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341por Poon, Rosana Wing-Shan, Lu, Lu, Fong, Carol Ho-Yan, Ip, Tak-Chuen, Chen, Lin-Lei, Zhang, Ricky Rui-Qi, Yip, Cyril Chik-Yan, Cheng, Vincent Chi-Chung, Chan, Kwok-Hung, Yuen, Kwok-Yung, To, Kelvin Kai-Wang“…However, the correlation between the anti-RBD or the anti-N IgG and the MN titer against the beta variant was poor. …”
Publicado 2021
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342por Septisetyani, Endah Puji, Prasetyaningrum, Pekik Wiji, Anam, Khairul, Santoso, AdiEnlace del recurso
Publicado 2021
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343por Kim, Seonghan, Liu, Yi, Ziarnik, Matthew, Cao, Yiwei, Zhang, X. Frank, Im, Wonpil“…Our MST data confirmed that the Omicron mutations in RBD are associated with a five-fold higher binding affinity to ACE2 compared to the RBD of the original strain. …”
Publicado 2022
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344por Santana-Mederos, Darielys, Perez-Nicado, Rocmira, Climent, Yanet, Rodriguez, Laura, Ramirez, Belinda Sanchez, Perez-Rodriguez, Sonia, Rodriguez, Meybi, Labrada, Claudia, Hernandez, Tays, Diaz, Marianniz, Orosa, Ivette, Ramirez, Ubel, Oliva, Reynaldo, Garrido, Raine, Cardoso, Felix, Landys, Mario, Martinez, Roselyn, Gonzalez, Humberto, Hernandez, Tamara, Ochoa-Azze, Rolando, Perez, Jose L., Enriquez, Juliet, Gonzalez, Nibaldo, Infante, Yenicet, Espinosa, Luis A., Ramos, Yassel, González, Luis Javier, Valenzuela, Carmen, Casadesus, Ana Victoria, Fernandez, Briandy, Rojas, Gertrudis, Pérez-Massón, Beatriz, Tundidor, Yaima, Bermudez, Ernesto, Plasencia, Claudia A., Boggiano, Tammy, Ojito, Eduardo, Chiodo, Fabrizio, Fernandez, Sonsire, Paquet, Françoise, Fang, Cheng, Chen, Guang-Wu, Rivera, Daniel G., Valdes-Balbin, Yury, Garcia-Rivera, Dagmar, Verez Bencomo, Vicente“…SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host's cellular receptor. Vaccines seek to block this interaction by eliciting neutralizing antibodies, most of which are directed toward the RBD. …”
Publicado 2021
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345por Xue, Jun-biao, Lai, Dan-yun, Jiang, He-wei, Qi, Huan, Guo, Shu-juan, Zhu, Yuan-shou, Xu, Hong, Zhou, Jie, Tao, Sheng-ceEnlace del recurso
Publicado 2022
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346“…The phytochemicals limonin and glycyrrhizic acid were docked with the SGp RBD of the variants WT, Delta and Omicron. The computed dock score revealed that limonin and glycyrrhizic acid binds effectively at the SGp RBD of all three variants, and showed almost similar binding affinity at the binding interface of ACE2. …”
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347por Cong, Mengqing, Yang, Yunru, Tong, Haiyang, Shimu, Ajmeri Sultana, Wang, Baolong, Li, Qing, Li, Fengyin, Yang, Yi, Jin, Tengchuan, Li, BofengEnlace del recurso
Publicado 2022
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348por Trofin, Felicia, Nastase, Eduard Vasile, Iancu, Luminita Smaranda, Constantinescu, Daniela, Cianga, Corina Maria, Lunca, Catalina, Ursu, Ramona Gabriela, Cianga, Petru, Dorneanu, Olivia Simona“…The anti-RBD IgA titers were approximately five-times higher than the anti-RBD IgG ones. …”
Publicado 2022
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349por Zhang, Lingbing, Zhang, Yandan, Qin, Xia, Jiang, Xuejun, Zhang, Jun, Mao, Lejiao, Jiang, Ziqi, Jiang, Yu, Liu, Gang, Qiu, Jingfu, Chen, Chengzhi, Qiu, Feng, Zou, Zhen“…Importantly, rACE2 remarkably reversed SARS-CoV-2 spike RBD protein-induced ALI by directly binding SARS-CoV-2 spike RBD protein, cleaving AngI or cleaving AngII. …”
Publicado 2022
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350por Silwal, Achut Prasad, Thennakoon, Siddhartha Kalpa Samadhi, Arya, Satya Prakash, Postema, Rick Mason, Jahan, Raunak, Phuoc, Chien Minh Tran, Tan, Xiaohong“…More importantly, the S2A2C1 aptamer does not bind to the RBD of the spike-protein, but it efficiently blocks the spike-protein/hACE2 interaction, suggesting an RBD-independent inhibition approach. …”
Publicado 2022
