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3441por Portillo, Vera, Fedeli, Chiara, Ustero Alonso, Pilar, Petignat, Ianis, Mereles Costa, Ellen Cristina, Sulstarova, Adi, Jaksic, Cyril, Yerly, Sabine, Calmy, Alexandra“…Both anti-N and anti-S1-receptor binding domain (RBD) antibodies were measured together with HIV-1 RNA levels after the first dose (M0) and then at 1 (M1), 2 (M2) and 6 (M6) months later. …”
Publicado 2022
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3442por Bosa, Luca, Di Chiara, Costanza, Gaio, Paola, Cosma, Chiara, Padoan, Andrea, Cozzani, Sandra, Perilongo, Giorgio, Plebani, Mario, Giaquinto, Carlo, Donà, Daniele, Cananzi, Mara“…Mean anti-SARS-CoV-2 IgG S-RBD titer was similar between IBD patients and controls (27.3 ± 43.8 vs. 36.8 ± 35.3 kAU/L, p = ns). …”
Publicado 2022
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3443por Yu, Wei, Zhong, Nan, Li, Xin, Ren, Jiayi, Wang, Yueming, Li, Chengming, Yao, Gui, Zhu, Rui, Wang, Xiaoli, Jia, Zhenxing, Wu, Changwen, Chen, Rongfeng, Zheng, Weihong, Liao, Huaxin, Wu, Xiaomin, Yuan, Xiaohui“…The additional hydrogen-bonding, hydrophobic interactions, as well as salt-bridges formed between the modified double-site mutated antibody and SARS-CoV-2 RBD were identified. The computational and experimental results clearly demonstrated that the affinity of the modified antibody has been greatly enhanced. …”
Publicado 2022
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3444por Ai, Jingwen, Zhang, Yi, Zhang, Haocheng, Zhang, Qiran, Fu, Zhangfan, Lin, Ke, Song, Jieyu, Zhao, Yuanhan, Fan, Mingxiang, Wang, Hongyu, Zhou, Yang, Chen, Xiaohua, Qiu, Chao, Zhang, Wenhong“…We conducted this prospective, open-label study in Huashan Hospital using a third 6.5U BBIBP-CorV administered at an interval of 4–8 months following the previous two doses in healthy adults. Safety, anti-RBD response and neutralizing titers against SARS-CoV-2 and VOCs were examined. …”
Publicado 2022
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3445Probabilistic classification of anti‐SARS‐CoV‐2 antibody responses improves seroprevalence estimatespor Castro Dopico, Xaquin, Muschiol, Sandra, Grinberg, Nastasiya F, Aleman, Soo, Sheward, Daniel J, Hanke, Leo, Ahl, Marcus, Vikström, Linnea, Forsell, Mattias, Coquet, Jonathan M, McInerney, Gerald, Dillner, Joakim, Bogdanovic, Gordana, Murrell, Ben, Albert, Jan, Wallace, Chris, Karlsson Hedestam, Gunilla B“…METHODS: Using robust ELISAs based on SARS‐CoV‐2 spike (S) and the receptor‐binding domain (RBD), we profiled antibody responses in a group of SARS‐CoV‐2 PCR+ individuals (n = 138). …”
Publicado 2022
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3446por Moharana, Maheswata, Das, Anuradha, Sahu, Satya Narayan, Pattanayak, Subrat Kumar, Khan, Fahmida“…Free energy landscape analysis was performed of the 6LU7- acacetin and 6Y2E-acacetin systems and spike RBD-acacetin system. From molecular docking study and molecular dynamics study revealed that, the compound acacetin shows promising inhibitor towards both main protease as well as mutant spike RBD of SARS-CoV-2 protein.…”
Publicado 2022
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3447por Tawinprai, Kriangkrai, Siripongboonsitti, Taweegrit, Porntharukchareon, Thachanun, Dechates, Bothamai, Monprach, Harnphadungkit, Sornsamdang, Gaidganok, Wittayasak, Kasiruck, Soonklang, Kamonwan, Mahanonda, Nithi“…This study evaluated the durability, contributing factors of anti-RBD antibody concentration, and reactogenicities after the single dose of AZD1222 vaccine in the Thai population. …”
Publicado 2022
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3448por Fang, Yi, Dai, Shaobing, Jin, Chongyao, Si, Xiaoli, Gu, Luyan, Song, Zhe, Gao, Ting, Chen, Ying, Yan, Yaping, Yin, Xinzhen, Pu, Jiali, Zhang, Baorong“…Furthermore, we examined if AQP4 SNPs moderated the association between REM sleep behavior disorder (RBD) and CSF biomarkers. RESULTS: In patients with PD, AQP4 rs162009 (AA/AG vs. …”
