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3521“…Notably, SARS-CoV-2 is mutation-prone in the spike receptor binding domain (RBD), allowing a better fit for ACE2 orthologs in animals. …”
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3522por Zhou, Biao, Zhou, Runhong, Chan, Jasper Fuk-Woo, Zeng, Jianwei, Zhang, Qi, Yuan, Shuofeng, Liu, Li, Robinot, Rémy, Shan, Sisi, Liu, Na, Ge, Jiwan, Kwong, Hugo Yat-Hei, Zhou, Dongyan, Xu, Haoran, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Chu, Hin, Yue, Ming, Kwan, Ka-Yi, Chan, Chun-Yin, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Du, Zhenglong, Au, Ka-Kit, Huang, Haode, Man, Hiu-On, Cao, Jianli, Li, Cun, Wang, Ziyi, Zhou, Jie, Song, Youqiang, Yeung, Man-Lung, To, Kelvin Kai-Wang, Ho, David D., Chakrabarti, Lisa A., Wang, Xinquan, Zhang, Linqi, Yuen, Kwok-Yung, Chen, Zhiwei“…Here, we report the efficacy of receptor binding domain (RBD)-specific monomeric B8-mIgA1 and B8-mIgA2, and dimeric B8-dIgA1, B8-dIgA2 and TH335-dIgA1 against intranasal SARS-CoV-2 challenge in Syrian hamsters. …”
Publicado 2023
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3523por Han, Ahram, Min, Sangil, Jo, Eun-Ah, Lee, Hajeong, Kim, Yong Chul, Han, Seung Seok, Kang, Hee Gyung, Ahn, Yo Han, Oh, Inseong, Song, Eun Young, Ha, Jongwon“…Anti-RBD IgG levels <200 AU/mL were a critical risk factor for hospitalization (HR=36.4, P=0.007). …”
Publicado 2024
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3524“…A predictive index for ICBs was generated, incorporating three baseline characteristics: anxiety, rapid eye movement sleep behavior disorder (RBD), and p-tau levels in cerebrospinal fluid (CSF). …”
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3525por Gould, Gillian Sandra, Watt, Kerrianne, McEwen, Andy, Cadet-James, Yvonne, Clough, Alan R“…The internal consistency of the RBD subscales and their patterns of correlation will be explored. …”
Publicado 2014
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3526por Cui, Shi-Shuang, Du, Juan-Juan, Fu, Rao, Lin, Yi-Qi, Huang, Pei, He, Ya-Chao, Gao, Chao, Wang, Hua-Long, Chen, Sheng-Di“…Female, depression, rapid eye movement behavior disorder (RBD), autonomic dysfunction and larger SN area were risk factors for PD with anxiety.…”
Publicado 2017
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3527por Tsolakos, N., Durrant, T. N., Chessa, T., Suire, S. M., Oxley, D., Kulkarni, S., Downward, J., Perisic, O., Williams, R. L., Stephens, L., Hawkins, P. T.“…Nevertheless, PI3Kβ contributes substantially to acute PDGF-stimulation of PIP(3) and PKB in MEFs because it is synergistically, and possibly sequentially, activated by receptor-recruitment and small GTPases (Rac/CDC42) via its RBD, whereas parallel activation of PI3Kα is independent of its RBD. …”
Publicado 2018
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3528por Xiang, Ya-qin, Xu, Qian, Sun, Qi-ying, Wang, Zhi-qin, Tian, Yun, Fang, Liang-juan, Yang, Yang, Tan, Jie-qiong, Yan, Xin-xiang, Tang, Bei-sha, Guo, Ji-feng“…Moreover, our study proved that many factors were associated with EDS, including male sex, age, cognitive impairment, PD-related sleep problems, RBD, and worse QoL. Understanding the clinical characteristics of EDS in PD patients may help identify EDS early, improve QoL, and reduce the occurrence of accidents.…”
Publicado 2019
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3529por Park, Sung Wook, Nhieu, Jennifer, Persaud, Shawna D., Miller, Michelle C., Xia, Youlin, Lin, Yi-Wei, Lin, Yu-Lung, Kagechika, Hiroyuki, Mayo, Kevin H., Wei, Li-Na“…However, Crabp1 can also compete with Ras for direct interaction with the RBD of Raf, thereby negatively modulating growth factor-stimulated Raf activation, which can be enhanced by atRA binding to Crabp1. …”
