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3461“…In this work, we investigated the binding affinity of the CR3022 antibody and H11-H4 nanobody to the SARS-CoV-2 receptor binding domain (RBD) using molecular modeling. Both all-atom steered molecular dynamics simulations and coarse-grained umbrella sampling showed that, consistent with the experiment, CR3022 associates with RBD more strongly than H11-H4. …”
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3462“…Utilizing combined molecular docking and molecular dynamics techniques, the binding affinities and features of the synthesized compounds were evaluated against four SARS-CoV-2 target enzymes, namely, main protease (M(pro)), papain-like protease (PL(pro)), RNA-dependent RNA polymerase (RdRp), and receptor-binding domain (RBD) of the spike protein. Compound 7 demonstrated promising binding affinities with the target enzymes M(pro), PL(pro), RdRp, and RBD with docking scores of −11.4, −9.4, −8.2, and −6.8 kcal/mol, respectively. …”
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3463A Randomized Clinical Trial of a Fractional Low Dose of BNT162b2 Booster in Adults Following AZD1222por Nantanee, Rapisa, Jantarabenjakul, Watsamon, Jaru-Ampornpan, Peera, Sodsai, Pimpayao, Himananto, Orawan, Athipunjapong, Jitthiwa, Sophonphan, Jiratchaya, Nanthapisal, Sira, Hirankarn, Nattiya, Puthanakit, Thanyawee“…At day 14, the geometric means (GMs) of anti-S-RBD IgG in half- vs. standard-dose group were 2329.8 vs. 2574.7 BAU/mL, with a geometric mean ratio (GMR) of 0.90 (0.77–1.06). …”
Publicado 2022
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3464por Gdoura, Mariem, Ghaloum, Fatma Ben, Hamida, Meriem Ben, Chamsa, Wafa, Triki, Henda, Bahloul, Chokri“…The validation was carried out by comparison to four commercial techniques (Vidas SARS-CoV-2 IgG anti-RBD Biomérieux, Elecsys Anti-Nucleocapsid of SARS-CoV-2 Roche, cPass GenScript and the quantitative Elecsys Anti-RBD of SARS-CoV-2, Roche). …”
Publicado 2022
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3465por Angelopoulou, Michailia, Makarona, Eleni, Salapatas, Alexandros, Misiakos, Konstantinos, Synolaki, Evgenia, Ioannidis, Anastasios, Chatzipanagiotou, Stylianos, Ritvos, Mikael A., Pasternack, Arja, Ritvos, Olli, Petrou, Panagiota S., Kakabakos, Sotirios E.“…Using a humanized rat antibody against SARS-CoV-2 RBD, a detection limit of 20 ng/mL was determined. …”
Publicado 2022
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3466por Watanabe, Yoshiyuki, Matsuba, Ikuro, Watanabe, Karin, Kunishima, Tomoyuki, Takechi, Yukako, Takuma, Tetsuo, Araki, Yasushi, Hirotsu, Nobuo, Sakai, Hiroyuki, Oikawa, Ritsuko, Danno, Hiroki, Fukuda, Masakazu, Futagami, Seiji, Wada, Kota, Yamamoto, Hiroyuki, Itoh, Fumio, Oda, Ichiro, Hatori, Yutaka, Degawa, Hisakazu“…Neutralization antibody (NAb, SARS‐CoV‐2 S‐RBD IgM/IgG) titers and two kinds of surrogate virus neutralization tests (sVNTs) were analyzed (UMIN000043851). …”
Publicado 2022
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3467por Wernike, Kerstin, Fischer, Luisa, Holsteg, Mark, Aebischer, Andrea, Petrov, Anja, Marquart, Katharina, Schotte, Ulrich, Schön, Jacob, Hoffmann, Donata, Hechinger, Silke, Neubauer‐Juric, Antonie, Blicke, Julia, Mettenleiter, Thomas C., Beer, Martin“…In an ELISA based on the receptor‐binding domain (RBD) of SARS‐CoV‐2, 25 out of 493 (5.1%) samples collected in autumn and winter 2021/2022 scored positive. …”
Publicado 2022
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3468“…The potential of mean force calculations reveals that the high binding affinity of SARS-CoV2 RBD to human ACE2 is primarily attributed to its ability to form a higher number of hydrogen bonds than the other ACE2-user CoVs. …”
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3469por Tunheim, Gro, Rø, Gunnar Øyvind Isaksson, Chopra, Adity, Aase, Audun, Kran, Anne‐Marte Bakken, Vaage, John Torgils, Lund‐Johansen, Fridtjof, Hungnes, Olav“…In IgG antibodies against the spike protein, the spike receptor binding domain (RBD) and the nucleocapsid protein of SARS‐CoV‐2 were measured by a bead‐based flow cytometric assay. …”
Publicado 2022
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3470por Alfonso-Dunn, Roberto, Lin, Jerry, Kirschner, Vanessa, Lei, Joyce, Feuer, Grant, Malin, Michaela, Liu, Jiayuan, Roche, Morgan, Sadiq, Saud A.“…Both IgG antibodies recognizing receptor binding domain (RBD) from CoV-2 spike protein and their blocking activity against RBD-hACE2 binding were significantly reduced in aCD20-MS patients, with a seroconversion rate of only 23.8%. …”
Publicado 2022
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3471por Chakraborty, Chiranjib, Bhattacharya, Manojit, Sharma, Ashish Ranjan, Dhama, Kuldeep, Agoramoorthy, Govindasamy“…Simultaneously, among six RBD mutations, G339D, G446S, and Q498R mutations increased the molecular flexibility of S-glycoprotein. …”
Publicado 2022
