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3481por Stahl, David, tho Pesch, Carola, Brück, Carolin, Esser, Ruth L, Thiele, Jan, Di Cristanziano, Veronica, Kofler, David M“…IgG targeting the receptor binding domain (RBD) of SARS-CoV-2 spike protein was measured at a median of 52.5 (range 2–147) days after a third dose of the SARS-CoV-2 mRNA vaccines BNT162b2 or mRNA-1273. …”
Publicado 2022
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3482por Chopra, Anand, Shukri, Ali H., Adhikary, Hemanta, Lukinović, Valentina, Hoekstra, Matthew, Cowpland, Michael, Biggar, Kyle K.“…Next, we scanned this 24-mer window along the ACE2 N-terminal helix and found that maximal binding to the SARS-CoV-2 receptor binding domain (CoV2-RBD) was increased when this window was shifted nine residues in the N-terminal direction. …”
Publicado 2022
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3483por Neamtu, Andrei, Mocci, Francesca, Laaksonen, Aatto, Barroso da Silva, Fernando L.“…Totally 235,000 mAbs structures were initially generated using the RosettaAntibodyDesign software, resulting in top 10 scored CR3022-like-RBD complexes with critical mutations and compared to the native one, all having the potential to block virus-host cell interaction. …”
Publicado 2023
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3484por Patel, Anamika, Kumar, Sanjeev, Lai, Lilin, Chakravarthy, Chennareddy, Valanparambil, Rajesh, Reddy, Elluri Seetharami, Gottimukkala, Kamalvishnu, Bajpai, Prashant, Raju, Dinesh Ravindra, Edara, Venkata Viswanadh, Davis-Gardner, Meredith E., Linderman, Susanne, Dixit, Kritika, Sharma, Pragati, Mantus, Grace, Cheedarla, Narayanaiah, Verkerke, Hans P., Frank, Filipp, Neish, Andrew S., Roback, John D., Davis, Carl W., Wrammert, Jens, Ahmed, Rafi, Suthar, Mehul S., Sharma, Amit, Murali-Krishna, Kaja, Chandele, Anmol, Ortlund, Eric A.“…Structural analysis of these three mAbs in complex with trimeric spike protein showed that all three mAbs are involved in bivalent spike binding with two mAbs targeting class-1 and one targeting class-4 Receptor Binding Domain (RBD) epitope. Comparison of immunogenetic makeup, structure, and function of these three mAbs with our recently reported class-3 RBD binding mAb that potently neutralized all SARS-CoV-2 variants revealed precise antibody footprint, specific molecular interactions associated with the most potent multi-variant binding / neutralization efficacy. …”
Publicado 2022
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3485por Moulana, Alief, Dupic, Thomas, Phillips, Angela M., Chang, Jeffrey, Nieves, Serafina, Roffler, Anne A., Greaney, Allison J., Starr, Tyler N., Bloom, Jesse D., Desai, Michael M.“…Many of these antibody-escape mutations individually decrease the spike receptor-binding domain (RBD) affinity for ACE2, but BA.1 still binds ACE2 with high affinity. …”
Publicado 2022
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3486por Chen, Ting-Hsu, Tsai, May-Jywan, Chang, Chun-Sheng, Xu, Linxi, Fu, Yaw-Syan, Weng, Ching-Feng“…METHODS: This study was conducted to perform molecular docking and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis of the potential phytocompounds and repurposing drugs against three targets of SARS-CoV-2 proteins (RNA dependent RNA polymerase, RdRp, Endoribonclease, S-protein of ACE2-RBD). RESULTS: The docking data illustrated Arachidonic acid, Rutin, Quercetin, and Curcumin were highly bound with coronavirus polyprotein replicase and Ebolavirus envelope protein. …”
Publicado 2023
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3487por Frommert, Leonie Maria, Arumahandi de Silva, Amanthi Nadira, Zernicke, Jan, Scholz, Veronika, Braun, Tanja, Jeworowski, Lara Maria, Schwarz, Tatjana, Tober-Lau, Pinkus, ten Hagen, Alexander, Habermann, Elisa, Kurth, Florian, Sander, Leif Erik, Corman, Victor Max, Burmester, Gerd-Rüdiger, Biesen, Robert, Albach, Fredrik N., Klotsche, Jens“…METHODS: Vaccination response was measured with a surrogate virus neutralisation test and by testing for antibodies directed against the receptor-binding-domain (RBD) of SARS-CoV-2 in 308 fully vaccinated patients with AIRD. …”
