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3541Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patientspor Isho, Baweleta, Abe, Kento T., Zuo, Michelle, Jamal, Alainna J., Rathod, Bhavisha, Wang, Jenny H., Li, Zhijie, Chao, Gary, Rojas, Olga L., Bang, Yeo Myong, Pu, Annie, Christie-Holmes, Natasha, Gervais, Christian, Ceccarelli, Derek, Samavarchi-Tehrani, Payman, Guvenc, Furkan, Budylowski, Patrick, Li, Angel, Paterson, Aimee, Yue, Feng Yun, Marin, Lina M., Caldwell, Lauren, Wrana, Jeffrey L., Colwill, Karen, Sicheri, Frank, Mubareka, Samira, Gray-Owen, Scott D., Drews, Steven J., Siqueira, Walter L., Barrios-Rodiles, Miriam, Ostrowski, Mario, Rini, James M., Durocher, Yves, McGeer, Allison J., Gommerman, Jennifer L., Gingras, Anne-Claude“…Lastly, IgG, IgM and to a lesser extent IgA responses to spike and RBD in the serum positively correlated with matched saliva samples. …”
Publicado 2020
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3542por Liu, Xiaoyun, Yang, Liling, Han, Yuxiang, Xu, Jingjing, Pang, Zaiying, Du, Yifeng, Feng, Yabo, Lin, Youting“…HMs were totally remitted in 3 patients and still persistent in 1, while evolved into REM sleep behavior disorder (RBD) in 4 with comorbid periodic limb movement syndrome (PLMS) in 3/4, and only PLMS in 2. …”
Publicado 2021
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3543por Bezerra, Matheus Filgueira, Machado, Lais Ceschini, De Carvalho, Viviane do Carmo Vasconcelos, Docena, Cássia, Brandão-Filho, Sinval Pinto, Ayres, Constância Flávia Junqueira, Paiva, Marcelo Henrique Santos, Wallau, Gabriel Luz“…All results from the Sanger sequencing method perfectly matched the mutational profile of VOCs and non-VOCs RBD's characterized by WGS. In summary, this approach allows a much broader network of laboratories to perform molecular surveillance of SARS-CoV-2 VOCs and report results within a shorter time frame, which is of utmost importance in the context of rapid public health decisions in a fast evolving worldwide pandemic.…”
Publicado 2021
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3544por Joyce, M. Gordon, Chen, Wei-Hung, Sankhala, Rajeshwer S., Hajduczki, Agnes, Thomas, Paul V., Choe, Misook, Chang, William, Peterson, Caroline E., Martinez, Elizabeth, Morrison, Elaine B., Smith, Clayton, Ahmed, Aslaa, Wieczorek, Lindsay, Anderson, Alexander, Chen, Rita E., Case, James Brett, Li, Yifan, Oertel, Therese, Rosado, Lorean, Ganesh, Akshaya, Whalen, Connor, Carmen, Joshua M., Mendez-Rivera, Letzibeth, Karch, Christopher, Gohain, Neelakshi, Villar, Zuzana, McCurdy, David, Beck, Zoltan, Kim, Jiae, Shrivastava, Shikha, Jobe, Ousman, Dussupt, Vincent, Molnar, Sebastian, Tran, Ursula, Kannadka, Chandrika B., Zemil, Michelle, Khanh, Htet, Wu, Weimin, Cole, Matthew A., Duso, Debra K., Kummer, Larry W., Lang, Tricia J., Muncil, Shania E., Currier, Jeffrey R., Krebs, Shelly J., Polonis, Victoria R., Rajan, Saravanan, McTamney, Patrick M., Esser, Mark T., Reiley, William W., Rolland, Morgane, de Val, Natalia, Diamond, Michael S., Gromowski, Gregory D., Matyas, Gary R., Rao, Mangala, Michael, Nelson L., Modjarrad, Kayvon“…A Spike-ferritin nanoparticle (SpFN) vaccine elicited neutralizing titers more than 20-fold higher than convalescent donor serum, following a single immunization, while RBD-Ferritin nanoparticle (RFN) immunogens elicited similar responses after two immunizations. …”