Publicado 2022
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3449por Sarkar, Anindya, Paul, Sathi, Singh, Charandeep, Chowdhury, Nilkanta, Nag, Papri, Das, Swarnava, Kumar, Sahil, Sharma, Anshul, Das, Deepjyoti Kumar, Dutta, Dipak, Thakur, Krishan Gopal, Bagchi, Angshuman, Shriti, Surbhi, Das, Kali P., Ringe, Rajesh P., Das, Sampa“…In silico docking studies revealed that NTL-125 has strong affinity to viral Spike RBD protein, preventing it from attaching to hACE2 receptor, the gateway to cellular entry. …”
Publicado 2022
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3450por Goel, Rishi R., Painter, Mark M., Lundgreen, Kendall A., Apostolidis, Sokratis A., Baxter, Amy E., Giles, Josephine R., Mathew, Divij, Pattekar, Ajinkya, Reynaldi, Arnold, Khoury, David S., Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Hicks, Amanda, Sharma, Harsh, Herring, Sarah, Korte, Scott, KC, Wumesh, Oldridge, Derek A., Erickson, Rachel I., Weirick, Madison E., McAllister, Christopher M., Awofolaju, Moses, Tanenbaum, Nicole, Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., McLaughlin, Maura, Williams, Justine C., Adamski, Sharon, Kuthuru, Oliva, Drapeau, Elizabeth M., Davenport, Miles P., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John“…Antibody decay stabilized between 6 and 9 months, and antibody quality continued to improve for at least 9 months after 2-dose vaccination. Spike- and RBD-specific memory B cells remained durable over time, and 40%–50% of RBD-specific memory B cells simultaneously bound the Alpha, Beta, Delta, and Omicron variants. …”
Publicado 2022
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3451por Hao, Ying, Yang, He S., Karbaschi, Mohsen, Racine-Brzostek, Sabrina E., Li, Pu, Zuk, Robert, Yang, Yawei J., Klasse, P.J., Shi, Yuanyuan, Zhao, Zhen“…This study developed a chaotrope- and label-free biolayer interferometry (BLI) assay for the real-time monitoring of receptor binding domain (RBD) binding kinetics with SARS-CoV-2 spike protein in convalescent COVID-19 patients. …”
Publicado 2022
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3452por Struble, Lucas R., Smith, Audrey L., Lutz, William E., Grubbs, Gabrielle, Sagar, Satish, Bayles, Kenneth W., Radhakrishnan, Prakash, Khurana, Surender, El‐Gamal, Dalia, Borgstahl, Gloria E. O.“…We developed a robust SARS‐CoV‐2 S spike expression and purification protocol from insect cells and studied four recombinant SARS‐CoV‐2 spike protein constructs based on the original SARS‐CoV‐2 sequence using a baculovirus expression system: a spike protein receptor‐binding domain that includes the SD1 domain (RBD) coupled to a fluorescent tag (S‐RBD‐eGFP), spike ectodomain coupled to a fluorescent tag (S‐Ecto‐eGFP), spike ectodomain with six proline mutations and a foldon domain (S‐Ecto‐HexaPro(+F)), and spike ectodomain with six proline mutations without the foldon domain (S‐Ecto‐HexaPro(‐F)). …”
Publicado 2022
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3453Immunogenicity of heterologous inactivated and adenoviral-vectored COVID-19 vaccine: Real-world datapor Wanlapakorn, Nasamon, Suntronwong, Nungruthai, Phowatthanasathian, Harit, Yorsaeng, Ritthideach, Thongmee, Thanunrat, Vichaiwattana, Preeyaporn, Auphimai, Chompoonut, Wongsrisang, Lakkhana, Klinfueng, Sirapa, Sudhinaraset, Natthinee, Poovorawan, Yong“…All sera samples were tested for anti-receptor-binding-domain IgG (anti-RBD IgG) using a chemiluminescent microparticle immunoassay (CMIA). …”
Publicado 2022
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3454por Agrati, Chiara, Castilletti, Concetta, Goletti, Delia, Sacchi, Alessandra, Bordoni, Veronica, Mariotti, Davide, Notari, Stefania, Matusali, Giulia, Meschi, Silvia, Petrone, Linda, Aiello, Alessandra, Najafi Fard, Saeid, Farroni, Chiara, Colavita, Francesca, Lapa, Daniele, Leone, Sara, Agresta, Alessandro, Capobianchi, Maria, Ippolito, Giuseppe, Vaia, Francesco, Puro, Vincenzo“…After 12 weeks from vaccination, the titer of anti-RBD antibodies as well as their neutralization function decreased while the Spike-specific T-cells persisted at the same level as soon after vaccine boost. …”