Publicado 2022
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3488por Yang, Jing, Yan, Jianhua, Zhang, Cheng, Li, Shanqin, Yuan, Manhua, Zhang, Chunge, Shen, Chenguang, Yang, Yang, Fu, Lifeng, Xu, Guanlong, Shi, Weifeng, Ma, Zhenghai, Luo, Ting Rong, Bi, Yuhai“…Moreover, HA K137N on the RBD was found in isolates from these three host species. …”
Publicado 2022
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3489por Li, Mingxi, Ren, Yifei, Aw, Zhen Qin, Chen, Bo, Yang, Ziqing, Lei, Yuqing, Cheng, Lin, Liang, Qingtai, Hong, Junxian, Yang, Yiling, Chen, Jing, Wong, Yi Hao, Wei, Jing, Shan, Sisi, Zhang, Senyan, Ge, Jiwan, Wang, Ruoke, Dong, Jay Zengjun, Chen, Yuxing, Shi, Xuanling, Zhang, Qi, Zhang, Zheng, Chu, Justin Jang Hann, Wang, Xinquan, Zhang, Linqi“…Crystal structure analysis of one representative nanobody, 3-2A2-4, discovers a highly conserved epitope located between the cryptic and the outer face of the receptor binding domain (RBD), distinctive from the receptor ACE2 binding site. …”
Publicado 2022
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3490por Wang, Qianran, Peng, Lu, Nie, Yanqiu, Shu, Yanni, Zhang, Huajun, Song, Zidan, Li, Yufeng, Hu, Hengrui, Li, Liushuai, Wang, Xi, Liu, Jia, Li, Jiang, Shi, Zhengli, Deng, Fei, Guo, Yu, Zhou, Yiwu, Yan, Bing, Hu, Zhihong, Wang, Manli“…In this study, we immunized mice with the receptor-binding domain (RBD) of the SARS-CoV-2 prototypic strain (WIV04) and screened 35 RBD-specific mAbs using hybridoma technology. …”
Publicado 2022
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3491por Hartwell, Brittany L., Melo, Mariane B., Xiao, Peng, Lemnios, Ashley A., Li, Na, Chang, Jason Y.H., Yu, Jingyou, Gebre, Makda S., Chang, Aiquan, Maiorino, Laura, Carter, Crystal, Moyer, Tyson J., Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Rodrigues, Kristen A., Silva, Murillo, Suh, Heikyung, Adams, Josetta, Fontenot, Jane, Love, J. Christopher, Barouch, Dan H., Villinger, Francois, Ruprecht, Ruth M., Irvine, Darrell J.“…Amph-RBD immunization induced high titers of SARS-CoV-2–neutralizing antibodies in serum, nasal washes, and bronchoalveolar lavage. …”
Publicado 2022
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3492por Köchl, Katharina, Schopper, Tobias, Durmaz, Vedat, Parigger, Lena, Singh, Amit, Krassnigg, Andreas, Cespugli, Marco, Wu, Wei, Yang, Xiaoli, Zhang, Yanchong, Wang, Welson Wen-Shang, Selluski, Crystal, Zhao, Tiehan, Zhang, Xin, Bai, Caihong, Lin, Leon, Hu, Yuxiang, Xie, Zhiwei, Zhang, Zaihui, Yan, Jun, Zatloukal, Kurt, Gruber, Karl, Steinkellner, Georg, Gruber, Christian C.“…The computational workflow presented here consists of molecular dynamics simulations for spike RBD-hACE2 binding affinity assessments of multiple spike RBD/hACE2 variants and a novel convolutional neural network architecture working on pairs of voxelized force-fields for efficient search-space reduction. …”
Publicado 2023
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3493“…An in silico docking study was also performed to examine the protein–protein interaction (PPI) between SARS-CoV-2 RBD and DC-SIGN as well as between serine carboxypeptidase and papain-like protease PLpro. …”
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3494“…The proposed sensor can quickly detect the COVID-19 virus in two different ligand-analyte environments: (i) the virus spike receptor-binding domain (RBD) as an analyte and monoclonal antibodies (mAbs) as a probe ligand, and (ii) monoclonal antibodies (IgG or IgM) as an analyte and the virus spike RBD as a probe ligand. …”
