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3581por Meyer, Benjamin, Martinez-Murillo, Paola Andrea, Lemaitre, Barbara, Blanchard-Rohner, Géraldine, Didierlaurent, Arnaud M., Fontannaz, Paola, Eugercios Manzanas, Chloé, Lambert, Paul-Henri, Loevy, Natasha, Kaiser, Laurent, Sartoretti, Julie, Tougne, Chantal, Villard, Jean, Huttner, Angela, Siegrist, Claire-Anne, Eberhardt, Christiane S.“…Antibody titers waned over time, whilst potent affinity maturation was observed for anti-RBD antibodies. Neutralizing antibodies against wild-type (WT) and variants decayed during the first 6 months but titers significantly increased for Alpha, Gamma and Delta between 6 months and one year. …”
Publicado 2022
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3582por Mariotto, Sara, Carta, Sara, Dinoto, Alessandro, Lippi, Giuseppe, Salvagno, Gian Luca, Masin, Laura, Alberti, Daniela, Marignier, Romain, Ferrari, Sergio“…SARS‐CoV‐2 immunoglobulin G (IgG) levels were analysed using an anti‐SARS‐CoV‐2 US Food and Drug Administration‐approved ELISA assay and confirmed with a trimeric anti‐SARS‐CoV‐2 S1/S2 IgG immunochemiluminescent test, concomitantly assaying the anti‐receptor binding domain (RBD) of spike protein IgG and anti‐RBD total Ig. …”
Publicado 2022
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3583por Adler, Julia Maria, Weber, Corinna, Wernike, Kerstin, Michelitsch, Anna, Friedrich, Karin, Trimpert, Jakob, Beer, Martin, Kohn, Barbara, Osterrieder, Klaus, Müller, Elisabeth“…Our results showed an overall SARS‐CoV‐2 seropositivity of 1.9% (n = 19) in a receptor‐binding domain (RBD)‐based ELISA, additional 0.8% (n = 8) were giving inconclusive results. …”
Publicado 2022
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3584por Dinç, Harika Öykü, Demirci, Mehmet, Özdemir, Yusuf Emre, Sirekbasan, Serhat, Aktaş, Ayse Nur, Karaali, Rıdvan, Tok, Yeşim Tuyji, Özbey, Doğukan, Akçin, Rüveyda, Gareayaghi, Nesrin, Kuşkucu, Mert Ahmet, Midilli, Kenan, Aygün, Gökhan, Sarıbaş, Suat, Kocazeybek, Bekir“…The first and second serum samples were taken 1 and 7 months, respectively, after the PCR positivity. S1/RBD-specific IgG antibody response was assayed using anti-SARS-CoV- 2 QuantiVac ELISA (IgG) kit (Euroimmun, Lübeck, Germany). …”
Publicado 2022
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3585“…In addition to quantitative determination of IgG antibody levels against the SARS-CoV-2 receptor-binding domain (RBD) of the spike protein subunit S1, a SARS-CoV-2 surrogate neutralization test (sVNT) was used to assess potential neutralization capacity. …”
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3586por Wu, Li, Xu, Qian, Zhou, Mengxi, Chen, Yajing, Jiang, Chunyan, Jiang, Yuhan, Lin, Yin, He, Qing, Zhao, Lei, Dong, Yourong, Liu, Jianren, Chen, Wei“…Plasma miR-223 level was decreased in patients with clinical possible rapid eye movement sleep behavior disorder (cpRBD) compared with those without cpRBD (p < 0.001), and its level was negatively associated with RBDSQ score (r = -0.334, p = 0.003). …”
Publicado 2022
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3587por Andreata-Santos, Robert, Machado, Rafael Rahal Guaragna, Alves, Rúbens Prince dos Santos, Sales, Natiely Silva, Soares, Camila Pereira, Rodrigues, Karine Bitencourt, Silva, Mariângela Oliveira, Favaro, Marianna Teixeira de Pinho, Rodrigues-Jesus, Mônica Josiane, Yamamoto, Márcio Massao, de Andrade, Juliana Bannwart, Fock, Ricardo Ambrósio, Margarido, Paulo Francisco Ramos, Carvalho, Cristiane Rodrigues Guzzo, Boscardin, Silvia Beatriz, Durigon, Edison Luiz, Ferreira, Luís C. S.“…We observed high sensitivity and specificity values with the Elecsys (96.92% and 98.78%, respectively) and N-ELISA (93.94% and 94.40%, respectively), compared with RBD-ELISA (90.91% sensitivity and 88.80% specificity) and the ΔS1-ELISA (77.27% sensitivity and 76% specificity). …”