Publicado 2022
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3455por Schrezenmeier, Eva, Rincon-Arevalo, Hector, Jens, Annika, Stefanski, Ana-Luisa, Hammett, Charlotte, Osmanodja, Bilgin, Koch, Nadine, Zukunft, Bianca, Beck, Julia, Oellerich, Michael, Proß, Vanessa, Stahl, Carolin, Choi, Mira, Bachmann, Friederike, Liefeldt, Lutz, Glander, Petra, Schütz, Ekkehard, Bornemann-Kolatzki, Kirsten, López del Moral, Covadonga, Schrezenmeier, Hubert, Ludwig, Carolin, Jahrsdörfer, Bernd, Eckardt, Kai-Uwe, Lachmann, Nils, Kotsch, Katja, Dörner, Thomas, Halleck, Fabian, Sattler, Arne, Budde, Klemens“…In line with humoral responses, counts and relative frequencies of spike receptor binding domain–specific (RBD-specific) B cells were markedly increased on day 7 after vaccination, with an increase in RBD-specific CD27(++)CD38(+) plasmablasts. …”
Publicado 2022
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3456por Tarrés-Freixas, Ferran, Trinité, Benjamin, Pons-Grífols, Anna, Romero-Durana, Miguel, Riveira-Muñoz, Eva, Ávila-Nieto, Carlos, Pérez, Mónica, Garcia-Vidal, Edurne, Perez-Zsolt, Daniel, Muñoz-Basagoiti, Jordana, Raïch-Regué, Dàlia, Izquierdo-Useros, Nuria, Andrés, Cristina, Antón, Andrés, Pumarola, Tomàs, Blanco, Ignacio, Noguera-Julián, Marc, Guallar, Victor, Lepore, Rosalba, Valencia, Alfonso, Urrea, Victor, Vergara-Alert, Júlia, Clotet, Bonaventura, Ballana, Ester, Carrillo, Jorge, Segalés, Joaquim, Blanco, Julià“…In silico modeling supported these findings by predicting B.1.351/Beta receptor binding domain (RBD) mutations result in an increased affinity for both human and murine ACE2 receptors, while BA.1/Omicron RBD mutations only show increased affinity for murine ACE2.…”
Publicado 2022
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3457por Pagneux, Quentin, Roussel, Alain, Saada, Hiba, Cambillau, Christian, Amigues, Béatrice, Delauzun, Vincent, Engelmann, Ilka, Alidjinou, Enagnon Kazali, Ogiez, Judith, Rolland, Anne Sophie, Faure, Emmanuel, Poissy, Julien, Duhamel, Alain, Boukherroub, Rabah, Devos, David, Szunerits, Sabine“…CONCLUSIONS: We believe this diagnostic concept, also validated for RBD mutants and successfully tested on Delta variant samples, to be a powerful tool to detect patients’ infection status, easily extendable to other viruses and capable of overcoming sensing-related mutation effects.…”
Publicado 2022
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3458por Ballesteros-Sanabria, Laura, Pelaez-Prestel, Hector F., Ras-Carmona, Alvaro, Reche, Pedro A.“…Most of the B cell epitope clusters map in the RBD domain (39 out of 54) and 20%, 50%, 37%, 44% and 57% of the total are mutated in SARS-CoV-2 Alpha, Beta, Gamma, Delta and Omicron variants, respectively. …”
Publicado 2022
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3459por Ranjan, Prashant, Neha, Devi, Chandra, Devar, Kaaviyapriya Arulmozhi, Das, Parimal“…However, the binding affinity of Omicron RBD variants for CR3022, B38, and P2B2F6 antibodies is lower as compared to Delta AY.3, which might promote immune evasion and reinfection and needs further experimental investigation.…”
Publicado 2022
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3460por Chen, Yuxin, Chen, Lin, Yin, Shengxia, Tao, Yue, Zhu, Liguo, Tong, Xin, Mao, Minxin, Li, Ming, Wan, Yawen, Ni, Jun, Ji, Xiaoyun, Dong, Xianchi, Li, Jie, Huang, Rui, Shen, Ya, Shen, Han, Bao, Changjun, Wu, Chao“…Furthermore, the booster dose induced potent B cells and memory B cells that cross-bound receptor-binding domain (RBD) proteins derived from VoCs, while Delta and Omicron RBD-specific memory B cell recognitions were reduced by 2.7-fold and 4.2-fold compared to that of ancestral strain, respectively. …”
Publicado 2022
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