Publicado 2019
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3530por Lin, Nan, Hao, Honglin, Guan, Hongzhi, Sun, Heyang, Liu, Qing, Lu, Qiang, Jin, Liri, Ren, Haitao, Huang, Yan“…The percentage for N3 and REM sleep was found to be 15.0% (0–34.6%) and 12.7% (0–22.2%), respectively. Both RBD and PLMS were observed more frequently in patients with LGI1-Ab encephalitis. …”
Publicado 2020
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3531por DomBourian, Melkon G., Annen, Kyle, Huey, Leah, Andersen, Gillian, Merkel, Patricia A., Jung, Sarah, Dominguez, Samuel R., Knight, Vijaya“…We compared two assays that had received the CE mark of regulatory approval and that used either the N antigen or S1-RBD antigen as the target for analysis of a large set of CCP samples. …”
Publicado 2020
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3532“…Although recent efforts have focused on the direct inhibition of S-protein receptor-binding domain (RBD) interactions with human angiotensin-converting enzyme 2 (hACE2), allosteric targeting remains an unexplored possibility. …”
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3533por Mariën, Joachim, Ceulemans, Ann, Michiels, Johan, Heyndrickx, Leo, Kerkhof, Karen, Foque, Nikki, Widdowson, Marc-Alain, Mortgat, Laure, Duysburgh, Els, Desombere, Isabelle, Jansens, Hilde, Van Esbroeck, Marjan, Ariën, Kevin K.“…In conclusion, our data supports the use of RBD and NP for the development of SARS-CoV-2 serological IgG bead-based assays.…”
Publicado 2021
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3534por Silva, Julio, Lucas, Carolina, Sundaram, Maria, Israelow, Benjamin, Wong, Patrick, Klein, Jon, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Liu, Feimei, Mao, Tianyang, Oh, Ji Eun, Park, Annsea, Casanovas-Massana, Arnau, Vogels, Chantal B. F., Muenker, M. Catherine, Zell, Joseph, Fournier, John B., Campbell, Melissa, Chiorazzi, Michael, Fuentes, Edwin Ruiz, Petrone, Mary E, Kalinich, Chaney C., Ott, Isabel M., Watkins, Annie, Moore, Adam J., Nakahata, Maura, Farhadian, Shelli, Cruz, Charles Dela, Ko, Albert I., Schulz, Wade L., Ring, Aaron, Ma, Shuangge, Omer, Saad, Wyllie, Anne L, Iwasaki, Akiko“…Anti-spike (S) and anti-receptor binding domain (RBD) IgG levels were negatively correlated with saliva viral load showing a strong temporal association that could help distinguish severity and mortality in COVID-19. …”
Publicado 2021
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3535por Sakkiah, Sugunadevi, Guo, Wenjing, Pan, Bohu, Ji, Zuowei, Yavas, Gokhan, Azevedo, Marli, Hawes, Jessica, Patterson, Tucker A., Hong, Huixiao“…Twenty interacting residues in the spike protein were identified that are likely to be responsible for tightly binding to ACE2, of which five residues (Val445, Thr478, Gly485, Phe490, and Ser494) were not reported in the crystal structure of the truncated spike protein receptor binding domain (RBD) complexed with ACE2. These data indicate that the interactions between ACE2 and the tertiary structure of the full-length spike protein trimer are different from those between ACE2 and the truncated monomer of the spike protein RBD. …”
Publicado 2021
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3536por Wacharapluesadee, Supaporn, Tan, Chee Wah, Maneeorn, Patarapol, Duengkae, Prateep, Zhu, Feng, Joyjinda, Yutthana, Kaewpom, Thongchai, Chia, Wan Ni, Ampoot, Weenassarin, Lim, Beng Lee, Worachotsueptrakun, Kanthita, Chen, Vivian Chih-Wei, Sirichan, Nutthinee, Ruchisrisarod, Chanida, Rodpan, Apaporn, Noradechanon, Kirana, Phaichana, Thanawadee, Jantarat, Niran, Thongnumchaima, Boonchu, Tu, Changchun, Crameri, Gary, Stokes, Martha M., Hemachudha, Thiravat, Wang, Lin-Fa“…Antisera raised against the receptor binding domain (RBD) of RmYN02 was able to cross-neutralize SARS-CoV-2 despite the fact that the RBD of RacCS203 or RmYN02 failed to bind ACE2. …”