Publicado 2022
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3588por Hanssen, D.A.T., Penders, J., Heijgele, K., de Leede, S., Mulder, M., Bank, L.E.A., Slaats, M.H.C., Savelkoul, P.H.M., van Loo, I.H.M.“…This study assesses correlations between qualitative total Ig, IgM, IgA, IgG, and quantitative anti-S-RBD antibody responses and participant characteristics. …”
Publicado 2022
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3589por Assawasaksakul, Theerada, Lertussavavivat, Tanat, Sathitratanacheewin, Seelwan, Oudomying, Nont, Vichaiwattana, Preeyaporn, Wanlapakorn, Nasamon, Poovorawan, Yong, Avihingsanon, Yingyos, Assawasaksakul, Nawaporn, Buranapraditkun, Supranee, Kittanamongkolchai, Wonngarm“…This was performed using the serum binding antibody level against the receptor-binding domain of the SARS-CoV-2 spike protein (anti-RBD Ig) and IFNy-ELISpot assay (ELISpot), respectively. …”
Publicado 2022
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3590por Meng, Ziyan, Ma, Danjing, Duan, Suqin, Zhang, Jingjing, Yue, Rong, Li, Xinghang, Gao, Yang, Li, Xueqi, Zeng, Fengyuan, Xu, Xiangxiong, Jiang, Guorun, Liao, Yun, Fan, Shengtao, Niu, Zhenye, Li, Dandan, Yu, Li, Zhao, Heng, Xu, Xingli, Wang, Lichun, Zhang, Ying, Liu, Longding, Li, Qihan“…Objective: We constructed two DNA vaccines containing the receptor-binding domain (RBD) genes of multiple SARS-CoV-2 variants and used them in combination with inactivated vaccines in a variety of different protocols to explore potential novel immunization strategies against SARS-CoV-2 variants. …”
Publicado 2022
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3591por Chantasrisawad, Napaporn, Puthanakit, Thanyawee, Tangsathapornpong, Auchara, Techasaensiri, Chonnamet, Phongsamart, Wanatpreeya, Suwanpakdee, Detchvijitr, Jaruampornpan, Peera, Sophonphan, Jiratchaya, Suntarattiwong, Piyarat, Chotpitayasunondh, Tawee“…Immunogenicity was determined by surrogate virus neutralization test (sVNT) and IgG against receptor-binding domain (RBD). From August to October 2021, 312 adolescents, with a median age (IQR) of 15 years (13.7–16.5), were enrolled (group A 100, group B 212). …”
Publicado 2022
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3592por Boadu, Akwasi, Agoni, Clement, Karpoormath, Rajshekhar, Soliman, Mahmoud, Nlooto, Manimbulu“…We identified Geraniin and 2-O-Caffeoyl-(+)-allohydroxycitric acid as potential SARS-CoV-2 inhibitor candidates targeting the SARS-CoV-2 RNA-dependent polymerase receptor-binding domain (RBD) of SARS-CoV-2 viral S-protein and the 3C-like main protease (3CL(pro)). …”
Publicado 2022
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3593“…Recently, we generated a novel chimeric protein (designated Tcd169), comprised of the glucosyltransferase domain (GT), the cysteine protease domain (CPD), and the receptor binding domain (RBD) of TcdB, and the RBD of TcdA. Parenteral immunizations with Tcd169 provide mice effective protection against infection with a ribotype (RT) 027 C. difficile strain. …”
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3594por Sáez-Llorens, Xavier, Lanata, Claudio, Aranguren, Elaine, Celis, Carlos R., Cornejo, Rubelio, DeAntonio, Rodrigo, Ecker, Lucie, Garrido, Diegi, Gil, Ana I., Gonzales, Marina, Hess-Holtz, Morgan, Leroux-Roels, Geert, Junker, Helga, Kays, Sarah-Katharina, Koch, Sven D., Lazzaro, Sandra, Mann, Philipp, Quintini, Gianluca, Srivastava, Barkha, Vahrenhorst, Dominik, von Eisenhart-Rothe, Philipp, Wolz, Olaf-Oliver, Oostvogels, Lidia“…Humoral immunogenicity was measured as neutralizing and receptor binding domain (RBD) IgG antibodies and cellular immunogenicity was assessed as CD4+/CD8 + T cell responses. …”
Publicado 2022