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3472por Chakraborty, Sandipan, Saha, Aditi, Saha, Chiranjeet, Ghosh, Sanjana, Mondal, Trisha“…The present study critically evaluates the effect of mutations observed in several omicron variants on the binding affinities of different classes of RBD-specific antibodies using a combined approach of immunoinformatics and binding free energy calculations. …”
Publicado 2022
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3473por Cortés-Sarabia, Karen, Luna-Pineda, Víctor Manuel, Rodríguez-Ruiz, Hugo Alberto, Leyva-Vázquez, Marco Antonio, Hernández-Sotelo, Daniel, Beltrán-Anaya, Fredy Omar, Vences-Velázquez, Amalia, Del Moral-Hernández, Oscar, Illades-Aguiar, Berenice“…All peptides were synthetized in MAP8 format, and recombinant S (trimer and RBD) and N proteins were used as antigens to search for antibodies in serum samples derived from COVID-19 patients, and for antibody response in New Zealand rabbits. …”
Publicado 2022
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3474Multi-predictor modeling for predicting early Parkinson’s disease and non-motor symptoms progression“…In addition, we constructed prognostic models for predicting the progression of non-motor symptoms [cognitive impairment, Rapid-eye-movement sleep Behavior Disorder (RBD), and depression] in de novo PD patients at 5 years of follow-up. …”
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3475por Kim, Dongjoo, Biancon, Giulia, Bai, Zhiliang, VanOudenhove, Jennifer, Liu, Yuxin, Kothari, Shalin, Gowda, Lohith, Kwan, Jennifer M., Buitrago-Pocasangre, Nicholas Carlos, Lele, Nikhil, Asashima, Hiromitsu, Racke, Michael K., Wilson, JoDell E., Givens, Tara S., Tomayko, Mary M., Schulz, Wade L., Longbrake, Erin E., Hafler, David A., Halene, Stephanie, Fan, Rong“…Here, we developed a novel microfluidic chip for high-plex immuno-serological assay to simultaneously measure up to 50 plasma or serum samples for up to 50 soluble markers including 35 plasma proteins, 11 anti-spike/RBD IgG antibodies spanning all major variants, and controls. …”
Publicado 2022
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3476Determinants of Neutralizing Antibody Response After SARS CoV-2 Vaccination in Patients With Myelomapor Nooka, Ajay K., Shanmugasundaram, Uma, Cheedarla, Narayana, Verkerke, Hans, Edara, Venkata V., Valanparambil, Rajesh, Kaufman, Jonathan L., Hofmeister, Craig C., Joseph, Nisha S., Lonial, Sagar, Azeem, Maryam, Manalo, Julia, Switchenko, Jeffrey M., Chang, Andres, Linderman, Susanne L., Roback, John D., Dhodapkar, Kavita M., Ahmed, Rafi, Suthar, Mehul S., Neish, Andrew S., Dhodapkar, Madhav V.“…In 33% of patients, vaccine-induced antispike RBD antibodies lack detectable neutralizing capacity, including against the B1.617.2 variant. …”
Publicado 2022
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3477“…Our analyses indicated that the diversity of N-terminal (NTD) and receptor-binding (RBD) domains exceeded that of any other regions but still contained extended low substitution density regions particularly considering significantly broader substitution profiles of Omicron BA.2 and BA.4/5. …”
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3478por Chong, Yong, Goto, Takeyuki, Tani, Naoki, Yonekawa, Akiko, Ikematsu, Hideyuki, Shimono, Nobuyuki, Tanaka, Yosuke, Akashi, Koichi“…RESULTS: The median anti‐spike (RBD) IgG level in SARS‐CoV‐2‐naive residents 6 months after the second dose was the lowest among the four groups, with a decreasing rate of over 90%. …”
Publicado 2022
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3479por Kumar, Sanjeev, Patel, Anamika, Lai, Lilin, Chakravarthy, Chennareddy, Valanparambil, Rajesh, Reddy, Elluri Seetharami, Gottimukkala, Kamalvishnu, Davis-Gardner, Meredith E., Edara, Venkata Viswanadh, Linderman, Susanne, Nayak, Kaustuv, Dixit, Kritika, Sharma, Pragati, Bajpai, Prashant, Singh, Vanshika, Frank, Filipp, Cheedarla, Narayanaiah, Verkerke, Hans P., Neish, Andrew S., Roback, John D., Mantus, Grace, Goel, Pawan Kumar, Rahi, Manju, Davis, Carl W., Wrammert, Jens, Godbole, Sucheta, Henry, Amy R., Douek, Daniel C., Suthar, Mehul S., Ahmed, Rafi, Ortlund, Eric, Sharma, Amit, Murali-Krishna, Kaja, Chandele, Anmol“…Structural studies of 002-S21F2 in complex with spike trimers of Omicron and WA.1 showed that it targets a conformationally conserved epitope on the outer face of RBD (class 3 surface) outside the ACE2-binding motif, thereby providing a mechanistic insights for its broad neutralization activity. …”
Publicado 2022
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3480por Fiorino, Fabio, Ciabattini, Annalisa, Sicuranza, Anna, Pastore, Gabiria, Santoni, Adele, Simoncelli, Martina, Polvere, Jacopo, Galimberti, Sara, Baratè, Claudia, Sammartano, Vincenzo, Montagnani, Francesca, Bocchia, Monica, Medaglini, Donata“…Plasma and peripheral blood mononuclear cells samples were collected before vaccination, post the second and the third doses and tested for spike-specific antibodies, ACE2/RBD antibody inhibition binding activity and spike-specific B cells. …”
Publicado 2022
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