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351por Segura-Villalobos, Deisy, Roa-Velázquez, Daniela, Zavala-Vargas, Dan I., Filisola-Villaseñor, Jessica G., Castillo Arellano, Jorge Ivan, Morales Ríos, Edgar, Reyes-Chilpa, Ricardo, González-Espinosa, Claudia“…The receptor-binding domain (RBD) of Spike (S) viral protein (S-RBD) is essential for virus infection and its interacting molecules in target cells are still under identification. …”
Publicado 2022
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352por Liu, Shuo, Jia, Zijing, Nie, Jianhui, Liang, Ziteng, Xie, Jingshu, Wang, Lei, Zhang, Li, Wang, Xiangxi, Wang, Youchun, Huang, WeijinEnlace del recurso
Publicado 2022
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353por He, Yunxia, Yu, Weili, Shen, Lijuan, Yan, Wenying, Xiao, Lucheng, Qi, Jinming, Hu, Tao“…Here, IC28 and mannan were both covalently conjugated with RBD from E. coli. The conjugate (RBD-IC28-M) elicited high RBD-specific IgG titers, and a neutralization antibody titer of 201.4. …”
Publicado 2022
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354por Ghaemi, Amir, Roshani Asl, Parisa, Zargaran, Hedieh, Ahmadi, Delaram, Hashimi, Asim Ali, Abdolalipour, Elahe, Bathaeian, Sahar, Miri, Seyed Mohammad“…The RBD and N were separately expressed in E. coli and purified using column chromatography. …”
Publicado 2022
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355“…In particular, the hotspot residues at Q493, Q498, and N501 on the S-RBD protein were determined as contributing factors to the employment stability of the relevant binding interface. …”
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356por Yilmaz, Aysun, Turan, Nuri, Kocazeybek, Bekir Sami, Dinc, Harika Oyku, Tali, Hasan Emre, Aydin, Ozge, Tali, Hamid Besim, Yilmaz, Semaha Gul, Konukoglu, Dildar, Borekci, Sermin, Bold, Dashzeveg, Roman Sosa, Gleyder, Gungordu, Nejdiye, Vardaloglu, Ilgim, Gareayaghi, Nesrin, Guzel, Mine, Guner, Ebru, Sadeyen, Jean-Remy, Chang, Pengxiang, Iqbal, Munir, Richt, Juergen A., Yilmaz, Huseyin“…(1) Background: The aim of this study was to produce in-house ELISAs which can be used to determine SARS-CoV-2-specific antibody levels directed against the spike protein (S), the S1 subunit of S and the receptor binding domain (RBD) of S in SARS-CoV-2 vaccinated and infected humans. (2) Methods: Three in-house ELISAs were developed by using recombinant proteins of SARS-CoV-2, namely the S, S1 and RBD proteins. …”
Publicado 2022
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357por Teng, Changcai, Meng, Xiongyan, Hu, Yeqin, Mao, Hongzhao, Li, Huiting, Yang, Jing, Sun, Tiantian, Meng, Shuai, Zong, Chengli“…In vivo, vaccination using the SARS-CoV-2 RBD trimer as the antigen and the conjugate as the adjuvant induced a significantly higher amount of IgG2a. …”
Publicado 2022
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358“…Since the host cell receptor plays a critical role in viral entry, inhibition of the RBD–ACE2 complex is a promising strategy for preventing COVID-19 infection. …”
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359por Rodriguez-Aponte, Sergio A., Dalvie, Neil C., Wong, Ting Y., Johnston, Ryan S., Naranjo, Christopher A., Bajoria, Sakshi, Kumru, Ozan S., Kaur, Kawaljit, Russ, Brynnan P., Lee, Katherine S., Cyphert, Holly A., Barbier, Mariette, Rao, Harish D., Rajurkar, Meghraj P., Lothe, Rakesh R., Shaligram, Umesh S., Batwal, Saurabh, Chandrasekaran, Rahul, Nagar, Gaurav, Kleanthous, Harry, Biswas, Sumi, Bevere, Justin R., Joshi, Sangeeta B., Volkin, David B., Damron, F. Heath, Love, J. Christopher“…We previously reported an engineered variant of the SARS-CoV-2 Spike protein receptor binding domain antigen (RBD-L452K-F490W; RBD-J) with enhanced manufacturability and immunogenicity compared to the ancestral RBD. …”
Publicado 2023
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360por Zhang, Haili, Jin, Hongli, Yan, Feihu, Song, Yumeng, Dai, Jiaxin, Jiao, Cuicui, Bai, Yujie, Sun, Jingxuan, Liu, Di, Wang, Shen, Zhang, Mengyao, Lu, Jilong, Huang, Jingbo, Huang, Pei, Li, Yuanyuan, Xia, Xianzhu, Wang, Hualei“…Notably, inactivated SRV-nCoV-RBD induced earlier antibody production than SRV-nCoV-S1, which was maintained at high levels for longer periods. …”
Publicado 2022
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