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3381por Pace, Ryan M., Williams, Janet E., Järvinen, Kirsi M., Belfort, Mandy B., Pace, Christina D.W., Lackey, Kimberly A., Gogel, Alexandra C., Nguyen-Contant, Phuong, Kanagaiah, Preshetha, Fitzgerald, Theresa, Ferri, Rita, Young, Bridget, Rosen-Carole, Casey, Diaz, Nichole, Meehan, Courtney L., Caffe, Beatrice, Sangster, Mark Y., Topham, David, McGuire, Mark A., Seppo, Antti, McGuire, Michelle K.“…All milk contained SARS-CoV-2-specific IgA and IgG, and levels of anti-RBD IgA correlated with SARS-CoV-2 neutralization. …”
Publicado 2020
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3382por Milani, Gregorio Paolo, Dioni, Laura, Favero, Chiara, Cantone, Laura, Macchi, Chiara, Delbue, Serena, Bonzini, Matteo, Montomoli, Emanuele, Bollati, Valentina“…This follow-up study was performed on the 31 asymptomatic subjects who presented a positive nasal swab or serology against SARS-CoV-2 (Ig against Spike-RBD) in the first part of the UNICORN study (March 2020) aimed at attesting previous or current contacts with the virus in the personnel of the University of Milan. …”
Publicado 2020
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3383por Peng, Tao, Sui, Zhiwei, Huang, Zhenghui, Xie, Jie, Wen, Kai, Zhang, Yongzhuo, Huang, Wenfeng, Mi, Wei, Peng, Ke, Dai, Xinhua, Fang, Xiang“…The POCT system contains colloidal gold-based lateral flow immunoassay test strips, homemade portable reader, and certified reference materials, which detected anti-N and anti-S-RBD IgG/IgM objectively in serum within 15 min. …”
Publicado 2021
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3384“…The interaction interfaces of SARS-CoV-2S RBD and ACE2 protein complex suggests pangolin as a potential intermediate host in SARS-CoV-2. …”
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3385“…We hypothesize that the pH hopping scheme captured a reversible transition between folded or Down conformation (pH ≥ ~7) and unfolded or Up (pH ~ 3) conformation of RBD (receptor binding domain). The acidic condition may also dimerize the S protein through RBD. …”
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3386por Wang, Pengfei, Liu, Lihong, Iketani, Sho, Luo, Yang, Guo, Yicheng, Wang, Maple, Yu, Jian, Zhang, Baoshan, Kwong, Peter D., Graham, Barney S., Mascola, John R., Chang, Jennifer Y., Yin, Michael T., Sobieszczyk, Magdalena, Kyratsous, Christos A., Shapiro, Lawrence, Sheng, Zizhang, Nair, Manoj S., Huang, Yaoxing, Ho, David D.“…We now report that B.1.1.7 is refractory to neutralization by most mAbs to the N-terminal domain (NTD) of spike and relatively resistant to a number of mAbs to the receptor-binding domain (RBD). It is modestly more resistant to convalescent plasma (~3 fold) and vaccinee sera (~2 fold). …”
Publicado 2021
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3387por Wang, Pengfei, Nair, Manoj S., Liu, Lihong, Iketani, Sho, Luo, Yang, Guo, Yicheng, Wang, Maple, Yu, Jian, Zhang, Baoshan, Kwong, Peter D., Graham, Barney S., Mascola, John R., Chang, Jennifer Y., Yin, Michael T., Sobieszczyk, Magdalena, Kyratsous, Christos A., Shapiro, Lawrence, Sheng, Zizhang, Huang, Yaoxing, Ho, David D.“…We now report that B.1.1.7 is refractory to neutralization by most mAbs to the N-terminal domain (NTD) of spike and relatively resistant to a few mAbs to the receptor-binding domain (RBD). It is not more resistant to convalescent plasma or vaccinee sera. …”
Publicado 2021
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3388por Xue, Xia, Shi, Jianxiang, Xu, Hongen, Qin, Yaping, Yang, Zengguang, Feng, Shuaisheng, Liu, Danhua, Jian, Liguo, Hua, Linlin, Wang, Yaohe, Zhang, Qi, Huang, Xueyong, Zhang, Xiaoju, Li, Xinxin, Chen, Chunguang, Guo, Jiancheng, Tang, Wenxue, Liu, Jianbo“…Compared with other regions in the S gene of SARS-CoV-2, the direct-binding sites of the receptor-binding domain (RBD) is more conserved. We focused on 3,860 amino acid mutations in spike protein RBD (T333-C525) of SARS-CoV-2 and simulated their differential stability and binding affinity to hACE2 (S19-D615). …”
Publicado 2021