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3495por Gupta, Money, Balachandran, Harikrishnan, Louie, Raymond H Y, Li, Hui, Agapiou, David, Keoshkerian, Elizabeth, Christ, Daniel, Rawlinson, William, Mina, Michael M, Post, Jeffrey J, Hudson, Bernard, Gilroy, Nicky, Konecny, Pamela, Bartlett, Adam W, Sasson, Sarah C, Ahlenstiel, Golo, Dwyer, Dominic, Lloyd, Andrew R, Martinello, Marianne, Luciani, Fabio, Bull, Rowena A“…Here, we performed single‐cell molecular analysis of the SARS‐CoV‐2 receptor‐binding domain (RBD)–specific MBC population in three patients after severe COVID‐19 and four patients after mild/moderate COVID‐19. …”
Publicado 2022
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3496por Haidar, Ghady, Jacobs, Jana L, Salese, Erin, Ludwig, Justin, Heaps, Amy, Parikh, Urvi, Sethi, Rahil, Caruso, Lori, Camacho, Haley, Chinakarn, Tina, Edick, Stacey, Fischer, Dawn, Kramer, Kailey Hughes, Lukanski, Amy, Marks, Kiersten, Saenz-Morales, Naomi, Sierra, Sara, Ferreira, Cátia, Glasser, Lisa, Heil, Kathleen, Talarico, Carla, Taylor, Sylvia, McCreary, Erin K, Mellors, John W“…SARS-CoV-2 variants and mutants were determined by whole genome sequencing and anti-RBD IgG levels by an enzyme immunoassay. RESULTS: From Mar 28, 2022, to Mar 3, 2023, 72% (174/243) of swabs were successfully sequenced from 170 pts (Table 1). …”
Publicado 2023
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3497por Borobia, Alberto M, Carcas, Antonio J, Pérez-Olmeda, Mayte, Castaño, Luis, Bertran, María Jesús, García-Pérez, Javier, Campins, Magdalena, Portolés, Antonio, González-Pérez, María, García Morales, María Teresa, Arana-Arri, Eunate, Aldea, Marta, Díez-Fuertes, Francisco, Fuentes, Inmaculada, Ascaso, Ana, Lora, David, Imaz-Ayo, Natale, Barón-Mira, Lourdes E, Agustí, Antonia, Pérez-Ingidua, Carla, Gómez de la Cámara, Agustín, Arribas, José Ramón, Ochando, Jordi, Alcamí, José, Belda-Iniesta, Cristóbal, Frías, Jesús“…The interventional:control ratio was 77·69 (95% CI 59·57–101·32) for RBD protein and 36·41 (29·31–45·23) for trimeric spike protein IgG. …”
Publicado 2021
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3498por Shu, Ya-Jun, He, Jian-Feng, Pei, Rong-Juan, He, Peng, Huang, Zhu-Hang, Chen, Shao-Min, Ou, Zhi-Qiang, Deng, Jing-Long, Zeng, Pei-Yu, Zhou, Jian, Min, Yuan-Qin, Deng, Fei, Peng, Hua, Zhang, Zheng, Wang, Bo, Xu, Zhong-Hui, Guan, Wu-Xiang, Hu, Zhong-Yu, Zhang, Ji-Kai“…A previous phase I trial indicated that the recombinant COVID-19 vaccine (V-01), which contains a fusion protein (IFN-PADRE-RBD-Fc dimer) as its antigen, is safe and well tolerated, capable of inducing rapid and robust immune responses, and warranted further testing in additional clinical trials. …”
Publicado 2021
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3499por Izaguirre, Natalie E, Sherman, Amy C, Crombie, Jennifer, Desjardins, Michaël, Cheng, Chi-An, Gilboa, Tal, Powell, Megan, Bausk, Bruce P, Abasciano, Noah, Baker, Peter, McDonough, Mikaela, Armand, Philippe, Walt, David, Issa, Nicolas C, Baden, Lindsey R“…An ultrasensitive, single molecule array (Simoa) assay detected anti-Spike (S), anti-S1, anti-receptor binding domain (RBD), and anti-Nucleocapsid (N) IgG from plasma at each timepoint. …”
Publicado 2021
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3500por Jyssum, Ingrid, Kared, Hassen, Tran, Trung T, Tveter, Anne T, Provan, Sella A, Sexton, Joseph, Jørgensen, Kristin K, Jahnsen, Jørgen, Kro, Grete B, Warren, David J, Vaage, Eline B, Kvien, Tore K, Nissen-Meyer, Lise-Sofie H, Anderson, Ane Marie, Grødeland, Gunnveig, Haavardsholm, Espen A, Vaage, John Torgils, Mjaaland, Siri, Syversen, Silje Watterdal, Lund-Johansen, Fridtjof, Munthe, Ludvig A, Goll, Guro Løvik“…Antibodies to the RBD of the SARS-CoV-2 spike protein were measured in serum 2–4 weeks after the second and third doses. …”
Publicado 2022
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