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  1. 3421
    “…When ranked for either viral infectivity or RBD binding, mouse ACE2 had a weak to undetectable affinity for S-protein while human ACE2 was the highest level detected and feline ACE2 had an intermediate phenotype. …”
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    Variations in cell-surface ACE2 levels alter direct binding of SARS-CoV-2 Spike protein and viral infectivity: Implications for measuring Spike protein interactions with animal ACE2 orthologs
  2. 3422
    “…CO(2) is a potent inhibitor of cellular proinflammatory responses caused by H(2)O(2) or the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. ERK1/2 activated by the combined action of RBD and cytokines crucial for the development of severe COVID-19, i.e. interferon-gamma (IFNγ) and tumour necrosis factor-α (TNFα), are more effectively inactivated by CO(2) than by dexamethasone or acetylsalicylic acid in human bronchial epithelial cells. …”
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    Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors
  3. 3423
    “…The S1 domain of S protein, which contains a critical receptor-binding domain (RBD) antigen, potentially induces protective immunoreactivities against SARS-CoV-2. …”
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    Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice
  4. 3424
    por Dashdorj, Naranjargal J., Wirz, Oliver F., Röltgen, Katharina, Haraguchi, Emily, Buzzanco, Anthony S., Sibai, Mamdouh, Wang, Hannah, Miller, Jacob A., Solis, Daniel, Sahoo, Malaya K., Arunachalam, Prabhu S., Lee, Alexandra S., Shah, Mihir M., Liu, James, Byambabaatar, Sumiya, Bat-Ulzii, Purevjargal, Enkhbat, Anir, Batbold, Enkhtuul, Zulkhuu, Delgersaikhan, Ochirsum, Byambasuren, Khurelsukh, Tungalag, Dalantai, Ganbold, Burged, Natsagdorj, Baatarsuren, Uurtsaikh, Ariungerel, Nomin, Oidovsambuu, Odgerel, Bungert, Andreas S., Genden, Zulkhuu, Yagaanbuyant, Dahgwahdorj, Mordorj, Altankhuu, Pulendran, Bali, Chinthrajah, Sharon, Nadeau, Kari C., Jardetzky, Theodore, Wilbur, James L., Wohlstadter, Jacob N., Sigal, George B., Pinsky, Benjamin A., Boyd, Scott D., Dashdorj, Naranbaatar D.
    Publicado 2021
    “…Functional antibody testing with a panel of nine SARS-CoV-2 viral variant receptor binding domain (RBD) proteins revealed marked differences in vaccine responses, with low antibody levels and RBD-ACE2 blocking activity stimulated by the Sinopharm and Sputnik V vaccines in comparison to the AstraZeneca or Pfizer/BioNTech vaccines. …”
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    Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia
  5. 3425
    “…Assays of IgG antibodies directed to SARS-CoV-2 NC, RBD and S1/S2 recombinant proteins were able to differentiate convalescent from uninfected/unvaccinated groups. …”
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    SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients
  6. 3426
    “…METHODS: The SARS-CoV-2 receptor-binding domain (RBD) and a stabilized version of the spike ectodomain as antigens were detected by CLIA. …”
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    An automated chemiluminescent immunoassay (CLIA) detects SARS-CoV-2 neutralizing antibody levels in COVID-19 patients and vaccinees
  7. 3427
    “…Mutations in the receptor-binding domain (RBD) and n-terminal domain (NTD) have been found throughout all five identified VoCs. …”
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    Efficacy of mRNA, adenoviral vector, and perfusion protein COVID-19 vaccines
  8. 3428
    “…For the micro‐neutralization assay, 19 serum samples, with positive IgG titers against Spike Receptor-Binding Domain (RBD) were tested. After 24 hours, infected cells were inspected for the presence of a cytopathic effect, lysed and RNA RT-PCR conducted for SARS-CoV-2. …”
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    A rapid real-time polymerase chain reaction-based live virus microneutralization assay for detection of neutralizing antibodies against SARS-CoV-2 in blood/serum
  9. 3429
    “…With logistic regression analysis for potentially related factors, age, UPDRS total score, RBD, hyposmia, depression, and fatigue may be associated with PD with AutD. …”
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    Characteristics of Autonomic Dysfunction in Parkinson’s Disease: A Large Chinese Multicenter Cohort Study
  10. 3430
    “…Crystallographic analysis of two VNARs found that they recognized separate epitopes on the RBD and had distinctly different mechanisms of virus neutralization unique to VNARs. …”