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3389por Marot, Stéphane, Malet, Isabelle, Leducq, Valentin, Zafilaza, Karen, Sterlin, Delphine, Planas, Delphine, Gothland, Adélie, Jary, Aude, Dorgham, Karim, Bruel, Timothée, Burrel, Sonia, Boutolleau, David, Schwartz, Olivier, Gorochov, Guy, Calvez, Vincent, Marcelin, Anne-Geneviève“…All the HCW had anti-receptor binding domain (RBD) IgA at D21, decreasing to 38.5% at M3 (p < 0.0001). …”
Publicado 2021
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3390por Valenzuela Nieto, Guillermo, Jara, Ronald, Watterson, Daniel, Modhiran, Naphak, Amarilla, Alberto A., Himelreichs, Johanna, Khromykh, Alexander A., Salinas-Rebolledo, Constanza, Pinto, Teresa, Cheuquemilla, Yorka, Margolles, Yago, López González del Rey, Natalia, Miranda-Chacon, Zaray, Cuevas, Alexei, Berking, Anne, Deride, Camila, González-Moraga, Sebastián, Mancilla, Héctor, Maturana, Daniel, Langer, Andreas, Toledo, Juan Pablo, Müller, Ananda, Uberti, Benjamín, Krall, Paola, Ehrenfeld, Pamela, Blesa, Javier, Chana-Cuevas, Pedro, Rehren, German, Schwefel, David, Fernandez, Luis Ángel, Rojas-Fernandez, Alejandro“…Here, we describe the fast-tracked development of an alpaca Nanobody specific for the receptor-binding-domain (RBD) of the SARS-CoV-2 Spike protein with potential therapeutic applicability. …”
Publicado 2021
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3391por McCallum, Matthew, De Marco, Anna, Lempp, Florian A., Tortorici, M. Alejandra, Pinto, Dora, Walls, Alexandra C., Beltramello, Martina, Chen, Alex, Liu, Zhuoming, Zatta, Fabrizia, Zepeda, Samantha, di Iulio, Julia, Bowen, John E., Montiel-Ruiz, Martin, Zhou, Jiayi, Rosen, Laura E., Bianchi, Siro, Guarino, Barbara, Fregni, Chiara Silacci, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Rothlauf, Paul W., Bloyet, Louis-Marie, Benigni, Fabio, Cameroni, Elisabetta, Neyts, Johan, Riva, Agostino, Snell, Gyorgy, Telenti, Amalio, Whelan, Sean P.J., Virgin, Herbert W., Corti, Davide, Pizzuto, Matteo Samuele, Veesler, David“…The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient plasma. …”
Publicado 2021
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3392por Cho, Hansam, Jang, Yuyeon, Park, Ki-Hoon, Choi, Hanul, Nowakowska, Aleksandra, Lee, Hee-Jung, Kim, Minjee, Kang, Min-Hee, Kim, Jin-Hoi, Shin, Ha Youn, Oh, Yu-Kyoung, Kim, Young Bong“…For MERS-CoV vaccine construction, DNA encoding MERS-CoV S-full, S1 subunit, or receptor-binding domain (RBD) was inserted into the genome of AcHERV. For COVID19 vaccine construction, DNA encoding SARS-CoV2 S-full or S1 or a MERS-CoV NTD domain-fused SARS-CoV2 RBD was inserted into the genome of AcHERV. …”
Publicado 2021
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3393por Kratzer, Bernhard, Trapin, Doris, Ettel, Paul, Körmöczi, Ulrike, Rottal, Arno, Tuppy, Friedrich, Feichter, Melanie, Gattinger, Pia, Borochova, Kristina, Dorofeeva, Yulia, Tulaeva, Inna, Weber, Milena, Grabmeier‐Pfistershammer, Katharina, Tauber, Peter A., Gerdov, Marika, Mühl, Bernhard, Perkmann, Thomas, Fae, Ingrid, Wenda, Sabine, Führer, Harald, Henning, Rainer, Valenta, Rudolf, Pickl, Winfried F.“…METHODS: We used multiparametric flow cytometry to analyze whole peripheral blood samples and determined SARS‐CoV‐2‐specific antibody levels against the S‐protein, its RBD‐subunit, and viral nucleocapsid in a cohort of COVID‐19 convalescent patients who had mild disease ~10 weeks after infection (n = 109) and healthy control subjects (n = 98). …”
Publicado 2020
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3394por Han, Xiaojian, Wang, Yingming, Li, Shenglong, Hu, Chao, Li, Tingting, Gu, Chenjian, Wang, Kai, Shen, Meiying, Wang, Jianwei, Hu, Jie, Wu, Ruixin, Mu, Song, Gong, Fang, Chen, Qian, Gao, Fengxia, Huang, Jingjing, Long, Yingyi, Luo, Feiyang, Song, Shuyi, Long, Shunhua, Hao, Yanan, Li, Luo, Wu, Yang, Xu, Wei, Cai, Xia, Gao, Qingzhu, Zhang, Guiji, He, Changlong, Deng, Kun, Du, Li, Nai, Yaru, Wang, Wang, Xie, Youhua, Qu, Di, Huang, Ailong, Tang, Ni, Jin, Aishun“…Using this method, we obtained 198 specific Abs against SARS-CoV-2 RBD from the blood samples of COVID-19 convalescent patients, and 96 of them showed neutralizing activity. …”