Publicado 2021
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3545por Shroff, Rachna T., Chalasani, Pavani, Wei, Ran, Pennington, Daniel, Quirk, Grace, Schoenle, Marta V., Peyton, Kameron L., Uhrlaub, Jennifer L., Ripperger, Tyler J., Jergović, Mladen, Dalgai, Shelby, Wolf, Alexander, Whitmer, Rebecca, Hammad, Hytham, Carrier, Amy, Scott, Aaron J., Nikolich-Žugich, Janko, Worobey, Michael, Sprissler, Ryan, Dake, Michael, LaFleur, Bonnie J., Bhattacharya, Deepta“…We therefore quantified RBD- and Spike S1-specific memory B cell subsets as predictors of anamnestic responses to additional immunizations. …”
Publicado 2021
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3546por van Keulen, Britt J., Romijn, Michelle, Bondt, Albert, Dingess, Kelly A., Kontopodi, Eva, van der Straten, Karlijn, den Boer, Maurits A., Burger, Judith A., Poniman, Meliawati, Bosch, Berend J., Brouwer, Philip J. M., de Groot, Christianne J. M., Hoek, Max, Li, Wentao, Pajkrt, Dasja, Sanders, Rogier W., Schoonderwoerd, Anne, Tamara, Sem, Timmermans, Rian A. H., Vidarsson, Gestur, Stittelaar, Koert J., Rispens, Theo T., Hettinga, Kasper A., van Gils, Marit J., Heck, Albert J. R., van Goudoever, Johannes B.“…To assess the presence of SARS-CoV-2 antibodies we used multiple complementary assays, namely ELISA with the SARS-CoV-2 spike protein (specific for IgA and IgG), receptor binding domain (RBD) and nucleocapsid (N) protein for IgG in serum, and bridging ELISA with the SARS-CoV-2 RBD and N protein for specific Ig (IgG, IgM and IgA in human milk and serum). …”
Publicado 2021
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3547por Jiang, Wen, Wang, Junchao, Jiao, Shasha, Gu, Chenjian, Xu, Wei, Chen, Ben, Wang, Rongjuan, Chen, Huilin, Xie, Youhua, Wang, An, Li, Gang, Zeng, Dadi, Zhang, Jinchao, Zhang, Min, Wang, Shuang, Wang, Mingzhu, Gui, Xun“…Here, we discover and characterize a fully human cross-reactive mAb, MW06, which binds to both SARS-CoV-2 and SARS-CoV spike receptor-binding domain (RBD) and disrupts their interaction with angiotensin-converting enzyme 2 (ACE2) receptors. …”
Publicado 2021
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3548por Bongiovanni, Marco, Liuzzi, Giammaria, Schiavon, Luca, Gianturco, Luigi, Giuliani, Giuseppe“…These results were confirmed also using anti-RBD antibodiy tests. Antibodies against nucleocapside were reactive only in subjects in Group 1 and remained stable during the study period. …”
Publicado 2021
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3549“…Briefly, the highest correlation was found for LIAISON SARS-CoV-2 TrimericS IgG (r=0.71), followed by ACCESS SARS-CoV-2 IgG II (r=0.65), Snibe S-RBD IgG (r=0.52), and then Roche Elecsys Anti-SARS-CoV-2 S (r=0.40). …”
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3550por Yosri, Nermeen, Abd El-Wahed, Aida A., Ghonaim, Reem, Khattab, Omar M., Sabry, Aya, Ibrahim, Mahmoud A. A., Moustafa, Mahmoud F., Guo, Zhiming, Zou, Xiaobo, Algethami, Ahmed F. M., Masry, Saad H. D., AlAjmi, Mohamed F., Afifi, Hanan S., Khalifa, Shaden A. M., El-Seedi, Hesham R.“…Among these compounds, retusapurpurin A has shown high affinity to 3CL(pro) (ΔG = −9.4 kcal/mol), RdRp (−7.5), RBD (−7.2), NSP13 (−9.4), and ACE2 (−10.4) and potent inhibition of viral entry by forming hydrogen bonds with amino acid residues within viral and human target proteins. …”