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3595por Bertini, Sabrina, Alekseeva, Anna, Elli, Stefano, Pagani, Isabel, Zanzoni, Serena, Eisele, Giorgio, Krishnan, Ravi, Maag, Klaus P., Reiter, Christian, Lenhart, Dominik, Gruber, Rudolf, Yates, Edwin A, Vicenzi, Elisa, Naggi, Annamaria, Bisio, Antonella, Guerrini, Marco“…Isothermal titration calorimetry and viral plaque-forming assays demonstrated size-dependent binding to S1 RBD and inhibition of Vero cell invasion, suggesting the potential application of PPS as a novel inhibitor of SARS-CoV-2 infection.…”
Publicado 2022
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3596por Yu, Meng, Zhu, Zhu, Wang, Yanqun, Wang, Pingzhang, Jia, Xiaodong, Wang, Jie, Liu, Lei, Liu, Wanbing, Zheng, Yaqiong, Kou, Guomei, Xu, Weiyan, Huang, Jing, Lu, Fengmin, Zou, Xiajuan, Zheng, Shangen, Lu, Yinying, Zhao, Jincun, Dai, Hui, Qiu, Xiaoyan“…We first predicted and synthesized several B cell epitopes on RBD and adjacent RBD of S protein, then the B cell epitopes were used to prepare affinity chromatography columns respectively and purify the binding IgG from serum samples of convalescent COVID-19 patients. …”
Publicado 2022
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3597por Muecksch, Frauke, Wang, Zijun, Cho, Alice, Gaebler, Christian, Ben Tanfous, Tarek, DaSilva, Justin, Bednarski, Eva, Ramos, Victor, Zong, Shuai, Johnson, Brianna, Raspe, Raphael, Schaefer-Babajew, Dennis, Shimeliovich, Irina, Daga, Mridushi, Yao, Kai-Hui, Schmidt, Fabian, Millard, Katrina G., Turroja, Martina, Jankovic, Mila, Oliveira, Thiago Y., Gazumyan, Anna, Caskey, Marina, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.“…We find that the third dose is accompanied by an increase in, and evolution of, receptor-binding domain (RBD)-specific memory B cells. The increase is due to expansion of memory B cell clones that were present after the second dose as well as the emergence of new clones. …”
Publicado 2022
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3598por Costa, Priscilla Ramos, Correia, Carolina Argondizo, Marmorato, Mariana Prado, de Carvalho Dias, Juliana Zanatta, Thomazella, Mateus Vailant, da Silva, Amanda Cabral, de Oliveira, Ana Carolina Soares, Gusmão, Arianne Fagotti, Ferrari, Lilian, Freitas, Angela Carvalho, Patiño, Elizabeth González, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Scharf, Rami, Kallas, Esper Georges, Terrassani Silveira, Cássia Gisele“…IgG levels against Wuhan/WH04/2020 N, S and receptor binding domain (RBD) antigens and the variants of concern (VOCs, including B.1.1.7/Alpha, B.1.351/Beta and P.1/Gamma) S and RBD antigens peaked 14 days after the second vaccine shot, and were mostly stable for a 1-year period. …”
Publicado 2022
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3599por Arnaldi, Dario, Mattioli, Pietro, Famà, Francesco, Girtler, Nicola, Brugnolo, Andrea, Pardini, Matteo, Donniaquio, Andrea, Massa, Federico, Orso, Beatrice, Raffa, Stefano, Bauckneht, Matteo, Morbelli, Silvia, Nobili, Flavio“…METHODS: Forty‐seven consecutive iRBD patients (68.53 ± 7.16 years, 40 males) underwent baseline clinical and neuropsychological assessment, olfaction test, resting electroencephalogram (EEG), and DAT‐SPECT. …”
Publicado 2021
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3600por Assawakosri, Suvichada, Kanokudom, Sitthichai, Chansaenroj, Jira, Suntronwong, Nungruthai, Auphimai, Chompoonut, Nilyanimit, Pornjarim, Vichaiwattana, Preeyaporn, Thongmee, Thanunrat, Duangchinda, Thaneeya, Chantima, Warangkana, Pakchotanon, Pattarakul, Srimuan, Donchida, Thatsanatorn, Thaksaporn, Klinfueng, Sirapa, Sudhinaraset, Natthinee, Mongkolsapaya, Juthathip, Wanlapakorn, Nasamon, Honsawek, Sittisak, Poovorawan, Yong“…Total receptor-binding domain (RBD) immunoglobulin (Ig) levels, anti-RBD IgG, and focus reduction neutralization test against Omicron BA.1 and BA.2 variants and T cell response peaked at 14-28 days after booster vaccination. …”
Publicado 2022
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