Publicado 2021
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3395por Zhang, Dayi, Zhang, Xiaoling, Ma, Rui, Deng, Songqiang, Wang, Xinzi, Wang, Xinquan, Zhang, Xian, Huang, Xia, Liu, Yi, Li, Guanghe, Qu, Jiuhui, Zhu, Yu, Li, Junyi“…The recognition and binding of receptor binding domain (RBD) of SARS-CoV-2 spike protein on SERS assay significantly quenched the spectral intensities of most peaks and exhibited a shift from 1189 to 1182 cm(−1). …”
Publicado 2021
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3396por Zhang, Yufei, Huang, Kun, Wang, Ting, Deng, Fei, Gong, Wenxiao, Hui, Xianfeng, Zhao, Ya, He, Xinlin, Li, Chengfei, Zhang, Qiang, Chen, Xi, Lv, Changjie, Lin, Xian, Yang, Ying, Sun, Xiaomei, Shi, Zhengli, Chen, Huanchun, Zou, Zhong, Jin, Meilin“…Our research demonstrated SARS-CoV-2 can rapidly adapt in aged BALB/c mice through causing mutations at the RBD of the S protein. Moreover, SARS-CoV-2-infected aged BALB/c mice indicated that alveolar damage, interstitial pneumonia, and inflammatory immune responses were similar to the clinical manifestations of human infections. …”
Publicado 2021
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3397por Jacob-Dolan, Catherine, Feldman, Jared, McMahan, Katherine, Yu, Jingyou, Zahn, Roland, Wegmann, Frank, Schuitemaker, Hanneke, Schmidt, Aaron G., Barouch, Dan H.“…Analysis of serum responses showed robust reactivity to the SARS-CoV-2 full-length spike protein and receptor binding domain (RBD), both included in the vaccine. However, serum cross-reactivity to the closely related sarbecovirus SARS-CoV-1 spike and RBD was reduced. …”
Publicado 2021
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3398por Liu, Yafei, Soh, Wai Tuck, Kishikawa, Jun-ichi, Hirose, Mika, Nakayama, Emi E., Li, Songling, Sasai, Miwa, Suzuki, Tatsuya, Tada, Asa, Arakawa, Akemi, Matsuoka, Sumiko, Akamatsu, Kanako, Matsuda, Makoto, Ono, Chikako, Torii, Shiho, Kishida, Kazuki, Jin, Hui, Nakai, Wataru, Arase, Noriko, Nakagawa, Atsushi, Matsumoto, Maki, Nakazaki, Yukoh, Shindo, Yasuhiro, Kohyama, Masako, Tomii, Keisuke, Ohmura, Koichiro, Ohshima, Shiro, Okamoto, Toru, Yamamoto, Masahiro, Nakagami, Hironori, Matsuura, Yoshiharu, Nakagawa, Atsushi, Kato, Takayuki, Okada, Masato, Standley, Daron M., Shioda, Tatsuo, Arase, Hisashi“…Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein prevent SARS-CoV-2 infection. …”
Publicado 2021
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3399por Wang, Ruoke, Zhang, Qi, Ge, Jiwan, Ren, Wenlin, Zhang, Rui, Lan, Jun, Ju, Bin, Su, Bin, Yu, Fengting, Chen, Peng, Liao, Huiyu, Feng, Yingmei, Li, Xuemei, Shi, Xuanling, Zhang, Zheng, Zhang, Fujie, Ding, Qiang, Zhang, Tong, Wang, Xinquan, Zhang, Linqi“…This resistance hierarchy corresponded with Y144del and 242–244del mutations in the N-terminal domain and K417N/T, E484K, and N501Y mutations in the receptor-binding domain (RBD) of SARS-CoV-2. Crystal structure analysis of the B.1.351 triple mutant (417N-484K-501Y) RBD complexed with the monoclonal antibody P2C-1F11 revealed the molecular basis for antibody neutralization and escape. …”
Publicado 2021
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3400por Gu, Chunyin, Cao, Xiaodan, Wang, Zongda, Hu, Xue, Yao, Yanfeng, Zhou, Yiwu, Liu, Peipei, Liu, Xiaowu, Gao, Ge, Hu, Xiao, Zhang, Yecheng, Chen, Zhen, Gao, Li, Peng, Yun, Jia, Fangfang, Shan, Chao, Yu, Li, Liu, Kunpeng, Li, Nan, Guo, Weiwei, Jiang, Guoping, Min, Juan, Zhang, Jianjian, Yang, Lu, Shi, Meng, Hou, Tianquan, Li, Yanan, Liang, Weichen, Lu, Guoqiao, Yang, Congyi, Wang, Yuting, Xia, Kaiwen, Xiao, Zheng, Xue, Jianhua, Huang, Xueyi, Chen, Xin, Ma, Haixia, Song, Donglin, Pan, Zhongzong, Wang, Xueping, Guo, Haibing, Liang, Hong, Yuan, Zhiming, Guan, Wuxiang, Deng, Su-Jun“…After the virus sequence was published, we identified two potent antibodies against the SARS-CoV-2 receptor binding domain (RBD) from antibody libraries using a phage-to-yeast (PtY) display platform in only 10 days. …”
Publicado 2021
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