Publicado 2021
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3551por Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, Pei-Hui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei“…Our study sheds light on the mechano-chemistry of spike activation and on developing a non-RBD-blocking but S1/S2-locking therapeutic strategy to prevent SARS2 invasion.…”
Publicado 2021
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3552por Shmueli, Einat S., Itay, Amit, Margalit, Ofer, Berger, Raanan, Halperin, Sharon, Jurkowicz, Menucha, Levin, Einav G., Levy, Itzchak, Olmer, Liraz, Regev-Yochay, Gili, Lustig, Yaniv, Rahav, Galia“…Serum titres of the receptor-binding domain (RBD) immunoglobulin G (IgG) and neutralising antibodies were measured 2–4 weeks after each vaccine dose. …”
Publicado 2021
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3553por Barh, Debmalya, Tiwari, Sandeep, Gabriel Rodrigues Gomes, Lucas, Weener, Marianna E., Alzahrani, Khalid J., Alsharif, Khalaf F., Aljabali, Alaa A. A., Tambuwala, Murtaza M., Lundstrom, Kenneth, Hassan, Sk. Sarif, Serrano-Aroca, Ángel, Takayama, Kazuo, Ghosh, Preetam, Redwan, Elrashdy M., Silva Andrade, Bruno, Soares, Siomar de Castro, Azevedo, Vasco, Uversky, Vladimir N.“…Here, we hypothesize a potential anti-tumor immune response of SARS-CoV-2 and based on a computational approach show that: (i) SARS-CoV-2 Spike-RBD may bind to the extracellular domains of CD15, CD27, CD45, and CD152 receptors of cHL or FL and may directly inhibit cell proliferation. …”
Publicado 2021
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3554por Jeewandara, Chandima, Aberathna, Inoka Sepali, Pushpakumara, Pradeep Darshana, Kamaladasa, Achala, Guruge, Dinuka, Wijesinghe, Ayesha, Gunasekera, Banuri, Tanussiya, Shyrar, Kuruppu, Heshan, Ranasinghe, Thushali, Dayarathne, Shashika, Dissanayake, Osanda, Gamalath, Nayanathara, Ekanayake, Dinithi, Jayamali, Jeewantha, Jayathilaka, Deshni, Dissanayake, Madushika, Jayadas, Tibutius Thanesh, Mudunkotuwa, Anushika, Somathilake, Gayasha, Harvie, Michael, Nimasha, Thashmi, Danasekara, Saubhagya, Wijayamuni, Ruwan, Schimanski, Lisa, Rijal, Pramila, Tan, Tiong K., Dong, Tao, Townsend, Alain, Ogg, Graham S., Malavige, Gathsaurie Neelika“…ACE2 receptor blocking antibodies (ACE2R-Ab), antibodies to the receptor binding domain (RBD) of the ancestral virus (WT) and variants of concern, were measured in a sub cohort. …”
Publicado 2021
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3555por Jarlhelt, Ida, Nielsen, Sif Kaas, Jahn, Camilla Xenia Holtermann, Hansen, Cecilie Bo, Pérez-Alós, Laura, Rosbjerg, Anne, Bayarri-Olmos, Rafael, Skjoedt, Mikkel-Ole, Garred, Peter“…The IgG response towards SARS-CoV-2 receptor-binding domain (RBD) after natural infection appeared to be mainly driven by IgG1 and IgG3 subclasses, which are the main ligands for C1q mediated classical complement pathway activation. …”
Publicado 2021
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3556por Mahindra, Amit, Tejeda, Gonzalo, Rossi, Mario, Janha, Omar, Herbert, Imogen, Morris, Caroline, Morgan, Danielle C., Beattie, Wendy, Montezano, Augusto C., Hudson, Brian, Tobin, Andrew B., Bhella, David, Touyz, Rhian M., Jamieson, Andrew G., Baillie, George S., Blair, Connor M.“…However, the RBM peptides demonstrated only modest effects in preventing S(RBD) internalisation and showed no antiviral activity in a spike protein trimer neutralisation assay. …”
