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3401por Flores-Torres, Mario H, Hughes, Katherine C, Molsberry, Samantha, Gao, Xiang, Kang, Jae H, Schwarzschild, Michael A, Ascherio, Alberto“…We evaluated the association of non-motor prodromal PD features, including hyposmia, constipation and probable REM sleep behaviour disorder (pRBD), with objective measures of cognitive function and self-reported cognitive decline. …”
Publicado 2021
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3402por Xiang, Tiandan, Liang, Boyun, Fang, Yaohui, Lu, Sihong, Li, Sumeng, Wang, Hua, Li, Huadong, Yang, Xiaoli, Shen, Shu, Zhu, Bin, Wang, Baoju, Wu, Jun, Liu, Jia, Lu, Mengji, Yang, Dongliang, Dittmer, Ulf, Trilling, Mirko, Deng, Fei, Zheng, Xin“…During a one-year period post symptom onset, we longitudinally collected 162 samples from 76 patients and quantified IgM and IgG antibodies recognizing the nucleocapsid (N) protein or the receptor binding domain (RBD) of the spike protein (S). After one year, approximately 90% of recovered patients still had detectable SARS-CoV-2-specific IgG antibodies recognizing N and RBD-S. …”
Publicado 2021
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3403por Moriyama, Saya, Adachi, Yu, Sato, Takashi, Tonouchi, Keisuke, Sun, Lin, Fukushi, Shuetsu, Yamada, Souichi, Kinoshita, Hitomi, Nojima, Kiyoko, Kanno, Takayuki, Tobiume, Minoru, Ishijima, Keita, Kuroda, Yudai, Park, Eun-Sil, Onodera, Taishi, Matsumura, Takayuki, Takano, Tomohiro, Terahara, Kazutaka, Isogawa, Masanori, Nishiyama, Ayae, Kawana-Tachikawa, Ai, Shinkai, Masaharu, Tachikawa, Natsuo, Nakamura, Shigeki, Okai, Takahiro, Okuma, Kazu, Matano, Tetsuro, Fujimoto, Tsuguto, Maeda, Ken, Ohnishi, Makoto, Wakita, Takaji, Suzuki, Tadaki, Takahashi, Yoshimasa“…Longitudinal evaluation of total RBD IgG and neutralizing antibody revealed declining total antibody titers but improved neutralization potency per antibody to original SARS-CoV-2, indicative of antibody response maturation. …”
Publicado 2021
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3404por Mariani, Marcello, Acquila, Maura, Tripodi, Gino, Spiazzi, Raffaele, Castagnola, Elio“…METHODS: Immunoglobulin class G (IgG) against SARS-CoV-2 spike RBD were detected by means of a chemiluminescence immunoassay for quantitative IgG antibodies using Maglumi SARS-CoV-2-S-RBD IgG kit during the 3rd week after vaccination completion. …”
Publicado 2021
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3405por Wang, Daji, Zhang, Bin, Ding, Hui, Liu, Dan, Xiang, Jianquan, Gao, Xuejiao J., Chen, Xuehui, Li, Zhongjun, Yang, Lei, Duan, Hongxia, Zheng, Jiyan, Liu, Zheng, Jiang, Bing, Liu, Yang, Xie, Ni, Zhang, Han, Yan, Xiyun, Fan, Kelong, Nie, Guohui“…This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundant amino acids on the surface of spike 1 RBD. …”
Publicado 2021
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3406“…In this review, we discuss some important characteristics of the main SARS‑CoV‑2 surface antigen, the spike (S) protein, such as (i) ability of the receptor-binding domain (RBD) to switch between the “standing-up” position (open pre-fusion conformation) for receptor binding and the “lying-down” position (closed pre-fusion conformation) for immune system evasion; (ii) advantage of a high binding affinity of the RBD open conformation to the human angiotensin-converting enzyme 2 (ACE2) receptor for efficient cell entry; and (iii) S protein preliminary activation by the intracellular furin-like proteases for facilitation of the virus spreading across different cell types. …”
