, Lianli, Yuan, Yue, Chen, Zhifu, Gou, Qiang, Xiong, Qingshan, Li, Sisi, Yang, Feng, Zeng, Hao, Zou, Quanming, Zhang, Jinyong“…Herein, we designed and obtained an RBD heptamer (mHla-RBD) based on a carrier protein-aided assembly strategy. …”
Publicado 2021
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338por Yi, Chunyan, Sun, Xiaoyu, Lin, Yixiao, Gu, Chenjian, Ding, Longfei, Lu, Xiao, Yang, Zhuo, Zhang, Yaguang, Ma, Liyan, Gu, Wangpeng, Qu, Aidong, Zhou, Xu, Li, Xiuling, Xu, Jianqing, Ling, Zhiyang, Xie, Youhua, Lu, Hongzhou, Sun, Bing“…BACKGROUND: The receptor-binding domain (RBD) variants of SARS-CoV-2 could impair antibody-mediated neutralization of the virus by host immunity; thus, prospective surveillance of antibody escape mutants and understanding the evolution of RBD are urgently needed. …”
Publicado 2021
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339“…Glycan-masking of Ad-S-D428N in the RBD resulted in a 3.0-fold and 2.0-fold increase in the IC-50 neutralization titer against the Alpha (B.1.1.7) and Beta (B.1.351) variants, respectively. …”
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340por Gurung, Arun Bahadur, Ali, Mohammad Ajmal, Lee, Joongku, Farah, Mohammad Abul, Al-Anazi, Khalid Mashay, Al-Hemaid, Fahad, Sami, Hiba“…The present study is aimed at understanding the impact of the major mutations (L452R, T478K and N501Y) in the receptor-binding domain (RBD) of spike protein and their consequences on the binding affinity to human ACE2 through protein–protein docking and molecular dynamics simulation approaches. …”
Publicado 2022
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