Publicado 2021
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3557por Olbrich, Laura, Castelletti, Noemi, Schälte, Yannik, Garí, Mercè, Pütz, Peter, Bakuli, Abhishek, Pritsch, Michael, Kroidl, Inge, Saathoff, Elmar, Guggenbuehl Noller, Jessica Michelle, Fingerle, Volker, Le Gleut, Ronan, Gilberg, Leonard, Brand, Isabel, Falk, Philine, Markgraf, Alisa, Deák, Flora, Riess, Friedrich, Diefenbach, Max, Eser, Tabea, Weinauer, Franz, Martin, Silke, Quenzel, Ernst-Markus, Becker, Marc, Durner, Jürgen, Girl, Philipp, Müller, Katharina, Radon, Katja, Fuchs, Christiane, Wölfel, Roman, Hasenauer, Jan, Hoelscher, Michael, Wieser, Andreas“…Neutralisation surrogate tests (GeneScriptcPass, Mikrogen-recomLine-RBD) were >94.9% sensitive and >98.1% specific. …”
Publicado 2021
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3558por Vanhove, Bernard, Marot, Stéphane, So, Ray T., Gaborit, Benjamin, Evanno, Gwénaëlle, Malet, Isabelle, Lafrogne, Guillaume, Mevel, Edwige, Ciron, Carine, Royer, Pierre-Joseph, Lheriteau, Elsa, Raffi, François, Bruzzone, Roberto, Mok, Chris Ka Pun, Duvaux, Odile, Marcelin, Anne-Geneviève, Calvez, Vincent“…XAV-19 is a swine glyco-humanized polyclonal neutralizing antibody raised against the receptor binding domain (RBD) of the Wuhan-Hu-1 Spike protein of SARS-CoV-2. …”
Publicado 2021
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3559por Redecke, Vanessa, Tawaratsumida, Kazuki, Larragoite, Erin T., Williams, Elizabeth S. C. P., Planelles, Vicente, Spivak, Adam M., Hirayama, Lincoln, Elgort, Marc, Swenson, Shane, Smith, Rick, Worthen, Bryan, Zimmerman, Russ, Slev, Patricia, Cahoon, Ben, Astill, Mark, Häcker, Hans“…We established a hemagglutination-based AB test that is based on bi-specific proteins which contain a dromedary-derived antibody (nanobody) binding red blood cells (RBD) and a SARS-CoV-2-derived antigen, such as the receptor-binding domain of the Spike protein (Spike-RBD). …”
Publicado 2021
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3560por Gräf, Tiago, Bello, Gonzalo, Venas, Taina Moreira Martins, Pereira, Elisa Cavalcante, Paixão, Anna Carolina Dias, Appolinario, Luciana Reis, Lopes, Renata Serrano, Mendonça, Ana Carolina Da Fonseca, da Rocha, Alice Sampaio Barreto, Motta, Fernando Couto, Gregianini, Tatiana Schäffer, Salvato, Richard Steiner, Fernandes, Sandra Bianchini, Rovaris, Darcita Buerger, Cavalcanti, Andrea Cony, Leite, Anderson Brandão, Riediger, Irina, Debur, Maria do Carmo, Bernardes, André Felipe Leal, Ribeiro-Rodrigues, Rodrigo, Grinsztejn, Beatriz, Alves do Nascimento, Valdinete, de Souza, Victor Costa, Gonçalves, Luciana, da Costa, Cristiano Fernandes, Mattos, Tirza, Dezordi, Filipe Zimmer, Wallau, Gabriel Luz, Naveca, Felipe Gomes, Delatorre, Edson, Siqueira, Marilda Mendonça, Resende, Paola Cristina“…Our evolutionary analyses estimate that P.1-ancestral strains carrying RBD mutations of concern probably circulated cryptically in the Amazonas for several months before the emergence of the VOC Gamma. …”
Publicado 2021
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