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3501por Abhishek, Abhishek, Boyton, Rosemary J, Peckham, Nicholas, McKnight, Áine, Coates, Laura C, Bluett, James, Barber, Vicki, Cureton, Lucy, Francis, Anne, Appelbe, Duncan, Eldridge, Lucy, Julier, Patrick, Valdes, Ana M, Brooks, Tim, Rombach, Ines, Altmann, Daniel M, Nguyen-Van-Tam, Jonathan S, Williams, Hywel C, Cook, Jonathan A“…The primary outcome was S1-RBD antibody titres 4 weeks after receiving the COVID-19 booster vaccine dose, assessed in the intention-to-treat population. …”
Publicado 2022
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3502por Tuan, Jessica J., Zapata, Heidi, Barakat, Lydia, Andrews, Laurie, Behnegar, Anousheh, Kim, Yee Won, Kayani, Jehanzeb, Mutic, Suzana, Ryall, Linda, Turcotte, Barbara, Critch-Gilfillan, Terese, Zhao, Min, Salahuddin, Syim, Gupta, Shaili, Sutton, Richard, Friedland, Gerald, Emu, Brinda, Ogbuagu, Onyema“…At Visit 3, 26/26 (100%) had detectable Anti-Spike-1-RBD (≥ 0.8 U/mL). Among 12 subjects presenting to Visit 2/3, median SARS-CoV-2 Anti-Spike 1-RBD was 2087 U/mL at Visit 2, falling to 581.5 U/mL at Visit 3 (p = 0.0923), with a median 3.305-fold decrease over 6 months. …”
Publicado 2022
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3503por Madhi, Shabir A, Kwatra, Gaurav, Richardson, Simone I, Koen, Anthonet L, Baillie, Vicky, Cutland, Clare L, Fairlie, Lee, Padayachee, Sherman D, Dheda, Keertan, Barnabas, Shaun L, Bhorat, Qasim Ebrahim, Briner, Carmen, Ahmed, Khatija, Aley, Parvinder K, Bhikha, Sutika, Bhorat, A E, Esmail, Aliasgar, Horne, Elizea, Kaldine, Haajira, Mukendi, Christian K, Madzorera, Vimbai Sharon, Manamela, Nelia P, Masilela, Mduduzi, Hermanus, S Tandile, Motlou, Thopisang, Mzindle, Nonkululeko, Oelofse, Suzette, Patel, Faeezah, Rhead, Sarah, Rossouw, Lindie, Taoushanis, Carol, van Eck, Samuel, Lambe, Teresa, Gilbert, Sarah C, Pollard, Andrew J, Moore, Penny L, Izu, Alane“…Binding IgG to spike (anti-S) and receptor binding domain (anti-RBD) were measured before the first dose (day 0), second dose (day 28), day 42, and day 180. …”
Publicado 2023
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3504“…This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, two proline-rich regions and a C-terminal PDZ (PSD-95, Discs-large, and ZO-1)-binding motif. …”
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3505“…[Image: see text] Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain complementarity-determining regions (HCDR) 1 and 2. …”
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3506“…In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS-CoV-2 to be a pandemic virus.…”
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3507por Ayoup, Mohammed Salah, ElShafey, Mariam M., Abdel-Hamid, Hamida, Ghareeb, Doaa A., Abu-Serie, Marwa M., Heikal, Lamia A., Teleb, Mohamed“…Inspired by the multitarget antiviral agents, the substitution pattern was rationalized to tune the scaffold's potency against other additional viral targets, especially the spike receptor binding domain (RBD) that is responsible for the viral invasion(.) …”
Publicado 2023
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3508por Bingula, Rea, Chabrolles, Hélène, Bonnet, Benjamin, Archimbaud, Christine, Brebion, Amélie, Cosme, Justine, Ollier, Amandine, Dutheil, Frédéric, Junda, Maud, Mirand, Audrey, Regagnon, Christel, Vidal, Magali, Henquell, Cécile, Evrard, Bertrand“…Interestingly, the subgroup of subjects with increasing anti-RBD IgG levels over time had a lower incidence of Omicron infection. …”
Publicado 2023
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3509por Hasíková, Lenka, Závada, Jakub, Serranová, Tereza, Kozlík, Petr, Kalíková, Květa, Kotačková, Lenka, Trnka, Jiří, Zogala, David, Šonka, Karel, Růžička, Evžen, Dušek, Petr“…Allantoin/UA ratios in serum and CSF were positively associated with the SCOPA-AUT score (p = 0.005 and 0.031, respectively) and RBD presence (p = 0.044 and 0.028, respectively). …”
Publicado 2023
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3510“…Neither acute levels of S1(RBD) or N proteins predicted progression to PASC. …”
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3511“…The S is divided with S1 and S2 region, and the S1 contains the receptor-binding domain (RBD), while the S2 contains the hydrophobic fusion domain for the entry into the host cell. …”