Publicado 2021
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3537por Mendoza, Rachelle P., Fyke, William, Daniel, David, Gabutan, Elmer, Das, Ballabh, Bajaj, Harsha, Easy, Maxine, Vasileva, Ana, Colbourn, Robert, Alawad, Mouyed, Dehghani, Amir, Lin, Bo, Emechebe, Dokpe, Patel, Purvi, Jabbar, Absia, Nikolov, Dimitar B., Giovaniello, Dominick, Kang, Steven, Tatem, Luis, Bromberg, Kenneth, Augenbraun, Michael, Premsrirut, Prem, Libien, Jenny, Norin, Allen J.“…Potential donors were screened with a lateral flow assay (LFA) for IgM and IgG antibodies against the SARS-CoV-2 S1 receptor-binding domain (RBD). Volunteers that were LFA positive were tested with an ELISA to measure IgG titers against the RBD. …”
Publicado 2021
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3538por Laing, Eric D., Sterling, Spencer L., Richard, Stephanie A., Epsi, Nusrat J., Coggins, Si’Ana, Samuels, Emily C., Phogat, Shreshta, Yan, Lianying, Moreno, Nicole, Coles, Christian L., Drew, Matthew, Mehalko, Jennifer, English, Caroline E., Merritt, Scott, Mende, Katrin, Munster, Vincent J., de Wit, Emmie, Chung, Kevin K., Millar, Eugene V., Tribble, David R., Simons, Mark P., Pollett, Simon D., Agan, Brian K., Esposito, Dominic, Lanteri, Charlotte, Clifton, G. Travis, Mitre, Edward, Burgess, Timothy H., Broder, Christopher C.“…We varied SARS-CoV-2 antigen compositions within the multiplex assay, allowing direct comparisons of the effects of spike protein, receptor-binding domain protein (RBD) and nucleocapsid protein (NP) based SARS-CoV-2 antibody detection. …”
Publicado 2021
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3539por Soltani-Zangbar, Mohammad Sadegh, Aghebati-Maleki, Leili, Hajivalili, Mahsa, Haji-Fatahaliha, Mostafa, Motavalli, Roza, Mahmoodpoor, Ata, Kafil, Hossein Samadi, Farhang, Sara, Pourakbari, Ramin, Jadidi-Niaragh, Farhad, Roshangar, Leila, Heris, Javad Ahmadian, Kamrani, Amin, Siahmansouri, Homayoon, Hosseini, Maryam, Miahipour, Abolfazl, Shareghi-Oskoue, Oldouz, Parhizkar, Forough, Yousefi, Mehdi“…In this study, 5.74% of participants had specific IgG against RBD, whereas the percentage for IgM positive individuals was 5.58%. …”
Publicado 2021
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3540por Tortorici, M. Alejandra, Czudnochowski, Nadine, Starr, Tyler N., Marzi, Roberta, Walls, Alexandra C., Zatta, Fabrizia, Bowen, John E., Jaconi, Stefano, di iulio, Julia, Wang, Zhaoqian, De Marco, Anna, Zepeda, Samantha K., Pinto, Dora, Liu, Zhuoming, Beltramello, Martina, Bartha, Istvan, Housley, Michael P., Lempp, Florian A., Rosen, Laura E., Dellota, Exequiel, Kaiser, Hannah, Montiel-Ruiz, Martin, Zhou, Jiayi, Addetia, Amin, Guarino, Barbara, Culap, Katja, Sprugasci, Nicole, Saliba, Christian, Vetti, Eneida, Giacchetto-Sasselli, Isabella, Silacci Fregni, Chiara, Abdelnabi, Rana, Caroline Foo, Shi-Yan, Havenar-Daughton, Colin, Schmid, Michael A., Benigni, Fabio, Cameroni, Elisabetta, Neyts, Johan, Telenti, Amalio, Snell, Gyorgy, Virgin, Herbert W., Whelan, Sean P.J., Bloom, Jesse D., Corti, Davide, Veesler, David, Pizzuto, Matteo Samuele“…Here, we describe a human monoclonal antibody (mAb), designated S2X259, recognizing a highly conserved cryptic receptor-binding domain (RBD) epitope and cross-reacting with spikes from all sarbecovirus clades. …”
Publicado 2021
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