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3407por Thiruvengadam, Ramachandran, Chattopadhyay, Souvick, Mehdi, Farha, Desiraju, Bapu Koundinya, Chaudhuri, Susmita, Singh, Savita, Bhartia, Vandita, Kshetrapal, Pallavi, Mouli Natchu, Uma Chandra, Wadhwa, Nitya, Sopory, Shailaja, Wahi, Mudita, Pandey, Anil K., Taneja, Juhi, Anand, Nidhi, Sharma, Nandini, Sharma, Pragya, Saxena, Sonal, Sindhu, Deepa, Sindhu, Brahmdeep, Sharma, Dharmendra, Shrivastava, Tripti, Dang, Arjun, Batra, Gaurav, Kang, Gagandeep, Bhatnagar, Shinjini“…The immunoglobulin G (IgG) responses to the receptor binding domain (RBD) and nucleocapsid were assessed at 0 to 7 days, 10 to 28 days, and 6 to 10 weeks after infection. …”
Publicado 2021
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3408“…We analyze 796,759 genome isolates from patients to identify 606 non-degenerate RBD mutations and investigate their impacts on 16 mAbs in clinical trials. …”
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3409por Dutta, Kunal, Elmezayen, Ammar D., Al-Obaidi, Anas, Zhu, Wei, Morozova, Olga V., Shityakov, Sergey, Khalifa, Ibrahim“…Antiviral peptides, i.e., Seq12, Seq12m, and Seq13m, can block the receptor-binding domain (RBD) of the SARS-CoV-2, which is necessary for communicating with the angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2021
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3410por Jawalagatti, Vijayakumar, Kirthika, Perumalraja, Park, Ji-Young, Hewawaduge, Chamith, Lee, John Hwa“…By exploiting the self-cleaving peptide, P2A, we fused four SARS-CoV-2 targets, including receptor-binding domain (RBD), heptad repeat domain (HR), membrane protein (M) and epitopes of nsp13, in a single open reading frame. …”
Publicado 2021
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3411por Forni, Diego, Cagliani, Rachele, Arrigoni, Federica, Benvenuti, Martino, Mozzi, Alessandra, Pozzoli, Uberto, Clerici, Mario, De Gioia, Luca, Sironi, Manuela“…Molecular dating for the HCoV-229E spike protein indicated that RBD Classes I, II, III, and IV emerged 3–9 years apart. …”
Publicado 2021
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3412por Du, Yanyun, Shi, Rui, Zhang, Ying, Duan, Xiaomin, Li, Li, Zhang, Jing, Wang, Fengze, Zhang, Ruixue, Shen, Hao, Wang, Yue, Wu, Zheng, Peng, Qianwen, Pan, Ting, Sun, Wanwei, Huang, Weijin, Feng, Yue, Feng, Hui, Xiao, Junyu, Tan, Wenjie, Wang, Youchun, Wang, Chenhui, Yan, Jinghua“…Analysis of the structures of the h11B11/ACE2 and receptor-binding domain (RBD)/ACE2 complexes shows hindrance and epitope competition of the MAb and RBD for the receptor. …”
Publicado 2021
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3413por Han, Songling, Zhao, Gaomei, Wei, Zhuanzhuan, Chen, Yin, Zhao, Jianqi, He, Yongwu, He, Ying-Juan, Gao, Jining, Chen, Shilei, Du, Changhong, Wang, Tao, Sun, Wei, Huang, Yi, Wang, Cheng, Wang, Junping“…Among the candidates, a peptide termed GK-7 (GKGDFRI), which was designed by extracting residues ranging from Gly353 to Ile359 in the ligand-binding domain of ACE2, exhibited the highest binding affinity (25.1 nM) with the SARS-CoV-2 spike receptor-binding domain (RBD). GK-7 bound to the RBD and decreased SARS-CoV-2 S1 attachment to A549 human alveolar epithelial cells. …”
Publicado 2021
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3414“…The proposed method has obtained the average classification accuracy of 84%, 83%, 81%, 78%, 77%, 76% and 72% for NFLE, healthy, SDB, narcolepsy, PLM, insomnia and RBD subjects, respectively in discriminating phases A and B using a balanced database. …”
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3415por Mahgoub, Shahenda, Kotb El-Sayed, Mohamed-I, El-Shehry, Mohamed F., Mohamed Awad, Samir, Mansour, Yara E., Fatahala, Samar S.“…Moreover, compounds 4a,b, 5a,b, 7a,b, 8a,c and 9a showed promising ACE2:SARS-CoV-2 Spike RBD inhibitory effect. Finally, compounds 5a, 7b and 9a exerted a promising anti-inflammatory effect by inhibition of CRP and IL-6 production. …”
Publicado 2021