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3512por Suntronwong, Nungruthai, Vichaiwattana, Preeyaporn, Klinfueng, Sirapa, Puenpa, Jiratchaya, Kanokudom, Sitthichai, Assawakosri, Suvichada, Chansaenroj, Jira, Srimuan, Donchida, Thatsanatorn, Thaksaporn, Songtaisarana, Siriporn, Sudhinaraset, Natthinee, Wanlapakorn, Nasamon, Poovorawan, Yong“…Samples were tested for anti-nucleocapsid (N) IgG and anti-receptor binding domain (RBD) IgG using a chemiluminescent microparticle immunoassay (CMIA), and total anti-RBD immunoglobulin (Ig) was detected using an electrochemiluminescence immunoassay (ECLIA). …”
Publicado 2023
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3513por Chen, Chen, Dai, Liyuan, Zheng, Cuiling, Li, Haolong, Li, Xiaomeng, Yang, Mengwei, Gao, Ruyun, Yao, Jiarui, Zhang, Zhishang, Shi, Yuankai, Han, Xiaohong“…We conducted a cross-sectional study in 260 LCs, 140 healthy controls (HC) and additional 40 LCs with serial samples by detecting total antibodies, IgG anti-RBD and neutralizing antibodies (NAb) toward WT and BA.4/5. …”
Publicado 2023
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3514“…The results showed that the receptor-Fc proteins efficiently bound to receptor binding domain (RBD) of CDV-H, meanwhile, these receptor-Fc proteins competitively inhibited the binding of His-tagged receptor proteins (SLAM-His or Nectin-His) to CDV-H-RBD-Flag protein. …”
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3515por Ribeiro, Rayssa, Botelho, Fernanda D., Pinto, Amanda M. V., La Torre, Antonia M. A., Almeida, Joyce S. F. D., LaPlante, Steven R., Franca, Tanos C. C., Veiga-Junior, Valdir F., dos Santos, Marcelo C.“…They were then exported to the Molegro Virtual Docking (MVD®) software, where they were docked onto the RBD of a 3D structure of the SC2Spike protein that was imported from the Protein Data Bank (PDB). …”
Publicado 2023
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3516por Lundin, Samuel B., Kann, Hanna, Fulurija, Alma, Andersson, Björn, Nakka, Sravya S., Andersson, Lars-Magnus, Gisslén, Magnus, Harandi, Ali M.“…These epitopes are located at positions 278-298 and 550-586, just proximal and distal to the RBD, as well as at position 1134-1156 in the HR2 subdomain and at 1248-1271 in the C-terminal subdomain of protein S. …”
Publicado 2023
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3517por Liu, Yi, Sánchez-Ovando, Stephany, Carolan, Louise, Dowson, Leslie, Khvorov, Arseniy, Hadiprodjo, Jessica, Tseng, Yeu Yang, Delahunty, Catherine, Khatami, Ameneh, Macnish, Marion, Dougherty, Sonia, Hagenauer, Michelle, Riley, Kathryn E., Jadhav, Ajay, Harvey, Joanne, Kaiser, Marti, Mathew, Suja, Hodgson, David, Leung, Vivian, Subbarao, Kanta, Cheng, Allen C., Macartney, Kristine, Koirala, Archana, Marshall, Helen, Clark, Julia, Blyth, Christopher C., Wark, Peter, Kucharski, Adam J., Sullivan, Sheena G., Fox, Annette“…Median percentages of memory B cells that recognized fluorescent-tagged spike and RBD were 2.9 and 8.3 times lower, respectively for AdV compared to mRNA vaccinees. …”
Publicado 2023
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3518por Zhang, Liang, Jiang, Yao, He, Jinhang, Chen, Junyu, Qi, Ruoyao, Yuan, Lunzhi, Shao, Tiange, Zhao, Hui, Chen, Congjie, Chen, Yaode, Wang, Xijing, Lei, Xing, Gao, Qingxiang, Zhuang, Chunlan, Zhou, Ming, Ma, Jian, Liu, Wei, Yang, Man, Fu, Rao, Wu, Yangtao, Chen, Feng, Xiong, Hualong, Nie, Meifeng, Chen, Yiyi, Wu, Kun, Fang, Mujin, Wang, Yingbin, Zheng, Zizheng, Huang, Shoujie, Ge, Shengxiang, Cheng, Shih Chin, Zhu, Huachen, Cheng, Tong, Yuan, Quan, Wu, Ting, Zhang, Jun, Chen, Yixin, Zhang, Tianying, Li, Changgui, Qi, Hai, Guan, Yi, Xia, Ningshao“…Intranasal delivery of dNS1-RBD induces innate immunity, trained immunity and tissue-resident memory T cells covering the upper and lower respiratory tract. …”
Publicado 2023
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3519por Reilly, Siobhan, Dhaliwal, Simran, Arshad, Usman, Husain, Nusrat, Macerollo, Antonella, Da Costa, Antonio“…CONCLUSION: There is evidence that rivastigmine is beneficial for RBD and apathy in Parkinson's disease, independently from the presence of dementia. …”
Publicado 2023
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3520por Peghin, Maddalena, De Martino, Maria, Palese, Alvisa, Chiappinotto, Stefania, Fonda, Federico, Gerussi, Valentina, Sartor, Assunta, Curcio, Francesco, Grossi, Paolo Antonio, Isola, Miriam, Tascini, Carlo“…The presence of receptor-binding domain (RBD) SARS-CoV-2 immunoglobulin G (IgG) and non-RBD SARS-CoV-2 IgG titers were not associated with the occurrence of post-COVID-19 syndrome. …”
Publicado 2023
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