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    Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography
  11. 3431
    “…One of these broadly neutralizing potent antibodies, R40-1G8, is a IGHV3-53 RBD-class-1 antibody. Remarkably, cryo-EM analysis revealed that R40-1G8 has a flexible binding mode, targeting both “up” and “down” conformations of the RBD. …”
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    Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers
  12. 3432
    “…We analyzed the binding pattern of wild type and mutants (Spike RBD) to the ACE2 receptor by deciphering variations in the amino acids’ interaction networks by graph kernels along with evolutionary, network metrics, and energetic information. …”
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    Computational modelling of potentially emerging SARS-CoV-2 spike protein RBDs mutations with higher binding affinity towards ACE2: A structural modelling study
  13. 3433
    “…With Ebola virus secreted glycoprotein (sGP) and a SARS-CoV-2 spike protein receptor binding domain (RBD) as targets, Nano2RED showed a high sensitivity (the limit of detection of ∼10 pg /mL, or 0.13 pM for sGP and ∼40 pg/mL, or ∼1.3 pM for RBD in diluted human serum), a high specificity, a large dynamic range (∼7 logs),and fast readout within minutes. …”
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    Synthetic nanobody-functionalized nanoparticles for accelerated development of rapid, accessible detection of viral antigens
  14. 3434
    “…We aimed to describe the SARS-CoV-2 lineages circulating early pandemic among samples with S gene dropout and characterize the receptor-binding domain (RBD) of viral spike protein. Adults and children older than 2 months with signs and symptoms of COVID-19 were prospectively enrolled from May to October in Porto Alegre, Brazil. …”
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    Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction
  15. 3435
    “…S5G2 targets the highly conserved RBD core region and exhibits comparable neutralization towards the variant panel. …”
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    Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein
  16. 3436
    “…SARS-CoV-2 variants of concern (VOCs) contain several single-nucleotide variants (SNVs) at key sites in the receptor-binding region (RBD) that enhance infectivity and transmission, as well as cause immune escape, resulting in an aggravation of the coronavirus disease 2019 (COVID-19) pandemic. …”
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    An encodable multiplex microsphere-phase amplification sensing platform detects SARS-CoV-2 mutations
  17. 3437
    “…The IgG and IgA responses were assessed to S1, S2, RBD, and N proteins in patients at 4 weeks and 12 weeks since the onset of illness or following vaccination. …”
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    Kinetics of immune responses to SARS-CoV-2 proteins in individuals with varying severity of infection and following a single dose of the AZD1222
  18. 3438
    “…Here, we established a novel detection technique for activated Rac/Cdc42 in human colon cancer FFPE tissues by using a p21-activated kinase (PAK)-Rac binding domain (RBD) detection probe fused with glutathione S-transferase (GST), designated GST-PAK-RBD, and novel rapid-immunohistochemistry (R-IHC) systems using noncontact alterating-current electric field mixing, although there is a technical limitation in that it may not distinguish between Rac members and Cdc42. …”
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    Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues
  19. 3439
    “…An evaluation to compare the neutralizing activity in the MNT assay to the IgG measured using the MSD ECL assay showed a strong correlation between the presence of neutralizing activity and amount of antibodies against the spike and RBD proteins in sera from both convalescent and vaccinated individuals. …”
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    Robust validation and performance comparison of immunogenicity assays assessing IgG and neutralizing antibodies to SARS-CoV-2
  20. 3440
    “…Consistent with targeting of conserved sites, select RBD bnAbs exhibited in vivo protective efficacy against diverse SARS-like coronaviruses in a prophylaxis challenge model. …”
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    Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses
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