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3416por Zhang, Wuji, Chua, Brendon, Selva, Kevin, Kedzierski, Lukasz, Ashhurst, Thomas, Haycroft, Ebene, Shoffner, Suzanne, Hensen, Luca, Boyd, David, James, Fiona, Mouhtouris, Effie, Kwong, Jason, Chua, Kyra, Drewett, George, Copaescu, Ana, Dobson, Julie, Rowntree, Louise, Habel, Jennifer, Allen, Lilith, Koay, Hui-Fern, Neil, Jessica, Gartner, Matthew, Lee, Christina, Andersson, Patiyan, Seemann, Torsten, Sherry, Norelle, Amanat, Fatima, Krammer, Florian, Londrigan, Sarah, Wakim, Linda, King, Nicholas, Godfrey, Dale, Mackay, Laura, Thomas, Paul, Nicholson, Suellen, Arnold, Kelly, Chung, Amy, Holmes, Natasha, Smibert, Olivia, Trubiano, Jason, Gordon, Claire, Nguyen, Thi, Kedzierska, Katherine“…SARS-CoV-2-specific IgM, IgG and IgA antibodies were detected using ELISA and multiplex assay in both the respiratory tract and blood of COVID-19 patients, although a higher receptor binding domain (RBD)-specific IgM and IgG seroconversion level was found in respiratory specimens. …”
Publicado 2021
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3417por De Rienzo, Mafalda, Foddai, Maria Laura, Conti, Laura, Mandoj, Chiara, Iaboni, Stefano, Saladini, Ilenia, Castilletti, Concetta, Matusali, Giulia, Donno, Davide Roberto, Marchioni, Luisa, Ianniello, Stefania, Corpolongo, Angela, Palange, Maria, Ciliberto, Gennaro, Piaggio, Giulia, De Marco, Federico“…No correlation was found between anti-S/anti-N IgG and IgM levels and viral NT, measured by either a microneutralization test or the surrogate RBD/ACE2-binding inhibition test. Conversely, NTs directly correlated with anti-S1 IgA levels. …”
Publicado 2021
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3418por Hamorsky, Krystal T., Bushau-Sprinkle, Adrienne M., Kitterman, Kathleen, Corman, Julia M., DeMarco, Jennifer, Keith, Rachel J., Bhatnagar, Aruni, Fuqua, Joshua L., Lasnik, Amanda, Joh, Joongho, Chung, Donghoon, Klein, Jon, Flynn, Joseph, Gardner, Marti, Barve, Shirish, Ghare, Smita S., Palmer, Kenneth E.“…Our analyses demonstrate a broad immune response among individuals and suggest some non-RBD specific S IgG and IgA antibodies neutralize SARS-CoV-2.…”
Publicado 2021
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3419por Wu, Xilin, Cheng, Lin, Fu, Ming, Huang, Bilian, Zhu, Linjing, Xu, Shijie, Shi, Haixia, Zhang, Doudou, Yuan, Huanyun, Nawaz, Waqas, Yang, Ping, Hu, Qinxue, Liu, Yalan, Wu, Zhiwei“…Nb(15)-Nb(H)-Nb(15), a trimer constituted of three Nbs, is constructed to be bispecific for human serum albumin (HSA) and RBD of SARS-CoV-2. Nb(15)-Nb(H)-Nb(15) exhibits single-digit ng/ml neutralization potency against the wild-type and Delta variants of SARS-CoV-2 with a long half-life in vivo. …”
Publicado 2021
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3420por Datta, Pratik, Ukey, Rahul, Bruiners, Natalie, Honnen, William, Carayannopoulos, Mary O., Reichman, Charles, Choudhary, Alok, Onyuka, Alberta, Handler, Deborah, Guerrini, Valentina, Mishra, Pankaj K., Dewald, Hannah K., Lardizabal, Alfred, Lederer, Leeba, Leiser, Aliza L., Hussain, Sabiha, Jagpal, Sugeet K., Radbel, Jared, Bhowmick, Tanaya, Horton, Daniel B., Barrett, Emily S., Xie, Yingda L., Fitzgerald-Bocarsly, Patricia, Weiss, Stanley H., Woortman, Melissa, Parmar, Heta, Roy, Jason, Dominguez-Bello, Maria Gloria, Blaser, Martin J., Carson, Jeffrey L., Panettieri, Reynold A., Libutti, Steven K., Raymond, Henry F., Pinter, Abraham, Gennaro, Maria Laura“…Here we show that our ELISA protocol, which is based on antibody binding to the Receptor Binding Domain (RBD) of the S1 subunit of the viral Spike protein expressed as a novel fusion protein, detects antibody responses to SARS-CoV-2 infection and vaccination. …”
Publicado 2021
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